Fluorouracil

"Fluorouracil" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.

Descriptor ID	D005472
MeSH Number(s)	D03.383.742.698.875.404
Concept/Terms	Fluorouracil Fluorouracil 5FU 5-FU 5-Fluorouracil 5 Fluorouracil Fluoruracil 5-FU Lederle 5-FU Lederle 5 FU Lederle 5-FU Medac 5-FU Medac 5 FU Medac 5-HU Hexal 5-HU Hexal 5 HU Hexal Adrucil Adrucil Carac Carac Efudix Efudix Fluoro-Uracile ICN Fluoro Uracile ICN Efudex Fluoroplex Fluoroplex Flurodex Fluorouracil Mononitrate Fluorouracil Mononitrate Fluorouracil Monopotassium Salt Fluorouracil Monopotassium Salt Fluorouracil Monosodium Salt Fluorouracil Monosodium Salt Fluorouracil Potassium Salt Fluorouracil Potassium Salt Fluorouracil-GRY Fluorouracil-GRY Fluorouracil GRY Fluorouracile Dakota Fluorouracile Dakota Dakota, Fluorouracile Fluorouracilo Ferrer Far Fluorouracilo Ferrer Far Fluracedyl Fluracedyl Haemato-FU Haemato-FU Haemato FU Neofluor Neofluor Onkofluor Onkofluor Ribofluor Ribofluor 5-Fluorouracil-Biosyn 5-Fluorouracil-Biosyn 5 Fluorouracil Biosyn

Below are MeSH descriptors whose meaning is more general than "Fluorouracil".

Chemicals and Drugs [D]
Heterocyclic Compounds [D03]
Heterocyclic Compounds, 1-Ring [D03.383]
Pyrimidines [D03.383.742]
Pyrimidinones [D03.383.742.698]
Uracil [D03.383.742.698.875]
Fluorouracil [D03.383.742.698.875.404]

Below are MeSH descriptors whose meaning is related to "Fluorouracil".

Below are MeSH descriptors whose meaning is more specific than "Fluorouracil".

Fluorouracil
Capecitabine
Tegafur

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Fluorouracil" by people in this website by year, and whether "Fluorouracil" was a major or minor topic of these publications.

Bar chart showing 37 publications over 17 distinct years, with a maximum of 4 publications in 2007 and 2023

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2003	0	1	1
2004	0	2	2
2005	1	1	2
2006	0	3	3
2007	1	3	4
2008	0	1	1
2009	1	1	2
2012	0	3	3
2014	0	1	1
2015	1	1	2
2016	0	2	2
2018	1	1	2
2020	1	1	2
2022	0	1	1
2023	1	3	4
2024	1	2	3
2025	1	1	2

Below are the most recent publications written about "Fluorouracil" by people in Profiles.

Matsui K, Miyawaki Y, Kobayashi R, Yoshizawa M, Toriumi T, Ebara G, Sato H, Sakuramoto S. Clinical advantages of two vs. three courses of neoadjuvant chemotherapy using docetaxel?+?cisplatin?+?5-fluorouracil to improve preoperative nutritional status and mitigate decreasing skeletal muscle in resectable esophageal cancer. Int J Clin Oncol. 2025 Oct; 30(10):1992-2002.

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Muralidharan J, Eswaran M, Bae S, Singh S, Mir H. Elevated CCL20 and IL-10 enhance 5-fluorouracil tolerance in colon cancer. Biomed Pharmacother. 2025 Aug; 189:118258.

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Green KA, Ma C, Hoffmann FW, Hoffmann PR, Green WR. Depletion of monocytic myeloid-derived suppressor cells in LP-BM5 murine retroviral infection has a positive impact on virus-induced host immunodeficiency. Virology. 2024 12; 600:110247.

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Sinicrope FA, Nelson GD, Saberzadeh-Ardestani B, Segovia DI, Graham RP, Wu C, Hagen CE, Shivji S, Savage P, Buchanan DD, Jenkins MA, Phipps AI, Swallow C, LeMarchand L, Gallinger S, Grant RC, Pai RK, Sinicrope SN, Yan D, Shanmugam K, Conner J, Cyr DP, Kirsch R, Banerjee I, Alberts SR, Shi Q, Pai RK. Use of Deep Learning to Evaluate Tumor Microenvironmental Features for Prediction of Colon Cancer Recurrence. Cancer Res Commun. 2024 05 23; 4(5):1344-1350.

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Frimpong E, Bulusu R, Okoro J, Inkoom A, Ndemazie N, Rogers S, Zhu X, Han B, Agyare E. Development of novel pyrimidine nucleoside analogs as potential anticancer agents: Synthesis, characterization, and In-vitro evaluation against pancreatic cancer. Eur J Pharm Sci. 2024 May 01; 196:106754.

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Afrin H, Esquivel SV, Kumar R, Zahid MI, Oporeza B, Rahman MF, Boland T, Nurunnabi M. ?-Glucan-Mediated Oral Codelivery of 5FU and Bcl2 siRNA Attenuates Stomach Cancer. ACS Appl Mater Interfaces. 2023 Jul 12; 15(27):32188-32200.

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Ndemazie NB, Bulusu R, Zhu XY, Frimpong EK, Inkoom A, Okoro J, Ebesoh D, Rogers S, Han B, Agyare E. Evaluation of Anticancer Activity of Zhubech, a New 5-FU Analog Liposomal Formulation, against Pancreatic Cancer. Int J Mol Sci. 2023 Feb 21; 24(5).

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Chen MC, Su HY, Su YH, Huang KH, Fang WL, Lin CW, Chen MH, Chao Y, Lo SS, Fen-Yau Li A, Wu CW. Reply to "Is it possible that advanced-stage gastric cancer patients can be cured by surgery alone?" J Chin Med Assoc. 2023 03 01; 86(3):350.

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Hamze K, Abdallah RH, Younis NK, Fardoun M, Darwiche N, Kobeissy F, Iratni R, Bouhadir K, Eid AH. 2-Nucleobase-substituted 4,6-Diaminotriazine Analogs: Synthesis and Anti-cancer Activity in 5-Fluorouracil-sensitive and Resistant Colorectal Cancer Cells. Curr Med Chem. 2023; 30(26):3032-3049.

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Ndemazie NB, Inkoom A, Ebesoh D, Bulusu R, Frimpong E, Trevino J, Han B, Zhu X, Agyare E. Synthesis, characterization, and anticancer evaluation of 1,3-bistetrahydrofuran-2yl-5-FU as a potential agent for pancreatic cancer. BMC Cancer. 2022 Dec 22; 22(1):1345.

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