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Sergei Nekhai

TitleCenter for Sickle Cell Disease
InstitutionHoward University
DepartmentMedicine
Address1840 7th street, NW HURB-1, Rm.203_
Washington DC 20001
Phone(202) 865-4545
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    Collapse Research 
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    R25HL003679     (NEKHAI, SERGEI)Sep 30, 1996 - Aug 31, 2012
    NIH/NHLBI
    Howard University Research Scientist Award
    Role: Principal Investigator

    R21AI056973     (NEKHAI, SERGEI)Jul 1, 2003 - Jun 30, 2007
    NIH/NIAID
    REGULATION OF HIV-1 TRANSCRIPTION BY CDK2
    Role: Principal Investigator

    SC1GM082325     (NEKHAI, SERGEI)Apr 1, 2008 - Sep 9, 2011
    NIH/NIGMS
    Regulation of HIV-1 Transcription by CDK2
    Role: Principal Investigator

    R01HL125005     (NEKHAI, SERGEI)May 5, 2014 - Mar 31, 2019
    NIH/NHLBI
    Inhibition of HIV-1 in Sickle Cell Disease
    Role: Principal Investigator

    R13HL138729     (FRANK, MARTIN)Sep 1, 2017 - Aug 31, 2018
    NIH/NHLBI
    Conference on Physiology and Pathophysiology of Sickle Cell Disease
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Zhang X, Kershaw KN, Minniti CP, Campbell A, Rana SR, Darbari DS, Luchtman-Jones L, Sable C, Dham N, Ensing G, Arteta M, Taylor JG, Hsu LL, Nekhai S, Gordeuk VR. Influence of single parenthood on cardiopulmonary function in pediatric patients with sickle cell anemia. Blood Adv. 2020 Jul 28; 4(14):3311-3314. PMID: 32706890.
      Citations:    Fields:    
    2. Zhang X, Song J, Shah BN, Nekhai S, Miasnikova G, Sergueeva A, Prchal JT, Gordeuk VR. Peripheral blood mononuclear cells show prominent gene expression by erythroid progenitors in diseases characterized by heightened erythropoiesis. Br J Haematol. 2020 Jul; 190(1):e42-e45. PMID: 32399971.
      Citations:    Fields:    
    3. Jerebtsova M, Taye A, Smith N, Afangbedji N, Stokes D, Niu X, Diaz S, Taylor JG, Nekhai S. Association between plasma and urinary orosomucoid and chronic kidney disease in adults with sickle cell disease. Br J Haematol. 2020 Jul; 190(1):e45-e48. PMID: 32372411.
      Citations:    Fields:    
    4. Nouraie M, Darbari DS, Rana S, Minniti CP, Castro OL, Luchtman-Jones L, Sable C, Dham N, Kato GJ, Gladwin MT, Ensing G, Arteta M, Campbell A, Taylor JG, Nekhai S, Gordeuk VR. Tricuspid regurgitation velocity and other biomarkers of mortality in children, adolescents and young adults with sickle cell disease in the United States: The PUSH study. Am J Hematol. 2020 07; 95(7):766-774. PMID: 32243618.
      Citations: 1     Fields:    
    5. Liu W, Zhang S, Nekhai S, Liu S. Depriving Iron Supply to the Virus Represents a Promising Adjuvant Therapeutic Against Viral Survival. Curr Clin Microbiol Rep. 2020 Apr 20; 1-7. PMID: 32318324.
      Citations:    
    6. Jerebtsova M, Ahmad A, Kumari N, Rutagarama O, Nekhai S. Macrophage HIV-1 Gene Expression and Delay Resolution of Inflammation in HIV-Tg Mice. Viruses. 2020 03 01; 12(3). PMID: 32121564.
      Citations:    Fields:    
    7. Jerebtsova M, Ahmad A, Niu X, Rutagarama O, Nekhai S. HIV-1 Transcription Inhibitor 1E7-03 Restores LPS-Induced Alteration of Lung Leukocytes' Infiltration Dynamics and Resolves Inflammation in HIV Transgenic Mice. Viruses. 2020 02 12; 12(2). PMID: 32059509.
      Citations:    Fields:    
    8. Zhang X, Shah BN, Zhang W, Saraf SL, Nouraie M, Nekhai S, Machado RF, Gladwin MT, Gordeuk VR. S100B has pleiotropic effects on vaso-occlusive manifestations in sickle cell disease. Am J Hematol. 2020 03; 95(3):E62-E65. PMID: 31805207.
      Citations: 1     Fields:    Translation:Humans
    9. Younan P, Santos RI, Ramanathan P, Iampietro M, Nishida A, Dutta M, Ammosova T, Meyer M, Katze MG, Popov VL, Nekhai S, Bukreyev A. Ebola virus-mediated T-lymphocyte depletion is the result of an abortive infection. PLoS Pathog. 2019 10; 15(10):e1008068. PMID: 31648236.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    10. Ivanov A, Ramanathan P, Parry C, Ilinykh PA, Lin X, Petukhov M, Obukhov Y, Ammosova T, Amarasinghe GK, Bukreyev A, Nekhai S. Global phosphoproteomic analysis of Ebola virions reveals a novel role for VP35 phosphorylation-dependent regulation of genome transcription. Cell Mol Life Sci. 2020 Jul; 77(13):2579-2603. PMID: 31562565.
      Citations:    Fields:    Translation:HumansAnimalsCells
    11. Lin X, Ammosova T, Choy MS, Pietzsch CA, Ivanov A, Ahmad A, Saygideger Y, Kumari N, Kovalskyy D, Üren A, Peti W, Bukreyev A, Nekhai S. Targeting the Non-catalytic RVxF Site of Protein Phosphatase-1 With Small Molecules for Ebola Virus Inhibition. Front Microbiol. 2019; 10:2145. PMID: 31572348.
      Citations:    
    12. Dokekias AE, Ngolet L, Salomon-Andonie J, Nekhai S, Taylor JG. Establishing a national sickle cell disease program in the Republic of Congo. Blood Adv. 2018 11 30; 2(Suppl 1):17-18. PMID: 30504190.
      Citations:    Fields:    Translation:Humans
    13. Ammosova T, Pietzsch CA, Saygideger Y, Ilatovsky A, Lin X, Ivanov A, Kumari N, Jerebtsova M, Kulkarni A, Petukhov M, Üren A, Bukreyev A, Nekhai S. Protein Phosphatase 1-Targeting Small-Molecule C31 Inhibits Ebola Virus Replication. J Infect Dis. 2018 11 22; 218(suppl_5):S627-S635. PMID: 30169869.
      Citations:    Fields:    Translation:HumansAnimalsCells
    14. Tigabu B, Ramanathan P, Ivanov A, Lin X, Ilinykh PA, Parry CS, Freiberg AN, Nekhai S, Bukreyev A. Phosphorylated VP30 of Marburg Virus Is a Repressor of Transcription J Virol. 2018 11 01; 92(21). PMID: 30135121.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    15. Carey BD, Ammosova T, Pinkham C, Lin X, Zhou W, Liotta LA, Nekhai S, Kehn-Hall K. Protein Phosphatase 1a Interacts with Venezuelan Equine Encephalitis Virus Capsid Protein and Regulates Viral Replication through Modulation of Capsid Phosphorylation. J Virol. 2018 08 01; 92(15). PMID: 29769351.
      Citations: 1     Fields:    Translation:AnimalsCells
    16. Ivanov A, Lin X, Ammosova T, Ilatovskiy AV, Kumari N, Lassiter H, Afangbedji N, Niu X, Petukhov MG, Nekhai S. HIV-1 Tat phosphorylation on Ser-16 residue modulates HIV-1 transcription. Retrovirology. 2018 05 23; 15(1):39. PMID: 29792216.
      Citations: 2     Fields:    Translation:HumansCells
    17. Du M, Van Ness S, Gordeuk V, Nouraie SM, Nekhai S, Gladwin M, Steinberg MH, Sebastiani P. Biomarker signatures of sickle cell disease severity. Blood Cells Mol Dis. 2018 09; 72:1-9. PMID: 29778312.
      Citations: 3     Fields:    Translation:Humans
    18. Pleet ML, Mathiesen A, DeMarino C, Akpamagbo YA, Barclay RA, Schwab A, Iordanskiy S, Sampey GC, Lepene B, Ilinykh PA, Bukreyev A, Nekhai S, Aman MJ, Kashanchi F. Corrigendum: Ebola VP40 in Exosomes Can Cause Immune Cell Dysfunction. Front Microbiol. 2018; 9:692. PMID: 29696006.
      Citations:    
    19. Khaibullina A, Adjei EA, Afangbedji N, Ivanov A, Kumari N, Almeida LEF, Quezado ZMN, Nekhai S, Jerebtsova M. RON kinase inhibition reduces renal endothelial injury in sickle cell disease mice. Haematologica. 2018 05; 103(5):787-798. PMID: 29519868.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    20. Richard CA, Rincheval V, Lassoued S, Fix J, Cardone C, Esneau C, Nekhai S, Galloux M, Rameix-Welti MA, Sizun C, Eléouët JF. RSV hijacks cellular protein phosphatase 1 to regulate M2-1 phosphorylation and viral transcription. PLoS Pathog. 2018 03; 14(3):e1006920. PMID: 29489893.
      Citations: 2     Fields:    Translation:HumansCells
    21. Jerebtsova M, Saraf SL, Soni S, Afangbedji N, Lin X, Raslan R, Gordeuk VR, Nekhai S. Urinary orosomucoid is associated with progressive chronic kidney disease stage in patients with sickle cell anemia. Am J Hematol. 2018 08; 93(4):E107-E109. PMID: 29327376.
      Citations: 2     Fields:    Translation:Humans
    22. Jerebtsova M, Saraf SL, Lin X, Lee G, Adjei EA, Kumari N, Afangbedji N, Raslan R, McLean C, Gordeuk VR, Nekhai S. Identification of ceruloplasmin as a biomarker of chronic kidney disease in urine of sickle cell disease patients by proteomic analysis. Am J Hematol. 2018 02; 93(2):E45-E47. PMID: 29127684.
      Citations: 2     Fields:    Translation:Humans
    23. Lin X, Kumari N, DeMarino C, Kont YS, Ammosova T, Kulkarni A, Jerebtsova M, Vazquez-Meves G, Ivanov A, Dmytro K, Üren A, Kashanchi F, Nekhai S. Inhibition of HIV-1 infection in humanized mice and metabolic stability of protein phosphatase-1-targeting small molecule 1E7-03. Oncotarget. 2017 Sep 29; 8(44):76749-76769. PMID: 29100346.
      Citations: 4     Fields:    
    24. Sergueeva A, Miasnikova G, Shah BN, Song J, Lisina E, Okhotin DJ, Nouraie M, Nekhai S, Ammosova T, Niu XM, Prchal JT, Zhang X, Gordeuk VR. Prospective study of thrombosis and thrombospondin-1 expression in Chuvash polycythemia. Haematologica. 2017 05; 102(5):e166-e169. PMID: 28104701.
      Citations: 2     Fields:    Translation:Humans
    25. Lin X, Ammosova T, Kumari N, Nekhai S. Protein Phosphatase-1 -targeted Small Molecules, Iron Chelators and Curcumin Analogs as HIV-1 Antivirals. Curr Pharm Des. 2017; 23(28):4122-4132. PMID: 28677499.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    26. Kumari N, Ammosova T, Diaz S, Lin X, Niu X, Ivanov A, Jerebtsova M, Dhawan S, Oneal P, Nekhai S. Increased iron export by ferroportin induces restriction of HIV-1 infection in sickle cell disease. Blood Adv. 2016 Dec 27; 1(3):170-183. PMID: 28203649.
      Citations: 5     Fields:    
    27. Ammosova T, Washington K, Rotimi J, Kumari N, Smith KA, Niu X, Jerebtsova M, Nekhai S. Protein Phosphatase-1 Regulates Expression of Neuregulin-1. Biology (Basel). 2016 Dec 02; 5(4). PMID: 27918433.
      Citations:    
    28. Dai Y, Sangerman J, Nouraie M, Faller AD, Oneal P, Rock A, Owoyemi O, Niu X, Nekhai S, Maharaj D, Cui S, Taylor R, Steinberg M, Perrine S. Effects of hydroxyurea on F-cells in sickle cell disease and potential impact of a second fetal globin inducer. Am J Hematol. 2017 Jan; 92(1):E10-E11. PMID: 27766663.
      Citations:    Fields:    Translation:HumansCells
    29. Fluitt MB, Kumari N, Nunlee-Bland G, Nekhai S, Gambhir KK. miRNA-15a, miRNA-15b, and miRNA-499 are Reduced in Erythrocytes of Pre-Diabetic African-American Adults. Jacobs J Diabetes Endocrinol. 2016 Dec; 2(1). PMID: 29399662.
      Citations:    
    30. Pleet ML, Mathiesen A, DeMarino C, Akpamagbo YA, Barclay RA, Schwab A, Iordanskiy S, Sampey GC, Lepene B, Nekhai S, Aman MJ, Kashanchi F. Ebola VP40 in Exosomes Can Cause Immune Cell Dysfunction. Front Microbiol. 2016; 7:1765. PMID: 27872619.
      Citations:    
    31. Zhang X, Shah BN, Zhang W, Saraf SL, Miasnikova G, Sergueeva A, Ammosova T, Niu X, Nouraie M, Nekhai S, Castro O, Gladwin MT, Prchal JT, Garcia JG, Machado RF, Gordeuk VR. A genetic variation associated with plasma erythropoietin and a non-coding transcript of PRKAR1A in sickle cell disease. Hum Mol Genet. 2016 10 15; 25(20):4601-4609. PMID: 28173069.
      Citations:    Fields:    Translation:HumansCells
    32. Santos S, Obukhov Y, Nekhai S, Pushkarsky T, Brichacek B, Bukrinsky M, Iordanskiy S. Cellular minichromosome maintenance complex component 5 (MCM5) is incorporated into HIV-1 virions and modulates viral replication in the newly infected cells. Virology. 2016 10; 497:11-22. PMID: 27414250.
      Citations: 1     Fields:    Translation:HumansCells
    33. Ogunwuyi O, Kumari N, Smith KA, Bolshakov O, Adesina S, Gugssa A, Anderson WA, Nekhai S, Akala EO. Antiretroviral Drugs-Loaded Nanoparticles Fabricated by Dispersion Polymerization with Potential for HIV/AIDS Treatment. Infect Dis (Auckl). 2016; 9:21-32. PMID: 27013886.
      Citations:    
    34. Baer A, Shafagati N, Benedict A, Ammosova T, Ivanov A, Hakami RM, Terasaki K, Makino S, Nekhai S, Kehn-Hall K. Protein Phosphatase-1 regulates Rift Valley fever virus replication. Antiviral Res. 2016 Mar; 127:79-89. PMID: 26801627.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    35. Huang H, Konduru K, Solovena V, Zhou ZH, Kumari N, Takeda K, Nekhai S, Bavari S, Kaplan GG, Yamada KM, Dhawan S. Therapeutic potential of the heme oxygenase-1 inducer hemin against Ebola virus infection. Curr Trends Immunol. 2016; 17:117-123. PMID: 28133423.
      Citations:    
    36. Kumari N, Kulkarni AA, Lin X, McLean C, Ammosova T, Ivanov A, Hipolito M, Nekhai S, Nwulia E. Inhibition of HIV-1 by curcumin A, a novel curcumin analog. Drug Des Devel Ther. 2015; 9:5051-60. PMID: 26366056.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    37. Tyagi M, Iordanskiy S, Ammosova T, Kumari N, Smith K, Breuer D, Ilatovskiy AV, Kont YS, Ivanov A, Üren A, Kovalskyy D, Petukhov M, Kashanchi F, Nekhai S. Reactivation of latent HIV-1 provirus via targeting protein phosphatase-1. Retrovirology. 2015 Jul 16; 12:63. PMID: 26178009.
      Citations: 8     Fields:    Translation:HumansCells
    38. Smith KA, Lin X, Bolshakov O, Griffin J, Niu X, Kovalskyy D, Ivanov A, Jerebtsova M, Taylor RE, Akala E, Nekhai S. Activation of HIV-1 with Nanoparticle-Packaged Small-Molecule Protein Phosphatase-1-Targeting Compound. Sci Pharm. 2015 Jul-Sep; 83(3):535-48. PMID: 26839837.
      Citations:    
    39. Zhang X, Zhang W, Saraf SL, Nouraie M, Han J, Gowhari M, Hassan J, Miasnikova G, Sergueeva A, Nekhai S, Kittles R, Machado RF, Garcia JG, Gladwin MT, Steinberg MH, Sebastiani P, McClain DA, Gordeuk VR. Genetic polymorphism of APOB is associated with diabetes mellitus in sickle cell disease. Hum Genet. 2015 Aug; 134(8):895-904. PMID: 26025476.
      Citations: 4     Fields:    Translation:Humans
    40. Jerebtsova M, Nekhai S. Therapeutics for postexposure treatment of Ebola virus infection. Future Virol. 2015 Mar; 10(3):221-232. PMID: 26213559.
      Citations:    
    41. Kassim OO, Copeland RL, Kenguele HM, Nekhai S, Ako-Nai KA, Kanaan YM. Antiproliferative activities of Fagara xanthoxyloides and Pseudocedrela kotschyi against prostate cancer cell lines. Anticancer Res. 2015 Mar; 35(3):1453-8. PMID: 25750297.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    42. Jerebtsova M, Nekhai S. Quantitative mass spectrometry of urinary biomarkers. J Integr OMICS. 2014 Dec 01; 4(2):69-78. PMID: 25984422.
      Citations:    
    43. van Beers EJ, Yang Y, Raghavachari N, Tian X, Allen DT, Nichols JS, Mendelsohn L, Nekhai S, Gordeuk VR, Taylor JG, Kato GJ. Iron, inflammation, and early death in adults with sickle cell disease. Circ Res. 2015 Jan 16; 116(2):298-306. PMID: 25378535.
      Citations: 16     Fields:    Translation:HumansCellsCTClinical Trials
    44. Ammosova T, Platonov M, Ivanov A, Kont YS, Kumari N, Kehn-Hall K, Jerebtsova M, Kulkarni AA, Uren A, Kovalskyy D, Nekhai S. 1E7-03, a low MW compound targeting host protein phosphatase-1, inhibits HIV-1 transcription. Br J Pharmacol. 2014 Nov; 171(22):5059-75. PMID: 25073485.
      Citations: 12     Fields:    Translation:AnimalsCells
    45. Kumari N, Iordanskiy S, Kovalskyy D, Breuer D, Niu X, Lin X, Xu M, Gavrilenko K, Kashanchi F, Dhawan S, Nekhai S. Phenyl-1-Pyridin-2yl-ethanone-based iron chelators increase I?B-a expression, modulate CDK2 and CDK9 activities, and inhibit HIV-1 transcription. Antimicrob Agents Chemother. 2014 Nov; 58(11):6558-71. PMID: 25155598.
      Citations: 3     Fields:    Translation:HumansCells
    46. Ilinykh PA, Tigabu B, Ivanov A, Ammosova T, Obukhov Y, Garron T, Kumari N, Kovalskyy D, Platonov MO, Naumchik VS, Freiberg AN, Nekhai S, Bukreyev A. Role of protein phosphatase 1 in dephosphorylation of Ebola virus VP30 protein and its targeting for the inhibition of viral transcription. J Biol Chem. 2014 Aug 15; 289(33):22723-38. PMID: 24936058.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    47. Chasnyk V, Fedorova E, Egorov A, Ammosova T, Nekhai S, Kostik M, Santimov A, Dubko M, Kalashnikova O, Masalova V, Likhacheva T, Snegireva L, Grom A. A130: Is the CCR5-delta32 Mutation Protective Against Systemic-Onset Juvenile Idiopathic Arthritis? Arthritis Rheumatol. 2014 Mar; 66 Suppl 3:S171. PMID: 24677884.
      Citations:    Fields:    
    48. Zhang X, Zhang W, Ma SF, Desai AA, Saraf S, Miasniakova G, Sergueeva A, Ammosova T, Xu M, Nekhai S, Abbasi T, Casanova NG, Steinberg MH, Baldwin CT, Sebastiani P, Prchal JT, Kittles R, Garcia JG, Machado RF, Gordeuk VR. Hypoxic response contributes to altered gene expression and precapillary pulmonary hypertension in patients with sickle cell disease. Circulation. 2014 Apr 22; 129(16):1650-8. PMID: 24515990.
      Citations: 15     Fields:    Translation:HumansCells
    49. Nekhai S, Petukhov M, Breuer D. Regulation of CDK9 activity by phosphorylation and dephosphorylation. Biomed Res Int. 2014; 2014:964964. PMID: 24524087.
      Citations: 10     Fields:    Translation:HumansCells
    50. Ashenafi M, Ammosova T, Nekhai S, Byrnes WM. Purification and characterization of aminoglycoside phosphotransferase APH(6)-Id, a streptomycin-inactivating enzyme. Mol Cell Biochem. 2014 Feb; 387(1-2):207-16. PMID: 24248535.
      Citations: 1     Fields:    Translation:Cells
    51. Salomon-Andonie J, Miasnikova G, Sergueeva A, Polyakova LA, Niu X, Nekhai S, Gordeuk VR. Effect of congenital upregulation of hypoxia inducible factors on percentage of fetal hemoglobin in the blood. Blood. 2013 Oct 24; 122(17):3088-9. PMID: 24159170.
      Citations: 2     Fields:    Translation:Humans
    52. Zhang X, Zhang W, Ma SF, Miasniakova G, Sergueeva A, Ammosova T, Xu M, Nekhai S, Nourai M, Wade MS, Prchal JT, Garcia JGN, Machado RF, Gordeuk VR. Iron deficiency modifies gene expression variation induced by augmented hypoxia sensing. Blood Cells Mol Dis. 2014 Jan; 52(1):35-45. PMID: 23993337.
      Citations: 5     Fields:    Translation:HumansCells
    53. Zhou ZH, Kumari N, Nekhai S, Clouse KA, Wahl LM, Yamada KM, Dhawan S. Heme oxygenase-1 induction alters chemokine regulation and ameliorates human immunodeficiency virus-type-1 infection in lipopolysaccharide-stimulated macrophages. Biochem Biophys Res Commun. 2013 Jun 07; 435(3):373-7. PMID: 23665328.
      Citations: 10     Fields:    Translation:HumansCells
    54. Nekhai S, Kumari N, Dhawan S. Role of cellular iron and oxygen in the regulation of HIV-1 infection. Future Virol. 2013 Mar; 8(3):301-311. PMID: 23678366.
      Citations:    
    55. Tomasic NL, Piterkova L, Huff C, Bilic E, Yoon D, Miasnikova GY, Sergueeva AI, Niu X, Nekhai S, Gordeuk V, Prchal JT. The phenotype of polycythemia due to Croatian homozygous VHL (571C>G:H191D) mutation is different from that of Chuvash polycythemia (VHL 598C>T:R200W). Haematologica. 2013 Apr; 98(4):560-7. PMID: 23403324.
      Citations: 11     Fields:    Translation:HumansCells
    56. Zhou ZH, Kumari N, Catalano J, Nekhai S, Wise J, Yamada KM, Dhawan S. Heme oxygenase-1-mediated host cell response inhibits the susceptibility of prostate cancer cells to retroviral infection and retards their proliferation. Curr Trends Immunol. 2013 Jan; 14:53-56. PMID: 25620854.
      Citations:    
    57. Van Duyne R, Guendel I, Jaworski E, Sampey G, Klase Z, Chen H, Zeng C, Kovalskyy D, El Kouni MH, Lepene B, Patanarut A, Nekhai S, Price DH, Kashanchi F. Effect of mimetic CDK9 inhibitors on HIV-1-activated transcription. J Mol Biol. 2013 Feb 22; 425(4):812-29. PMID: 23247501.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    58. Breuer D, Kotelkin A, Ammosova T, Kumari N, Ivanov A, Ilatovskiy AV, Beullens M, Roane PR, Bollen M, Petukhov MG, Kashanchi F, Nekhai S. CDK2 regulates HIV-1 transcription by phosphorylation of CDK9 on serine 90. Retrovirology. 2012 Nov 09; 9:94. PMID: 23140174.
      Citations: 21     Fields:    Translation:HumansCells
    59. Nekhai S, Xu M, Foster A, Kasvosve I, Diaz S, Machado RF, Castro OL, Kato GJ, Taylor JG, Gordeuk VR. Reduced sensitivity of the ferroportin Q248H mutant to physiological concentrations of hepcidin. Haematologica. 2013 Mar; 98(3):455-63. PMID: 23065513.
      Citations: 4     Fields:    Translation:HumansCells
    60. Jerebtsova M, Kumari N, Obuhkov Y, Nekhai S. Adenoviral E4 gene stimulates secretion of pigmental epithelium derived factor (PEDF) that maintains long-term survival of human glomerulus-derived endothelial cells. Mol Cell Proteomics. 2012 Nov; 11(11):1378-88. PMID: 22915824.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    61. Debebe Z, Nekhai S, Ashenafi M, Lovejoy DB, Kalinowski DS, Gordeuk VR, Byrnes WM, Richardson DR, Karla PK. Development of a sensitive HPLC method to measure in vitro permeability of E- and Z-isomeric forms of thiosemicarbazones in Caco-2 monolayers. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Oct 01; 906:25-32. PMID: 22954966.
      Citations: 4     Fields:    Translation:HumansCells
    62. Santos S, Obukhov Y, Nekhai S, Bukrinsky M, Iordanskiy S. Virus-producing cells determine the host protein profiles of HIV-1 virion cores. Retrovirology. 2012 Aug 13; 9:65. PMID: 22889230.
      Citations: 29     Fields:    Translation:HumansCells
    63. Jerebtsova M, Kumari N, Xu M, de Melo GB, Niu X, Jeang KT, Nekhai S. HIV-1 Resistant CDK2-Knockdown Macrophage-Like Cells Generated from 293T Cell-Derived Human Induced Pluripotent Stem Cells. Biology (Basel). 2012 Jul 26; 1(2):175-195. PMID: 22934150.
      Citations:    
    64. Narayanan A, Sampey G, Van Duyne R, Guendel I, Kehn-Hall K, Roman J, Currer R, Galons H, Oumata N, Joseph B, Meijer L, Caputi M, Nekhai S, Kashanchi F. Use of ATP analogs to inhibit HIV-1 transcription. Virology. 2012 Oct 10; 432(1):219-31. PMID: 22771113.
      Citations: 9     Fields:    Translation:HumansCells
    65. Ammosova T, Platonov M, Yedavalli VR, Obukhov Y, Gordeuk VR, Jeang KT, Kovalskyy D, Nekhai S. Small molecules targeted to a non-catalytic "RVxF" binding site of protein phosphatase-1 inhibit HIV-1. PLoS One. 2012; 7(6):e39481. PMID: 22768081.
      Citations: 16     Fields:    Translation:HumansCells
    66. Nouraie M, Nekhai S, Gordeuk VR. Sickle cell disease is associated with decreased HIV but higher HBV and HCV comorbidities in U.S. hospital discharge records: a cross-sectional study. Sex Transm Infect. 2012 Nov; 88(7):528-33. PMID: 22628662.
      Citations: 9     Fields:    Translation:Humans
    67. Gordeuk VR, Miasnikova GY, Sergueeva AI, Niu X, Nouraie M, Okhotin DJ, Polyakova LA, Ammosova T, Nekhai S, Ganz T, Prchal JT. Chuvash polycythemia VHLR200W mutation is associated with down-regulation of hepcidin expression. Blood. 2011 Nov 10; 118(19):5278-82. PMID: 21876117.
      Citations: 16     Fields:    Translation:HumansCells
    68. Van Duyne R, Guendel I, Narayanan A, Gregg E, Shafagati N, Tyagi M, Easley R, Klase Z, Nekhai S, Kehn-Hall K, Kashanchi F. Varying modulation of HIV-1 LTR activity by Baf complexes. J Mol Biol. 2011 Aug 19; 411(3):581-96. PMID: 21699904.
      Citations: 22     Fields:    Translation:HumansCells
    69. Ammosova T, Obukhov Y, Kotelkin A, Breuer D, Beullens M, Gordeuk VR, Bollen M, Nekhai S. Protein phosphatase-1 activates CDK9 by dephosphorylating Ser175. PLoS One. 2011 Apr 21; 6(4):e18985. PMID: 21533037.
      Citations: 29     Fields:    Translation:HumansCells
    70. Thuma PE, van Dijk J, Bucala R, Debebe Z, Nekhai S, Kuddo T, Nouraie M, Weiss G, Gordeuk VR. Distinct clinical and immunologic profiles in severe malarial anemia and cerebral malaria in Zambia. J Infect Dis. 2011 Jan 15; 203(2):211-9. PMID: 21288821.
      Citations: 24     Fields:    Translation:HumansAnimals
    71. Xu M, Kashanchi F, Foster A, Rotimi J, Turner W, Gordeuk VR, Nekhai S. Hepcidin induces HIV-1 transcription inhibited by ferroportin. Retrovirology. 2010 Dec 02; 7:104. PMID: 21126372.
      Citations: 21     Fields:    Translation:HumansCells
    72. Ammosova T, Yedavalli VR, Niu X, Jerebtsova M, Van Eynde A, Beullens M, Bollen M, Jeang KT, Nekhai S. Expression of a protein phosphatase 1 inhibitor, cdNIPP1, increases CDK9 threonine 186 phosphorylation and inhibits HIV-1 transcription. J Biol Chem. 2011 Feb 04; 286(5):3798-804. PMID: 21098020.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    73. Debebe Z, Ammosova T, Breuer D, Lovejoy DB, Kalinowski DS, Kumar K, Jerebtsova M, Ray P, Kashanchi F, Gordeuk VR, Richardson DR, Nekhai S. Iron chelators of the di-2-pyridylketone thiosemicarbazone and 2-benzoylpyridine thiosemicarbazone series inhibit HIV-1 transcription: identification of novel cellular targets--iron, cyclin-dependent kinase (CDK) 2, and CDK9. Mol Pharmacol. 2011 Jan; 79(1):185-96. PMID: 20956357.
      Citations: 32     Fields:    Translation:HumansCells
    74. Jerebtsova M, Klotchenko SA, Artamonova TO, Ammosova T, Washington K, Egorov VV, Shaldzhyan AA, Sergeeva MV, Zatulovskiy EA, Temkina OA, Petukhov MG, Vasin AV, Khodorkovskii MA, Orlov YN, Nekhai S. Mass spectrometry and biochemical analysis of RNA polymerase II: targeting by protein phosphatase-1. Mol Cell Biochem. 2011 Jan; 347(1-2):79-87. PMID: 20941529.
      Citations: 11     Fields:    Translation:HumansCells
    75. Kasvosve I, Debebe Z, Nekhai S, Gordeuk VR. Ferroportin (SLC40A1) Q248H mutation is associated with lower circulating plasma tumor necrosis factor-alpha and macrophage migration inhibitory factor concentrations in African children. Clin Chim Acta. 2010 Sep 06; 411(17-18):1248-52. PMID: 20460119.
      Citations: 3     Fields:    Translation:Humans
    76. Charles S, Ammosova T, Cardenas J, Foster A, Rotimi J, Jerebtsova M, Ayodeji AA, Niu X, Ray PE, Gordeuk VR, Kashanchi F, Nekhai S. Regulation of HIV-1 transcription at 3% versus 21% oxygen concentration. J Cell Physiol. 2009 Nov; 221(2):469-79. PMID: 19626680.
      Citations: 8     Fields:    Translation:HumansCells
    77. Gordeuk VR, Campbell A, Rana S, Nouraie M, Niu X, Minniti CP, Sable C, Darbari D, Dham N, Onyekwere O, Ammosova T, Nekhai S, Kato GJ, Gladwin MT, Castro OL. Relationship of erythropoietin, fetal hemoglobin, and hydroxyurea treatment to tricuspid regurgitation velocity in children with sickle cell disease. Blood. 2009 Nov 19; 114(21):4639-44. PMID: 19724057.
      Citations: 22     Fields:    Translation:Humans
    78. Niu X, Miasnikova GY, Sergueeva AI, Polyakova LA, Okhotin DJ, Tuktanov NV, Nouraie M, Ammosova T, Nekhai S, Gordeuk VR. Altered cytokine profiles in patients with Chuvash polycythemia. Am J Hematol. 2009 Feb; 84(2):74-8. PMID: 19062180.
      Citations: 9     Fields:    Translation:Humans
    79. Gordeuk VR, Diaz SF, Onojobi GO, Kasvosve I, Debebe Z, Edossa A, Pantin JM, Xiong S, Nekhai S, Nouraie M, Tsukamoto H, Taylor RE. Ferroportin Q248h, dietary iron, and serum ferritin in community African-Americans with low to high alcohol consumption. Alcohol Clin Exp Res. 2008 Nov; 32(11):1947-53. PMID: 18782341.
      Citations: 4     Fields:    Translation:Humans
    80. Berro R, Pedati C, Kehn-Hall K, Wu W, Klase Z, Even Y, Genevière AM, Ammosova T, Nekhai S, Kashanchi F. CDK13, a new potential human immunodeficiency virus type 1 inhibitory factor regulating viral mRNA splicing. J Virol. 2008 Jul; 82(14):7155-66. PMID: 18480452.
      Citations: 22     Fields:    Translation:HumansCells
    81. Sergueeva AI, Miasnikova GY, Okhotin DJ, Levina AA, Debebe Z, Ammosova T, Niu X, Romanova EA, Nekhai S, DiBello PM, Jacobsen DW, Prchal JT, Gordeuk VR. Elevated homocysteine, glutathione and cysteinylglycine concentrations in patients homozygous for the Chuvash polycythemia VHL mutation. Haematologica. 2008 Feb; 93(2):279-82. PMID: 18223282.
      Citations: 5     Fields:    Translation:Humans
    82. Debebe Z, Ammosova T, Jerebtsova M, Kurantsin-Mills J, Niu X, Charles S, Richardson DR, Ray PE, Gordeuk VR, Nekhai S. Iron chelators ICL670 and 311 inhibit HIV-1 transcription. Virology. 2007 Oct 25; 367(2):324-33. PMID: 17631934.
      Citations: 29     Fields:    Translation:HumansCells
    83. Berro R, de la Fuente C, Klase Z, Kehn K, Parvin L, Pumfery A, Agbottah E, Vertes A, Nekhai S, Kashanchi F. Identifying the membrane proteome of HIV-1 latently infected cells. J Biol Chem. 2007 Mar 16; 282(11):8207-18. PMID: 17237230.
      Citations: 19     Fields:    Translation:HumansCells
    84. Nekhai S, Jerebtsova M, Jackson A, Southerland W. Regulation of HIV-1 transcription by protein phosphatase 1. Curr HIV Res. 2007 Jan; 5(1):3-9. PMID: 17266553.
      Citations: 16     Fields:    Translation:Cells
    85. Nekhai S, Bhat UG, Ammosova T, Radhakrishnan SK, Jerebtsova M, Niu X, Foster A, Layden TJ, Gartel AL. A novel anticancer agent ARC antagonizes HIV-1 and HCV. Oncogene. 2007 May 31; 26(26):3899-903. PMID: 17173067.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    86. Nekhai S, Jeang KT. Transcriptional and post-transcriptional regulation of HIV-1 gene expression: role of cellular factors for Tat and Rev. Future Microbiol. 2006 Dec; 1(4):417-26. PMID: 17661632.
      Citations: 47     Fields:    Translation:HumansCells
    87. Ammosova T, Berro R, Jerebtsova M, Jackson A, Charles S, Klase Z, Southerland W, Gordeuk VR, Kashanchi F, Nekhai S. Phosphorylation of HIV-1 Tat by CDK2 in HIV-1 transcription. Retrovirology. 2006 Nov 03; 3:78. PMID: 17083724.
      Citations: 43     Fields:    Translation:HumansCells
    88. Epie N, Ammosova T, Turner W, Nekhai S. Inhibition of PP2A by LIS1 increases HIV-1 gene expression. Retrovirology. 2006 Oct 02; 3:65. PMID: 17018134.
      Citations: 9     Fields:    Translation:HumansCells
    89. Bushuev VI, Miasnikova GY, Sergueeva AI, Polyakova LA, Okhotin D, Gaskin PR, Debebe Z, Nekhai S, Castro OL, Prchal JT, Gordeuk VR. Endothelin-1, vascular endothelial growth factor and systolic pulmonary artery pressure in patients with Chuvash polycythemia. Haematologica. 2006 Jun; 91(6):744-9. PMID: 16769575.
      Citations: 33     Fields:    Translation:Humans
    90. Kasvosve I, Gomo ZA, Nathoo KJ, Matibe P, Mudenge B, Loyevsky M, Nekhai S, Gordeuk VR. Association of serum transferrin receptor concentration with markers of inflammation in Zimbabwean children. Clin Chim Acta. 2006 Sep; 371(1-2):130-6. PMID: 16603144.
      Citations: 6     Fields:    Translation:HumansCells
    91. Nekhai S, Jerebtsova M. Therapies for HIV with RNAi. Curr Opin Mol Ther. 2006 Feb; 8(1):52-61. PMID: 16506526.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    92. Pumfery A, de la Fuente C, Berro R, Nekhai S, Kashanchi F, Chao SH. Potential use of pharmacological cyclin-dependent kinase inhibitors as anti-HIV therapeutics. Curr Pharm Des. 2006; 12(16):1949-61. PMID: 16787240.
      Citations: 14     Fields:    Translation:Humans
    93. Ammosova T, Jerebtsova M, Beullens M, Lesage B, Jackson A, Kashanchi F, Southerland W, Gordeuk VR, Bollen M, Nekhai S. Nuclear targeting of protein phosphatase-1 by HIV-1 Tat protein. J Biol Chem. 2005 Oct 28; 280(43):36364-71. PMID: 16131488.
      Citations: 28     Fields:    Translation:HumansCells
    94. Ammosova T, Berro R, Kashanchi F, Nekhai S. RNA interference directed to CDK2 inhibits HIV-1 transcription. Virology. 2005 Oct 25; 341(2):171-8. PMID: 16085226.
      Citations: 20     Fields:    Translation:HumansCells
    95. Ammosova T, Washington K, Debebe Z, Brady J, Nekhai S. Dephosphorylation of CDK9 by protein phosphatase 2A and protein phosphatase-1 in Tat-activated HIV-1 transcription. Retrovirology. 2005 Jul 27; 2:47. PMID: 16048649.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    96. Epie N, Ammosova T, Sapir T, Voloshin Y, Lane WS, Turner W, Reiner O, Nekhai S. HIV-1 Tat interacts with LIS1 protein. Retrovirology. 2005 Feb 07; 2:6. PMID: 15698475.
      Citations: 16     Fields:    Translation:HumansCells
    97. Ammosova T, Jerebtsova M, Beullens M, Voloshin Y, Ray PE, Kumar A, Bollen M, Nekhai S. Nuclear protein phosphatase-1 regulates HIV-1 transcription. J Biol Chem. 2003 Aug 22; 278(34):32189-94. PMID: 12788939.
      Citations: 24     Fields:    Translation:HumansCells
    98. Washington K, Ammosova T, Beullens M, Jerebtsova M, Kumar A, Bollen M, Nekhai S. Protein phosphatase-1 dephosphorylates the C-terminal domain of RNA polymerase-II. J Biol Chem. 2002 Oct 25; 277(43):40442-8. PMID: 12185079.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    99. Deng L, Ammosova T, Pumfery A, Kashanchi F, Nekhai S. HIV-1 Tat interaction with RNA polymerase II C-terminal domain (CTD) and a dynamic association with CDK2 induce CTD phosphorylation and transcription from HIV-1 promoter. J Biol Chem. 2002 Sep 13; 277(37):33922-9. PMID: 12114499.
      Citations: 31     Fields:    Translation:HumansCells
    100. Nekhai S, Zhou M, Fernandez A, Lane WS, Lamb NJ, Brady J, Kumar A. HIV-1 Tat-associated RNA polymerase C-terminal domain kinase, CDK2, phosphorylates CDK7 and stimulates Tat-mediated transcription. Biochem J. 2002 Jun 15; 364(Pt 3):649-57. PMID: 12049628.
      Citations: 25     Fields:    Translation:HumansCells
    101. Bharucha DC, Zhou M, Nekhai S, Brady JN, Shukla RR, Kumar A. A protein phosphatase from human T cells augments tat transactivation of the human immunodeficiency virus type 1 long-terminal repeat. Virology. 2002 Apr 25; 296(1):6-16. PMID: 12036313.
      Citations: 6     Fields:    Translation:HumansCells
    102. Nekhai SA, Beletzkij VE, Graifer DM. Influence of systematic error on the shape of the scatchard plot of tRNAPhe binding to eukaryotic ribosomes. Biochem J. 1997 Jul 15; 325 ( Pt 2):401-4. PMID: 9230119.
      Citations: 2     Fields:    Translation:HumansCells
    103. Nekhai SA, Parfenov DV, Saminsky EM. tRNA regions which contact with the ribosomal poly(U)-programmed P-site. Biochim Biophys Acta. 1994 Aug 02; 1218(3):481-4. PMID: 8049279.
      Citations: 3     Fields:    Translation:AnimalsCells
    104. Nekhai SA, Saminskii EM. [Study of the poly(U)-dependent interaction of tRNA(Phe) with the P-site of Escherichia coli ribosomes by chemical modification with nitrosoethylurea]. Mol Biol (Mosk). 1994 Jul-Aug; 28(4):926-31. PMID: 7990821.
      Citations:    Fields:    Translation:Cells
    105. Nekhai SA, Saminsky EM. On the binding of isolated yeast tRNA(Phe) anticodon arm to Escherichia coli 30S and 70S ribosomes. Guanosine-42 is important for the binding. Biochim Biophys Acta. 1994 May 17; 1218(1):21-6. PMID: 8193162.
      Citations: 2     Fields:    Translation:Cells
    106. Nekhai SA, Saminskii EM. [Binding of a fragment of yeast phenylalanyl tRNA containing an anticodon loop with 30S and 70S ribosomes from Escherichia coli. The role of guanosine-42 in this interaction]. Mol Biol (Mosk). 1994 May-Jun; 28(3):658-64. PMID: 8052257.
      Citations:    Fields:    Translation:AnimalsCells
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