Diindolylmethane, a naturally occurring compound, induces CYP3A4 and MDR1 gene expression by activating human PXR.

Pondugula SR, Flannery PC, Abbott KL, Coleman ES, Mani S, Samuel T, Xie W. Diindolylmethane, a naturally occurring compound, induces CYP3A4 and MDR1 gene expression by activating human PXR. Toxicol Lett. 2015 Feb 03; 232(3):580-9.

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subject areas

Cell Line
Cytochrome P-450 CYP3A
Epithelial Cells
Gene Expression Regulation
Hepatocytes
Humans
Indoles
Intestinal Mucosa
Promoter Regions, Genetic
Receptors, Steroid
RNA Interference
RNA, Small Interfering

authors with profiles

Temesgen Samuel

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