Insulin-Like Growth Factor II

"Insulin-Like Growth Factor II" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A well-characterized neutral peptide believed to be secreted by the LIVER and to circulate in the BLOOD. It has growth-regulating, insulin-like and mitogenic activities. The growth factor has a major, but not absolute, dependence on SOMATOTROPIN. It is believed to be a major fetal growth factor in contrast to INSULIN-LIKE GROWTH FACTOR I, which is a major growth factor in adults.

Descriptor ID	D007335
MeSH Number(s)	D12.644.276.937.420 D12.776.124.862.425 D12.776.467.937.420 D23.529.937.420
Concept/Terms	Insulin-Like Growth Factor II Insulin-Like Growth Factor II IGF-II Insulin Like Growth Factor II Insulin-Like Somatomedin Peptide II Insulin Like Somatomedin Peptide II Multiplication-Stimulating Factor Factor, Multiplication-Stimulating Multiplication Stimulating Factor Somatomedin A Somatomedin MSA IGF-2 Multiplication-Stimulating Activity Multiplication Stimulating Activity

Below are MeSH descriptors whose meaning is more general than "Insulin-Like Growth Factor II".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intercellular Signaling Peptides and Proteins [D12.644.276]
Somatomedins [D12.644.276.937]
Insulin-Like Growth Factor II [D12.644.276.937.420]
Proteins [D12.776]
Blood Proteins [D12.776.124]
Somatomedins [D12.776.124.862]
Insulin-Like Growth Factor II [D12.776.124.862.425]
Intercellular Signaling Peptides and Proteins [D12.776.467]
Somatomedins [D12.776.467.937]
Insulin-Like Growth Factor II [D12.776.467.937.420]
Biological Factors [D23]
Intercellular Signaling Peptides and Proteins [D23.529]
Somatomedins [D23.529.937]
Insulin-Like Growth Factor II [D23.529.937.420]

Below are MeSH descriptors whose meaning is related to "Insulin-Like Growth Factor II".

Below are MeSH descriptors whose meaning is more specific than "Insulin-Like Growth Factor II".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Insulin-Like Growth Factor II" by people in this website by year, and whether "Insulin-Like Growth Factor II" was a major or minor topic of these publications.

Bar chart showing 18 publications over 13 distinct years, with a maximum of 2 publications in 1998 and 2004 and 2009 and 2011 and 2017

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1998	1	1	2
2000	0	1	1
2003	1	0	1
2004	2	0	2
2005	0	1	1
2008	1	0	1
2009	2	0	2
2011	1	1	2
2013	0	1	1
2015	1	0	1
2016	0	1	1
2017	1	1	2
2018	1	0	1

Below are the most recent publications written about "Insulin-Like Growth Factor II" by people in Profiles.

Song MA, Ernst T, Tiirikainen M, Tost J, Wilkens LR, Chang L, Kolonel LN, Le Marchand L, Lim U. Methylation of imprinted IGF2 regions is associated with total, visceral, and hepatic adiposity in postmenopausal women. Epigenetics. 2018; 13(8):858-865.

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Hamilton N, Austin D, M?rquez-Garb?n D, Sanchez R, Chau B, Foos K, Wu Y, Vadgama J, Pietras R. Receptors for Insulin-Like Growth Factor-2 and Androgens as Therapeutic Targets in Triple-Negative Breast Cancer. Int J Mol Sci. 2017 Nov 02; 18(11).

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Yamasato K, Tsai PS, Davis J, Yamamoto SY, Bryant-Greenwood GD. Human relaxins (RLNH1, RLNH2), their receptor (RXFP1) and fetoplacental growth. Reproduction. 2017 07; 154(1):67-77.

View in: PubMed
Merritt MA, Strickler HD, Einstein MH, Yang HP, Sherman ME, Wentzensen N, Brouwer-Visser J, Cossio MJ, Whitney KD, Yu H, Gunter MJ, Huang GS. Insulin/IGF and sex hormone axes in human endometrium and associations with endometrial cancer risk factors. Cancer Causes Control. 2016 06; 27(6):737-48.

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Hamilton N, M?rquez-Garb?n D, Mah V, Fernando G, Elshimali Y, Garb?n H, Elashoff D, Vadgama J, Goodglick L, Pietras R. Biologic roles of estrogen receptor-? and insulin-like growth factor-2 in triple-negative breast cancer. Biomed Res Int. 2015; 2015:925703.

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Kojima G, Terada KY, Miki N, Miki K. Non-islet cell tumor hypoglycemia associated with recurrent carcinosarcoma of the ovary. Endocr Pract. 2013 Jul-Aug; 19(4):e83-7.

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Garcia LA, King KK, Ferrini MG, Norris KC, Artaza JN. 1,25(OH)2vitamin D3 stimulates myogenic differentiation by inhibiting cell proliferation and modulating the expression of promyogenic growth factors and myostatin in C2C12 skeletal muscle cells. Endocrinology. 2011 Aug; 152(8):2976-86.

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Zuo QS, Yan R, Feng DX, Zhao R, Chen C, Jiang YM, Cruz-Correa M, Casson AG, Kang XD, Han F, Chen T. Loss of imprinting and abnormal expression of the insulin-like growth factor 2 gene in gastric cancer. Mol Carcinog. 2011 May; 50(5):390-6.

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Zhang J, Li Y, Liu J, Liu De, Liu N, Chen X. [Effect of 7-day gonadotropin-releasing hormone agonist protocol on IGF-II and IGFBP-4 levels in the follicular fluid]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2009 Mar; 34(3):190-4.

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Cruz-Correa M, Zhao R, Oviedo M, Bernabe RD, Lacourt M, Cardona A, Lopez-Enriquez R, Wexner S, Cuffari C, Hylind L, Platz E, Cui H, Feinberg AP, Giardiello FM. Temporal stability and age-related prevalence of loss of imprinting of the insulin-like growth factor-2 gene. Epigenetics. 2009 Feb 16; 4(2):114-8.

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