Immunoglobulin A

"Immunoglobulin A" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Represents 15-20% of the human serum immunoglobulins, mostly as the 4-chain polymer in humans or dimer in other mammals. Secretory IgA (IMMUNOGLOBULIN A, SECRETORY) is the main immunoglobulin in secretions.

Descriptor ID	D007070
MeSH Number(s)	D12.776.124.486.485.114.619.026 D12.776.124.790.651.114.619.026 D12.776.377.715.548.114.619.026
Concept/Terms	Immunoglobulin A Immunoglobulin A IgA IgA1 IgA1 IgA2 IgA2

Below are MeSH descriptors whose meaning is more general than "Immunoglobulin A".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Blood Proteins [D12.776.124]
Immunoproteins [D12.776.124.486]
Immunoglobulins [D12.776.124.486.485]
Antibodies [D12.776.124.486.485.114]
Immunoglobulin Isotypes [D12.776.124.486.485.114.619]
Immunoglobulin A [D12.776.124.486.485.114.619.026]
Serum Globulins [D12.776.124.790]
Immunoglobulins [D12.776.124.790.651]
Antibodies [D12.776.124.790.651.114]
Immunoglobulin Isotypes [D12.776.124.790.651.114.619]
Immunoglobulin A [D12.776.124.790.651.114.619.026]
Globulins [D12.776.377]
Serum Globulins [D12.776.377.715]
Immunoglobulins [D12.776.377.715.548]
Antibodies [D12.776.377.715.548.114]
Immunoglobulin Isotypes [D12.776.377.715.548.114.619]
Immunoglobulin A [D12.776.377.715.548.114.619.026]

Below are MeSH descriptors whose meaning is related to "Immunoglobulin A".

Below are MeSH descriptors whose meaning is more specific than "Immunoglobulin A".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Immunoglobulin A" by people in this website by year, and whether "Immunoglobulin A" was a major or minor topic of these publications.

Bar chart showing 44 publications over 26 distinct years, with a maximum of 4 publications in 2004

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1997	0	1	1
1999	0	2	2
2001	0	2	2
2002	0	2	2
2003	0	2	2
2004	1	3	4
2005	1	2	3
2006	0	2	2
2007	1	1	2
2008	1	1	2
2009	1	0	1
2010	0	1	1
2011	0	2	2
2012	1	1	2
2013	1	0	1
2014	0	1	1
2015	1	1	2
2016	1	0	1
2017	1	0	1
2018	1	0	1
2019	0	2	2
2020	0	1	1
2021	0	1	1
2022	0	3	3
2024	1	0	1
2025	0	1	1

Below are the most recent publications written about "Immunoglobulin A" by people in Profiles.

Cardona-Ospina JA, Roy V, Marcano-Jim?nez DE, Bos S, Duarte E, Zambrana JV, Bal A, An BK, Dias AG, Zhiteneva J, Huffaker J, Montenegro C, Kuan G, Ramos-Benitez MJ, Balmaseda A, Alter G, Harris E. IgA-driven neutrophil activation underlies severe dengue disease after primary Zika virus infection in humans. Nat Immunol. 2026 Jan; 27(1):126-134.

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Thavornwatanayong T, Wiantoro S, Kaczmarek ME, Kantorski M, Segovia E, Reyes K, Vuong BQ, Tsang SM. Comparative analysis of bat immunoglobulin constant regions identifies adaptations of bat immunity. Ann N Y Acad Sci. 2025 Oct; 1552(1):239-248.

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Kroll KW, Hueber B, Balachandran H, Afifi A, Manickam C, Nettere D, Pollara J, Hudson A, Woolley G, Ndhlovu LC, Reeves RK. FcaRI (CD89) is upregulated on subsets of mucosal and circulating NK cells and regulates IgA-class specific signaling and functions. Mucosal Immunol. 2024 Aug; 17(4):692-699.

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Handley KF, Mehta S, Martin AL, Biswas S, Maharaj K, Nagy MZ, Mine JA, Cortina C, Yu X, Sprenger K, Mandal G, Innamarato P, Powers JJ, Harro CM, Chaurio RA, Anadon CM, Shahzad MM, Flores I, Conejo-Garcia JR. Actionable spontaneous antibody responses antagonize malignant progression in ovarian carcinoma. Gynecol Oncol. 2023 06; 173:114-121.

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Saadatmand F, Abbas M, Apprey V, Tailor K, Kwabi-Addo B. Sex differences in saliva-based DNA methylation changes and environmental stressor in young African American adults. PLoS One. 2022; 17(9):e0273717.

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Goyins KA, Yu JJ, Papp SB, Beddard R, Murthy AK, Chambers JP, Arulanandam BP. Isotyping and quantitation of the humoral immune response to SARS-CoV-2. Exp Biol Med (Maywood). 2022 06; 247(12):1055-1060.

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Currie EG, Coburn B, Porfilio EA, Lam P, Rojas OL, Novak J, Yang S, Chowdhury RB, Ward LA, Wang PW, Khaleghi K, An J, Crome SQ, Hladunewich MA, Barbour SJ, Cattran DC, Parekh RS, Licht C, John R, Kaul R, Croitoru K, Gray-Owen SD, Guttman DS, Gommerman JL, Reich HN. Immunoglobulin A nephropathy is characterized by anticommensal humoral immune responses. JCI Insight. 2022 03 08; 7(5).

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Yang H, Yang YL, Li GQ, Yu Q, Yang J. Identifications of immune-responsive genes for adaptative traits by comparative transcriptome analysis of spleen tissue from Kazakh and Suffolk sheep. Sci Rep. 2021 02 04; 11(1):3157.

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Diorio C, Anderson EM, McNerney KO, Goodwin EC, Chase JC, Bolton MJ, Arevalo CP, Weirick ME, Gouma S, Vella LA, Henrickson SE, Chiotos K, Fitzgerald JC, Kilbaugh TJ, John ARO, Blatz AM, Lambert MP, Sullivan KE, Tartaglione MR, Zambrano D, Martin M, Lee JH, Young P, Friedman D, Sesok-Pizzini DA, Hensley SE, Behrens EM, Bassiri H, Teachey DT. Convalescent plasma for pediatric patients with SARS-CoV-2-associated acute respiratory distress syndrome. Pediatr Blood Cancer. 2020 11; 67(11):e28693.

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Sharma S, Gupta P, Aggarwal R, Malhotra P, Minz RW, Bansal F. Demystifying Biclonal Gammopathy: A Pathologist's Perspective. Lab Med. 2019 Oct 10; 50(4):357-363.

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