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Jaideep Chaudhary

Faculty RankProfessor
InstitutionClark Atlanta University
DepartmentBiological Sciences
AddressClark Atlanta University
Center for Cancer Research and Theraputic Development
223 James P. Brawley Drive, S.W.
Atlanta GA 30314
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    Other Positions
    InstitutionClark Atlanta University
    DepartmentBiological Sciences

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    Our research focus is to understand molecular basis of prostate cancer development and progression. We currently have two projects in this area. The first project is focused on understanding the role of Inhibitor of differentiation 4 (Id4) in prostate development, castration resistant prostate cancer and chemo-sensitivity around the p53/ PTEN pathway. The second, project addresses how inflammation and infection causes prostate cancer. The observation that body’s failure to effectively fight inflammation or infection causes cancer is the basis of this project. Our group is looking at molecular signatures in genes (SNP and expression) that cause inflammation that we hope will indicate if a person has increased susceptibility to prostate cancer. Our overall hypothesis is that body’s inflammatory response, under the genetic control and influenced by race, environment and dietary habits is a major determinant of prostate cancer.

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    R01CA128914     (CHAUDHARY, JAIDEEP)Sep 1, 2009 - Aug 31, 2014
    Inhibitor of Differentiation Gene Expression and Function in Prostate Cells
    Role: Principal Investigator

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Qu X, Lin J, Chaudhary JP, Sun B, Wei F, Fan M, Sun D. Defect enrich ultrathin TiO2 nanosheets for rapid adsorption and visible light mediated PPCPs degradation. Chemosphere. 2020 Oct 28; 128782. PMID: 33168288.
      Citations:    Fields:    
    2. Singh JK, Hutt DM, Tait B, Guy NC, Sivils JC, Ortiz NR, Payan AN, Komaragiri SK, Owens JJ, Culbertson D, Blair LJ, Dickey C, Kuo SY, Finley D, Dyson HJ, Cox MB, Chaudhary J, Gestwicki JE, Balch WE. Management of Hsp90-Dependent Protein Folding by Small Molecules Targeting the Aha1 Co-Chaperone. Cell Chem Biol. 2020 03 19; 27(3):292-305.e6. PMID: 32017918.
      Citations: 1     Fields:    
    3. Wojnarowicz PM, Lima E Silva R, Ohnaka M, Lee SB, Chin Y, Kulukian A, Chang SH, Desai B, Garcia Escolano M, Shah R, Garcia-Cao M, Xu S, Kadam R, Goldgur Y, Miller MA, Ouerfelli O, Yang G, Arakawa T, Albanese SK, Garland WA, Stoller G, Chaudhary J, Norton L, Soni RK, Philip J, Hendrickson RC, Iavarone A, Dannenberg AJ, Chodera JD, Pavletich N, Lasorella A, Campochiaro PA, Benezra R. A Small-Molecule Pan-Id Antagonist Inhibits Pathologic Ocular Neovascularization. Cell Rep. 2019 10 01; 29(1):62-75.e7. PMID: 31577956.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    4. Khan H, Chaudhary JP, Meena R. Anionic carboxymethylagarose-based pH-responsive smart superabsorbent hydrogels for controlled release of anticancer drug. Int J Biol Macromol. 2019 Mar 01; 124:1220-1229. PMID: 30529202.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    5. Mahto A, Kumar A, Chaudhary JP, Bhatt M, Sharma AK, Paul P, Nataraj SK, Meena R. Solvent-free production of nano-FeS anchored graphene from Ulva fasciata: A scalable synthesis of super-adsorbent for lead, chromium and dyes. J Hazard Mater. 2018 07 05; 353:190-203. PMID: 29674094.
      Citations: 2     Fields:    Translation:AnimalsCellsPHPublic Health
    6. Joshi JB, Patel D, Morton DJ, Sharma P, Zou J, Hewa Bostanthirige D, Gorantla Y, Nagappan P, Komaragiri SK, Sivils JC, Xie H, Palaniappan R, Wang G, Cox MB, Chaudhary J. Inactivation of ID4 promotes a CRPC phenotype with constitutive AR activation through FKBP52. Mol Oncol. 2017 04; 11(4):337-357. PMID: 28252832.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    7. Morton DJ, Patel D, Joshi J, Hunt A, Knowell AE, Chaudhary J. ID4 regulates transcriptional activity of wild type and mutant p53 via K373 acetylation. Oncotarget. 2017 Jan 10; 8(2):2536-2549. PMID: 27911860.
      Citations: 1     Fields:    Translation:HumansCells
    8. Korang-Yeboah M, Patel D, Morton D, Sharma P, Gorantla Y, Joshi J, Nagappan P, Pallaniappan R, Chaudhary J. Intra-tumoral delivery of functional ID4 protein via PCL/maltodextrin nano-particle inhibits prostate cancer growth. Oncotarget. 2016 Oct 18; 7(42):68072-68085. PMID: 27487149.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    9. Komaragiri SK, Bostanthirige DH, Morton DJ, Patel D, Joshi J, Upadhyay S, Chaudhary J. ID4 promotes AR expression and blocks tumorigenicity of PC3 prostate cancer cells. Biochem Biophys Res Commun. 2016 09 09; 478(1):60-66. PMID: 27462022.
      Citations: 4     Fields:    Translation:HumansAnimals
    10. Bhosle SM, Hunt A, Chaudhary J. A Modified Coupled Spectrophotometric Method to Detect 2-5 Oligoadenylate Synthetase Activity in Prostate Cell Lines. Biol Proced Online. 2016; 18:9. PMID: 26997919.
    11. Rohani L, Morton DJ, Wang XQ, Chaudhary J. Relative Stability of Wild-Type and Mutant p53 Core Domain: A Molecular Dynamic Study. J Comput Biol. 2016 Feb; 23(2):80-89. PMID: 26675082.
      Citations: 1     Fields:    
    12. Patel D, Chinaranagari S, Chaudhary J. Basic helix loop helix (bHLH) transcription factor 3 (TCF3, E2A) is regulated by androgens in prostate cancer cells. Am J Cancer Res. 2015; 5(11):3407-21. PMID: 26807321.
    13. Korang-Yeboah M, Gorantla Y, Paulos SA, Sharma P, Chaudhary J, Palaniappan R. Polycaprolactone/maltodextrin nanocarrier for intracellular drug delivery: formulation, uptake mechanism, internalization kinetics, and subcellular localization. Int J Nanomedicine. 2015; 10:4763-81. PMID: 26251597.
      Citations: 3     Fields:    Translation:HumansCells
    14. Sharma P, Chinaranagari S, Chaudhary J. Inhibitor of differentiation 4 (ID4) acts as an inhibitor of ID-1, -2 and -3 and promotes basic helix loop helix (bHLH) E47 DNA binding and transcriptional activity. Biochimie. 2015 May; 112:139-50. PMID: 25778840.
      Citations: 12     Fields:    Translation:HumansCells
    15. Chinaranagari S, Sharma P, Bowen NJ, Chaudhary J. Prostate cancer epigenome. Methods Mol Biol. 2015; 1238:125-40. PMID: 25421658.
      Citations: 1     Fields:    Translation:Humans
    16. Patel D, Morton DJ, Carey J, Havrda MC, Chaudhary J. Inhibitor of differentiation 4 (ID4): From development to cancer. Biochim Biophys Acta. 2015 Jan; 1855(1):92-103. PMID: 25512197.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    17. Brown SG, Knowell AE, Hunt A, Patel D, Bhosle S, Chaudhary J. Interferon inducible antiviral MxA is inversely associated with prostate cancer and regulates cell cycle, invasion and Docetaxel induced apoptosis. Prostate. 2015 Feb 15; 75(3):266-79. PMID: 25327819.
      Citations: 12     Fields:    Translation:HumansCells
    18. Chinaranagari S, Sharma P, Chaudhary J. EZH2 dependent H3K27me3 is involved in epigenetic silencing of ID4 in prostate cancer. Oncotarget. 2014 Aug 30; 5(16):7172-82. PMID: 25115397.
      Citations: 25     Fields:    Translation:HumansCells
    19. Patel D, Knowell AE, Korang-Yeboah M, Sharma P, Joshi J, Glymph S, Chinaranagari S, Nagappan P, Palaniappan R, Bowen NJ, Chaudhary J. Inhibitor of differentiation 4 (ID4) inactivation promotes de novo steroidogenesis and castration-resistant prostate cancer. Mol Endocrinol. 2014 Aug; 28(8):1239-53. PMID: 24921661.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    20. Yahirun JJ, Hamplová D. CHILDREN'S UNION STATUS AND CONTACT WITH MOTHERS: A CROSS-NATIONAL STUDY. Demogr Res. 2014 Jan-Jun; 30:1413-1444. PMID: 7789331.
      Citations: 3     Fields:    Translation:AnimalsCells
    21. Abid SN, Richardson TE, Powell HM, Jaichander P, Chaudhary J, Chapman KM, Hamra FK. A-single spermatogonia heterogeneity and cell cycles synchronize with rat seminiferous epithelium stages VIII-IX. Biol Reprod. 2014 Feb; 90(2):32. PMID: 24389876.
      Citations: 9     Fields:    Translation:AnimalsCells
    22. Mandal S, Abebe F, Chaudhary J. -174G/C polymorphism in the interleukin-6 promoter is differently associated with prostate cancer incidence depending on race. Genet Mol Res. 2014 Jan 10; 13(1):139-51. PMID: 24446297.
      Citations: 11     Fields:    Translation:HumansCells
    23. Knowell AE, Patel D, Morton DJ, Sharma P, Glymph S, Chaudhary J. Id4 dependent acetylation restores mutant-p53 transcriptional activity. Mol Cancer. 2013 Dec 13; 12:161. PMID: 24330748.
      Citations: 13     Fields:    Translation:HumansCells
    24. Carey JP, Knowell AE, Chinaranagari S, Chaudhary J. Id4 promotes senescence and sensitivity to doxorubicin-induced apoptosis in DU145 prostate cancer cells. Anticancer Res. 2013 Oct; 33(10):4271-8. PMID: 24122992.
      Citations: 12     Fields:    Translation:HumansCells
    25. Reuven DG, Shashikala HB, Mandal S, Williams MN, Chaudhary J, Wang XQ. Supramolecular Assembly of DNA on Graphene Nanoribbons. J Mater Chem B. 2013 Aug 28; 1(32):3926-3931. PMID: 24032074.
      Citations: 1     Fields:    
    26. Chapman KM, Powell HM, Chaudhary J, Shelton JM, Richardson JA, Richardson TE, Hamra FK. Linking spermatid ribonucleic acid (RNA) binding protein and retrogene diversity to reproductive success. Mol Cell Proteomics. 2013 Nov; 12(11):3221-36. PMID: 23938467.
      Citations: 4     Fields:    Translation:AnimalsCells
    27. Sharma P, Knowell AE, Chinaranagari S, Komaragiri S, Nagappan P, Patel D, Havrda MC, Chaudhary J. Id4 deficiency attenuates prostate development and promotes PIN-like lesions by regulating androgen receptor activity and expression of NKX3.1 and PTEN. Mol Cancer. 2013 Jun 21; 12:67. PMID: 23786676.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    28. Glymph S, Mandal S, Knowell AE, Abebe F, Chaudhary J. The myxovirus resistance A (MxA) gene -88G>T single nucleotide polymorphism is associated with prostate cancer. Infect Genet Evol. 2013 Jun; 16:186-90. PMID: 23438650.
      Citations: 2     Fields:    Translation:Humans
    29. Strong N, Millena AC, Walker L, Chaudhary J, Khan SA. Inhibitor of differentiation 1 (Id1) and Id3 proteins play different roles in TGFß effects on cell proliferation and migration in prostate cancer cells. Prostate. 2013 May; 73(6):624-33. PMID: 23060149.
      Citations: 13     Fields:    Translation:HumansCells
    30. Sharma P, Patel D, Chaudhary J. Id1 and Id3 expression is associated with increasing grade of prostate cancer: Id3 preferentially regulates CDKN1B. Cancer Med. 2012 Oct; 1(2):187-97. PMID: 23342268.
      Citations: 22     Fields:    Translation:HumansCells
    31. Sharma P, Chinaranagari S, Patel D, Carey J, Chaudhary J. Epigenetic inactivation of inhibitor of differentiation 4 (Id4) correlates with prostate cancer. Cancer Med. 2012 Oct; 1(2):176-86. PMID: 23342267.
      Citations: 17     Fields:    Translation:HumansCells
    32. Patel D, Chaudhary J. Increased expression of bHLH transcription factor E2A (TCF3) in prostate cancer promotes proliferation and confers resistance to doxorubicin induced apoptosis. Biochem Biophys Res Commun. 2012 May 25; 422(1):146-51. PMID: 22564737.
      Citations: 21     Fields:    Translation:HumansCells
    33. Mandal S, Abebe F, Chaudhary J. 2'-5' oligoadenylate synthetase 1 polymorphism is associated with prostate cancer. Cancer. 2011 Dec 15; 117(24):5509-18. PMID: 21638280.
      Citations: 14     Fields:    Translation:HumansCells
    34. Schmidt M, Asirvatham AJ, Chaudhary J. Inhibitor of differentiation 1 (ID1) promotes cell survival and proliferation of prostate epithelial cells. Cell Mol Biol Lett. 2010 Jun; 15(2):272-95. PMID: 20186495.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    35. Carey JP, Asirvatham AJ, Galm O, Ghogomu TA, Chaudhary J. Inhibitor of differentiation 4 (Id4) is a potential tumor suppressor in prostate cancer. BMC Cancer. 2009 Jun 07; 9:173. PMID: 19500415.
      Citations: 37     Fields:    Translation:HumansCells
    36. Bethel CR, Chaudhary J, Anway MD, Brown TR. Gene expression changes are age-dependent and lobe-specific in the brown Norway rat model of prostatic hyperplasia. Prostate. 2009 Jun 01; 69(8):838-50. PMID: 19204916.
      Citations: 4     Fields:    Translation:AnimalsCells
    37. Ifere GO, Barr E, Equan A, Gordon K, Singh UP, Chaudhary J, Igietseme JU, Ananaba GA. Differential effects of cholesterol and phytosterols on cell proliferation, apoptosis and expression of a prostate specific gene in prostate cancer cell lines. Cancer Detect Prev. 2009; 32(4):319-28. PMID: 19186008.
      Citations: 8     Fields:    Translation:HumansCells
    38. Shah GV, Thomas S, Muralidharan A, Liu Y, Hermonat PL, Williams J, Chaudhary J. Calcitonin promotes in vivo metastasis of prostate cancer cells by altering cell signaling, adhesion, and inflammatory pathways. Endocr Relat Cancer. 2008 Dec; 15(4):953-64. PMID: 18784182.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    39. Asirvatham AJ, Carey JP, Chaudhary J. ID1-, ID2-, and ID3-regulated gene expression in E2A positive or negative prostate cancer cells. Prostate. 2007 Sep 15; 67(13):1411-20. PMID: 17639499.
      Citations: 16     Fields:    Translation:HumansCells
    40. Chaudhary J, Schmidt M. The impact of genomic alterations on the transcriptome: a prostate cancer cell line case study. Chromosome Res. 2006; 14(5):567-86. PMID: 16823619.
      Citations: 3     Fields:    Translation:HumansCells
    41. Asirvatham AJ, Schmidt MA, Chaudhary J. Non-redundant inhibitor of differentiation (Id) gene expression and function in human prostate epithelial cells. Prostate. 2006 Jun 15; 66(9):921-35. PMID: 16541417.
      Citations: 25     Fields:    Translation:HumansCells
    42. Asirvatham AJ, Schmidt M, Gao B, Chaudhary J. Androgens regulate the immune/inflammatory response and cell survival pathways in rat ventral prostate epithelial cells. Endocrinology. 2006 Jan; 147(1):257-71. PMID: 16195407.
      Citations: 21     Fields:    Translation:AnimalsCells
    43. Chaudhary J, Schmidt M, Sadler-Riggleman I. Negative acting HLH proteins Id 1, Id 2, Id 3, and Id 4 are expressed in prostate epithelial cells. Prostate. 2005 Aug 01; 64(3):253-64. PMID: 15717313.
      Citations: 10     Fields:    Translation:AnimalsCells
    44. Chaudhary J, Sadler-Riggleman I, Ague JM, Skinner MK. The helix-loop-helix inhibitor of differentiation (ID) proteins induce post-mitotic terminally differentiated Sertoli cells to re-enter the cell cycle and proliferate. Biol Reprod. 2005 May; 72(5):1205-17. PMID: 15647457.
      Citations: 21     Fields:    Translation:AnimalsCells
    45. Chaudhary J, Sadler-Riggleman I, Skinner MK. Identification of a novel Sertoli cell gene product SERT that influences follicle stimulating hormone actions. Gene. 2004 Jan 07; 324:79-88. PMID: 14693373.
      Citations:    Fields:    Translation:AnimalsCells
    46. Chaudhary J, Skinner MK. Identification of a novel gene product, Sertoli cell gene with a zinc finger domain, that is important for FSH activation of testicular Sertoli cells. Endocrinology. 2002 Feb; 143(2):426-35. PMID: 11796495.
      Citations: 9     Fields:    Translation:AnimalsCells
    47. Chaudhary J, Skinner MK. Role of the transcriptional coactivator CBP/p300 in linking basic helix-loop-helix and CREB responses for follicle-stimulating hormone-mediated activation of the transferrin promoter in Sertoli cells. Biol Reprod. 2001 Aug; 65(2):568-74. PMID: 11466227.
      Citations: 8     Fields:    Translation:AnimalsCells
    48. Chaudhary J, Johnson J, Kim G, Skinner MK. Hormonal regulation and differential actions of the helix-loop-helix transcriptional inhibitors of differentiation (Id1, Id2, Id3, and Id4) in Sertoli cells. Endocrinology. 2001 May; 142(5):1727-36. PMID: 11316735.
      Citations: 17     Fields:    Translation:AnimalsCells
    49. Chaudhary J, Skinner MK. Characterization of a novel transcript of 14-3-3 theta in Sertoli cells. J Androl. 2000 Sep-Oct; 21(5):730-8. PMID: 10975420.
      Citations: 6     Fields:    Translation:AnimalsCells
    50. Chaudhary J, Mosher R, Kim G, Skinner MK. Role of winged helix transcription factor (WIN) in the regulation of Sertoli cell differentiated functions: WIN acts as an early event gene for follicle-stimulating hormone. Endocrinology. 2000 Aug; 141(8):2758-66. PMID: 10919260.
      Citations:    Fields:    Translation:AnimalsCells
    51. Chaudhary J, Skinner MK. Basic helix-loop-helix proteins can act at the E-box within the serum response element of the c-fos promoter to influence hormone-induced promoter activation in Sertoli cells. Mol Endocrinol. 1999 May; 13(5):774-86. PMID: 10319327.
      Citations: 26     Fields:    Translation:AnimalsCells
    52. Chaudhary J, Kim G, Skinner MK. Expression of the basic helix-loop-helix protein REBalpha in rat testicular Sertoli cells. Biol Reprod. 1999 May; 60(5):1244-50. PMID: 10208991.
      Citations: 3     Fields:    Translation:AnimalsCells
    53. Chaudhary J, Skinner MK. E-box and cyclic adenosine monophosphate response elements are both required for follicle-stimulating hormone-induced transferrin promoter activation in Sertoli cells. Endocrinology. 1999 Mar; 140(3):1262-71. PMID: 10067852.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    54. Chaudhary J, Skinner MK. Comparative sequence analysis of the mouse and human transferrin promoters: hormonal regulation of the transferrin promoter in Sertoli cells. Mol Reprod Dev. 1998 Jul; 50(3):273-83. PMID: 9621303.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    55. Lee HY, Chaudhary J, Walsh GL, Hong WK, Kurie JM. Suppression of c-Fos gene transcription with malignant transformation of human bronchial epithelial cells. Oncogene. 1998 Jun 11; 16(23):3039-46. PMID: 9662337.
      Citations: 8     Fields:    Translation:HumansCells
    56. Chaudhary J, Cupp AS, Skinner MK. Role of basic-helix-loop-helix transcription factors in Sertoli cell differentiation: identification of an E-box response element in the transferrin promoter. Endocrinology. 1997 Feb; 138(2):667-75. PMID: 9003001.
      Citations: 2     Fields:    Translation:AnimalsCells
    57. Chaudhary J, Whaley PD, Cupp A, Skinner MK. Transcriptional regulation of sertoli cell differentiation by follicle-stimulating hormone at the level of the c-fos and transferrin promoters. Biol Reprod. 1996 Mar; 54(3):692-9. PMID: 8835393.
      Citations:    Fields:    Translation:AnimalsCells
    58. Chaudhary J, Skinner MK. Transcriptional regulation of Sertoli cell differentiation (transferrin promoter activation) during testicular development. Dev Genet. 1995; 16(2):114-8. PMID: 7736661.
      Citations: 1     Fields:    Translation:AnimalsCells
    59. Bhattacharya S, Chaudhary J, Das C. Responsiveness to gonadotropin releasing hormone of human term trophoblast cells in vitro: induction by estradiol. Biochem Int. 1992 Oct; 28(2):363-71. PMID: 1333770.
      Citations: 1     Fields:    Translation:HumansCells
    60. Chaudhary J, Bhattacharyya S, Das C. Regulation of progesterone secretion in human syncytiotrophoblast in culture by human chorionic gonadotropin. J Steroid Biochem Mol Biol. 1992 May; 42(3-4):425-32. PMID: 1376614.
      Citations: 3     Fields:    Translation:HumansCells
    61. Bhattacharyya S, Chaudhary J, Das C. Antibodies to hCG inhibit progesterone production from human syncytiotrophoblast cells. Placenta. 1992 Mar-Apr; 13(2):135-9. PMID: 1631026.
      Citations: 1     Fields:    Translation:HumansCells
    62. Chaudhary J, Sharma RK, Majumdar SS, Bhatti DP, Misro MM, Das RP. Effect of STS-557 (17 alpha-cyanomethyl 17 beta-hydroxy-estra-4, 9(10)-dien-3-one) on blood hormone levels, the testis, accessory sex organs and fertility of rats. Int J Androl. 1990 Oct; 13(5):398-407. PMID: 2126530.
      Citations: 1     Fields:    Translation:Animals
    63. Majumdar SS, Chaudhary J, Sharma RK, Das RP. Contraceptive potentiality of STS-557--a feasibility study in male bonnet monkey (Macaca radiata). Contraception. 1990 Jun; 41(6):641-53. PMID: 2361371.
      Citations: 1     Fields:    Translation:AnimalsCells
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