DOT1L inhibitor EPZ-5676 displays synergistic antiproliferative activity in combination with standard of care drugs and hypomethylating agents in MLL-rearranged leukemia cells.

Klaus CR, Iwanowicz D, Johnston D, Campbell CA, Smith JJ, Moyer MP, Copeland RA, Olhava EJ, Scott MP, Pollock RM, Daigle SR, Raimondi A. DOT1L inhibitor EPZ-5676 displays synergistic antiproliferative activity in combination with standard of care drugs and hypomethylating agents in MLL-rearranged leukemia cells. J Pharmacol Exp Ther. 2014 Sep; 350(3):646-56.

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subject areas

Antineoplastic Agents
Benzimidazoles
Cell Line, Tumor
Cell Proliferation
Drug Synergism
Growth Inhibitors
Histone-Lysine N-Methyltransferase
Humans
Leukemia, Myeloid, Acute
Methylation
Methyltransferases

authors with profiles

Robert L. Copeland

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