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Edward Agyare

TitleVice Director and Associate Professor
Faculty RankAssociate Professor
InstitutionFlorida A&M University
DepartmentCoPPS, IPH Pharmaceutical Sciences
Address1415 S Martin Luther King Jr Blvd
LL2-222 East Wing
Tallahassee FL 32307
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    Other Positions
    TitleVisiting Scientist
    InstitutionMD Anderson Cancer Center, Houston TX
    DepartmentExperimental Radiation

    Collapse Biography 
    Collapse awards and honors
    2002Travel Grant Award, American Association for Clinical Chemistry
    2005Travel Grant Award, American Association for Clinical Chemistry
    2007Best Poster Presentation Award , Annual Graduate Students Research Association in Pharmaceutical Sciences, Rutgers Universi
    2009Leadership Award, College of Pharmacy, Florida A&M University
    2010Graduate Student Symposium Award - Biotechnology, AAPS
    2011Dr. Isreal Tribble Jr. Award, College of Pharmacy, Florida A&M University
    2013Teacher of the Year, Divison of Basic Pharmaceutical Sciences, College of Pharmacy, Florida A&M University

    Collapse Overview 
    Collapse overview
    I began my quest for a medical research career with bachelors and masters degrees from the University of Science and Technology, Ghana; and followed through with another masters and a doctorate in Pharmaceutics from Florida A&M University. My prior experience has groomed me to be a multidisciplinary researcher seeking to bridge the divide between fields as disparate as pharmaceutics, neurobiology and nanotechnology – my doctoral research work focused on the development of a theranostic nanovehicle capable of targeting amyloid deposits in the cerebrovasculature. The nanovehicle was designed to consist of cyclophosphamide and magnevist (Gd-DTPA) in its core with biosensor grafted on its surface that specifically recognizes and docks to amyloid plaques. These investigations form the basis of very original techniques to address issues of nanoparticle penetration of the blood brain barrier, quantifying drug release within the brain and imaging nanoparticle biodistribution and pharmacokinetics.
    My extensive research experience on interaction of nanoparticles and ionizing radiation in treating pancreatic cancer as a postdoctoral fellow at Department of Radiation Oncology, UT MD Anderson Cancer Center, Houston, TX has unraveled a means of generating radiation dose enhancement using clinically relevant (low) concentrations of systemically administered bioconjugated gold nanoparticles, a finding that has tremendous translational significance. I have no doubt that I have the skills and the motivation to become a successful, independent and innovative pancreatic cancer researcher.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Ndemazie NB, Bulusu R, Zhu XY, Frimpong EK, Inkoom A, Okoro J, Ebesoh D, Rogers S, Han B, Agyare E. Evaluation of Anticancer Activity of Zhubech, a New 5-FU Analog Liposomal Formulation, against Pancreatic Cancer. Int J Mol Sci. 2023 Feb 21; 24(5). PMID: 36901721.
      Citations:    Fields:    Translation:Animals
    2. Telisnor G, DeRemer DL, Frimpong E, Agyare E, Allen J, Ricks-Santi L, Han B, George T, Rogers SC. Review of genetic and pharmacogenetic differences in cytotoxic and targeted therapies for pancreatic cancer in African Americans. J Natl Med Assoc. 2023 Feb 17. PMID: 36801148.
      Citations:    Fields:    
    3. Ndemazie NB, Inkoom A, Ebesoh D, Bulusu R, Frimpong E, Trevino J, Han B, Zhu X, Agyare E. Synthesis, characterization, and anticancer evaluation of 1,3-bistetrahydrofuran-2yl-5-FU as a potential agent for pancreatic cancer. BMC Cancer. 2022 Dec 22; 22(1):1345. PMID: 36550419.
      Citations: 1     Fields:    Translation:AnimalsCells
    4. Ndemazie NB, Inkoom A, Morfaw EF, Smith T, Aghimien M, Ebesoh D, Agyare E. Multi-disciplinary Approach for Drug and Gene Delivery Systems to the Brain. AAPS PharmSciTech. 2021 Dec 03; 23(1):11. PMID: 34862567.
      Citations: 3     Fields:    Translation:Humans
    5. Smith T, Affram K, Nottingham EL, Han B, Amissah F, Krishnan S, Trevino J, Agyare E. Application of smart solid lipid nanoparticles to enhance the efficacy of 5-fluorouracil in the treatment of colorectal cancer. Sci Rep. 2020 10 12; 10(1):16989. PMID: 33046724.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    6. Inkoom A, Ndemazie N, Affram K, Smith T, Zhu X, Underwood P, Krishnan S, Ofori E, Han B, Trevino J, Agyare E. Enhancing efficacy of gemcitabine in pancreatic patient-derived xenograft mouse models. Int J Pharm X. 2020 Dec; 2:100056. PMID: 33015617.
    7. Affram K, Smith T, Helsper S, Rosenberg JT, Han B, Trevino J, Agyare E. Comparative study on contrast enhancement of Magnevist and Magnevist-loaded nanoparticles in pancreatic cancer PDX model monitored by MRI. Cancer Nanotechnol. 2020; 11. PMID: 32714466.
    8. Affram KO, Smith T, Ofori E, Krishnan S, Underwood P, Trevino JG, Agyare E. Cytotoxic effects of gemcitabine-loaded solid lipid nanoparticles in pancreatic cancer cells. J Drug Deliv Sci Technol. 2020 Feb; 55. PMID: 31903101.
    9. Smith T, Affram K, Bulumko E, Agyare E. Evaluation of in-vitro cytotoxic effect of 5-FU loaded-chitosan nanoparticles against spheroid models. J Nat Sci. 2018 Oct; 4(10). PMID: 30740523.
    10. Scarton L, Yoon S, Oh S, Agyare E, Trevino J, Han B, Lee E, Setiawan VW, Permuth JB, Schmittgen TD, Odedina FG, Wilkie DJ. Pancreatic Cancer Related Health Disparities: A Commentary. Cancers (Basel). 2018 Jul 18; 10(7). PMID: 30021952.
    11. Affram K, Udofot O, Singh M, Krishnan S, Reams R, Rosenberg J, Agyare E. Smart thermosensitive liposomes for effective solid tumor therapy and in vivo imaging. PLoS One. 2017; 12(9):e0185116. PMID: 28934281.
      Citations: 11     Fields:    Translation:AnimalsCells
    12. Udofot O, Affram K, Smith T, Tshabe B, Krishnan S, Sachdeva M, Agyare E. Pharmacokinetic, biodistribution and therapeutic efficacy of 5-fluorouracil-loaded pH-sensitive PEGylated liposomal nanoparticles in HCT-116 tumor bearing mouse. J Nat Sci. 2016; 2(1). PMID: 27200415.
    13. Udofot O, Affram K, Israel B, Agyare E. Cytotoxicity of 5-fluorouracil-loaded pH-sensitive liposomal nanoparticles in colorectal cancer cell lines. Integr Cancer Sci Ther. 2015; 2(5):245-252. PMID: 26691592.
    14. Affram K, Udofot O, Cat A, Agyare E. In vitro and in vivo antitumor activity of gemcitabine loaded thermosensitive liposomal nanoparticles and mild hyperthermia in pancreatic cancer. Int J Adv Res (Indore). 2015 Oct; 3(10):859-874. PMID: 26677454.
    15. Affram K, Udofot O, Agyare E. Cytotoxicity of gemcitabine-loaded thermosensitive liposomes in pancreatic cancer cell lines. Integr Cancer Sci Ther. 2015; 2(2):133-142. PMID: 26090123.
    16. Agyare EK, Jaruszewski KM, Curran GL, Rosenberg JT, Grant SC, Lowe VJ, Ramakrishnan S, Paravastu AK, Poduslo JF, Kandimalla KK. Engineering theranostic nanovehicles capable of targeting cerebrovascular amyloid deposits. J Control Release. 2014 Jul 10; 185:121-9. PMID: 24735640.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    17. Edward Agyare and Karunyna Kandimalla. Biomolecular Research & Therapeutics. Delivery of Polymeric Nanoparticles to Target Vascular Diseases. 2014.
    18. Agyare E, Kandimalla K. Delivery of Polymeric Nanoparticles to Target Vascular Diseases. J Biomol Res Ther. 2014 Jan; 3(1). PMID: 26069867.
    19. Udofot O, Jaruszewski K, Spencer S, Agyare E. Development of a novel approach to enhance the solubility of ftibamzone formulation. Integr Mol Med. 2014; 1(3):61-66. PMID: 26120473.
    20. Agyare EK, Leonard SR, Curran GL, Yu CC, Lowe VJ, Paravastu AK, Poduslo JF, Kandimalla KK. Traffic jam at the blood-brain barrier promotes greater accumulation of Alzheimer's disease amyloid-? proteins in the cerebral vasculature. Mol Pharm. 2013 May 06; 10(5):1557-65. PMID: 23249146.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    21. K. Jaruszewski, E. Agyare, G. Curran, S. Grant, J. Poduslo, K. Kandimalla . American Association of Pharmaceutical Scientists Meeting. Targeting Cerebral Vasculature with Nanotheranostics. 2011. View Publication.
    22. Agyare, Edward; Curran, Geoffry; Lowe, Val; Poduslo, Joseph; Kandimalla, Karunya . American Association of Pharmaceutical Scientists Meeting. Biodistribution of Theranostic Nanovehicles in Wild Type and Alzheimer’s Disease Transgenic. 2010. View Publication.
    23. Agyare EK, Curran GL, Ramakrishnan M, Yu CC, Poduslo JF, Kandimalla KK. Development of a smart nano-vehicle to target cerebrovascular amyloid deposits and brain parenchymal plaques observed in Alzheimer's disease and cerebral amyloid angiopathy. Pharm Res. 2008 Nov; 25(11):2674-84. PMID: 18712585.
      Citations: 21     Fields:    Translation:AnimalsCells
    24. Chougule, Mahavir; Patlolla, Ram; Agyare, Edward; Kandimalla, Karunya; Sachdeva, Mandip . American Asscociation of Pharmaceutical Scientists Meeting. pH-Dependent Bidirectional Transport of Noscapine across Caco-2 and MDCK Monolayers: Implications for intestinal absorption. 2008. View Publication.
    25. Agyare, Edward; Malik, Priya,;Curran, Geoffry; Ramakrishnan, Muthu; Patlolla, Ram; Sachdeva, Mandip; Ramirez-Alvarado, Marina; Poduslo, Joseph; Kandimalla, Karunya . American Association of Pharmaceutical Scientists Meeting. Chitosan nanoparticles chelate divalent metal ions and prevent amyloid fibril formation associated with Alzheimer's disease and cerebral amyloid angiopathy. 2008. View Publication.
    26. Jaruszewski, Kristen; Agyare, Edward; Omtri, Rajesh; Patlolla, Ram; Ramakrishnan, Muthu Curran, Geoffry; Chougule, Mahavir; Singh, Mandip; Sarkaria, Jann; Poduslo, Joseph Kandimalla, Karunya . American Association of Pharmaceutical Scientists Meeting. Development of a Nano-Delivery System Targeted to Glioblastomas. 2008. View Publication.
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