Myelin Sheath

"Myelin Sheath" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The lipid-rich sheath surrounding AXONS in both the CENTRAL NERVOUS SYSTEMS and PERIPHERAL NERVOUS SYSTEM. The myelin sheath is an electrical insulator and allows faster and more energetically efficient conduction of impulses. The sheath is formed by the cell membranes of glial cells (SCHWANN CELLS in the peripheral and OLIGODENDROGLIA in the central nervous system). Deterioration of the sheath in DEMYELINATING DISEASES is a serious clinical problem.

Descriptor ID	D009186
MeSH Number(s)	A08.637.600.500 A08.637.800.500 A08.675.542.512.560 A08.800.800.690.500 A10.755.503 A11.284.149.165.600 A11.650.600.500 A11.650.800.500 A11.671.501.512.560 A11.671.514.553
Concept/Terms	Myelin Sheath Myelin Sheath Myelin Sheaths Sheath, Myelin Sheaths, Myelin Myelin Myelin

Below are MeSH descriptors whose meaning is more general than "Myelin Sheath".

Anatomy [A]
Nervous System [A08]
Neuroglia [A08.637]
Oligodendroglia [A08.637.600]
Myelin Sheath [A08.637.600.500]
Schwann Cells [A08.637.800]
Myelin Sheath [A08.637.800.500]
Neurons [A08.675]
Nerve Fibers [A08.675.542]
Nerve Fibers, Myelinated [A08.675.542.512]
Myelin Sheath [A08.675.542.512.560]
Peripheral Nervous System [A08.800]
Peripheral Nerves [A08.800.800]
Schwann Cells [A08.800.800.690]
Myelin Sheath [A08.800.800.690.500]
Tissues [A10]
Nerve Tissue [A10.755]
Myelin Sheath [A10.755.503]
Cells [A11]
Cellular Structures [A11.284]
Cell Membrane [A11.284.149]
Cell Membrane Structures [A11.284.149.165]
Myelin Sheath [A11.284.149.165.600]
Neuroglia [A11.650]
Oligodendroglia [A11.650.600]
Myelin Sheath [A11.650.600.500]
Schwann Cells [A11.650.800]
Myelin Sheath [A11.650.800.500]
Neurons [A11.671]
Nerve Fibers [A11.671.501]
Nerve Fibers, Myelinated [A11.671.501.512]
Myelin Sheath [A11.671.501.512.560]
Nerve Fibers, Myelinated [A11.671.514]
Myelin Sheath [A11.671.514.553]

Below are MeSH descriptors whose meaning is related to "Myelin Sheath".

Below are MeSH descriptors whose meaning is more specific than "Myelin Sheath".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Myelin Sheath" by people in this website by year, and whether "Myelin Sheath" was a major or minor topic of these publications.

Bar chart showing 32 publications over 23 distinct years, with a maximum of 4 publications in 2011

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	1	1
1998	0	1	1
1999	0	1	1
2000	1	0	1
2001	0	1	1
2002	0	1	1
2004	1	0	1
2006	1	1	2
2007	0	1	1
2008	1	0	1
2010	0	2	2
2011	3	1	4
2012	0	1	1
2013	1	0	1
2014	1	2	3
2015	1	0	1
2016	1	0	1
2019	1	0	1
2020	1	0	1
2022	0	1	1
2023	0	2	2
2024	1	0	1
2025	1	1	2

Below are the most recent publications written about "Myelin Sheath" by people in Profiles.

Ma C, Wurlitzer K, Nunes LGA, Hoffmann PR, Pitts MW. Iron and selenium: At the crossroads of development and death in oligodendrocytes. Arch Biochem Biophys. 2025 Sep; 771:110509.

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Huang J, Che J, Kee MZL, Tan AP, Law EC, Silveira PP, Pokhvisneva I, Patel S, Godfrey KM, Daniel LM, Tan KH, Chong YS, Chan SY, Eriksson JG, Wang D, Huang JY. Linking obesity-associated genotype to child language development: the role of early-life neurology-related proteomics and brain myelination. EBioMedicine. 2025 Mar; 113:105579.

View in: PubMed
Nunes LGA, Ma C, Hoffmann FW, Shay AE, Pitts MW, Hoffmann PR. Selenoprotein I is indispensable for ether lipid homeostasis and proper myelination. J Biol Chem. 2024 05; 300(5):107259.

View in: PubMed
Jammoul M, Jammoul D, Wang KK, Kobeissy F, Depalma RG. Traumatic Brain Injury and Opioids: Twin Plagues of the Twenty-First Century. Biol Psychiatry. 2024 01 01; 95(1):6-14.

View in: PubMed
Chuang YC, Alcantara A, Fabris G, Abderezaei J, Lu TA, Melendez-Vasquez CV, Kurt M. Myelination dictates axonal viscoelasticity. Eur J Neurosci. 2023 04; 57(8):1225-1240.

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Mendiola AS, Church KA, Cardona SM, Vanegas D, Garcia SA, Macklin W, Lira SA, Ransohoff RM, Kokovay E, Lin CA, Cardona AE. Defective fractalkine-CX3CR1 signaling aggravates neuroinflammation and affects recovery from cuprizone-induced demyelination. J Neurochem. 2022 09; 162(5):430-443.

View in: PubMed
Domingues HS, Urbanski MM, Macedo-Ribeiro S, Almaktari A, Irfan A, Hernandez Y, Wang H, Relvas JB, Rubinstein B, Melendez-Vasquez CV, Pinto IM. Pushing myelination - developmental regulation of myosin expression drives oligodendrocyte morphological differentiation. J Cell Sci. 2020 08 05; 133(15).

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Ban Y, Dong W, Zhang L, Zhou T, Altiti AS, Ali K, Mootoo DR, Blaho VA, Hla T, Ren Y, Ma X. Abrogation of Endogenous Glycolipid Antigen Presentation on Myelin-Laden Macrophages by D-Sphingosine Ameliorates the Pathogenesis of Experimental Autoimmune Encephalomyelitis. Front Immunol. 2019; 10:404.

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Urbanski MM, Kingsbury L, Moussouros D, Kassim I, Mehjabeen S, Paknejad N, Melendez-Vasquez CV. Myelinating glia differentiation is regulated by extracellular matrix elasticity. Sci Rep. 2016 09 20; 6:33751.

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Sosa RA, Murphey C, Robinson RR, Forsthuber TG. IFN-? ameliorates autoimmune encephalomyelitis by limiting myelin lipid peroxidation. Proc Natl Acad Sci U S A. 2015 Sep 08; 112(36):E5038-47.

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