Broadly neutralizing antibody PGT121 allosterically modulates CD4 binding via recognition of the HIV-1 gp120 V3 base and multiple surrounding glycans.

Julien JP, Sok D, Khayat R, Lee JH, Doores KJ, Walker LM, Ramos A, Diwanji DC, Pejchal R, Cupo A, Katpally U, Depetris RS, Stanfield RL, McBride R, Marozsan AJ, Paulson JC, Sanders RW, Moore JP, Burton DR, Poignard P, Ward AB, Wilson IA. Broadly neutralizing antibody PGT121 allosterically modulates CD4 binding via recognition of the HIV-1 gp120 V3 base and multiple surrounding glycans. PLoS Pathog. 2013; 9(5):e1003342.

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subject areas

Allosteric Regulation
Antibodies, Neutralizing
Antibodies, Viral
Binding Sites, Antibody
Crystallography, X-Ray
Epitopes
Glycoproteins
HIV Envelope Protein gp120
HIV-1
Humans
Immunoglobulin Heavy Chains
Protein Structure, Quaternary

authors with profiles

Reza Khayat

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