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Bernard Kwabi-Addo

TitleAssociate Professor
Faculty RankAssociate Professor
InstitutionHoward University
DepartmentBiochemistry & Molecular Biology
AddressHoward University Cancer Center
2041 Georgia Ave. NW
Washington DC 20060
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    Other Positions
    TitleAdjunct Associate Professor
    InstitutionJohns Hopkins Medical School

    Collapse Biography 
    Collapse awards and honors
    1988First class Award in Calculus and Chemistry, University of Dundee (Scotland)
    1993 - 1997Ph.D Scholarship Award, Medical Research Council, U.K
    2004Minority Serving Institution Scholar Award, American Association for Cancer Research
    2004 - 2007New Investigator Award, Department of Defense
    2010Minority Serving Institution Faculty Scholar Award, American Association for Cancer Research
    2010Travel Award, Junior Faculty Abstract competition, Howard University College of Medicine
    2012Travel Award, 13th RCMI International Symposium on Health Disparities, RCMI/NIH
    2014American Association for Cancer Research Minority-Serving Institution Faculty Scholar Award, American Association for Cancer Research

    Collapse Overview 
    Collapse overview
    I am an Associate Professor of Biochemistry and Molecular Biology at Howard University, Washington D.C. I obtained my PhD in Molecular Biology from Queen Mary & Westfield College (University of London, UK) where I carried out studies using Cre-loxP site-specific recombination system to design chromosomal translation in transgenic animal model. I carried out my post-doctoral training at Baylor College of Medicine, Houston TX where I undertook research studies of the molecular mechanisms underlying dys-regulation of receptor tyrosine signaling in prostate cancer. I subsequently joined Howard University cancer Center in 2007 as an Assistant Professor and become an Associate Professor in 2011. Currently, I serve as a Principle Investigator of a prostate cancer research laboratory. The focus of my research is 3 fold: First, to understand the role of epigenetic alterations in regulating gene expression in prostate cancer. Second, to evaluate and implement tools for quantitative DNA methylation analysis in support of differences in prostate cancer tumor biology and prostate cancer disparity and finally, to understand how DNA methylation changes can be explored as potential biomarkers (ethnic sensitive biomarkers) for the early detection of cancer and/or progression of the disease.

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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Keith SW, Kwabi-Addo B, Zeigler-Johnson C. Interactions Between Obesity and One-Carbon Metabolism Genes in Predicting Prostate Cancer Outcomes Among White and Black Patients. J Racial Ethn Health Disparities. 2021 Jan 11. PMID: 33432479.
      Citations:    Fields:    
    2. Wang S, Tailor K, Kwabi-Addo B. Androgen-induced Epigenetic Profiles of Polycomb and Trithorax Genes in Prostate Cancer Cells. Anticancer Res. 2020 May; 40(5):2559-2565. PMID: 32366400.
      Citations: 1     Fields:    Translation:HumansCells
    3. Apprey V, Wang S, Tang W, Kittles RA, Southerland WM, Ittmann M, Kwabi-Addo B. Association of Genetic Ancestry With DNA Methylation Changes in Prostate Cancer Disparity. Anticancer Res. 2019 Nov; 39(11):5861-5866. PMID: 31704810.
      Citations: 3     Fields:    Translation:HumansCells
    4. Moses-Fynn E, Tang W, Beyene D, Apprey V, Copeland R, Kanaan Y, Kwabi-Addo B. Correlating blood-based DNA methylation markers and prostate cancer risk in African-American men. PLoS One. 2018; 13(9):e0203322. PMID: 30204798.
      Citations: 3     Fields:    Translation:HumansCells
    5. Bernard Kwabi-Addo. Health Outcomes in a Foreign Land- A Role for Epigenomic and Environmental Interaction. 2017; 324. View Publication.
    6. Wang S, Clarke PAG, Davis R, Mumuni S, Kwabi-Addo B. Sex steroid-induced DNA methylation changes and inflammation response in prostate cancer. Cytokine. 2016 10; 86:110-118. PMID: 27500645.
      Citations: 3     Fields:    Translation:HumansCells
    7. Akinboye ES, Bamji ZD, Kwabi-Addo B, Ejeh D, Copeland RL, Denmeade SR, Bakare O. Design, synthesis and cytotoxicity studies of dithiocarbamate ester derivatives of emetine in prostate cancer cell lines. Bioorg Med Chem. 2015 Sep 01; 23(17):5839-45. PMID: 26187015.
      Citations: 2     Fields:    Translation:HumansCells
    8. Devaney JM, Wang S, Furbert-Harris P, Apprey V, Ittmann M, Wang BD, Olender J, Lee NH, Kwabi-Addo B. Genome-wide differentially methylated genes in prostate cancer tissues from African-American and Caucasian men. Epigenetics. 2015; 10(4):319-28. PMID: 25864488.
      Citations: 18     Fields:    Translation:HumansCells
    9. Wing MR, Devaney JM, Joffe MM, Xie D, Feldman HI, Dominic EA, Guzman NJ, Ramezani A, Susztak K, Herman JG, Cope L, Harmon B, Kwabi-Addo B, Gordish-Dressman H, Go AS, He J, Lash JP, Kusek JW, Raj DS. DNA methylation profile associated with rapid decline in kidney function: findings from the CRIC study. Nephrol Dial Transplant. 2014 Apr; 29(4):864-72. PMID: 24516231.
      Citations: 38     Fields:    Translation:HumansCells
    10. Devaney JM, Wang S, Funda S, Long J, Taghipour DJ, Tbaishat R, Furbert-Harris P, Ittmann M, Kwabi-Addo B. Identification of novel DNA-methylated genes that correlate with human prostate cancer and high-grade prostatic intraepithelial neoplasia. Prostate Cancer Prostatic Dis. 2013 Dec; 16(4):292-300. PMID: 23896626.
      Citations: 23     Fields:    Translation:HumansCells
    11. Akinboye ES, Rosen MD, Denmeade SR, Kwabi-Addo B, Bakare O. Design, synthesis, and evaluation of pH-dependent hydrolyzable emetine analogues as treatment for prostate cancer. J Med Chem. 2012 Sep 13; 55(17):7450-9. PMID: 22867001.
      Citations: 5     Fields:    Translation:HumansCells
    12. Wang S, Dorsey TH, Terunuma A, Kittles RA, Ambs S, Kwabi-Addo B. Relationship between tumor DNA methylation status and patient characteristics in African-American and European-American women with breast cancer. PLoS One. 2012; 7(5):e37928. PMID: 22701537.
      Citations: 32     Fields:    Translation:HumansCells
    13. Vaughn MP, Biswal Shinohara D, Castagna N, Hicks JL, Netto G, De Marzo AM, Speed TJ, Reichert ZR, Kwabi-Addo B, Henderson CJ, Wolf CR, Yegnasubramanian S, Nelson WG. Humanizing p-class glutathione S-transferase regulation in a mouse model alters liver toxicity in response to acetaminophen overdose. PLoS One. 2011; 6(10):e25707. PMID: 22022436.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    14. Darimipourain M, Wang S, Ittmann M, Kwabi-Addo B. Transcriptional and post-transcriptional regulation of Sprouty1, a receptor tyrosine kinase inhibitor in prostate cancer. Prostate Cancer Prostatic Dis. 2011 Dec; 14(4):279-85. PMID: 21826097.
      Citations: 9     Fields:    Translation:HumansCells
    15. Bernard Kwabi-Addo and Tia Laura Lindstrom. Cancer Causes and Controversies- Understanding Risk Reduction and Prevention. 2011; 241. View Publication.
    16. Kwabi-Addo B, Wang S, Chung W, Jelinek J, Patierno SR, Wang BD, Andrawis R, Lee NH, Apprey V, Issa JP, Ittmann M. Identification of differentially methylated genes in normal prostate tissues from African American and Caucasian men. Clin Cancer Res. 2010 Jul 15; 16(14):3539-47. PMID: 20606036.
      Citations: 54     Fields:    Translation:HumansCells
    17. Kwabi-Addo B, Ren C, Ittmann M. DNA methylation and aberrant expression of Sprouty1 in human prostate cancer. Epigenetics. 2009 Jan; 4(1):54-61. PMID: 19164898.
      Citations: 12     Fields:    Translation:HumansCells
    18. Kondo Y, Shen L, Cheng AS, Ahmed S, Boumber Y, Charo C, Yamochi T, Urano T, Furukawa K, Kwabi-Addo B, Gold DL, Sekido Y, Huang TH, Issa JP. Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation. Nat Genet. 2008 Jun; 40(6):741-50. PMID: 18488029.
      Citations: 266     Fields:    Translation:HumansCells
    19. Chung W, Kwabi-Addo B, Ittmann M, Jelinek J, Shen L, Yu Y, Issa JP. Identification of novel tumor markers in prostate, colon and breast cancer by unbiased methylation profiling. PLoS One. 2008 Apr 30; 3(4):e2079. PMID: 18446232.
      Citations: 47     Fields:    Translation:HumansCells
    20. Kwabi-Addo B, Chung W, Shen L, Ittmann M, Wheeler T, Jelinek J, Issa JP. Age-related DNA methylation changes in normal human prostate tissues. Clin Cancer Res. 2007 Jul 01; 13(13):3796-802. PMID: 17606710.
      Citations: 86     Fields:    Translation:HumansCells
    21. Feng S, Agoulnik IU, Bogatcheva NV, Kamat AA, Kwabi-Addo B, Li R, Ayala G, Ittmann MM, Agoulnik AI. Relaxin promotes prostate cancer progression. Clin Cancer Res. 2007 Mar 15; 13(6):1695-702. PMID: 17363522.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    22. Wang J, Thompson B, Ren C, Ittmann M, Kwabi-Addo B. Sprouty4, a suppressor of tumor cell motility, is down regulated by DNA methylation in human prostate cancer. Prostate. 2006 May 01; 66(6):613-24. PMID: 16388505.
      Citations: 31     Fields:    Translation:HumansCells
    23. Rosa AL, Wu YQ, Kwabi-Addo B, Coveler KJ, Reid Sutton V, Shaffer LG. Allele-specific methylation of a functional CTCF binding site upstream of MEG3 in the human imprinted domain of 14q32. Chromosome Res. 2005; 13(8):809-18. PMID: 16331412.
      Citations: 16     Fields:    Translation:HumansCells
    24. Kwabi-Addo B, Ozen M, Ittmann M. The role of fibroblast growth factors and their receptors in prostate cancer. Endocr Relat Cancer. 2004 Dec; 11(4):709-24. PMID: 15613447.
      Citations: 112     Fields:    Translation:HumansCells
    25. Kwabi-Addo B, Wang J, Erdem H, Vaid A, Castro P, Ayala G, Ittmann M. The expression of Sprouty1, an inhibitor of fibroblast growth factor signal transduction, is decreased in human prostate cancer. Cancer Res. 2004 Jul 15; 64(14):4728-35. PMID: 15256439.
      Citations: 53     Fields:    Translation:HumansCells
    26. Polnaszek N, Kwabi-Addo B, Wang J, Ittmann M. FGF17 is an autocrine prostatic epithelial growth factor and is upregulated in benign prostatic hyperplasia. Prostate. 2004 Jun 15; 60(1):18-24. PMID: 15129425.
      Citations: 8     Fields:    Translation:HumansCells
    27. Polnaszek N, Kwabi-Addo B, Peterson LE, Ozen M, Greenberg NM, Ortega S, Basilico C, Ittmann M. Fibroblast growth factor 2 promotes tumor progression in an autochthonous mouse model of prostate cancer. Cancer Res. 2003 Sep 15; 63(18):5754-60. PMID: 14522896.
      Citations: 36     Fields:    Translation:AnimalsCells
    28. Lu S, Chen GL, Ren C, Kwabi-Addo B, Epner DE. Methionine restriction selectively targets thymidylate synthase in prostate cancer cells. Biochem Pharmacol. 2003 Sep 01; 66(5):791-800. PMID: 12948860.
      Citations: 3     Fields:    Translation:HumansCells
    29. Kwabi-Addo B, Giri D, Schmidt K, Podsypanina K, Parsons R, Greenberg N, Ittmann M. Haploinsufficiency of the Pten tumor suppressor gene promotes prostate cancer progression. Proc Natl Acad Sci U S A. 2001 Sep 25; 98(20):11563-8. PMID: 11553783.
      Citations: 98     Fields:    Translation:HumansAnimals
    30. Kwabi-Addo B, Ropiquet F, Giri D, Ittmann M. Alternative splicing of fibroblast growth factor receptors in human prostate cancer. Prostate. 2001 Feb 01; 46(2):163-72. PMID: 11170144.
      Citations: 27     Fields:    Translation:HumansCells
    31. Ropiquet F, Giri D, Kwabi-Addo B, Schmidt K, Ittmann M. FGF-10 is expressed at low levels in the human prostate. Prostate. 2000 Sep 01; 44(4):334-8. PMID: 10951499.
      Citations: 3     Fields:    Translation:HumansCells
    32. Ropiquet F, Giri D, Kwabi-Addo B, Mansukhani A, Ittmann M. Increased expression of fibroblast growth factor 6 in human prostatic intraepithelial neoplasia and prostate cancer. Cancer Res. 2000 Aug 01; 60(15):4245-50. PMID: 10945637.
      Citations: 25     Fields:    Translation:HumansCells
    33. Kwabi-Addo B, Thompson TC, Ittmann M. Absence of PTEN/MMAC1 pseudogene in mice. DNA Cell Biol. 2000 May; 19(5):301-5. PMID: 10855797.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    34. Smith AJ, De Sousa MA, Kwabi-Addo B, Heppell-Parton A, Impey H, Rabbitts P. A site-directed chromosomal translocation induced in embryonic stem cells by Cre-loxP recombination. Nat Genet. 1995 Apr; 9(4):376-85. PMID: 7795643.
      Citations: 78     Fields:    Translation:HumansAnimalsCells
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