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Wayne W. Harding

TitleAssistant Professor of Chemistry
InstitutionHunter College, CUNY
Departmentchemistry
AddressRoom 1307 HN, Hunter College, CUNY
695 Park Avenue
New York NY 10065
Phone(212) 772-5359
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Dorogan M, Namballa HK, Harding WW. Natural Product-Inspired Dopamine Receptor Ligands. J Med Chem. 2024 Jul 22. PMID: 39038276.
      Citations:    Fields:    
    2. Namballa HK, Decker AM, Dorogan M, Gudipally A, Goclon J, Harding WW. Fluoroalkoxylated C-3 and C-9 (S)-12-bromostepholidine analogues with D1R antagonist activity. Bioorg Chem. 2023 12; 141:106862. PMID: 37722267.
      Citations:    Fields:    
    3. Giri R, Namballa HK, Emogaje V, Harding WW. Structure-Activity Relationship Studies on 6-Chloro-1-phenylbenzazepines Leads to the Identification of a New Dopamine D1 Receptor Antagonist. Molecules. 2023 Aug 11; 28(16). PMID: 37630262.
      Citations:    Fields:    
    4. Namballa HK, Dorogan M, Gudipally AR, Okafor S, Gadhiya S, Harding WW. Discovery of Selective Dopamine Receptor Ligands Derived from (-)-Stepholidine via C-3 Alkoxylation and C-3/C-9 Dialkoxylation. J Med Chem. 2023 07 27; 66(14):10060-10079. PMID: 37421373.
      Citations: 1     Fields:    
    5. Cai T, Xie L, Zhang S, Chen M, He D, Badkul A, Liu Y, Namballa HK, Dorogan M, Harding WW, Mura C, Bourne PE, Xie L. End-to-end sequence-structure-function meta-learning predicts genome-wide chemical-protein interactions for dark proteins. PLoS Comput Biol. 2023 01; 19(1):e1010851. PMID: 36652496.
      Citations: 1     Fields:    Translation:HumansCells
    6. Namballa HK, Madapa S, Sigalapalli DK, Harding WW. Semisynthetic Transformations on (+)-Boldine Reveal a 5-HT2A/2CR Antagonist. J Nat Prod. 2022 09 23; 85(9):2149-2158. PMID: 36001775.
      Citations:    Fields:    Translation:HumansCells
    7. Giri R, Namballa HK, Sarker A, Alberts I, Harding WW. Further studies on C2'-substituted 1-phenylbenzazepines as dopamine D1 receptor ligands. Bioorg Chem. 2022 10; 127:105953. PMID: 35772367.
      Citations: 1     Fields:    
    8. Cordone P, Namballa HK, Muniz B, Pal RK, Gallicchio E, Harding WW. New tetrahydroisoquinoline-based D3R ligands with an o-xylenyl linker motif. Bioorg Med Chem Lett. 2021 06 15; 42:128047. PMID: 33882273.
      Citations:    Fields:    Translation:HumansCells
    9. Bennett A, Barrera E, Namballa H, Harding W, Ranaldi R. (-)-Stepholidine blocks expression, but not development, of cocaine conditioned place preference in rats. Neurosci Lett. 2020 08 24; 734:135151. PMID: 32531529.
      Citations: 2     Fields:    Translation:Animals
    10. Karki A, Namballa HK, Alberts I, Harding WW. Structural manipulation of aporphines via C10 nitrogenation leads to the identification of new 5-HT7AR ligands. Bioorg Med Chem. 2020 08 01; 28(15):115578. PMID: 32631561.
      Citations: 1     Fields:    Translation:HumansCells
    11. Giri R, Namballa HK, Sarker A, Alberts I, Harding WW. Synthesis and dopamine receptor pharmacological evaluations on ring C ortho halogenated 1-phenylbenzazepines. Bioorg Med Chem Lett. 2020 08 15; 30(16):127305. PMID: 32631525.
      Citations: 3     Fields:    Translation:Cells
    12. Giri R, Alberts I, Harding WW. Synthesis, pharmacological evaluations, and molecular docking studies on a new 1,3,4,11b-tetrahydro-1H-fluoreno[9,1-cd]azepine framework: Rigidification of D1 receptor selective 1-phenylbenzazepines and discovery of a new 5-HT6 receptor scaffold. Chem Biol Drug Des. 2020 08; 96(2):825-835. PMID: 32279445.
      Citations:    Fields:    Translation:Cells
    13. Cordone P, Namballa HK, Harding WW. First synthesis of thiazepino[3,4-a]isoquinolines, a facile new synthetic route to diazepino[3,4-a]isoquinolines and assessment of their dopamine and s receptor affinities. J Heterocycl Chem. 2020 Oct; 57(10):3709-3713. PMID: 34565832.
      Citations:    
    14. Karki A, Juarez R, Namballa HK, Alberts I, Harding WW. Identification of C10 nitrogen-containing aporphines with dopamine D1 versus D5 receptor selectivity. Bioorg Med Chem Lett. 2020 04 15; 30(8):127053. PMID: 32107165.
      Citations: 2     Fields:    Translation:HumansCells
    15. Pal RK, Gadhiya S, Ramsey S, Cordone P, Wickstrom L, Harding WW, Kurtzman T, Gallicchio E. Inclusion of enclosed hydration effects in the binding free energy estimation of dopamine D3 receptor complexes. PLoS One. 2019; 14(9):e0222902. PMID: 31568493.
      Citations: 3     Fields:    Translation:HumansCells
    16. Marchant JS, Harding WW, Chan JD. Structure-activity profiling of alkaloid natural product pharmacophores against a Schistosoma serotonin receptor. Int J Parasitol Drugs Drug Resist. 2018 12; 8(3):550-558. PMID: 30297303.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    17. Gadhiya S, Cordone P, Pal RK, Gallicchio E, Wickstrom L, Kurtzman T, Ramsey S, Harding WW. New Dopamine D3-Selective Receptor Ligands Containing a 6-Methoxy-1,2,3,4-tetrahydroisoquinolin-7-ol Motif. ACS Med Chem Lett. 2018 Oct 11; 9(10):990-995. PMID: 30344905.
      Citations:    
    18. Manuszak M, Harding W, Gadhiya S, Ranaldi R. (-)-Stepholidine reduces cue-induced reinstatement of cocaine seeking and cocaine self-administration in rats. Drug Alcohol Depend. 2018 08 01; 189:49-54. PMID: 29879681.
      Citations: 7     Fields:    Translation:Animals
    19. Madapa S, Gadhiya S, Kurtzman T, Alberts IL, Ramsey S, Reith M, Harding WW. Synthesis and evaluation of C9 alkoxy analogues of (-)-stepholidine as dopamine receptor ligands. Eur J Med Chem. 2017 Jan 05; 125:255-268. PMID: 27688181.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    20. Galaj E, Harding W, Ranaldi R. Dopamine D1 and D3 receptor interactions in cocaine reward and seeking in rats. Psychopharmacology (Berl). 2016 Dec; 233(23-24):3881-3890. PMID: 27582181.
      Citations: 8     Fields:    Translation:Animals
    21. Kapadia N, Ahmed S, Harding WW. New halogenated tris-(phenylalkyl)amines as h5-HT2B receptor ligands. Bioorg Med Chem Lett. 2016 07 15; 26(14):3216-3219. PMID: 27261181.
      Citations: 2     Fields:    Translation:HumansCells
    22. Gadhiya SV, Hu C, Harding WW. An alternative synthesis and x-ray crystallographic confirmation of (-)-stepholidine. Tetrahedron Lett. 2016 May 11; 57(19):2090-2092. PMID: 27152055.
      Citations: 3     Fields:    
    23. Gadhiya S, Madapa S, Kurtzman T, Alberts IL, Ramsey S, Pillarsetty NK, Kalidindi T, Harding WW. Tetrahydroprotoberberine alkaloids with dopamine and s receptor affinity. Bioorg Med Chem. 2016 May 01; 24(9):2060-71. PMID: 27032890.
      Citations: 4     Fields:    
    24. Ponnala S, Kapadia N, Madapa S, Alberts IL, Harding WW. Synthesis and evaluation of aporphine analogs containing C1 allyl isosteres at the h5-HT(2A) receptor. Bioorg Med Chem Lett. 2015 Nov 15; 25(22):5102-6. PMID: 26475518.
      Citations: 3     Fields:    Translation:Humans
    25. Kapadia N, Harding WW. C4 phenyl aporphines with selective h5-HT(2B) receptor affinity. Bioorg Med Chem Lett. 2015 Sep 01; 25(17):3451-4. PMID: 26227772.
      Citations: 2     Fields:    Translation:Cells
    26. Gadhiya S, Ponnala S, Harding WW. A divergent route to 9, 10-oxygenated tetrahydroprotoberberine and 8-oxoprotoberberine alkaloids: synthesis of (?)-isocorypalmine and oxypalmatine. Tetrahedron. 2015 Feb 25; 71(8):1227-1231. PMID: 25691805.
      Citations: 8     Fields:    
    27. Madapa S, Harding WW. Semisynthetic Studies on and Biological Evaluation of N-Methyllaurotetanine Analogues as Ligands for 5-HT Receptors. J Nat Prod. 2015 Apr 24; 78(4):722-9. PMID: 25695425.
      Citations: 3     Fields:    Translation:Cells
    28. Ponnala S, Kapadia N, Navarro HA, Harding WW. Aporphinoid antagonists of 5-HT2A receptors: further evaluation of ring A substituents and the size of ring C. Chem Biol Drug Des. 2014 Nov; 84(5):558-66. PMID: 24766771.
      Citations: 3     Fields:    
    29. Ponnala S, Gonzales J, Kapadia N, Navarro HA, Harding WW. Evaluation of structural effects on 5-HT(2A) receptor antagonism by aporphines: identification of a new aporphine with 5-HT(2A) antagonist activity. Bioorg Med Chem Lett. 2014 Apr 01; 24(7):1664-7. PMID: 24630561.
      Citations: 6     Fields:    Translation:HumansCells
    30. Kapadia N, Harding W. Facile synthesis of 4,5,6a,7-tetrahydrodibenzo[de,g]chromene heterocycles and their transformation to phenanthrene alkaloids. Tetrahedron. 2013 Oct 21; 69(42). PMID: 24187388.
      Citations: 2     Fields:    
    31. Ponnala S, Harding WW. A New Route to Azafluoranthene Natural Products via Direct Arylation. European J Org Chem. 2013 Feb 01; 3013(6):1107-1115. PMID: 23503080.
      Citations:    
    32. He F, Lindqvist C, Harding WW. Leonurenones A-C: Labdane diterpenes from Leonotis leonurus. Phytochemistry. 2012 Nov; 83:168-72. PMID: 22892215.
      Citations: 2     Fields:    Translation:AnimalsCells
    33. Chaudhary S, Ponnala S, Legendre O, Gonzales JA, Navarro HA, Harding WW. New aporphinoid 5-HT2A and a1A antagonists via structural manipulations of nantenine. Bioorg Med Chem. 2011 Oct 01; 19(19):5861-8. PMID: 21900013.
      Citations: 7     Fields:    
    34. Ponnala S, Chaudhary S, Gonz?lez-Sarrias A, Seeram NP, Harding WW. Cytotoxicity of aporphines in human colon cancer cell lines HCT-116 and Caco-2: an SAR study. Bioorg Med Chem Lett. 2011 Aug 01; 21(15):4462-4. PMID: 21724394.
      Citations: 10     Fields:    Translation:HumansCells
    35. Chaudhary S, Harding WW. Synthesis of C-Homoaporphines via Microwave-Assisted Direct Arylation. Tetrahedron. 2011 Jan 21; 67(3):569-575. PMID: 21399710.
      Citations: 6     Fields:    
    36. Pecic S, McAnuff MA, Harding WW. Nantenine as an acetylcholinesterase inhibitor: SAR, enzyme kinetics and molecular modeling investigations. J Enzyme Inhib Med Chem. 2011 Feb; 26(1):46-55. PMID: 20583856.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    37. Pecic S, Makkar P, Chaudhary S, Reddy BV, Navarro HA, Harding WW. Affinity of aporphines for the human 5-HT2A receptor: insights from homology modeling and molecular docking studies. Bioorg Med Chem. 2010 Aug 01; 18(15):5562-75. PMID: 20621490.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    38. Legendre O, Pecic S, Chaudhary S, Zimmerman SM, Fantegrossi WE, Harding WW. Synthetic studies and pharmacological evaluations on the MDMA ('Ecstasy') antagonist nantenine. Bioorg Med Chem Lett. 2010 Jan 15; 20(2):628-31. PMID: 19963380.
      Citations: 9     Fields:    Translation:AnimalsCells
    39. Chaudhary S, Pecic S, Legendre O, Harding WW. Microwave-Assisted Direct Biaryl Coupling: First Application to the Synthesis of Aporphines. Tetrahedron Lett. 2009 May 20; 50(20):2437-2439. PMID: 20161231.
      Citations: 13     Fields:    
    40. Chaudhary S, Pecic S, Legendre O, Navarro HA, Harding WW. (+/-)-Nantenine analogs as antagonists at human 5-HT(2A) receptors: C1 and flexible congeners. Bioorg Med Chem Lett. 2009 May 01; 19(9):2530-2. PMID: 19328689.
      Citations: 14     Fields:    Translation:HumansCells
    41. Tidgewell K, Groer CE, Harding WW, Lozama A, Schmidt M, Marquam A, Hiemstra J, Partilla JS, Dersch CM, Rothman RB, Bohn LM, Prisinzano TE. Herkinorin analogues with differential beta-arrestin-2 interactions. J Med Chem. 2008 Apr 24; 51(8):2421-31. PMID: 18380425.
      Citations: 31     Fields:    Translation:HumansCells
    42. Chaudhary S, Thomas V, Todaro L, Legendre O, Pecic S, Harding WW. New Drimane Sesquiterpenoids from Tidestromia oblongifolia. Nat Prod Commun. 2008; 3(11):1747-1750. PMID: 21552503.
      Citations:    Fields:    
    43. Simpson DS, Katavic PL, Lozama A, Harding WW, Parrish D, Deschamps JR, Dersch CM, Partilla JS, Rothman RB, Navarro H, Prisinzano TE. Synthetic studies of neoclerodane diterpenes from Salvia divinorum: preparation and opioid receptor activity of salvinicin analogues. J Med Chem. 2007 Jul 26; 50(15):3596-603. PMID: 17580847.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    44. Groer CE, Tidgewell K, Moyer RA, Harding WW, Rothman RB, Prisinzano TE, Bohn LM. An opioid agonist that does not induce mu-opioid receptor--arrestin interactions or receptor internalization. Mol Pharmacol. 2007 Feb; 71(2):549-57. PMID: 17090705.
      Citations: 116     Fields:    Translation:HumansAnimalsCells
    45. Tidgewell K, Harding WW, Lozama A, Cobb H, Shah K, Kannan P, Dersch CM, Parrish D, Deschamps JR, Rothman RB, Prisinzano TE. Synthesis of salvinorin A analogues as opioid receptor probes. J Nat Prod. 2006 Jun; 69(6):914-8. PMID: 16792410.
      Citations: 33     Fields:    Translation:AnimalsCells
    46. Harding WW, Schmidt M, Tidgewell K, Kannan P, Holden KG, Dersch CM, Rothman RB, Prisinzano TE. Synthetic studies of neoclerodane diterpenes from Salvia divinorum: selective modification of the furan ring. Bioorg Med Chem Lett. 2006 Jun 15; 16(12):3170-4. PMID: 16621556.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    47. Harding WW, Schmidt M, Tidgewell K, Kannan P, Holden KG, Gilmour B, Navarro H, Rothman RB, Prisinzano TE. Synthetic studies of neoclerodane diterpenes from Salvia divinorum: semisynthesis of salvinicins A and B and other chemical transformations of salvinorin A. J Nat Prod. 2006 Jan; 69(1):107-12. PMID: 16441078.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    48. Schmidt MD, Schmidt MS, Butelman ER, Harding WW, Tidgewell K, Murry DJ, Kreek MJ, Prisinzano TE. Pharmacokinetics of the plant-derived kappa-opioid hallucinogen salvinorin A in nonhuman primates. Synapse. 2005 Dec 01; 58(3):208-10. PMID: 16138318.
      Citations: 37     Fields:    Translation:Animals
    49. McAnuff MA, Harding WW, Omoruyi FO, Jacobs H, Morrison EY, Asemota HN. Hypoglycemic effects of steroidal sapogenins isolated from Jamaican bitter yam, Dioscorea polygonoides. Food Chem Toxicol. 2005 Nov; 43(11):1667-72. PMID: 16000232.
      Citations: 25     Fields:    Translation:Animals
    50. Prisinzano TE, Tidgewell K, Harding WW. Kappa opioids as potential treatments for stimulant dependence. AAPS J. 2005 Oct 19; 7(3):E592-9. PMID: 16353938.
      Citations: 27     Fields:    Translation:HumansAnimals
    51. Harding WW, Tidgewell K, Byrd N, Cobb H, Dersch CM, Butelman ER, Rothman RB, Prisinzano TE. Neoclerodane diterpenes as a novel scaffold for mu opioid receptor ligands. J Med Chem. 2005 Jul 28; 48(15):4765-71. PMID: 16033256.
      Citations: 68     Fields:    Translation:HumansAnimalsCells
    52. Harding WW, Tidgewell K, Schmidt M, Shah K, Dersch CM, Snyder J, Parrish D, Deschamps JR, Rothman RB, Prisinzano TE. Salvinicins A and B, new neoclerodane diterpenes from Salvia divinorum. Org Lett. 2005 Jul 07; 7(14):3017-20. PMID: 15987194.
      Citations: 18     Fields:    Translation:AnimalsCells
    53. Harding WW, Hodge M, Wang Z, Woolverton WL, Parrish D, Deschamps JR, Prisinzano TE. Enantioselective synthesis of (2R,3R)- and (2S,3S)-2- [(3-chlorophenyl)-(2-methoxyphenoxy)methyl]morpholine. Tetrahedron Asymmetry. 2005 Jul 04; 16(13):2249-2256. PMID: 16841092.
      Citations:    
    54. Schmidt MS, Prisinzano TE, Tidgewell K, Harding W, Butelman ER, Kreek MJ, Murry DJ. Determination of Salvinorin A in body fluids by high performance liquid chromatography-atmospheric pressure chemical ionization. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Apr 25; 818(2):221-5. PMID: 15734162.
      Citations: 17     Fields:    Translation:HumansAnimals
    55. Tidgewell K, Harding WW, Schmidt M, Holden KG, Murry DJ, Prisinzano TE. A facile method for the preparation of deuterium labeled salvinorin A: synthesis of [2,2,2-2H3]-salvinorin A. Bioorg Med Chem Lett. 2004 Oct 18; 14(20):5099-102. PMID: 15380207.
      Citations: 30     Fields:    Translation:HumansPHPublic Health
    56. Denton RW, Harding WW, Anderson CI, Jacobs H, McLean S, Reynolds WF. New diterpenes from Jatropha divaricata. J Nat Prod. 2001 Jun; 64(6):829-31. PMID: 11421758.
      Citations: 4     Fields:    Translation:AnimalsCells
    57. Harding WW, Jacobs H, Lewis PA, McLean S, Reynolds WF. Cycloartanes, protolimonoids, a pregnane and a new ergostane from Trichilia reticulata. Nat Prod Lett. 2001; 15(4):253-60. PMID: 11833620.
      Citations:    Fields:    Translation:AnimalsCells
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