"Clofibrate" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A fibric acid derivative used in the treatment of HYPERLIPOPROTEINEMIA TYPE III and severe HYPERTRIGLYCERIDEMIA. (From Martindale, The Extra Pharmacopoeia, 30th ed, p986)
| Descriptor ID |
D002994
|
| MeSH Number(s) |
D02.241.081.114.968.500.500.195 D02.355.726.305.500.195 D02.455.426.559.389.657.654.305.500.195
|
| Concept/Terms |
Clofibrate- Clofibrate
- Ethyl Chlorophenoxyisobutyrate
- Chlorophenoxyisobutyrate, Ethyl
- Clofibric Acid, Ethyl Ester
|
Below are MeSH descriptors whose meaning is more general than "Clofibrate".
Below are MeSH descriptors whose meaning is more specific than "Clofibrate".
This graph shows the total number of publications written about "Clofibrate" by people in this website by year, and whether "Clofibrate" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 0 | 2 | 2 |
| 2008 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Clofibrate" by people in Profiles.
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Oyagbemi AA, Adejumobi OA, Jarikre TA, Ajani OS, Asenuga ER, Gbadamosi IT, Adedapo ADA, Aro AO, Ogunpolu BS, Hassan FO, Falayi OO, Ogunmiluyi IO, Omobowale TO, Arojojoye OA, Ola-Davies OE, Saba AB, Adedapo AA, Emikpe BO, Oyeyemi MO, Nkadimeng SM, McGaw LJ, Kayoka-Kabongo PN, Oguntibeju OO, Yakubu MA. Clofibrate, a Peroxisome Proliferator-Activated Receptor-Alpha (PPARa) Agonist, and Its Molecular Mechanisms of Action against Sodium Fluoride-Induced Toxicity. Biol Trace Elem Res. 2022 Mar; 200(3):1220-1236.
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Yousefipour Z, Newaz M. PPARa ligand clofibrate ameliorates blood pressure and vascular reactivity in spontaneously hypertensive rats. Acta Pharmacol Sin. 2014 Apr; 35(4):476-82.
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Yakubu MA, Nsaif RH, Oyekan AO. Regulation of cerebrovascular endothelial peroxisome proliferator activator receptor alpha expression and nitric oxide production by clofibrate. Bratisl Lek Listy. 2010; 111(5):258-64.
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Banks T, Oyekan A. Peroxisome proliferator-activated receptor alpha activation attenuated angiotensin type 1-mediated but enhanced angiotensin type 2-mediated hemodynamic effects to angiotensin II in the rat. J Hypertens. 2008 Mar; 26(3):468-77.
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Yakubu MA, Nsaif RH, Oyekan AO. peroxisome proliferator-activated receptor alpha activation-mediated regulation of endothelin-1 production via nitric oxide and protein kinase C signaling pathways in piglet cerebral microvascular endothelial cell culture. J Pharmacol Exp Ther. 2007 Feb; 320(2):774-81.
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Newaz M, Yousefipour Z, Oyekan A. Role of PPAR-gamma on the pathogenesis and vascular changes in glycerol-induced acute renal failure. Pharmacol Res. 2006 Sep; 54(3):234-40.
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Newaz M, Blanton A, Fidelis P, Oyekan A. NAD(P)H oxidase/nitric oxide interactions in peroxisome proliferator activated receptor (PPAR)alpha-mediated cardiovascular effects. Mutat Res. 2005 Nov 11; 579(1-2):163-71.
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Newaz MA, Ranganna K, Oyekan AO. Relationship between PPARalpha activation and NO on proximal tubular Na+ transport in the rat. BMC Pharmacol. 2004 Feb 06; 4:1.
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Small GM, Burdett K, Connock MJ. Localization of carnitine acyltransferases and acyl-CoA beta-oxidation enzymes in small intestinal microperoxisomes (peroxisomes) of normal and clofibrate treated mice. Biochem Int. 1983 Aug; 7(2):263-72.