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Zaki Sherif

TitleDr.
Faculty RankAssociate Professor
InstitutionHoward University
DepartmentBiochemsitry & Molecular Biology
Address520 W Street, NW
Suite # 3430
Adams Building
Washington DC 20059
Phone202-806-7731
Fax202-806-9757
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    Other Positions
    TitleAdjunct Professor
    InstitutionGeorgetown University
    DepartmentOncology

    TitleParticipant / Mentor
    InstitutionGeorgetown & Howard Universities
    DepartmentGHUCCTS


    Collapse Biography 
    Collapse awards and honors
    1996 - 2001NCI Travel Grant Award, National Cancer Institute / NIH
    1999 - 1999Post-Doctoral 13th Annual Research Day Award Winner, Georgetown University
    2001 - 2001Outstanding Alumunus Award, Howard University
    2004 - 2004Science & Technology Award Inductee, The Hall of Fame Honor Society
    2006 - 2006Best Instructor Award, Georgetown University
    2006 - 2006Best Investigator Award, American Cancer Society
    2008 - 2008Best Abstract-Cancer Research Award, American Association for Cancer Research
    2011 - 2011Certificate of Appreciation, Mayo Clinic
    2012 - 2012Research Scholarship Award, University of Pittsburg
    2013 - 2015AACR Faculty Scholar, American Association for Cancer Research
    2015 - 2016Certificate of Recognition - Judge, American Association for Cancer Research
    2015 - 2015Research Day Award Winner, Howard University
    2017 - 2017Outstanding Scientist Sevice Award, The SEED Foundation

    Collapse Overview 
    Collapse overview
    I have a broad background in the fields of biochemistry, molecular genetics, cellular biology and molecular biology through which I have studied the nature and underlying causes of cancer and especially breast cancer and hepatocellular carcinoma using the Li-Fraumeni Syndrome (LFS) as a critical model system to study the mechanisms of carcinogenesis and tumorigenesis. My Post-doctoral training at Stanford University under the esteemed cancer cell biologist, Esther Chang, and the subsequent trainings at Georgetown University have provided me with exceptional technical skills to study and decipher the molecular basis and mechanisms of cancer initiation, development and progression. As a PI on my NIH and university-funded grants, I used LFS skin fibroblast cell lines to lay the groundwork (with K01 award initially) for the delineation of the tumor microenvironment that enables initiation and progression of oncogenesis through the mutation of p53, Cav-1 or DLL4 as documented in a sample of the publications listed in PubMed. As a result, our lab has identified two genes downstream of p53 whose mutated versions contribute to cell proliferation and breast cancer development. Another gene, DLL4, which we identified as missing in the cell lines of LFS family members is localized in a breakpoint region of a balanced reciprocal chromosomal translocation. DLL4 is a ligand that is involved in Notch signaling and is influential in the generation of hematopoietic stem cells by regulating the T cell lineage and subsequent stages of thymopoiesis. DLL4 may also be involved in cancer immune-surveillance since it is reduced or abrogated in various types of human cancer cell lines and tissues. In addition, as one of two PI’s on a multi-center CTSA project, and a U01-funded project, I have administered, mentored, managed, staffed, budgeted and successfully recruited research coordinators and patient volunteers for collaborative study in GC/LC-MS-based metabolic analysis of human liver tissues and blood for biomarker discovery and investigation of health disparities in hepatocellular carcinoma. In this vein, I have collaborated extensively with Dr. Habtom Ressom on a number of health disparity-related research projects and especially with regard to the U01 grant. In the past, I have also collaborated with other researchers such as Drs. Ashktorab, Brim, Laiyemo, Chang, Boulares, Smulson, Sultan, etc and produced several peer-reviewed publications. The central theme of my research studies is to develop a critical understanding of the mechanisms of carcinogenesis and tumorigenesis whether via p53 dysregulation or failure of cancer immune-surveillance or through cross-talk with the tumor microenvironment or epigenetic modifications. The results of these studies will have a major impact on diagnosis, prognosis and treatment of a variety of human cancers.

    Collapse Research 
    Collapse research activities and funding
    K01CA087554     (SHERIF, ZAKI ABDULLAHI)Aug 4, 2000 - Jul 31, 2006
    NIH/NCI
    CHARACTERIZATION OF A NEW GENE IN P53 MUTANT LFS FAMILY
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Ashktorab H, Brim H, Hassan S, Nouraie M, Gebreselassie A, Laiyemo AO, Kibreab A, Aduli F, Latella G, Brant SR, Sherif Z, Habtezion A. Inflammatory polyps occur more frequently in inflammatory bowel disease than other colitis patients. BMC Gastroenterol. 2020 Jun 05; 20(1):170. PMID: 32503428.
      Citations:    Fields:    
    2. Sherif ZA. Unmasking a Stealth Killer: The Need for Increased Awareness of NASH. Dig Dis Sci. 2020 04; 65(4):987-989. PMID: 31531818.
      Citations:    Fields:    Translation:Humans
    3. Sherif ZA, Nouraie M, Begum R, Afsari A, Shokrani B, Lee E, Laiyemo AO, Brim H, Ashktorab H. Factors influencing treatment outcome in hepatitis C virus minority patients at an inner-city hospital: A STROBE-complaint article. Medicine (Baltimore). 2020 Apr; 99(14):e19505. PMID: 32243366.
      Citations:    Fields:    Translation:Humans
    4. Varghese RS, Zhou Y, Barefoot M, Chen Y, Di Poto C, Balla AK, Oliver E, Sherif ZA, Kumar D, Kroemer AH, Tadesse MG, Ressom HW. Identification of miRNA-mRNA associations in hepatocellular carcinoma using hierarchical integrative model. BMC Med Genomics. 2020 Mar 30; 13(1):56. PMID: 32228601.
      Citations:    Fields:    
    5. Yao Z, Di Poto C, Mavodza G, Oliver E, Ressom HW, Sherif ZA. DNA Methylation Activates TP73 Expression in Hepatocellular Carcinoma and Gastrointestinal Cancer. Sci Rep. 2019 12 18; 9(1):19367. PMID: 31852961.
      Citations:    Fields:    
    6. Ashktorab H, Sherif Z, Tarjoman T, Azam S, Lee E, Shokrani B, Okereke I, Soleimani A, Carethers JM, Laiyemo AO, Aduli F, Nouraie M, Habtezion A, Brim H. Elevated Risk for Sessile Serrated Polyps in African Americans with Endometrial Polyps. Dig Dis Sci. 2020 Sep; 65(9):2686-2690. PMID: 31832971.
      Citations:    Fields:    
    7. Ferrarini A, Di Poto C, He S, Tu C, Varghese RS, Kara Balla A, Jayatilake M, Li Z, Ghaffari K, Fan Z, Sherif ZA, Kumar D, Kroemer A, Tadesse MG, Ressom HW. Metabolomic Analysis of Liver Tissues for Characterization of Hepatocellular Carcinoma. J Proteome Res. 2019 08 02; 18(8):3067-3076. PMID: 31188000.
      Citations:    Fields:    Translation:Humans
    8. Di Poto C, He S, Varghese RS, Zhao Y, Ferrarini A, Su S, Karabala A, Redi M, Mamo H, Rangnekar AS, Fishbein TM, Kroemer AH, Tadesse MG, Roy R, Sherif ZA, Kumar D, Ressom HW. Identification of race-associated metabolite biomarkers for hepatocellular carcinoma in patients with liver cirrhosis and hepatitis C virus infection. PLoS One. 2018; 13(3):e0192748. PMID: 29538406.
      Citations: 3     Fields:    Translation:HumansCellsCTClinical Trials
    9. Brim H, Yooseph S, Lee E, Sherif ZA, Abbas M, Laiyemo AO, Varma S, Torralba M, Dowd SE, Nelson KE, Pathmasiri W, Sumner S, de Vos W, Liang Q, Yu J, Zoetendal E, Ashktorab H. A Microbiomic Analysis in African Americans with Colonic Lesions Reveals Streptococcus sp.VT162 as a Marker of Neoplastic Transformation. Genes (Basel). 2017 11 09; 8(11). PMID: 29120399.
      Citations: 2     Fields:    
    10. Afsari A, Lee E, Shokrani B, Boortalary T, Sherif ZA, Nouraie M, Laiyemo AO, Alkhalloufi K, Brim H, Ashktorab H. Clinical and Pathological Risk Factors Associated with Liver Fibrosis and Steatosis in African-Americans with Chronic Hepatitis C. Dig Dis Sci. 2017 08; 62(8):2159-2165. PMID: 28612194.
      Citations:    Fields:    Translation:HumansCells
    11. Yao Z, Sherif ZA. The effect of epigenetic silencing and TP53 mutation on the expression of DLL4 in human cancer stem disorder. Oncotarget. 2016 Sep 27; 7(39):62976-62988. PMID: 27542210.
      Citations: 3     Fields:    Translation:HumansCells
    12. Idowu KA, Adenuga B, Otubu O, Narasimhan K, Kamara F, Hunter-Richardson F, Larbi D, Sherif ZA, Laiyemo AO. Place of birth, cancer beliefs and being current with colon cancer screening among US adults. Ann Gastroenterol. 2016 Jul-Sep; 29(3):336-40. PMID: 27366035.
      Citations:    
    13. Sherif ZA, Saeed A, Ghavimi S, Nouraie SM, Laiyemo AO, Brim H, Ashktorab H. Global Epidemiology of Nonalcoholic Fatty Liver Disease and Perspectives on US Minority Populations. Dig Dis Sci. 2016 May; 61(5):1214-25. PMID: 27038448.
      Citations: 23     Fields:    Translation:Humans
    14. Malki A, Mohsen M, Aziz H, Rizk O, Shaban O, El-Sayed M, Sherif ZA, Ashour H. New 3-Cyano-2-Substituted Pyridines Induce Apoptosis in MCF 7 Breast Cancer Cells. Molecules. 2016 Feb 18; 21(2). PMID: 26901182.
      Citations: 2     Fields:    Translation:HumansCells
    15. Laiyemo AO, Thompson N, Williams CD, Idowu KA, Bull-Henry K, Sherif ZA, Lee EL, Brim H, Ashktorab H, Platz EA, Smoot DT. Race and colorectal cancer screening compliance among persons with a family history of cancer. World J Gastrointest Endosc. 2015 Dec 10; 7(18):1300-5. PMID: 26672497.
      Citations:    
    16. Sherif ZA. Caspase Activation and Aberrant Cell Growth in a p53(+/+) Cell Line from a Li-Fraumeni Syndrome Family. Genet Res Int. 2015; 2015:789201. PMID: 25866679.
      Citations:    
    17. Sherif ZA, Broome CW. Restoration of Mitochondrial Gene Expression Using a Cloned Human Gene in Chinese Hamster Lung Cell Mutant. Adv Tech Biol Med. 2015; 3(1). PMID: 26052559.
      Citations:    
    18. El-Bagary RI, Elkady EF, El-Sherif ZA, Kadry AM. LC-MS-MS simultaneous determination of atorvastatin and ezetimibe in human plasma. J Chromatogr Sci. 2014 Sep; 52(8):773-80. PMID: 23885041.
      Citations: 1     Fields:    Translation:Humans
    19. Sherif ZA, Sultan AS. Divergent control of Cav-1 expression in non-cancerous Li-Fraumeni syndrome and human cancer cell lines. Cancer Biol Ther. 2013 Jan; 14(1):29-38. PMID: 23114650.
      Citations: 7     Fields:    Translation:HumansCells
    20. Rida SM, Youssef AM, Badr MH, Malki A, Sherif ZA, Sultan AS. Design, synthesis and evaluation of novel benzimidazoles, benzothiazoles and benzofurans incorporating pyrazole moiety as antiangiogenic agents. Arzneimittelforschung. 2012 Feb; 62(2):63-74. PMID: 22344550.
      Citations: 2     Fields:    Translation:HumansCells
    21. Abdel-Fattah LS, El-Sherif ZA, Kilani KM, El-Haddad DA. HPLC, TLC, and first-derivative spectrophotometry stability-indicating methods for the determination of tropisetron in the presence of its acid degradates. J AOAC Int. 2010 Jul-Aug; 93(4):1180-91. PMID: 20922950.
      Citations:    Fields:    
    22. Sultan AS, Brim H, Sherif ZA. Co-overexpression of Janus kinase 2 and signal transducer and activator of transcription 5a promotes differentiation of mammary cancer cells through reversal of epithelial-mesenchymal transition. Cancer Sci. 2008 Feb; 99(2):272-9. PMID: 18271926.
      Citations: 22     Fields:    Translation:HumansCells
    23. Bailly N, Sherif ZA, Pleyer U, Rieck P. [Confocal microscopy in corneal dystrophies: a comparison between confocal slit scanning (ConfoScan P2) and laser scanning microscopy (Rostock Cornea Modul-HRT II)]. Klin Monbl Augenheilkd. 2006 Sep; 223(9):735-42. PMID: 16986083.
      Citations: 2     Fields:    Translation:Humans
    24. Sherif ZA, Danielsen M. Balanced t(11;15)(q23;q15) in a TP53+/+ breast cancer patient from a Li-Fraumeni syndrome family. Cancer Genet Cytogenet. 2006 Jul 01; 168(1):50-8. PMID: 16772121.
      Citations: 5     Fields:    Translation:HumansCells
    25. Sultan AS, S el G, Hessien M, Mahmoud el S, Ibrahim AS, Sherif ZA. Molecular markers of hepatitis C virus-related hepatocellular carcinoma. Cancer Biol Ther. 2006 Jun; 5(6):623-9. PMID: 16627984.
      Citations:    Fields:    Translation:HumansCells
    26. El-Sherif ZA, Mohamed AO, El-Bardicy MG, El-Tarras MF. Reversed-phase high performance liquid chromatographic method for the determination of lansoprazole, omeprazole and pantoprazole sodium sesquihydrate in presence of their Acid-induced degradation products. Chem Pharm Bull (Tokyo). 2006 Jun; 54(6):814-8. PMID: 16755049.
      Citations:    Fields:    
    27. Boulares AH, Zoltoski AJ, Sherif ZA, Jolly P, Massaro D, Smulson ME. Gene knockout or pharmacological inhibition of poly(ADP-ribose) polymerase-1 prevents lung inflammation in a murine model of asthma. Am J Respir Cell Mol Biol. 2003 Mar; 28(3):322-9. PMID: 12594058.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    28. Boulares AH, Zoltoski AJ, Sherif ZA, Yakovlev AG, Smulson ME. The Poly(ADP-ribose) polymerase-1-regulated endonuclease DNAS1L3 is required for etoposide-induced internucleosomal DNA fragmentation and increases etoposide cytotoxicity in transfected osteosarcoma cells. Cancer Res. 2002 Aug 01; 62(15):4439-44. PMID: 12154052.
      Citations: 8     Fields:    Translation:HumansCells
    29. Boulares AH, Zoltoski AJ, Sherif ZA, Yakovlev A, Smulson ME. Roles of DNA fragmentation factor and poly(ADP-ribose) polymerase-1 in sensitization of fibroblasts to tumor necrosis factor-induced apoptosis. Biochem Biophys Res Commun. 2002 Jan 18; 290(2):796-801. PMID: 11785971.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    30. Sherif ZA, Nakai S, Pirollo KF, Rait A, Chang EH. Downmodulation of bFGF-binding protein expression following restoration of p53 function. Cancer Gene Ther. 2001 Oct; 8(10):771-82. PMID: 11687900.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    31. Sherif ZA, Pleyer U, Rieck P, Hartmann C. [Confocal microscopy in corneal dystrophies]. Klin Monbl Augenheilkd. 1999 Jan; 214(1):12-21. PMID: 10198876.
      Citations: 1     Fields:    Translation:HumansCells
    32. Sherif ZA, Jefferson LM, Whitfield-Broome CD. Nuclear inheritance of a gene affecting mitochondrial gene expression. Somat Cell Mol Genet. 1996 Nov; 22(6):443-51. PMID: 9131014.
      Citations: 1     Fields:    Translation:AnimalsCells
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