Hypoxia-inducible factor-1 alpha expression is induced by IL-2 via the PI3K/mTOR pathway in hypoxic NK cells and supports effector functions in NKL cells and ex vivo expanded NK cells.

Cluff E, Magdaleno CC, Fernandez E, House T, Swaminathan S, Varadaraj A, Rajasekaran N. Hypoxia-inducible factor-1 alpha expression is induced by IL-2 via the PI3K/mTOR pathway in hypoxic NK cells and supports effector functions in NKL cells and ex vivo expanded NK cells. Cancer Immunol Immunother. 2022 Aug; 71(8):1989-2005.

View in: PubMed

subject areas

Cell Hypoxia
Cell Line, Tumor
Humans
Hypoxia-Inducible Factor 1, alpha Subunit
Interleukin-2
Killer Cells, Natural
Neoplasms
Signal Transduction

authors with profiles

Archana Varadaraj
Narendiran Rajasekaran

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