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Jorge Miranda

TitlePhD
Faculty RankProfessor
InstitutionUniversity of Puerto Rico
DepartmentSchool of Medicine
AddressUPR-Medical Sciences Campus, School of Medicine
San Juan PR 936
Phone7877582525 ext. 1631
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    Our research interest is in the area of developmental neurobiology, specifically on nerve regeneration and axonal outgrowth. Spinal Cord Injury (SCI) results in a series of time-dependent structural and physiological changes at the site of the trauma producing a non-permissive environment for axonal outgrowth. The focus of this laboratory is to analyze at the mRNA and protein level the temporal and spatial expression of molecular signals with repellent properties that may be upregulated after SCI, inhibiting axonal elongation. At the present, we are investigating the expression of purinergic-, estrogen- and Eph-receptors and its ligands the ephrins after SCI. In addition, we are interested in determine the possible role that these receptors play in the non-favorable environment for axonal regeneration and function recovery. Molecular biology, protein biochemistry, neuroimaging traicing strategies, physiological recordings and behavioral assays are used in conjuction with injured rats at the T10 level to analyze the expression of these proteins. Defining the specific temporal and spatial expression of individual inhibitory molecules, both on the regenerating fibers and in the local microenvironment, may lead to novel therapeutic strategies to enhanced regeneration and functional recovery after SCI.

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Martínez M, Martínez NA, Miranda JD, Maldonado HM, Silva Ortiz WI. Caveolin-1 Regulates P2Y2 Receptor Signaling during Mechanical Injury in Human 1321N1 Astrocytoma. Biomolecules. 2019 10 18; 9(10). PMID: 31635212.
      Citations:    Fields:    Translation:HumansCells
    2. Colón JM, González PA, Cajigas Á, Maldonado WI, Torrado AI, Santiago JM, Salgado IK, Miranda JD. Continuous tamoxifen delivery improves locomotor recovery 6h after spinal cord injury by neuronal and glial mechanisms in male rats. Exp Neurol. 2018 01; 299(Pt A):109-121. PMID: 29037533.
      Citations: 1     Fields:    Translation:AnimalsCells
    3. Colón JM, Miranda JD. Tamoxifen: an FDA approved drug with neuroprotective effects for spinal cord injury recovery. Neural Regen Res. 2016 Aug; 11(8):1208-11. PMID: 27651756.
      Citations:    
    4. Cruz N, Miranda JD, Crespo MJ. Modulation of Vascular ACE by Oxidative Stress in Young Syrian Cardiomyopathic Hamsters: Therapeutic Implications. J Clin Med. 2016 Jul 13; 5(7). PMID: 27420103.
      Citations:    
    5. Martinez NA, Ayala AM, Martinez M, Martinez-Rivera FJ, Miranda JD, Silva WI. Caveolin-1 Regulates the P2Y2 Receptor Signaling in Human 1321N1 Astrocytoma Cells. J Biol Chem. 2016 Jun 03; 291(23):12208-22. PMID: 27129210.
      Citations: 4     Fields:    Translation:HumansCells
    6. Colón JM, Torrado AI, Cajigas Á, Santiago JM, Salgado IK, Arroyo Y, Miranda JD. Tamoxifen Administration Immediately or 24 Hours after Spinal Cord Injury Improves Locomotor Recovery and Reduces Secondary Damage in Female Rats. J Neurotrauma. 2016 09 15; 33(18):1696-708. PMID: 26896212.
      Citations: 9     Fields:    Translation:Animals
    7. Figueroa JD, Serrano-Illan M, Licero J, Cordero K, Miranda JD, De Leon M. Fatty Acid Binding Protein 5 Modulates Docosahexaenoic Acid-Induced Recovery in Rats Undergoing Spinal Cord Injury. J Neurotrauma. 2016 08 01; 33(15):1436-49. PMID: 26715431.
      Citations: 2     Fields:    Translation:Animals
    8. Mosquera L, Shepherd L, Torrado AI, Torres-Diaz YM, Miranda JD, Segarra AC. Comparison of Two Methods of Estradiol Replacement: their Physiological and Behavioral Outcomes. J Vet Sci Technol. 2015 Nov 30; 6(6):276. PMID: 26962471.
      Citations:    
    9. Salgado IK, Torrado AI, Santiago JM, Miranda JD. Tamoxifen and Src kinase inhibitors as neuroprotective/neuroregenerative drugs after spinal cord injury. Neural Regen Res. 2015 Mar; 10(3):385-90. PMID: 25878585.
      Citations:    
    10. Rosas OR, Torrado AI, Santiago JM, Rodriguez AE, Salgado IK, Miranda JD. Long-term treatment with PP2 after spinal cord injury resulted in functional locomotor recovery and increased spared tissue. Neural Regen Res. 2014 Dec 15; 9(24):2164-73. PMID: 25657738.
      Citations:    
    11. Mosquera L, Colón JM, Santiago JM, Torrado AI, Meléndez M, Segarra AC, Rodríguez-Orengo JF, Miranda JD. Tamoxifen and estradiol improved locomotor function and increased spared tissue in rats after spinal cord injury: their antioxidant effect and role of estrogen receptor alpha. Brain Res. 2014 May 02; 1561:11-22. PMID: 24637260.
      Citations: 24     Fields:    Translation:AnimalsCells
    12. Santos-Vera B, Vázquez-Torres R, Marrero HG, Acevedo JM, Arencibia-Albite F, Vélez-Hernández ME, Miranda JD, Jiménez-Rivera CA. Cocaine sensitization increases I h current channel subunit 2 (HCN2) protein expression in structures of the mesocorticolimbic system. J Mol Neurosci. 2013 May; 50(1):234-45. PMID: 23203153.
      Citations: 4     Fields:    Translation:Animals
    13. Santiago JM, Torrado AI, Arocho LC, Rosas OR, Rodríguez AE, Toro FK, Salgado IK, Torres YA, Silva WI, Miranda JD. Expression profile of flotillin-2 and its pathophysiological role after spinal cord injury. J Mol Neurosci. 2013 Feb; 49(2):347-59. PMID: 22878913.
      Citations: 1     Fields:    Translation:AnimalsCells
    14. Figueroa JD, Cordero K, Baldeosingh K, Torrado AI, Walker RL, Miranda JD, Leon MD. Docosahexaenoic acid pretreatment confers protection and functional improvements after acute spinal cord injury in adult rats. J Neurotrauma. 2012 Feb 10; 29(3):551-66. PMID: 21970623.
      Citations: 23     Fields:    Translation:AnimalsCells
    15. Rosas OR, Figueroa JD, Torrado AI, Rivera M, Santiago JM, Konig-Toro F, Miranda JD. Expression and activation of ephexin is altered after spinal cord injury. Dev Neurobiol. 2011 Jul; 71(7):595-607. PMID: 20949525.
      Citations: 7     Fields:    Translation:AnimalsCells
    16. Rodríguez-Zayas AE, Torrado AI, Rosas OR, Santiago JM, Figueroa JD, Miranda JD. Blockade of P2 nucleotide receptors after spinal cord injury reduced the gliotic response and spared tissue. J Mol Neurosci. 2012 Jan; 46(1):167-76. PMID: 21647706.
      Citations: 3     Fields:    Translation:AnimalsCells
    17. Arocho LC, Figueroa JD, Torrado AI, Santiago JM, Vera AE, Miranda JD. Expression profile and role of EphrinA1 ligand after spinal cord injury. Cell Mol Neurobiol. 2011 Oct; 31(7):1057-69. PMID: 21603973.
      Citations: 6     Fields:    Translation:Animals
    18. Rodríguez-Zayas AE, Torrado AI, Miranda JD. P2Y2 receptor expression is altered in rats after spinal cord injury. Int J Dev Neurosci. 2010 Oct; 28(6):413-21. PMID: 20619335.
      Citations: 12     Fields:    Translation:Animals
    19. Santiago JM, Rosas O, Torrado AI, González MM, Kalyan-Masih PO, Miranda JD. Molecular, anatomical, physiological, and behavioral studies of rats treated with buprenorphine after spinal cord injury. J Neurotrauma. 2009 Oct; 26(10):1783-93. PMID: 19653810.
      Citations: 14     Fields:    Translation:AnimalsCells
    20. Cruz-Orengo L, Figueroa JD, Torrado A, Puig A, Whittemore SR, Miranda JD. Reduction of EphA4 receptor expression after spinal cord injury does not induce axonal regeneration or return of tcMMEP response. Neurosci Lett. 2007 May 11; 418(1):49-54. PMID: 17418490.
      Citations: 11     Fields:    Translation:AnimalsCells
    21. Figueroa JD, Benton RL, Velazquez I, Torrado AI, Ortiz CM, Hernandez CM, Diaz JJ, Magnuson DS, Whittemore SR, Miranda JD. Inhibition of EphA7 up-regulation after spinal cord injury reduces apoptosis and promotes locomotor recovery. J Neurosci Res. 2006 Nov 15; 84(7):1438-51. PMID: 16983667.
      Citations: 24     Fields:    Translation:AnimalsCells
    22. Willson CA, Foster RD, Onifer SM, Whittemore SR, Miranda JD. EphB3 receptor and ligand expression in the adult rat brain. J Mol Histol. 2006 Nov; 37(8-9):369-80. PMID: 17103029.
      Citations: 8     Fields:    Translation:Animals
    23. Cruz-Orengo L, Figueroa JD, Velázquez I, Torrado A, Ortíz C, Hernández C, Puig A, Segarra AC, Whittemore SR, Miranda JD. Blocking EphA4 upregulation after spinal cord injury results in enhanced chronic pain. Exp Neurol. 2006 Dec; 202(2):421-33. PMID: 16959251.
      Citations: 21     Fields:    Translation:AnimalsCells
    24. Irizarry-Ramírez M, Willson CA, Cruz-Orengo L, Figueroa J, Velázquez I, Jones H, Foster RD, Whittemore SR, Miranda JD. Upregulation of EphA3 receptor after spinal cord injury. J Neurotrauma. 2005 Aug; 22(8):929-35. PMID: 16083359.
      Citations: 17     Fields:    Translation:AnimalsCells
    25. Willson CA, Miranda JD, Foster RD, Onifer SM, Whittemore SR. Transection of the adult rat spinal cord upregulates EphB3 receptor and ligand expression. Cell Transplant. 2003; 12(3):279-90. PMID: 12797382.
      Citations: 16     Fields:    Translation:AnimalsCells
    26. Willson CA, Irizarry-Ramírez M, Gaskins HE, Cruz-Orengo L, Figueroa JD, Whittemore SR, Miranda JD. Upregulation of EphA receptor expression in the injured adult rat spinal cord. Cell Transplant. 2002; 11(3):229-39. PMID: 12075988.
      Citations: 31     Fields:    Translation:AnimalsCells
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