"Quinine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It was used commonly and as a bitter and flavoring agent, and is still useful for the treatment of babesiosis. Quinine is also useful in some muscular disorders, especially nocturnal leg cramps and myotonia congenita, because of its direct effects on muscle membrane and sodium channels. The mechanisms of its antimalarial effects are not well understood.
| Descriptor ID |
D011803
|
| MeSH Number(s) |
D03.132.206.719 D03.605.687.762 D03.633.100.810.762
|
| Concept/Terms |
Quinine Sulfate- Quinine Sulfate
- Sulfate, Quinine
- Quinine Sulphate
- Sulphate, Quinine
|
Below are MeSH descriptors whose meaning is more general than "Quinine".
Below are MeSH descriptors whose meaning is more specific than "Quinine".
This graph shows the total number of publications written about "Quinine" by people in this website by year, and whether "Quinine" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2018 | 0 | 1 | 1 |
| 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "Quinine" by people in Profiles.
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Powers RE, Fogel PA, Reeves JH, Madrid P, Moschak TM. Distinct populations suppress or escalate intake of cocaine paired with aversive quinine. Drug Alcohol Depend. 2024 Dec 01; 265:112475.
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Moschak TM, Wang X, Carelli RM. A Neuronal Ensemble in the Rostral Agranular Insula Tracks Cocaine-Induced Devaluation of Natural Reward and Predicts Cocaine Seeking. J Neurosci. 2018 09 26; 38(39):8463-8472.
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Zou L, Xue Y, Jones M, Heinbockel T, Ying M, Zhan X. The Effects of Quinine on Neurophysiological Properties of Dopaminergic Neurons. Neurotox Res. 2018 07; 34(1):62-73.
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Huertas A, Wessinger WD, Kucheryavykh YV, Sanabria P, Eaton MJ, Skatchkov SN, Rojas LV, Maldonado-Mart?nez G, Inyushin MY. Quinine enhances the behavioral stimulant effect of cocaine in mice. Pharmacol Biochem Behav. 2015 Feb; 129:26-33.
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Crabbe JC, Spence SE, Brown LL, Metten P. Alcohol preference drinking in a mouse line selectively bred for high drinking in the dark. Alcohol. 2011 Aug; 45(5):427-40.
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Iniouchine MY, Sibarov DA, Volnova AB, Jimenez-Rivera CA, Nozdrachev AD. Blockers of monoamine transporters influence high dopamine concentration uptake in rat brain slices. Dokl Biol Sci. 2008 Mar-Apr; 419:80-2.
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Dolmans DE, Thuma PE, Mabeza GF, Biemba G, Parry D, McLaren CE, Gordeuk VR. A prospective study of combination antimalarial therapy and of anaemia in Zambian children with cerebral malaria. Ann Trop Med Parasitol. 1999 Jul; 93(5):527-31.
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Mabeza GF, Biemba G, Brennan AG, Moyo VM, Thuma PE, Gordeuk VR. The association of pallor with haemoglobin concentration and mortality in severe malaria. Ann Trop Med Parasitol. 1998 Sep; 92(6):663-9.
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van der Torn M, Thuma PE, Mabeza GF, Biemba G, Moyo VM, McLaren CE, Brittenham GM, Gordeuk VR. Loading dose of quinine in African children with cerebral malaria. Trans R Soc Trop Med Hyg. 1998 May-Jun; 92(3):325-31.
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Thuma PE, Mabeza GF, Biemba G, Bhat GJ, McLaren CE, Moyo VM, Zulu S, Khumalo H, Mabeza P, M'Hango A, Parry D, Poltera AA, Brittenham GM, Gordeuk VR. Effect of iron chelation therapy on mortality in Zambian children with cerebral malaria. Trans R Soc Trop Med Hyg. 1998 Mar-Apr; 92(2):214-8.