Central Nervous System Depressants

"Central Nervous System Depressants" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A very loosely defined group of drugs that tend to reduce the activity of the central nervous system. The major groups included here are ethyl alcohol, anesthetics, hypnotics and sedatives, narcotics, and tranquilizing agents (antipsychotics and antianxiety agents).

Descriptor ID	D002492
MeSH Number(s)	D27.505.696.277 D27.505.954.427.210
Concept/Terms	Central Nervous System Depressants Central Nervous System Depressants CNS Depressants Depressants, CNS

Below are MeSH descriptors whose meaning is more general than "Central Nervous System Depressants".

Chemicals and Drugs [D]
Chemical Actions and Uses [D27]
Pharmacologic Actions [D27.505]
Physiological Effects of Drugs [D27.505.696]
Central Nervous System Depressants [D27.505.696.277]
Therapeutic Uses [D27.505.954]
Central Nervous System Agents [D27.505.954.427]
Central Nervous System Depressants [D27.505.954.427.210]

Below are MeSH descriptors whose meaning is related to "Central Nervous System Depressants".

Below are MeSH descriptors whose meaning is more specific than "Central Nervous System Depressants".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Central Nervous System Depressants" by people in this website by year, and whether "Central Nervous System Depressants" was a major or minor topic of these publications.

Bar chart showing 30 publications over 17 distinct years, with a maximum of 4 publications in 2018

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1997	1	0	1
1999	2	0	2
2002	1	1	2
2003	1	0	1
2005	1	1	2
2007	3	0	3
2008	1	0	1
2009	0	1	1
2011	2	1	3
2013	3	0	3
2014	2	0	2
2015	0	1	1
2016	1	0	1
2017	1	0	1
2018	2	2	4
2020	1	0	1
2024	0	1	1

Below are the most recent publications written about "Central Nervous System Depressants" by people in Profiles.

Murillo Gonzalez DJ, Hernandez Granados BA, Sabandal PR, Han KA. Social setting interacts with hyper dopamine to boost the stimulant effect of ethanol. Addict Biol. 2024 06; 29(6):e13420.

View in: PubMed
Boa-Amponsem O, Zhang C, Burton D, Williams KP, Cole GJ. Ethanol and Cannabinoids Regulate Zebrafish GABAergic Neuron Development and Behavior in a Sonic Hedgehog and Fibroblast Growth Factor-Dependent Mechanism. Alcohol Clin Exp Res. 2020 07; 44(7):1366-1377.

View in: PubMed
Getachew B, Hudson T, Heinbockel T, Csoka AB, Tizabi Y. Protective Effects of Donepezil Against Alcohol-Induced Toxicity in Cell Culture: Role of Caspase-3. Neurotox Res. 2018 Oct; 34(3):757-762.

View in: PubMed
Kosnicki KL, Penprase JC, Cintora P, Torres PJ, Harris GL, Brasser SM, Kelley ST. Effects of moderate, voluntary ethanol consumption on the rat and human gut microbiome. Addict Biol. 2019 07; 24(4):617-630.

View in: PubMed
Zaveri NT, Marquez PV, Meyer ME, Polgar WE, Hamid A, Lutfy K. A Novel and Selective Nociceptin Receptor (NOP) Agonist (1-(1-((cis)-4-isopropylcyclohexyl)piperidin-4-yl)-1H-indol-2-yl)methanol (AT-312) Decreases Acquisition of Ethanol-Induced Conditioned Place Preference in Mice. Alcohol Clin Exp Res. 2018 Feb; 42(2):461-471.

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Tizabi Y, Getachew B, Ferguson CL, Csoka AB, Thompson KM, Gomez-Paz A, Ruda-Kucerova J, Taylor RE. Low Vs. High Alcohol: Central Benefits Vs. Detriments. Neurotox Res. 2018 Nov; 34(4):860-869.

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Manavalan S, Getachew B, Manaye KF, Khundmiri SJ, Csoka AB, McKinley R, Tamas A, Reglodi D, Tizabi Y. PACAP Protects Against Ethanol and Nicotine Toxicity in SH-SY5Y Cells: Implications for Drinking-Smoking Co-morbidity. Neurotox Res. 2017 Jul; 32(1):8-13.

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Vel?zquez-Marrero C, Burgos A, Garc?a JO, Palacio S, Marrero HG, Bernardo A, P?rez-Laspiur J, Rivera-Oliver M, Seale G, Treistman SN. Alcohol Regulates BK Surface Expression via Wnt/?-Catenin Signaling. J Neurosci. 2016 10 12; 36(41):10625-10639.

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Banerjee A, Abdelmegeed MA, Jang S, Song BJ. Increased Sensitivity to Binge Alcohol-Induced Gut Leakiness and Inflammatory Liver Disease in HIV Transgenic Rats. PLoS One. 2015; 10(10):e0140498.

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Hwa LS, Shimamoto A, Kayyali T, Norman KJ, Valentino RJ, DeBold JF, Miczek KA. Dissociation of ?-opioid receptor and CRF-R1 antagonist effects on escalated ethanol consumption and mPFC serotonin in C57BL/6J mice. Addict Biol. 2016 Jan; 21(1):111-24.

View in: PubMed

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