"Plicamycin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A tricyclic pentaglycosidic antibiotic from Streptomyces strains that inhibits RNA and protein synthesis by adhering to DNA. It is used as a fluorescent dye and as an antineoplastic agent, especially in bone and testicular tumors. Plicamycin is also used to reduce hypercalcemia, especially that due to malignancies.
| Descriptor ID |
D008926
|
| MeSH Number(s) |
D02.455.426.559.847.562.050.650 D04.615.562.050.650 D09.408.051.059.650
|
| Concept/Terms |
Plicamycin- Plicamycin
- Mitramycin
- Aureolic Acid
- Acid, Aureolic
- Mithramycin
|
Below are MeSH descriptors whose meaning is more general than "Plicamycin".
Below are MeSH descriptors whose meaning is more specific than "Plicamycin".
This graph shows the total number of publications written about "Plicamycin" by people in this website by year, and whether "Plicamycin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2011 | 0 | 3 | 3 |
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click here.
Below are the most recent publications written about "Plicamycin" by people in Profiles.
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Zhao Y, Chen X, Yang H, Zhou L, Okoro EU, Guo Z. A novel function of apolipoprotein E: upregulation of ATP-binding cassette transporter A1 expression. PLoS One. 2011; 6(7):e21453.
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Lin X, Yang H, Zhou L, Guo Z. Nrf2-dependent induction of NQO1 in mouse aortic endothelial cells overexpressing catalase. Free Radic Biol Med. 2011 Jul 01; 51(1):97-106.
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Chen X, Zhao Y, Guo Z, Zhou L, Okoro EU, Yang H. Transcriptional regulation of ATP-binding cassette transporter A1 expression by a novel signaling pathway. J Biol Chem. 2011 Mar 18; 286(11):8917-23.
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Tang T, Lin X, Yang H, Zhou L, Wang Z, Shan G, Guo Z. Overexpression of antioxidant enzymes upregulates aryl hydrocarbon receptor expression via increased Sp1 DNA-binding activity. Free Radic Biol Med. 2010 Aug 01; 49(3):487-92.
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Cai F, Chen B, Zhou W, Zis O, Liu S, Holt RA, Honer WG, Song W. SP1 regulates a human SNAP-25 gene expression. J Neurochem. 2008 Apr; 105(2):512-23.
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Arinze IJ, Kawai Y. Sp family of transcription factors is involved in valproic acid-induced expression of Galphai2. J Biol Chem. 2003 May 16; 278(20):17785-91.