"Desipramine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
| Descriptor ID |
D003891
|
| MeSH Number(s) |
D03.633.300.240.281
|
| Concept/Terms |
Desipramine- Desipramine
- Desmethylimipramine
- Demethylimipramine
|
Below are MeSH descriptors whose meaning is more general than "Desipramine".
Below are MeSH descriptors whose meaning is more specific than "Desipramine".
This graph shows the total number of publications written about "Desipramine" by people in this website by year, and whether "Desipramine" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 1 | 2 |
| 2005 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 1 | 1 | 2 |
| 2009 | 0 | 1 | 1 |
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Below are the most recent publications written about "Desipramine" by people in Profiles.
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Friedman A, Merenlender A, Lax E, Rosenstein M, Lubin N, Yadid G. Early prediction of the effectiveness of antidepressants: inputs from an animal model. J Mol Neurosci. 2009 Sep; 39(1-2):256-61.
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Serafine KM, Riley AL. Possible role of norepinephrine in cocaine-induced conditioned taste aversions. Pharmacol Biochem Behav. 2009 Mar; 92(1):111-6.
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Friedman A, Friedman Y, Dremencov E, Yadid G. VTA dopamine neuron bursting is altered in an animal model of depression and corrected by desipramine. J Mol Neurosci. 2008 Mar; 34(3):201-9.
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Basile AS, Janowsky A, Golembiowska K, Kowalska M, Tam E, Benveniste M, Popik P, Nikiforuk A, Krawczyk M, Nowak G, Krieter PA, Lippa AS, Skolnick P, Koustova E. Characterization of the antinociceptive actions of bicifadine in models of acute, persistent, and chronic pain. J Pharmacol Exp Ther. 2007 Jun; 321(3):1208-25.
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Piletz J, Baker R, Halaris A. Platelet imidazoline receptors as state marker of depressive symptomatology. J Psychiatr Res. 2008 Jan; 42(1):41-9.
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Friedman A, Dremencov E, Crown H, Levy D, Mintz M, Overstreet DH, Yadid G. Variability of the mesolimbic neuronal activity in a rat model of depression. Neuroreport. 2005 Apr 04; 16(5):513-6.
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Piletz JE, Halaris AE, Chikkala D, Qu Y. Platelet I1-imidazoline binding sites are decreased by two dissimilar antidepressant agents in depressed patients. J Psychiatr Res. 1996 May-Jun; 30(3):169-84.
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Piletz JE, Halaris A, Nelson J, Qu Y, Bari M. Platelet I1-imidazoline binding sites are elevated in depression but not generalized anxiety disorder. J Psychiatr Res. 1996 May-Jun; 30(3):147-68.
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Piletz JE, DeMet E, Gwirtsman HE, Halaris A. Disruption of circadian MHPG rhythmicity in major depression. Biol Psychiatry. 1994 Jun 01; 35(11):830-42.
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Piletz JE, Halaris A, Saran A, Marler MR. Desipramine lowers tritiated para-aminoclonidine binding in platelets of depressed patients. Arch Gen Psychiatry. 1991 Sep; 48(9):813-20.