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Georges Haddad

TitleDr.
InstitutionHoward University
DepartmentPhysiology & Biophysics
Address520 W street, Numa PG Adams Bldg
Room 2309
Washington DC 20059
Phone202-806 6305
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    My main focus of research is to characterize the mechanism of action of intracellular signaling pathways involved in the development of cardiac hypertrophy and its transition into heart failure, using different models such as the alcohol cardiomyopathy and volume-overload-induced cardiac hypertrophy. Of specific interest is the modulation of ion channels activities, and as such cardiac inotropy, by these pathways. Thus, I am actively working on the apoptotic and anti-apoptotic signaling related to the beneficial as well as the detrimental effects of chronic low versus high alcohol exposure, respectively, in the development of cardiac dysfunction and heart failure. My laboratory has found that alcohol activate the MAPKs and PI3K/Akt pathways, which have been shown to play a crucial role in the progression of cardiac contractile dysfunction and failure. Thus, my laboratory is on the forefront of studying the interactions between these kinases to modulate ionic channels activities and survival, especially in eccentric hypertrophy. In that regards, we have shown that not only PI3K/Akt activation is important for survival during cardiac hypertrophy and failure, but also acquires a major regulatory role on ion channels activities (IK1, IK and ICa,L). Such effects were found to be associated with cardiac dysfunctions during cardiomyopathy. On another note, my laboratory in collboartion with Boston University and Harvard university has undertaken an important endeavor in linking a genetic fingerprint to alcoholic cardiomyopathy in human. Due to the similarity in the volume-overload induced cardiac hypertrophy and obesity-related cardiac dysfunction, it is of great interest to elucidate the intricate relationship between apoptotic pathways and their causal relationship to changes in contractility during the setting of obesity-associated heart failure. In addition, I am starting to explore the role of cardiotropic peptides, such as CGRP and adipocytokines, in the precipitation of cardiac dysfunction and heart failure associated with obesity. My laboratory has already fostered collaborative relationships with other investigators in the field of cardiovascular diseases, gene therapy, gene sequencing and stem cell research which expanded our capabilities.

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    R15AA019816     (HADDAD, GEORGES E)Sep 20, 2011 - Aug 31, 2014
    NIH/NIAAA
    MECHANISMS OF ALCOHOL-INDUCED CARDIOMYOPATHY.
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. LaRocca TJ, Altman P, Jarrah AA, Gordon R, Wang E, Hadri L, Burke MW, Haddad GE, Hajjar RJ, Tarzami ST. CXCR4 Cardiac Specific Knockout Mice Develop a Progressive Cardiomyopathy. Int J Mol Sci. 2019 May 08; 20(9). PMID: 31071921.
      Citations:    Fields:    Translation:HumansAnimalsCells
    2. Obad A, Peeran A, Little JI, Haddad GE, Tarzami ST. Alcohol-Mediated Organ Damages: Heart and Brain. Front Pharmacol. 2018; 9:81. PMID: 29487525.
      Citations:    
    3. Guers JJ, Gwathmey J, Haddad G, Vatner DE, Vatner SF. Minority investigators lack NIH funding. Science. 2017 Jun 09; 356(6342):1018-1019. PMID: 28596331.
      Citations:    Fields:    
    4. Haddad GE. Modified mRNAs in the Cardiovascular System: A New Platform for Gene Therapy. Mol Ther. 2017 06 07; 25(6):1266-1268. PMID: 28550973.
      Citations:    Fields:    
    5. Nakhoul MR, Seif KE, Haddad N, Haddad GE. Fetal Alcohol Exposure: The Common Toll. J Alcohol Drug Depend. 2017 Feb; 5(1). PMID: 28868323.
      Citations:    
    6. Rodriguez A, Chawla K, Umoh NA, Cousins VM, Ketegou A, Reddy MG, AlRubaiee M, Haddad GE, Burke MW. Alcohol and Apoptosis: Friends or Foes? Biomolecules. 2015 Nov 19; 5(4):3193-203. PMID: 26610584.
      Citations: 9     Fields:    Translation:AnimalsCells
    7. Bamji ZD, Haddad GE. Convergence of theories of alcohol administration postanabolic stimulation on mTOR signaling: lessons for exercise regimen. Alcohol Clin Exp Res. 2015 May; 39(5):787-9. PMID: 25845444.
      Citations: 2     Fields:    Translation:HumansCells
    8. Haddad GE, Chams S, Chams N. The role of coronary microvascular disorder in congestive heart failure. Am J Physiol Heart Circ Physiol. 2015 Apr 15; 308(8):H814-5. PMID: 25724488.
      Citations: 2     Fields:    Translation:Animals
    9. Umoh NA, Walker RK, Al-Rubaiee M, Jeffress MA, Haddad GE. Acute alcohol modulates cardiac function as PI3K/Akt regulates oxidative stress. Alcohol Clin Exp Res. 2014 Jul; 38(7):1847-64. PMID: 24962888.
      Citations: 13     Fields:    Translation:AnimalsCells
    10. Bond V, Curry BH, Adams RG, Asadi MS, Stancil KA, Millis RM, Haddad GE. Effects of Nitrate Supplementation on Cardiovascular and Autonomic Reactivity in African-American Females. ISRN Physiol. 2014 Feb 23; 2014. PMID: 25401100.
      Citations:    
    11. Umoh NA, Walker RK, Millis RM, Al-Rubaiee M, Gangula PR, Haddad GE. Calcitonin Gene-Related Peptide Regulates Cardiomyocyte Survival through Regulation of Oxidative Stress by PI3K/Akt and MAPK Signaling Pathways. Ann Clin Exp Hypertens. 2014 Jan; 2(1):1007. PMID: 25478604.
      Citations:    
    12. Bond V, Curry BH, Adams RG, Asadi MS, Millis RM, Haddad GE. Effects of dietary nitrates on systemic and cerebrovascular hemodynamics. Cardiol Res Pract. 2013; 2013:435629. PMID: 24455404.
      Citations:    
    13. Bond V, Curry BH, Adams RG, Millis RM, Haddad GE. Cardiorespiratory function associated with dietary nitrate supplementation. Appl Physiol Nutr Metab. 2014 Feb; 39(2):168-72. PMID: 24476472.
      Citations: 9     Fields:    Translation:Humans
    14. Wang W, McKinnie SM, Patel VB, Haddad G, Wang Z, Zhabyeyev P, Das SK, Basu R, McLean B, Kandalam V, Penninger JM, Kassiri Z, Vederas JC, Murray AG, Oudit GY. Loss of Apelin exacerbates myocardial infarction adverse remodeling and ischemia-reperfusion injury: therapeutic potential of synthetic Apelin analogues. J Am Heart Assoc. 2013 Jul 01; 2(4):e000249. PMID: 23817469.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    15. Georges E. Haddad • Invited radio interview on Super Human Radio hosted by Mr. Carl Lanore, aired live on April 16, 2013 (1:00-2:00 pm) entitled “Alcohol: the Good, the Bad and the Ugly”: http://www.superhumanradio.com/components/com_podcast/media/mp3s/SHR_Show_1173.mp3. Alcohol: the Good, the Bad and the Ugly. 2013. View Publication.
    16. Al-Rubaiee M, Gangula PR, Millis RM, Walker RK, Umoh NA, Cousins VM, Jeffress MA, Haddad GE. Inotropic and lusitropic effects of calcitonin gene-related peptide in the heart. Am J Physiol Heart Circ Physiol. 2013 Jun 01; 304(11):H1525-37. PMID: 23585136.
      Citations: 7     Fields:    Translation:AnimalsCells
    17. Walker RK, Cousins VM, Umoh NA, Jeffress MA, Taghipour D, Al-Rubaiee M, Haddad GE. The good, the bad, and the ugly with alcohol use and abuse on the heart. Alcohol Clin Exp Res. 2013 Aug; 37(8):1253-60. PMID: 23527963.
      Citations: 20     Fields:    Translation:HumansCells
    18. Gangula PR, Dong YL, Al-Hendy A, Richard-Davis G, Montgomery-Rice V, Haddad G, Millis R, Nicholas SB, Moseberry D. Protective cardiovascular and renal actions of vitamin D and estrogen. Front Biosci (Schol Ed). 2013 Jan 01; 5:134-48. PMID: 23277041.
      Citations: 1     Fields:    Translation:HumansAnimals
    19. Millis RM, Bond V, Asadi MS, Haddad GE, Adams RG. Oxygen Consumption at 30 W of Exercise Is Surrogate for Peak Oxygen Consumption in Evaluation of Cardiorespiratory Fitness in Young-Adult African-American Females. ISRN Physiol. 2013; 2013:756276. PMID: 24490144.
      Citations:    
    20. Millis RM, Alvin ZV, Zhao A, Haddad GE. Effects of IGF-1 on I(K) and I(K1) Channels via PI3K/Akt Signaling in Neonatal Cardiac Myocytes. Int J Cell Biol. 2012; 2012:712153. PMID: 22761619.
      Citations:    
    21. Alvin ZV, Millis RM, Hajj-Mousssa W, Haddad GE. ATP-Sensitive Potassium Channel Currents in Eccentrically Hypertrophied Cardiac Myocytes of Volume-Overloaded Rats. Int J Cell Biol. 2011; 2011:838951. PMID: 21845191.
      Citations:    
    22. Alvin ZV, Laurence GG, Coleman BR, Zhao A, Hajj-Moussa M, Haddad GE. Regulation of the instantaneous inward rectifier and the delayed outward rectifier potassium channels by Captopril and Angiotensin II via the Phosphoinositide-3 kinase pathway in volume-overload-induced hypertrophied cardiac myocytes. Med Sci Monit. 2011 Jul; 17(7):BR165-72. PMID: 21709626.
      Citations: 2     Fields:    Translation:AnimalsCells
    23. Alvin Z, Laurence GG, Coleman BR, Zhao A, Hajj-Moussa M, Haddad GE. Regulation of L-type inward calcium channel activity by captopril and angiotensin II via the phosphatidyl inositol 3-kinase pathway in cardiomyocytes from volume-overload hypertrophied rat hearts. Can J Physiol Pharmacol. 2011 Mar; 89(3):206-15. PMID: 21423294.
      Citations: 10     Fields:    Translation:AnimalsCells
    24. LaRocca TJ, Schwarzkopf M, Altman P, Zhang S, Gupta A, Gomes I, Alvin Z, Champion HC, Haddad G, Hajjar RJ, Devi LA, Schecter AD, Tarzami ST. ß2-Adrenergic receptor signaling in the cardiac myocyte is modulated by interactions with CXCR4. J Cardiovasc Pharmacol. 2010 Nov; 56(5):548-59. PMID: 20729750.
      Citations: 32     Fields:    Translation:AnimalsCells
    25. Zhao A, Alvin Z, Laurence G, Li C, Haddad GE. Cross-talk between MAPKs and PI-3K pathways alters the functional density of I(K) channels in hypertrophied hearts. Ethn Dis. 2010; 20(1 Suppl 1):S1-219-24. PMID: 20521419.
      Citations: 5     Fields:    Translation:AnimalsCells
    26. Teos LY, Zhao A, Alvin Z, Laurence GG, Li C, Haddad GE. Basal and IGF-I-dependent regulation of potassium channels by MAP kinases and PI3-kinase during eccentric cardiac hypertrophy. Am J Physiol Heart Circ Physiol. 2008 Nov; 295(5):H1834-45. PMID: 18757484.
      Citations: 16     Fields:    Translation:AnimalsCells
    27. Haddad GE, Saunders L, Carles M, Crosby SD, del Monte F, Macgillivray TE, Semigran MJ, Dec GW, Hajjar RJ, Doye AA, Glass R, El M, Gwathmey JK. Fingerprint profile of alcohol-associated heart failure in human hearts. Alcohol Clin Exp Res. 2008 May; 32(5):814-21. PMID: 18336640.
      Citations: 4     Fields:    Translation:Humans
    28. Haddad GE, Saunders LJ, Crosby SD, Carles M, del Monte F, King K, Bristow MR, Spinale FG, Macgillivray TE, Semigran MJ, Dec GW, Williams SA, Hajjar RJ, Gwathmey JK. Human cardiac-specific cDNA array for idiopathic dilated cardiomyopathy: sex-related differences. Physiol Genomics. 2008 Apr 22; 33(2):267-77. PMID: 18303083.
      Citations: 13     Fields:    Translation:Humans
    29. Haddad GE. Gene therapy for diabetic cardiomyopathy: a new approach for a difficult problem. Mol Ther. 2006 May; 13(5):835-8. PMID: 16581303.
      Citations: 1     Fields:    Translation:AnimalsCells
    30. Haddad GE, Scheer A, Clarke E, Arguinzoni JK, Sobrian SK. Prenatal cocaine alone and combined with nicotine alters ANG II and IGF-1 induced left atrial contractions in aging male offspring. Can J Physiol Pharmacol. 2005 Nov; 83(11):957-65. PMID: 16391704.
      Citations: 1     Fields:    Translation:Animals
    31. Ha T, Hua F, Li Y, Ma J, Gao X, Kelley J, Zhao A, Haddad GE, Williams DL, Browder IW, Kao RL, Li C. Blockade of MyD88 attenuates cardiac hypertrophy and decreases cardiac myocyte apoptosis in pressure overload-induced cardiac hypertrophy in vivo. Am J Physiol Heart Circ Physiol. 2006 Mar; 290(3):H985-94. PMID: 16199478.
      Citations: 26     Fields:    Translation:AnimalsCells
    32. Ha T, Li Y, Gao X, McMullen JR, Shioi T, Izumo S, Kelley JL, Zhao A, Haddad GE, Williams DL, Browder IW, Kao RL, Li C. Attenuation of cardiac hypertrophy by inhibiting both mTOR and NFkappaB activation in vivo. Free Radic Biol Med. 2005 Dec 15; 39(12):1570-80. PMID: 16298682.
      Citations: 30     Fields:    Translation:AnimalsCells
    33. Ha T, Li Y, Hua F, Ma J, Gao X, Kelley J, Zhao A, Haddad GE, Williams DL, William Browder I, Kao RL, Li C. Reduced cardiac hypertrophy in toll-like receptor 4-deficient mice following pressure overload. Cardiovasc Res. 2005 Nov 01; 68(2):224-34. PMID: 15967420.
      Citations: 47     Fields:    Translation:AnimalsCells
    34. Haddad GE, Coleman BR, Zhao A, Blackwell KN. Regulation of atrial contraction by PKA and PKC during development and regression of eccentric cardiac hypertrophy. Am J Physiol Heart Circ Physiol. 2005 Feb; 288(2):H695-704. PMID: 15486031.
      Citations: 2     Fields:    Translation:Animals
    35. Haddad GE, Coleman BR, Zhao A, Blackwell KN. Modulation of atrial contraction by PKA and PKC during the compensated phase of eccentric cardiac hypertrophy. Basic Res Cardiol. 2004 Sep; 99(5):317-27. PMID: 15309409.
      Citations: 3     Fields:    Translation:Animals
    36. Haddad GE, Blackwell K, Bikhazi A. Regulation of insulin-like growth factor-1 by the renin-angiotensin system during regression of cardiac eccentric hypertrophy through angiotensin-converting enzyme inhibitor and AT1 antagonist. Can J Physiol Pharmacol. 2003 Feb; 81(2):142-9. PMID: 12710528.
      Citations: 4     Fields:    Translation:Animals
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