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Yamil Gerena

Faculty RankAssociate Professor
InstitutionUniversity of Puerto Rico
DepartmentSchool of Pharmacy
AddressUPR-Medical Sciences Campus, School of Pharmacy
San Juan PR 936
Phone7877582525 ext. 1249
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    Collapse Overview 
    Collapse overview
    Dr. Gerena is Assistant Professor of Pharmacology and Toxicology at the School of Pharmacy, and Adjunct
    Professor in the Department of Pharmacology and Toxicology at the School of Medicine, University of
    Puerto Rico Medical Sciences Campus.
    Dr. Gerena received his PhD in Pharmacology from the University of Puerto Rico and completed a
    postdoctoral fellowship in immunology and molecular biology in the Department of Microbiology of the
    School of Medicine at the University of Puerto Rico. He gained research experience in flow cytometry and
    molecular biology at CUNY Hunter College, New York and Los Alamos National Laboratories, New Mexico.
    Research efforts focus on the role of the soluble insulin receptor and insulin signaling pathways in the development and progression of insulin resistance and cognitive impairment in HIV-seropositive patients
    using combined antiretroviral treatment (cART).

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Castillo-Ocampo Y, Colón M, Hernández A, Lopez P, Gerena Y, Porter JT. Plasticity of GluN1 at Ventral Hippocampal Synapses in the Infralimbic Cortex. Front Synaptic Neurosci. 2021; 13:695964. PMID: 34335223.
    2. Collazo BJ, Morales-Vázquez D, Álvarez-Del Valle J, Sierra-Pagan JE, Medina JC, Méndez-Álvarez J, Gerena Y. Angiotensin II Induces Differentiation of Human Neuroblastoma Cells by Increasing MAP2 and ROS Levels. J Renin Angiotensin Aldosterone Syst. 2021; 2021:6191417. PMID: 34285710.
      Citations:    Fields:    
    3. Gerena Y, Menéndez-Delmestre R, Delgado-Nieves A, Vélez J, Méndez-Álvarez J, Sierra-Pagan JE, Skolasky RL, Henderson L, Nath A, Wojna V. Release of Soluble Insulin Receptor From Neurons by Cerebrospinal Fluid From Patients With Neurocognitive Dysfunction and HIV Infection. Front Neurol. 2019; 10:285. PMID: 30972014.
    4. Gerena Y, Lozada JG, Collazo BJ, Méndez-Álvarez J, Méndez-Estrada J, De Mello WC. Losartan counteracts the effects of cardiomyocyte swelling on glucose uptake and insulin receptor substrate-1 levels. Peptides. 2017 Oct; 96:38-43. PMID: 28889965.
      Citations:    Fields:    Translation:AnimalsCells
    5. De Mello WC, Gerena Y, Ayala-Peña S. Angiotensins and Huntington's Disease: A Study on Immortalized Progenitor Striatal Cell Lines. Front Endocrinol (Lausanne). 2017; 8:108. PMID: 28596754.
    6. Humphries-Bickley T, Castillo-Pichardo L, Hernandez-O'Farrill E, Borrero-Garcia LD, Forestier-Roman I, Gerena Y, Blanco M, Rivera-Robles MJ, Rodriguez-Medina JR, Cubano LA, Vlaar CP, Dharmawardhane S. Characterization of a Dual Rac/Cdc42 Inhibitor MBQ-167 in Metastatic Cancer. . 2017 05; 16(5):805-818. PMID: 28450422.
    7. Ferrario CM, Frohlich ED, Gerena Y. Walmor C. De Mello: "Your Heart Is Still With Us". Hypertension. 2017 06; 69(6):992-993. PMID: 28396538.
      Citations:    Fields:    Translation:Humans
    8. De Mello WC, Gerena Y. Measurement of Cardiac Angiotensin II by Immunoassays, HPLC-Chip/Mass Spectrometry, and Functional Assays. Methods Mol Biol. 2017; 1527:127-137. PMID: 28116712.
      Citations: 1     Fields:    Translation:HumansAnimals
    9. Rivera Rivera A, Castillo-Pichardo L, Gerena Y, Dharmawardhane S. Anti-Breast Cancer Potential of Quercetin via the Akt/AMPK/Mammalian Target of Rapamycin (mTOR) Signaling Cascade. PLoS One. 2016; 11(6):e0157251. PMID: 27285995.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    10. Delgado-Vélez M, Báez-Pagán CA, Gerena Y, Quesada O, Santiago-Pérez LI, Capó-Vélez CM, Wojna V, Meléndez L, León-Rivera R, Silva W, Lasalde-Dominicci JA. The a7-nicotinic receptor is upregulated in immune cells from HIV-seropositive women: consequences to the cholinergic anti-inflammatory response. Clin Transl Immunology. 2015 Dec; 4(12):e53. PMID: 26719799.
    11. Gerena Y, Menéndez-Delmestre R, Skolasky RL, Hechavarria RM, Pérez S, Hilera C, González C, Nath A, Wojna V. Soluble insulin receptor as a source of insulin resistance and cognitive impairment in HIV-seropositive women. J Neurovirol. 2015 Apr; 21(2):113-9. PMID: 25604495.
      Citations: 5     Fields:    Translation:Humans
    12. Cantres-Rosario Y, Plaud-Valentín M, Gerena Y, Skolasky RL, Wojna V, Meléndez LM. Cathepsin B and cystatin B in HIV-seropositive women are associated with infection and HIV-1-associated neurocognitive disorders. AIDS. 2013 Jan 28; 27(3):347-56. PMID: 23291538.
      Citations: 16     Fields:    Translation:HumansCells
    13. De Mello W, Rivera M, Rabell A, Gerena Y. Aliskiren, at low doses, reduces the electrical remodeling in the heart of the TGR(mRen2)27 rat independently of blood pressure. J Renin Angiotensin Aldosterone Syst. 2013 Mar; 14(1):23-33. PMID: 23118038.
      Citations: 5     Fields:    Translation:Animals
    14. Gerena Y, Skolasky RL, Velez JM, Toro-Nieves D, Mayo R, Nath A, Wojna V. Soluble and cell-associated insulin receptor dysfunction correlates with severity of HAND in HIV-infected women. PLoS One. 2012; 7(5):e37358. PMID: 22629383.
      Citations: 8     Fields:    Translation:HumansCells
    15. Gerena Y, Gonzalez-Pons M, Serrano AE. Cytofluorometric detection of rodent malaria parasites using red-excited fluorescent dyes. Cytometry A. 2011 Nov; 79(11):965-72. PMID: 22015734.
      Citations: 1     Fields:    Translation:AnimalsCells
    16. Kraft-Terry S, Gerena Y, Wojna V, Plaud-Valentin M, Rodriguez Y, Ciborowski P, Mayo R, Skolasky R, Gendelman HE, Meléndez LM. Proteomic analyses of monocytes obtained from Hispanic women with HIV-associated dementia show depressed antioxidants. Proteomics Clin Appl. 2010 Sep; 4(8-9):706-14. PMID: 21137088.
      Citations: 17     Fields:    Translation:HumansCells
    17. De Mello WC, Gerena Y. Prolonged exposure of cardiac cells to renin plus angiotensinogen reduces intracellular renin in the failing heart. On the role of angiotensin II-AT1 complex internalization. Regul Pept. 2009 Jun 05; 155(1-3):139-44. PMID: 19303904.
      Citations: 2     Fields:    Translation:AnimalsCells
    18. De Mello WC, Gerena Y. Eplerenone inhibits the intracrine and extracellular actions of angiotensin II on the inward calcium current in the failing heart. On the presence of an intracrine renin angiotensin aldosterone system. Regul Pept. 2008 Nov 29; 151(1-3):54-60. PMID: 18585409.
      Citations: 10     Fields:    Translation:AnimalsCells
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