"Desipramine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
| Descriptor ID |
D003891
|
| MeSH Number(s) |
D03.633.300.240.281
|
| Concept/Terms |
Desipramine- Desipramine
- Desmethylimipramine
- Demethylimipramine
|
Below are MeSH descriptors whose meaning is more general than "Desipramine".
Below are MeSH descriptors whose meaning is more specific than "Desipramine".
This graph shows the total number of publications written about "Desipramine" by people in this website by year, and whether "Desipramine" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 |
| 1996 | 1 | 1 | 2 |
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
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Below are the most recent publications written about "Desipramine" by people in Profiles.
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Serafine KM, Riley AL. Possible role of norepinephrine in cocaine-induced conditioned taste aversions. Pharmacol Biochem Behav. 2009 Mar; 92(1):111-6.
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Basile AS, Janowsky A, Golembiowska K, Kowalska M, Tam E, Benveniste M, Popik P, Nikiforuk A, Krawczyk M, Nowak G, Krieter PA, Lippa AS, Skolnick P, Koustova E. Characterization of the antinociceptive actions of bicifadine in models of acute, persistent, and chronic pain. J Pharmacol Exp Ther. 2007 Jun; 321(3):1208-25.
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Piletz J, Baker R, Halaris A. Platelet imidazoline receptors as state marker of depressive symptomatology. J Psychiatr Res. 2008 Jan; 42(1):41-9.
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Piletz JE, Halaris AE, Chikkala D, Qu Y. Platelet I1-imidazoline binding sites are decreased by two dissimilar antidepressant agents in depressed patients. J Psychiatr Res. 1996 May-Jun; 30(3):169-84.
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Piletz JE, Halaris A, Nelson J, Qu Y, Bari M. Platelet I1-imidazoline binding sites are elevated in depression but not generalized anxiety disorder. J Psychiatr Res. 1996 May-Jun; 30(3):147-68.
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Piletz JE, DeMet E, Gwirtsman HE, Halaris A. Disruption of circadian MHPG rhythmicity in major depression. Biol Psychiatry. 1994 Jun 01; 35(11):830-42.
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Piletz JE, Halaris A, Saran A, Marler MR. Desipramine lowers tritiated para-aminoclonidine binding in platelets of depressed patients. Arch Gen Psychiatry. 1991 Sep; 48(9):813-20.
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Piletz JE, Sarasua M, Chotani M, Saran A, Halaris A. Relationship between membrane fluidity and adrenoceptor binding in depression. Psychiatry Res. 1991 Jul; 38(1):1-12.
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Piletz JE, Halaris A. Super high affinity 3H-para-aminoclonidine binding to platelet adrenoceptors in depression. Prog Neuropsychopharmacol Biol Psychiatry. 1988; 12(4):541-53.
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Banerjee SP, Kung LS, Riggi SJ, Chanda SK. Development of beta-adrenergic receptor subsensitivity by antidepressants. Nature. 1977 Aug 04; 268(5619):455-6.