"Apamin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A highly neurotoxic polypeptide from the venom of the honey bee (Apis mellifera). It consists of 18 amino acids with two disulfide bridges and causes hyperexcitability resulting in convulsions and respiratory paralysis.
| Descriptor ID |
D001030
|
| MeSH Number(s) |
D20.888.065.115.060 D23.946.833.065.115.060
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Apamin".
Below are MeSH descriptors whose meaning is more specific than "Apamin".
This graph shows the total number of publications written about "Apamin" by people in this website by year, and whether "Apamin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 1 | 1 | 2 |
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2007 | 1 | 0 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
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Below are the most recent publications written about "Apamin" by people in Profiles.
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Deister CA, Chan CS, Surmeier DJ, Wilson CJ. Calcium-activated SK channels influence voltage-gated ion channels to determine the precision of firing in globus pallidus neurons. J Neurosci. 2009 Jul 01; 29(26):8452-61.
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Andres MA, Baptista NC, Efird JT, Ogata KK, Bellinger FP, Zeyda T. Depletion of SK1 channel subunits leads to constitutive insulin secretion. FEBS Lett. 2009 Jan 22; 583(2):369-76.
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Teagarden M, Atherton JF, Bevan MD, Wilson CJ. Accumulation of cytoplasmic calcium, but not apamin-sensitive afterhyperpolarization current, during high frequency firing in rat subthalamic nucleus cells. J Physiol. 2008 Feb 01; 586(3):817-33.
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D?az-R?os M, Dombeck DA, Webb WW, Harris-Warrick RM. Serotonin modulates dendritic calcium influx in commissural interneurons in the mouse spinal locomotor network. J Neurophysiol. 2007 Oct; 98(4):2157-67.
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Wilson CJ. The mechanism of intrinsic amplification of hyperpolarizations and spontaneous bursting in striatal cholinergic interneurons. Neuron. 2005 Feb 17; 45(4):575-85.
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Paladini CA, Williams JT. Noradrenergic inhibition of midbrain dopamine neurons. J Neurosci. 2004 May 12; 24(19):4568-75.
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Wilson CJ, Weyrick A, Terman D, Hallworth NE, Bevan MD. A model of reverse spike frequency adaptation and repetitive firing of subthalamic nucleus neurons. J Neurophysiol. 2004 May; 91(5):1963-80.
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Hallworth NE, Wilson CJ, Bevan MD. Apamin-sensitive small conductance calcium-activated potassium channels, through their selective coupling to voltage-gated calcium channels, are critical determinants of the precision, pace, and pattern of action potential generation in rat subthalamic nucleus neurons in vitro. J Neurosci. 2003 Aug 20; 23(20):7525-42.