Cardiomegaly

"Cardiomegaly" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.

Descriptor ID	D006332
MeSH Number(s)	C14.280.195 C23.300.775.250
Concept/Terms	Cardiomegaly Cardiomegaly Heart Enlargement Enlargement, Heart Enlarged Heart Heart, Enlarged Cardiac Hypertrophy Cardiac Hypertrophy Heart Hypertrophy

Below are MeSH descriptors whose meaning is more general than "Cardiomegaly".

Diseases [C]
Cardiovascular Diseases [C14]
Heart Diseases [C14.280]
Cardiomegaly [C14.280.195]
Pathological Conditions, Signs and Symptoms [C23]
Pathological Conditions, Anatomical [C23.300]
Hypertrophy [C23.300.775]
Cardiomegaly [C23.300.775.250]

Below are MeSH descriptors whose meaning is more specific than "Cardiomegaly".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Cardiomegaly" by people in this website by year, and whether "Cardiomegaly" was a major or minor topic of these publications.

Bar chart showing 42 publications over 18 distinct years, with a maximum of 7 publications in 2011

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	1	1
1998	1	0	1
2002	1	1	2
2003	4	0	4
2004	3	0	3
2005	3	0	3
2006	2	0	2
2007	2	0	2
2008	3	0	3
2009	3	0	3
2010	2	0	2
2011	6	1	7
2012	1	1	2
2013	1	0	1
2014	2	0	2
2017	0	1	1
2018	0	1	1
2019	1	1	2

Below are the most recent publications written about "Cardiomegaly" by people in Profiles.

Nakayama Y, Yoshioka J. ADAM12 controls a hypertrophic response in the heart through the distinct descending pathways. Am J Physiol Heart Circ Physiol. 2020 02 01; 318(2):H209-H211.

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Horton JS, Shiraishi T, Alfulaij N, Small-Howard AL, Turner HC, Kurokawa T, Mori Y, Stokes AJ. "TRPV1 is a component of the atrial natriuretic signaling complex, and using orally delivered antagonists, presents a valid therapeutic target in the longitudinal reversal and treatment of cardiac hypertrophy and heart failure". Channels (Austin). 2019 12; 13(1):1-16.

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Lim WK, Davila S, Teo JX, Yang C, Pua CJ, Bl?cker C, Lim JQ, Ching J, Yap JJL, Tan SY, Sahl?n A, Chin CW, Teh BT, Rozen SG, Cook SA, Yeo KK, Tan P. Beyond fitness tracking: The use of consumer-grade wearable data from normal volunteers in cardiovascular and lipidomics research. PLoS Biol. 2018 02; 16(2):e2004285.

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Ceholski DK, Turnbull IC, Pothula V, Lecce L, Jarrah AA, Kho C, Lee A, Hadri L, Costa KD, Hajjar RJ, Tarzami ST. CXCR4 and CXCR7 play distinct roles in cardiac lineage specification and pharmacologic ?-adrenergic response. Stem Cell Res. 2017 08; 23:77-86.

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Wang ER, Jarrah AA, Benard L, Chen J, Schwarzkopf M, Hadri L, Tarzami ST. Deletion of CXCR4 in cardiomyocytes exacerbates cardiac dysfunction following isoproterenol administration. Gene Ther. 2014 May; 21(5):496-506.

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Hern?ndez JS, Barreto-Torres G, Kuznetsov AV, Khuchua Z, Javadov S. Crosstalk between AMPK activation and angiotensin II-induced hypertrophy in cardiomyocytes: the role of mitochondria. J Cell Mol Med. 2014 Apr; 18(4):709-20.

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Horton JS, Buckley CL, Alvarez EM, Schorlemmer A, Stokes AJ. The calcium release-activated calcium channel Orai1 represents a crucial component in hypertrophic compensation and the development of dilated cardiomyopathy. Channels (Austin). 2014; 8(1):35-48.

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Horton JS, Buckley CL, Stokes AJ. Successful TRPV1 antagonist treatment for cardiac hypertrophy and heart failure in mice. Channels (Austin). 2013 Jan 01; 7(1):17-22.

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Larocca TJ, Jeong D, Kohlbrenner E, Lee A, Chen J, Hajjar RJ, Tarzami ST. CXCR4 gene transfer prevents pressure overload induced heart failure. J Mol Cell Cardiol. 2012 Aug; 53(2):223-32.

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Leychenko A, Konorev E, Jijiwa M, Matter ML. Stretch-induced hypertrophy activates NFkB-mediated VEGF secretion in adult cardiomyocytes. PLoS One. 2011; 6(12):e29055.

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