Computer-aided design of negative allosteric modulators of metabotropic glutamate receptor 5 (mGluR5): Comparative molecular field analysis of aryl ether derivatives.

Selvam C, Thilagavathi R, Narasimhan B, Kumar P, Jordan BC, Ranganna K. Computer-aided design of negative allosteric modulators of metabotropic glutamate receptor 5 (mGluR5): Comparative molecular field analysis of aryl ether derivatives. Bioorg Med Chem Lett. 2016 Feb 15; 26(4):1140-4.

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subject areas

Allosteric Regulation
Computer-Aided Design
Ethers
Inhibitory Concentration 50
Molecular Conformation
Protein Binding
Quantitative Structure-Activity Relationship

authors with profiles

Kasturi Ranganna
Selvam Chelliah

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