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Maryam Foroozesh

TitleFaculty, Department of Chemistry
Faculty RankProfessor
InstitutionXavier University of Louisiana
AddressXavier University of Louisiana
1 Drexel Drive
New Orleans LA 70125
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    R25GM060926     (FOROOZESH, MARYAM)Apr 1, 2000 - Jul 31, 2019
    RISE Option II at Xavier University of Louisiana
    Role: Principal Investigator

    R15CA159059     (FOROOZESH, MARYAM)Mar 1, 2011 - Feb 28, 2015
    Multi-Target, Mechanism-Based Drug Design for the Treatment of Breast Cancer: Syn
    Role: Principal Investigator

    RL5GM118966     (FOROOZESH, MARYAM)Sep 26, 2014 - Jun 30, 2024
    BUILD at Xavier, Project Pathways II
    Role: Principal Investigator

    TL4GM118968     (FOROOZESH, MARYAM)Sep 26, 2014 - Jun 30, 2024
    BUILD at Xavier, Project Pathways II
    Role: Principal Investigator

    UL1GM118967     (FOROOZESH, MARYAM)Sep 26, 2014 - Jun 30, 2024
    BUILD at Xavier, Project Pathways II
    Role: Principal Investigator

    R15CA242991     (FOROOZESH, MARYAM)Jul 15, 2019 - Jun 30, 2022
    Ceramides for Breast Cancer Treatment
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Ponnapakkam T, Bongay-Williams K, Beamon T, Hooks R, Cheatham D, Goyal N, Anbalagan M, Foroozesh M. Acute toxicity evaluation of a novel ceramide analog for the treatment of breast cancer. Toxicol Rep. 2021; 8:1521-1526. PMID: 34401362.
    2. Goyal N, Sridhar J, Do C, Bratton M, Shaik S, Jiang Q, Foroozesh M. Identification of CYP 2A6 inhibitors in an effort to mitigate the harmful effects of the phytochemical nicotine. J Cancer Metastasis Treat. 2021; 7. PMID: 34722929.
    3. Chen J, Goyal N, Dai L, Lin Z, Del Valle L, Zabaleta J, Liu J, Post SR, Foroozesh M, Qin Z. Developing new ceramide analogs and identifying novel sphingolipid-controlled genes against a virus-associated lymphoma. Blood. 2020 11 05; 136(19):2175-2187. PMID: 32518949.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    4. Norris KC, McCreath HE, Hueffer K, Aley SB, Chavira G, Christie CA, Crespi CM, Crespo C, D'Amour G, Eagan K, Echegoyen LE, Feig A, Foroozesh M, Guerrero LR, Johanson K, Kamangar F, Kingsford L, LaCourse W, Maccalla NM, Márquez-Magaña L, Mathur A, Maton K, Mehravaran S, Morales DX, Nakazono T, Ofili E, Okuyemi K, Ott L, Parangan-Smith A, Pfund C, Purnell D, Reynolds A, Rous PJ, Saetermoe C, Snyder K, Vishwanatha JK, Wagler A, Wallace SP, Seeman T. Baseline Characteristics of the 2015-2019 First Year Student Cohorts of the NIH Building Infrastructure Leading to Diversity (BUILD) Program. Ethn Dis. 2020; 30(4):681-692. PMID: 32989368.
      Citations:    Fields:    Translation:Humans
    5. Foroozesh M, Sridhar J, Goyal N, Liu J. Coumarins and P450s, Studies Reported to-Date. Molecules. 2019 Apr 24; 24(8). PMID: 31022888.
      Citations: 6     Fields:    Translation:Humans
    6. Chen J, Foroozesh M, Qin Z. Transactivation of human endogenous retroviruses by tumor viruses and their functions in virus-associated malignancies. Oncogenesis. 2019 Jan 14; 8(1):6. PMID: 30643113.
    7. Ponnapakkam T, Saulsberry T, Hill T, Hill-Odom M, Goyal N, Anbalagan M, Liu J, Foroozesh M. Inhibition of breast tumor growth in mice after treatment with ceramide analog 315. Anticancer Drugs. 2018 10; 29(9):898-903. PMID: 30044300.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    8. Goyal N, Donahue JP, Do C, Perry T, Bongay-Williams K, Foroozesh M. A dibenzofuran derivative: 2-(pentyloxy)dibenzo[b,d]furan. IUCrdata. 2018 Sep; 3(9). PMID: 31363506.
    9. Goyal N, Do C, Donahue JP, Mague JT, Foroozesh M. Ethyl 2-[2-(4-oxo-4H-chromen-2-yl)phenoxy]acetate. IUCrdata. 2018 Jul; 3(7). PMID: 30984887.
    10. Dai L, Smith CD, Foroozesh M, Miele L, Qin Z. The sphingosine kinase 2 inhibitor ABC294640 displays anti-non-small cell lung cancer activities in vitro and in vivo. Int J Cancer. 2018 05 15; 142(10):2153-2162. PMID: 29277894.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    11. Goyal N, Bongay-Williams K, Do C, Perry T, Kantrow E, Hill-Odom M, Sridhar J, Foroozesh M. DESIGN AND SYNTHESIS OF DIBENZYLFURAN BASED ETHER AND ESTER DERIVATIVES AS POTENTIAL P450 INHIBITORS. J Undergrad Chem Res. 2018; 17(4):102-104. PMID: 31363349.
    12. Foroozesh M, Giguette M, Morgan K, Johanson K, D'Amour G, Coston T, Wilkins-Green C. Building integrated pathways to independence for diverse biomedical researchers: Project Pathways, the BUILD program at Xavier University of Louisiana. BMC Proc. 2017; 11(Suppl 12):28. PMID: 29375669.
    13. Sridhar J, Goyal N, Liu J, Foroozesh M. Review of Ligand Specificity Factors for CYP1A Subfamily Enzymes from Molecular Modeling Studies Reported to-Date. Molecules. 2017 Jul 08; 22(7). PMID: 28698457.
      Citations: 14     Fields:    Translation:Humans
    14. Foroozesh M, Goyal N, Jackson T, Do C, Booker S, Hill T, Liu J. OPTIMIZATION OF SCALE-UP SYNTHESIS OF ANTI-CANCER CERAMIDE ANALOG 315. J Undergrad Chem Res. 2017; 16(3):89-90. PMID: 30220887.
    15. Sridhar J, Liu J, Komati R, Schroeder R, Jiang Q, Tram P, Riley K, Foroozesh M. Ortho-Methylarylamines as Time-Dependent Inhibitors of Cytochrome P450 1A1 Enzyme. Drug Metab Lett. 2017; 10(4):270-277. PMID: 28000546.
      Citations: 4     Fields:    Translation:HumansCells
    16. Shimada T, Takenaka S, Kakimoto K, Murayama N, Lim YR, Kim D, Foroozesh MK, Yamazaki H, Guengerich FP, Komori M. Structure-Function Studies of Naphthalene, Phenanthrene, Biphenyl, and Their Derivatives in Interaction with and Oxidation by Cytochromes P450 2A13 and 2A6. Chem Res Toxicol. 2016 06 20; 29(6):1029-40. PMID: 27137136.
      Citations: 10     Fields:    Translation:HumansCells
    17. Schroeder RL, Tram P, Liu J, Foroozesh M, Sridhar J. Novel functionalized 5-(phenoxymethyl)-1,3-dioxane analogs exhibiting cytochrome P450 inhibition: a patent evaluation WO2015048311 (A1). Expert Opin Ther Pat. 2016; 26(1):139-47. PMID: 26514241.
      Citations: 1     Fields:    Translation:Humans
    18. Liu J, Pham PT, Skripnikova EV, Zheng S, Lovings LJ, Wang Y, Goyal N, Bellow SM, Mensah LM, Chatters AJ, Bratton MR, Wiese TE, Zhao M, Wang G, Foroozesh M. A Ligand-Based Drug Design. Discovery of 4-Trifluoromethyl-7,8-pyranocoumarin as a Selective Inhibitor of Human Cytochrome P450 1A2. J Med Chem. 2015 Aug 27; 58(16):6481-93. PMID: 26222195.
      Citations: 6     Fields:    Translation:HumansCells
    19. Shimada T, Takenaka S, Murayama N, Kramlinger VM, Kim JH, Kim D, Liu J, Foroozesh MK, Yamazaki H, Guengerich FP, Komori M. Oxidation of pyrene, 1-hydroxypyrene, 1-nitropyrene and 1-acetylpyrene by human cytochrome P450 2A13. Xenobiotica. 2016; 46(3):211-24. PMID: 26247835.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    20. Goyal N, Liu J, Lovings L, Dupart P, Taylor S, Bellow S, Mensah L, McClain E, Dotson B, Sridhar J, Zhang X, Zhao M, Foroozesh M. Ethynylflavones, highly potent, and selective inhibitors of cytochrome P450 1A1. Chem Res Toxicol. 2014 Aug 18; 27(8):1431-9. PMID: 25033111.
      Citations: 2     Fields:    Translation:Cells
    21. Ponnapakam AP, Liu J, Bhinge KN, Drew BA, Wang TL, Antoon JW, Nguyen TT, Dupart PS, Wang Y, Zhao M, Liu YY, Foroozesh M, Beckman BS. 3-Ketone-4,6-diene ceramide analogs exclusively induce apoptosis in chemo-resistant cancer cells. Bioorg Med Chem. 2014 Feb 15; 22(4):1412-20. PMID: 24457089.
      Citations: 6     Fields:    Translation:HumansCells
    22. Liu J, Sridhar J, Foroozesh M. Cytochrome P450 family 1 inhibitors and structure-activity relationships. Molecules. 2013 Nov 25; 18(12):14470-95. PMID: 24287985.
      Citations: 33     Fields:    Translation:HumansAnimals
    23. Foroozesh M, Jiang Q, Sridhar J, Liu J, Dotson B, McClain E. DESIGN, SYNTHESIS, AND EVALUATION OF CARBAZOLE ANALOGS AS POTENTIAL CYTOCHROME P450 INHIBITORS. J Undergrad Chem Res. 2013 Sep; 12(4):92-95. PMID: 25580095.
    24. Liu J, Beckman BS, Foroozesh M. A review of ceramide analogs as potential anticancer agents. Future Med Chem. 2013 Aug; 5(12):1405-21. PMID: 23919551.
      Citations: 27     Fields:    Translation:HumansCells
    25. Liu J, Taylor SF, Dupart PS, Arnold CL, Sridhar J, Jiang Q, Wang Y, Skripnikova EV, Zhao M, Foroozesh M. Pyranoflavones: a group of small-molecule probes for exploring the active site cavities of cytochrome P450 enzymes 1A1, 1A2, and 1B1. J Med Chem. 2013 May 23; 56(10):4082-92. PMID: 23600958.
      Citations: 12     Fields:    Translation:HumansCells
    26. Shimada T, Kim D, Murayama N, Tanaka K, Takenaka S, Nagy LD, Folkman LM, Foroozesh MK, Komori M, Yamazaki H, Guengerich FP. Binding of diverse environmental chemicals with human cytochromes P450 2A13, 2A6, and 1B1 and enzyme inhibition. Chem Res Toxicol. 2013 Apr 15; 26(4):517-28. PMID: 23432429.
      Citations: 15     Fields:    Translation:HumansCells
    27. Zhang H, Gay SC, Shah M, Foroozesh M, Liu J, Osawa Y, Zhang Q, Stout CD, Halpert JR, Hollenberg PF. Potent mechanism-based inactivation of cytochrome P450 2B4 by 9-ethynylphenanthrene: implications for allosteric modulation of cytochrome P450 catalysis. Biochemistry. 2013 Jan 15; 52(2):355-64. PMID: 23276288.
      Citations: 14     Fields:    Translation:AnimalsCells
    28. Foroozesh M, Jiang Q, Sridhar J, Liu J, Dotson B, McClain E. DESIGN, SYNTHESIS, AND EVALUATION OF A FAMILY OF PROPARGYL PYRIDINYL ETHERS AS POTENTIAL CYTOCHROME P450 INHIBITORS. J Undergrad Chem Res. 2013; 12(4):91-94. PMID: 25544835.
    29. Sridhar J, Liu J, Foroozesh M, Stevens CL. Insights on cytochrome p450 enzymes and inhibitors obtained through QSAR studies. Molecules. 2012 Aug 03; 17(8):9283-305. PMID: 22864238.
      Citations: 18     Fields:    Translation:HumansCells
    30. Liu J, Nguyen TT, Dupart PS, Sridhar J, Zhang X, Zhu N, Stevens CL, Foroozesh M. 7-Ethynylcoumarins: selective inhibitors of human cytochrome P450s 1A1 and 1A2. Chem Res Toxicol. 2012 May 21; 25(5):1047-57. PMID: 22443586.
      Citations: 10     Fields:    Translation:HumansCells
    31. Sridhar J, Liu J, Foroozesh M, Klein Stevens CL. Inhibition of cytochrome p450 enzymes by quinones and anthraquinones. Chem Res Toxicol. 2012 Feb 20; 25(2):357-65. PMID: 22185593.
      Citations: 15     Fields:    Translation:HumansAnimals
    32. Sridhar J, Ellis J, Dupart P, Liu J, Stevens CL, Foroozesh M. Development of flavone propargyl ethers as potent and selective inhibitors of cytochrome P450 enzymes 1A1 and 1A2. Drug Metab Lett. 2012; 6(4):275-84. PMID: 23506553.
      Citations: 9     Fields:    
    33. Shimada T, Tanaka K, Takenaka S, Murayama N, Martin MV, Foroozesh MK, Yamazaki H, Guengerich FP, Komori M. Structure-function relationships of inhibition of human cytochromes P450 1A1, 1A2, 1B1, 2C9, and 3A4 by 33 flavonoid derivatives. Chem Res Toxicol. 2010 Dec 20; 23(12):1921-35. PMID: 21053930.
      Citations: 47     Fields:    Translation:HumansCells
    34. Liu J, Antoon JW, Ponnapakkam A, Beckman BS, Foroozesh M. Novel anti-viability ceramide analogs: design, synthesis, and structure-activity relationship studies of substituted (S)-2-(benzylideneamino)-3-hydroxy-N-tetradecylpropanamides. Bioorg Med Chem. 2010 Jul 15; 18(14):5316-22. PMID: 20639111.
      Citations: 7     Fields:    Translation:HumansCells
    35. Zhu N, Lightsey D, Liu J, Foroozesh M, Morgan KM, Stevens ED, Klein Stevens CL. Ethynyl and Propynylpyrene Inhibitors of Cytochrome P450. J Chem Crystallogr. 2010 Apr 01; 40(4):343-352. PMID: 20473363.
    36. Sridhar J, Jin P, Liu J, Foroozesh M, Stevens CL. In silico studies of polyaromatic hydrocarbon inhibitors of cytochrome P450 enzymes 1A1, 1A2, 2A6, and 2B1. Chem Res Toxicol. 2010 Mar 15; 23(3):600-7. PMID: 20078084.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    37. Antoon JW, Liu J, Ponnapakkam AP, Gestaut MM, Foroozesh M, Beckman BS. Novel D: -erythro N-octanoyl sphingosine analogs as chemo- and endocrine-resistant breast cancer therapeutics. Cancer Chemother Pharmacol. 2010 May; 65(6):1191-5. PMID: 20155475.
      Citations: 14     Fields:    Translation:HumansCells
    38. Antoon JW, Liu J, Gestaut MM, Burow ME, Beckman BS, Foroozesh M. Design, synthesis, and biological activity of a family of novel ceramide analogues in chemoresistant breast cancer cells. J Med Chem. 2009 Sep 24; 52(18):5748-52. PMID: 19694470.
      Citations: 17     Fields:    Translation:HumansCells
    39. Shimada T, Tanaka K, Takenaka S, Foroozesh MK, Murayama N, Yamazaki H, Guengerich FP, Komori M. Reverse type I binding spectra of human cytochrome P450 1B1 induced by flavonoid, stilbene, pyrene, naphthalene, phenanthrene, and biphenyl derivatives that inhibit catalytic activity: a structure-function relationship study. Chem Res Toxicol. 2009 Jul; 22(7):1325-33. PMID: 19563207.
      Citations: 21     Fields:    Translation:HumansCells
    40. Shimada T, Murajama N, Tanaka K, Takenaka S, Imai Y, Hopkins NE, Foroozesh MK, Alworth WL, Yamazaki H, Guengerich FP, Komori M. Interaction of polycyclic aromatic hydrocarbons with human cytochrome P450 1B1 in inhibiting catalytic activity. Chem Res Toxicol. 2008 Dec; 21(12):2313-23. PMID: 19548353.
      Citations: 23     Fields:    Translation:HumansCells
    41. Sridar C, Kent UM, Noon K, McCall A, Alworth B, Foroozesh M, Hollenberg PF. Differential inhibition of cytochromes P450 3A4 and 3A5 by the newly synthesized coumarin derivatives 7-coumarin propargyl ether and 7-(4-trifluoromethyl)coumarin propargyl ether. Drug Metab Dispos. 2008 Nov; 36(11):2234-43. PMID: 18653744.
      Citations: 6     Fields:    Translation:HumansCells
    42. Bergander L, Wincent E, Rannug A, Foroozesh M, Alworth W, Rannug U. Metabolic fate of the Ah receptor ligand 6-formylindolo[3,2-b]carbazole. Chem Biol Interact. 2004 Oct 15; 149(2-3):151-64. PMID: 15501436.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    43. Cantrell CL, Nuñez IS, Castañeda-Acosta J, Foroozesh M, Fronczek FR, Fischer NH, Franzblau SG. Antimycobacterial activities of dehydrocostus lactone and its oxidation products. J Nat Prod. 1998 Oct; 61(10):1181-6. PMID: 9784148.
      Citations: 8     Fields:    Translation:AnimalsCells
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