A conditional mouse expressing an activating mutation in NRF2 displays hyperplasia of the upper gastrointestinal tract and decreased white adipose tissue.

Bowman BM, Montgomery SA, Schrank TP, Simon JM, Ptacek TS, Tamir TY, Mulvaney KM, Weir SJ, Nguyen TT, Murphy RM, Makowski L, Hayes DN, Chen XL, Randell SH, Weissman BE, Major MB. A conditional mouse expressing an activating mutation in NRF2 displays hyperplasia of the upper gastrointestinal tract and decreased white adipose tissue. J Pathol. 2020 10; 252(2):125-137.

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subject areas

Adipose Tissue, White
Animals
Carcinoma, Squamous Cell
Disease Models, Animal
Esophagus
Humans
Hyperplasia
Mice
Mutation
NF-E2-Related Factor 2
Precancerous Conditions
Tongue
Upper Gastrointestinal Tract

authors with profiles

Luke Chen

RCMI CC is supported by the National Institute on Minority Health and Health Disparities, National Institutes of Health (NIH), through Grant Number U24MD015970. The contents of this site are solely the responsibility of the authors and do not necessarily represent the official views of the NIH

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