CHANGE-seq reveals genetic and epigenetic effects on CRISPR-Cas9 genome-wide activity.

Lazzarotto CR, Malinin NL, Li Y, Zhang R, Yang Y, Lee G, Cowley E, He Y, Lan X, Jividen K, Katta V, Kolmakova NG, Petersen CT, Qi Q, Strelcov E, Maragh S, Krenciute G, Ma J, Cheng Y, Tsai SQ. CHANGE-seq reveals genetic and epigenetic effects on CRISPR-Cas9 genome-wide activity. Nat Biotechnol. 2020 11; 38(11):1317-1327.

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subject areas

Base Sequence
Cell Line
Chromatin
Epigenesis, Genetic
Genetic Variation
Genome, Human
Humans

authors with profiles

Yanghua He, PhD

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