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Bindong Liu

Faculty RankProfessor
InstitutionMeharry Medical College
DepartmentMicrobiology, Immunology and Microbiology, Immunology, & Physiology
Address5029 Hubbard Hospital BLDG
1005 Dr. D. B. Todd BLVD
Nashville TN 37208
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    Other Positions
    InstitutionMeharry Medical College
    DepartmentMicrobiology, Immunology and Physiology

    InstitutionMeharry Medical College

    TitleAssociate Director
    InstitutionTennessee Center for AIDS Research

    Collapse Affiliation 

    Collapse Biography 
    Collapse awards and honors
    1993Third Place: Outstanding Paper on Science and Technology, Heilongjiang Province
    1995National Science and Technology Progress Award, Equine Infectious Anemia (EIA)

    Collapse Overview 
    Collapse overview
    The research in our lab focuses on delineating the interactions between HIV-1 and host, as well as HIV-1 and other human microbes with the effort on finding a solution to inhibit HIV-1 replication. We have following three ongoing projects.

    1. Mucosal surfaces serve as the predominant point of transmission for human immunodeficiency virus (HIV-1). However, it is well-documented that the transmission/acquisition of HIV-1 through oro-genital contact is rare. The risk associated with the vaginal acquisition of HIV-1 after sexual contact with a HIV-1 positive individual is 0.03% to 0.2%, while the risk of oral acquisition is estimated to be 20 times less. This indicates that the protection provided by the innate and adaptive immune system of the host is robust, but varies according to the mucosal site. APOBEC3G (A3G) is a potent host restriction factor of HIV-1. It has been shown that A3G blocks HIV-1 replication or transmission when its expression is up-regulated. Streptococcus Cristatus CC5A is a non-pathogenic oral bacterial. We found that a small molecule of Streptococcus cristatus CC5A (S. cristatus CC5A) was able to up-regulate APOBEC3G expression and inhibit HIV replication. Now we are working on developing a novel, efficient anti-HIV/AIDS strategy using this molecule.

    2. GB virus type C (GBV-C, also called hepatitis G virus) is a single, positive strand RNA virus in the Flaviviridae family. It has not been conclusively associated with any known disease, although it is a very common infection in humans. Most of the cohort studies about the interaction of GBV-C and HIV-1 showed that GBV-C infection could prolong AIDS patient survival. Since GBV-C shares the same transmission pathway with HIV-1 and replicates in CD4+ T cells, it could be a very promising candidate for establishing novel anti-AIDS therapy strategies and gene therapy vectors which specifically deliver anti-HIV genes to CD4+ T cells. In our study, we found that when one of GBV-C structural protein E2 was co-expressed with the HIV-1 proviral construct, HIV-1 Gag processing was dramatically inhibited resulting less virus has been released. This may shed light on developing GBV-C as novel anti-HIV/AIDS strategy. We are working on elucidating the mechanism of GBV-C’s anti-HIV/AIDS effect and testing whether we could develop a novel anti-HIV/AIDS drug based on this discovery.

    3. We are trying to understand the interaction between HIV-1 Vif and APOBEC3G (A3G). A3G is a host restriction factor of HIV-1. HIV encodes Vif to overcome A3G antiviral effect. It is well-established that Vif counteracts A3G via proteasome-mediated A3G degradation and repression of A3G translation. Such a mechanism is essential for the production of infectious virions because inclusion of A3G in Vif-deficient virions has been shown to result in non-infectious particles. However, clinical and laboratory evidence, including that of our group, has shown that A3G is detectable in Vif competent HIV-1 viral particles without affecting their infectivity. How HIV solves this conundrum remains unclear. We have been addressing the above paradox by examining A3G activities in the presence of Vif. We showed that besides depleting A3G, Vif directly inhibits A3G cytidine deaminase activity, which is necessary for G-to-A hypermutation in an exogenous protein expression system. As a result, the presence of functional Vif significantly reduces the rate of G-to-A hypermutations generated by A3G to promote HIV replication. Right now we are further evaluating this phenotype under physiologically relevant condition and working on the identification of the specific interaction domains which play a role in inhibiting A3G cytidine deaminase activity. Understanding details of the interaction between APOBEC and HIV-1 Vif will shed light on anti-HIV/AIDS drug design.

    Collapse Research 
    Collapse research activities and funding
    SC1GM089269     (LIU, BINDONG)Sep 8, 2009 - May 31, 2021
    Characterizing a small molecule of Streptococcus cristatus for HIV drug design
    Role: Principal Investigator
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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Zheng J, Yin Q, Wang SY, Wang YY, Xiao JJ, Tang TT, Ni WJ, Ren LQ, Liu H, Zhang XL, Liu BC, Wang B. Ultrasound-assessed diaphragm dysfunction predicts clinical outcomes in hemodialysis patients. Sci Rep. 2022 10 03; 12(1):16550. PMID: 36192453.
      Citations: 1     Fields:    Translation:Humans
    2. Chen J, Tang TT, Cao JY, Li ZL, Zhong X, Wen Y, Shen AR, Liu BC, Lv LL. KIM-1 augments hypoxia-induced tubulointerstitial inflammation through uptake of small extracellular vesicles by tubular epithelial cells. Mol Ther. 2023 05 03; 31(5):1437-1450. PMID: 35982620.
      Citations: 6     Fields:    Translation:AnimalsCells
    3. Mungin JW, Chen X, Liu B. Interferon Epsilon Signaling Confers Attenuated Zika Replication in Human Vaginal Epithelial Cells. Pathogens. 2022 Jul 29; 11(8). PMID: 36014974.
    4. Wu QY, Liu BC, Ruan XZ, Ma KL. Intestinal microbiota-derived membrane vesicles and their role in chronic kidney disease. Biochim Biophys Acta Mol Basis Dis. 2022 10 01; 1868(10):166478. PMID: 35787946.
      Citations: 1     Fields:    Translation:Humans
    5. Yin Q, Zhao YJ, Ni WJ, Tang TT, Wang Y, Cao JY, Yin D, Wen Y, Li ZL, Zhang YL, Jiang W, Zhang Y, Lu XY, Zhang AQ, Gan WH, Lv LL, Liu BC, Wang B. MiR-155 deficiency protects renal tubular epithelial cells from telomeric and genomic DNA damage in cisplatin-induced acute kidney injury. Theranostics. 2022; 12(10):4753-4766. PMID: 35832084.
      Citations: 5     Fields:    Translation:AnimalsCells
    6. Wang LT, Wang YJ, Zhang YX, Chen SJ, Liu ZX, Cao JY, Ni WJ, Tang TT, Tang RN, Zhang XL, Liu BC. High phosphorus mediated the release of C-X-C motif chemokine ligand 8 in valvular interstitial cells-induced endothelial-to-mesenchymal transition via miR-214/phosphatase and tensin homolog to promote valvular calcification in chronic kidney disease. Clin Transl Med. 2022 05; 12(5):e733. PMID: 35605059.
      Citations:    Fields:    Translation:HumansCells
    7. Gao YM, Feng ST, Yang Y, Li ZL, Wen Y, Wang B, Lv LL, Xing GL, Liu BC. Development and External Validation of a Nomogram and a Risk Table for Prediction of Type 2 Diabetic Kidney Disease Progression Based on a Retrospective Cohort Study in China. Diabetes Metab Syndr Obes. 2022; 15:799-811. PMID: 35313680.
    8. Lv LL, Wang C, Li ZL, Cao JY, Zhong X, Feng Y, Chen J, Tang TT, Ni HF, Wu QL, Wang B, Lan HY, Liu BC. SAP130 released by damaged tubule drives necroinflammation via miRNA-219c/Mincle signaling in acute kidney injury. Cell Death Dis. 2021 09 23; 12(10):866. PMID: 34556635.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    9. Jia X, Shao Q, Chaudhry AR, Kinlock BL, Izban MG, Zhang HY, Villalta F, Hildreth JEK, Liu B. Medroxyprogesterone Acetate (MPA) Enhances HIV-1 Accumulation and Release in Primary Cervical Epithelial Cells by Inhibiting Lysosomal Activity. Pathogens. 2021 Sep 14; 10(9). PMID: 34578224.
    10. Wang B, Qian JY, Tang TT, Lin LL, Yu N, Guo HL, Ni WJ, Lv LL, Wen Y, Li ZL, Wu M, Cao JY, Liu BC. VDR/Atg3 Axis Regulates Slit Diaphragm to Tight Junction Transition via p62-Mediated Autophagy Pathway in Diabetic Nephropathy. Diabetes. 2021 11; 70(11):2639-2651. PMID: 34376476.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    11. Li ZL, Ji JL, Wen Y, Cao JY, Kharbuja N, Ni WJ, Yin D, Feng ST, Liu H, Lv LL, Liu BC, Wang B. HIF-1a is transcriptionally regulated by NF-?B in acute kidney injury. Am J Physiol Renal Physiol. 2021 08 01; 321(2):F225-F235. PMID: 34229478.
      Citations: 7     Fields:    Translation:AnimalsCells
    12. Tang TT, Wang B, Li ZL, Wen Y, Feng ST, Wu M, Liu D, Cao JY, Yin Q, Yin D, Fu YQ, Gao YM, Ding ZY, Qian JY, Wu QL, Lv LL, Liu BC. Kim-1 Targeted Extracellular Vesicles: A New Therapeutic Platform for RNAi to Treat AKI. J Am Soc Nephrol. 2021 10; 32(10):2467-2483. PMID: 34127536.
      Citations: 25     Fields:    Translation:AnimalsCells
    13. Cao JY, Wang B, Tang TT, Wen Y, Li ZL, Feng ST, Wu M, Liu D, Yin D, Ma KL, Tang RN, Wu QL, Lan HY, Lv LL, Liu BC. Exosomal miR-125b-5p deriving from mesenchymal stem cells promotes tubular repair by suppression of p53 in ischemic acute kidney injury. Theranostics. 2021; 11(11):5248-5266. PMID: 33859745.
      Citations: 72     Fields:    Translation:HumansAnimalsCells
    14. Lu J, Chen PP, Zhang JX, Li XQ, Wang GH, Yuan BY, Huang SJ, Liu XQ, Jiang TT, Wang MY, Liu WT, Ruan XZ, Liu BC, Ma KL. GPR43 deficiency protects against podocyte insulin resistance in diabetic nephropathy through the restoration of AMPKa activity. Theranostics. 2021; 11(10):4728-4742. PMID: 33754024.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    15. Feng Y, Zhong X, Tang TT, Wang C, Wang LT, Li ZL, Ni HF, Wang B, Wu M, Liu D, Liu H, Tang RN, Liu BC, Lv LL. Rab27a dependent exosome releasing participated in albumin handling as a coordinated approach to lysosome in kidney disease. Cell Death Dis. 2020 07 08; 11(7):513. PMID: 32641688.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    16. Yang Y, Lin LH, Gao M, Tang RN, Ma KL, Tu Y, Liu H, Liu BC. Association Between the Serum Uric Acid Level and the Severity of Coronary Artery Disease in a Retrospective Study of China Nondialysis CKD Patients. Metab Syndr Relat Disord. 2020 05; 18(4):206-211. PMID: 32069163.
      Citations: 3     Fields:    Translation:Humans
    17. Wang B, Yin Q, Wang YY, Tu Y, Han Y, Gao M, Pan M, Yang Y, Xue Y, Zhang L, Zhang L, Liu H, Tang R, Zhang X, Xiao J, Wang XH, Liu BC. Diaphragmatic dysfunction associates with dyspnoea, fatigue, and hiccup in haemodialysis patients: a cross-sectional study. Sci Rep. 2019 12 18; 9(1):19382. PMID: 31853002.
      Citations: 5     Fields:    Translation:Humans
    18. Jiang M, Fan J, Qu X, Li S, Nilsson SK, Sun YBY, Chen Y, Yu D, Liu D, Liu BC, Tang M, Chen W, Ren Y, Nikolic-Paterson DJ, Jiang X, Li J, Yu X. Combined Blockade of Smad3 and JNK Pathways Ameliorates Progressive Fibrosis in Folic Acid Nephropathy. Front Pharmacol. 2019; 10:880. PMID: 31447676.
    19. Chen N, Hao C, Peng X, Lin H, Yin A, Hao L, Tao Y, Liang X, Liu Z, Xing C, Chen J, Luo L, Zuo L, Liao Y, Liu BC, Leong R, Wang C, Liu C, Neff T, Szczech L, Yu KP. Roxadustat for Anemia in Patients with Kidney Disease Not Receiving Dialysis. N Engl J Med. 2019 09 12; 381(11):1001-1010. PMID: 31340089.
      Citations: 194     Fields:    Translation:HumansCTClinical Trials
    20. Chen N, Hao C, Liu BC, Lin H, Wang C, Xing C, Liang X, Jiang G, Liu Z, Li X, Zuo L, Luo L, Wang J, Zhao MH, Liu Z, Cai GY, Hao L, Leong R, Wang C, Liu C, Neff T, Szczech L, Yu KP. Roxadustat Treatment for Anemia in Patients Undergoing Long-Term Dialysis. N Engl J Med. 2019 09 12; 381(11):1011-1022. PMID: 31340116.
      Citations: 208     Fields:    Translation:HumansCTClinical Trials
    21. Ni LH, Yuan C, Song KY, Wang XC, Chen SJ, Wang LT, Zhang YX, Liu H, Liu BC, Tang RN. Efficacy and safety of cinacalcet and active vitamin D in the treatment of secondary hyperparathyroidism in patients with chronic kidney disease: a network meta-analysis. Ann Transl Med. 2019 Jul; 7(14):322. PMID: 31475192.
    22. Ni LH, Tang RN, Yuan C, Song KY, Wang LT, Zhang XL, Lv LL, Wang B, Wu M, Tang TT, Li ZL, Yin D, Cao JY, Wang XC, Liu H, Chen Q, Liu BC. Cinacalcet attenuated bone loss via inhibiting parathyroid hormone-induced endothelial-to-adipocyte transition in chronic kidney disease rats. Ann Transl Med. 2019 Jul; 7(14):312. PMID: 31475182.
    23. Ni LH, Tang RN, Yuan C, Song KY, Wang LT, Wang XC, Zhang YX, Zhang XL, Zhu DD, Liu BC. FK506 prevented bone loss in streptozotocin-induced diabetic rats via enhancing osteogenesis and inhibiting adipogenesis. Ann Transl Med. 2019 Jun; 7(12):265. PMID: 31355232.
    24. Lv LL, Feng Y, Wu M, Wang B, Li ZL, Zhong X, Wu WJ, Chen J, Ni HF, Tang TT, Tang RN, Lan HY, Liu BC. Exosomal miRNA-19b-3p of tubular epithelial cells promotes M1 macrophage activation in kidney injury. Cell Death Differ. 2020 01; 27(1):210-226. PMID: 31097789.
      Citations: 147     Fields:    Translation:HumansAnimalsCells
    25. Wu M, Feng Y, Ye GX, Han YC, Wang SS, Ni HF, Wang FM, Gao M, Lv LL, Liu BC. Calcium-sensing receptor activation attenuates collagen expression in renal proximal tubular epithelial cells. Am J Physiol Renal Physiol. 2019 05 01; 316(5):F1006-F1015. PMID: 30838870.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    26. Li ZL, Lv LL, Tang TT, Wang B, Feng Y, Zhou LT, Cao JY, Tang RN, Wu M, Liu H, Crowley SD, Liu BC. HIF-1a inducing exosomal microRNA-23a expression mediates the cross-talk between tubular epithelial cells and macrophages in tubulointerstitial inflammation. Kidney Int. 2019 02; 95(2):388-404. PMID: 30551896.
      Citations: 91     Fields:    Translation:HumansAnimalsCells
    27. Dong XH, Ho MH, Liu B, Hildreth J, Dash C, Goodwin JS, Balasubramaniam M, Chen CH, Xie H. Role of Porphyromonas gingivalis outer membrane vesicles in oral mucosal transmission of HIV. Sci Rep. 2018 06 11; 8(1):8812. PMID: 29891956.
      Citations: 11     Fields:    Translation:HumansCellsPHPublic Health
    28. Wen Y, Liu YR, Tang TT, Pan MM, Xu SC, Ma KL, Lv LL, Liu H, Liu BC. mROS-TXNIP axis activates NLRP3 inflammasome to mediate renal injury during ischemic AKI. Int J Biochem Cell Biol. 2018 05; 98:43-53. PMID: 29477360.
      Citations: 32     Fields:    Translation:AnimalsCells
    29. Lv LL, Feng Y, Wen Y, Wu WJ, Ni HF, Li ZL, Zhou LT, Wang B, Zhang JD, Crowley SD, Liu BC. Exosomal CCL2 from Tubular Epithelial Cells Is Critical for Albumin-Induced Tubulointerstitial Inflammation. J Am Soc Nephrol. 2018 03; 29(3):919-935. PMID: 29295871.
      Citations: 101     Fields:    Translation:HumansAnimalsCells
    30. Liu HF, Liu H, Lv LL, Ma KL, Wen Y, Chen L, Liu BC. CCN3 suppresses TGF-?1-induced extracellular matrix accumulation in human mesangial cells in vitro. Acta Pharmacol Sin. 2018 Feb; 39(2):222-229. PMID: 28858296.
      Citations: 10     Fields:    Translation:HumansCells
    31. Zhou LT, Cao YH, Lv LL, Ma KL, Chen PS, Ni HF, Lei XD, Liu BC. Feature selection and classification of urinary mRNA microarray data by iterative random forest to diagnose renal fibrosis: a two-stage study. Sci Rep. 2017 01 03; 7:39832. PMID: 28045061.
      Citations: 10     Fields:    Translation:Humans
    32. Lv LL, Tang PM, Li CJ, You YK, Li J, Huang XR, Ni J, Feng M, Liu BC, Lan HY. The pattern recognition receptor, Mincle, is essential for maintaining the M1 macrophage phenotype in acute renal inflammation. Kidney Int. 2017 03; 91(3):587-602. PMID: 28017324.
      Citations: 69     Fields:    Translation:HumansAnimalsCells
    33. Zhou LT, Lv LL, Pan MM, Cao YH, Liu H, Feng Y, Ni HF, Liu BC. Are Urinary Tubular Injury Markers Useful in Chronic Kidney Disease? A Systematic Review and Meta Analysis. PLoS One. 2016; 11(12):e0167334. PMID: 27907168.
      Citations: 14     Fields:    Translation:Humans
    34. Wei Q, Liu H, Tu Y, Tang RN, Wang YL, Pan MM, Liu BC. The characteristics and mortality risk factors for acute kidney injury in different age groups in China-a cross sectional study. Ren Fail. 2016 Oct; 38(9):1413-1417. PMID: 27756185.
      Citations: 6     Fields:    Translation:HumansPHPublic Health
    35. Sun L, Zou LX, Han YC, Huang HM, Tan ZM, Gao M, Ma KL, Liu H, Liu BC. Forecast of the incidence, prevalence and burden of end-stage renal disease in Nanjing, China to the Year 2025. BMC Nephrol. 2016 06 13; 17(1):60. PMID: 27295981.
      Citations: 13     Fields:    Translation:Humans
    36. Turner T, Shao Q, Wang W, Wang Y, Wang C, Kinlock B, Liu B. Differential Contributions of Ubiquitin-Modified APOBEC3G Lysine Residues to HIV-1 Vif-Induced Degradation. J Mol Biol. 2016 08 28; 428(17):3529-39. PMID: 27297094.
      Citations: 5     Fields:    Translation:Cells
    37. Zhu DD, Tang RN, Lv LL, Wen Y, Liu H, Zhang XL, Ma KL, Liu BC. Interleukin-1? mediates high glucose induced phenotypic transition in human aortic endothelial cells. Cardiovasc Diabetol. 2016 Mar 05; 15:42. PMID: 26944557.
      Citations: 8     Fields:    Translation:HumansCells
    38. Han YC, Huang HM, Sun L, Tan CM, Gao M, Liu H, Tang RN, Wang YL, Wang B, Ma KL, Liu BC. Epidemiological Study of RRT-Treated ESRD in Nanjing - A Ten-Year Experience in Nearly Three Million Insurance Covered Population. PLoS One. 2016; 11(2):e0149038. PMID: 26889828.
      Citations: 5     Fields:    Translation:Humans
    39. Wang C, Timmons CL, Shao Q, Kinlock BL, Turner TM, Iwamoto A, Zhang H, Liu H, Liu B. GB virus type C E2 protein inhibits human immunodeficiency virus type 1 Gag assembly by downregulating human ADP-ribosylation factor 1. Oncotarget. 2015 Dec 22; 6(41):43293-309. PMID: 26675377.
      Citations: 1     Fields:    Translation:HumansCells
    40. Liu D, Wen Y, Tang TT, Lv LL, Tang RN, Liu H, Ma KL, Crowley SD, Liu BC. Megalin/Cubulin-Lysosome-mediated Albumin Reabsorption Is Involved in the Tubular Cell Activation of NLRP3 Inflammasome and Tubulointerstitial Inflammation. J Biol Chem. 2015 Jul 17; 290(29):18018-18028. PMID: 26025362.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    41. Liu J, Ma KL, Zhang Y, Wu Y, Hu ZB, Lv LL, Tang RN, Liu H, Ruan XZ, Liu BC. Activation of mTORC1 disrupted LDL receptor pathway: a potential new mechanism for the progression of non-alcoholic fatty liver disease. Int J Biochem Cell Biol. 2015 Apr; 61:8-19. PMID: 25622557.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    42. Wang Y, Kinlock BL, Shao Q, Turner TM, Liu B. HIV-1 Vif inhibits G to A hypermutations catalyzed by virus-encapsidated APOBEC3G to maintain HIV-1 infectivity. Retrovirology. 2014 Oct 11; 11:89. PMID: 25304135.
      Citations: 10     Fields:    Translation:HumansCells
    43. Wang Z, Luo Y, Shao Q, Kinlock BL, Wang C, Hildreth JE, Xie H, Liu B. Heat-stable molecule derived from Streptococcus cristatus induces APOBEC3 expression and inhibits HIV-1 replication. PLoS One. 2014; 9(8):e106078. PMID: 25165817.
      Citations: 4     Fields:    Translation:HumansCells
    44. Kinlock BL, Wang Y, Turner TM, Wang C, Liu B. Transcytosis of HIV-1 through vaginal epithelial cells is dependent on trafficking to the endocytic recycling pathway. PLoS One. 2014; 9(5):e96760. PMID: 24830293.
      Citations: 26     Fields:    Translation:HumansCells
    45. Liu H, Zhang XM, Wang YL, Liu BC. Prevalence of hyperuricemia among Chinese adults: a national cross-sectional survey using multistage, stratified sampling. J Nephrol. 2014 Dec; 27(6):653-8. PMID: 24687401.
      Citations: 91     Fields:    Translation:Humans
    46. Chen JF, Liu H, Ni HF, Lv LL, Zhang MH, Zhang AH, Tang RN, Chen PS, Liu BC. Improved mitochondrial function underlies the protective effect of pirfenidone against tubulointerstitial fibrosis in 5/6 nephrectomized rats. PLoS One. 2013; 8(12):e83593. PMID: 24349535.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    47. Lv LL, Cao Y, Liu D, Xu M, Liu H, Tang RN, Ma KL, Liu BC. Isolation and quantification of microRNAs from urinary exosomes/microvesicles for biomarker discovery. Int J Biol Sci. 2013; 9(10):1021-31. PMID: 24250247.
      Citations: 102     Fields:    Translation:Cells
    48. Ma KL, Liu J, Wang CX, Ni J, Zhang Y, Wu Y, Lv LL, Ruan XZ, Liu BC. Activation of mTOR modulates SREBP-2 to induce foam cell formation through increased retinoblastoma protein phosphorylation. Cardiovasc Res. 2013 Dec 01; 100(3):450-60. PMID: 24068000.
      Citations: 31     Fields:    Translation:AnimalsCells
    49. Song M, Chen D, Lu B, Wang C, Zhang J, Huang L, Wang X, Timmons CL, Hu J, Liu B, Wu X, Wang L, Wang J, Liu H. PTEN loss increases PD-L1 protein expression and affects the correlation between PD-L1 expression and clinical parameters in colorectal cancer. PLoS One. 2013; 8(6):e65821. PMID: 23785454.
      Citations: 138     Fields:    Translation:HumansCells
    50. Pan MM, Zhang MH, Ni HF, Chen JF, Xu M, Phillips AO, Liu BC. Inhibition of TGF-?1/Smad signal pathway is involved in the effect of Cordyceps sinensis against renal fibrosis in 5/6 nephrectomy rats. Food Chem Toxicol. 2013 Aug; 58:487-94. PMID: 23624380.
      Citations: 12     Fields:    Translation:AnimalsCells
    51. Li Q, Lv LL, Wu M, Zhang XL, Liu H, Liu BC. Dexamethasone prevents monocyte-induced tubular epithelial-mesenchymal transition in HK-2 cells. J Cell Biochem. 2013 Mar; 114(3):632-8. PMID: 23060286.
      Citations: 6     Fields:    Translation:HumansCells
    52. Ma KL, Liu J, Ni J, Zhang Y, Lv LL, Tang RN, Ni HF, Ruan XZ, Liu BC. Inflammatory stress exacerbates the progression of cardiac fibrosis in high-fat-fed apolipoprotein E knockout mice via endothelial-mesenchymal transition. Int J Med Sci. 2013; 10(4):420-6. PMID: 23471419.
      Citations: 22     Fields:    Translation:Animals
    53. Timmons CL, Shao Q, Wang C, Liu L, Liu H, Dong X, Liu B. GB virus type C E2 protein inhibits human immunodeficiency virus type 1 assembly through interference with HIV-1 gag plasma membrane targeting. J Infect Dis. 2013 Apr; 207(7):1171-80. PMID: 23303812.
      Citations: 8     Fields:    Translation:HumansCells
    54. Liu J, Ma KL, Gao M, Wang CX, Ni J, Zhang Y, Zhang XL, Liu H, Wang YL, Liu BC. Inflammation disrupts the LDL receptor pathway and accelerates the progression of vascular calcification in ESRD patients. PLoS One. 2012; 7(10):e47217. PMID: 23115640.
      Citations: 11     Fields:    Translation:Humans
    55. Chen L, Wu YG, Liu D, Lv LL, Zheng M, Ni HF, Cao YH, Liu H, Zhang P, Zhang JD, Liu BC. Urinary mRNA expression of CCN2/CCN3 as a noninvasive marker for monitoring glomerular structure changes in nondiabetic chronic kidney disease. Biomarkers. 2012 Dec; 17(8):714-20. PMID: 23061738.
      Citations: 2     Fields:    Translation:Humans
    56. Zheng M, Lv LL, Cao YH, Liu H, Ni J, Dai HY, Liu D, Lei XD, Liu BC. A pilot trial assessing urinary gene expression profiling with an mRNA array for diabetic nephropathy. PLoS One. 2012; 7(5):e34824. PMID: 22629296.
      Citations: 12     Fields:    Translation:HumansPHPublic Health
    57. Zheng M, Lv LL, Cao YH, Zhang JD, Wu M, Ma KL, Phillips AO, Liu BC. Urinary mRNA markers of epithelial-mesenchymal transition correlate with progression of diabetic nephropathy. Clin Endocrinol (Oxf). 2012 May; 76(5):657-64. PMID: 21824169.
      Citations: 14     Fields:    Translation:Humans
    58. Dey A, Mantri CK, Pandhare-Dash J, Liu B, Pratap S, Dash C. Downregulation of APOBEC3G by xenotropic murine leukemia-virus related virus (XMRV) in prostate cancer cells. Virol J. 2011 Dec 12; 8:531. PMID: 22152111.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    59. Tang RN, Lv LL, Zhang JD, Dai HY, Li Q, Zheng M, Ni J, Ma KL, Liu BC. Effects of angiotensin II receptor blocker on myocardial endothelial-to-mesenchymal transition in diabetic rats. Int J Cardiol. 2013 Jan 10; 162(2):92-9. PMID: 21704391.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    60. Li Q, Liu BC, Lv LL, Ma KL, Zhang XL, Phillips AO. Monocytes induce proximal tubular epithelial-mesenchymal transition through NF-kappa B dependent upregulation of ICAM-1. J Cell Biochem. 2011 Jun; 112(6):1585-92. PMID: 21344487.
      Citations: 29     Fields:    Translation:HumansCells
    61. Zheng M, Lv LL, Ni J, Ni HF, Li Q, Ma KL, Liu BC. Urinary podocyte-associated mRNA profile in various stages of diabetic nephropathy. PLoS One. 2011; 6(5):e20431. PMID: 21655212.
      Citations: 43     Fields:    Translation:HumansCells
    62. Dai HY, Zheng M, Tang RN, Ni J, Ma KL, Li Q, Liu BC. Effects of angiotensin receptor blocker on phenotypic alterations of podocytes in early diabetic nephropathy. Am J Med Sci. 2011 Mar; 341(3):207-14. PMID: 21326079.
      Citations: 13     Fields:    Translation:AnimalsCells
    63. Wang Y, Shao Q, Yu X, Kong W, Hildreth JE, Liu B. N-terminal hemagglutinin tag renders lysine-deficient APOBEC3G resistant to HIV-1 Vif-induced degradation by reduced polyubiquitination. J Virol. 2011 May; 85(9):4510-9. PMID: 21345952.
      Citations: 18     Fields:    Translation:HumansCells
    64. Liu H, Zhang YZ, Gao M, Liu BC. Elevation of B-type natriuretic peptide is a sensitive marker of left ventricular diastolic dysfunction in patients with maintenance haemodialysis. Biomarkers. 2010 Sep; 15(6):533-7. PMID: 20536328.
      Citations: 4     Fields:    Translation:Humans
    65. Shao Q, Wang Y, Hildreth JE, Liu B. Polyubiquitination of APOBEC3G is essential for its degradation by HIV-1 Vif. J Virol. 2010 May; 84(9):4840-4. PMID: 20147392.
      Citations: 16     Fields:    Translation:HumansCells
    66. Tie Y, Liu B, Fu H, Zheng X. Circulating miRNA and cancer diagnosis. Sci China C Life Sci. 2009 Dec; 52(12):1117-22. PMID: 20016968.
      Citations: 16     Fields:    Translation:HumansAnimals
    67. Moorman J, Zhang Y, Liu B, LeSage G, Chen Y, Stuart C, Prayther D, Yin D. HIV-1 gp120 primes lymphocytes for opioid-induced, beta-arrestin 2-dependent apoptosis. Biochim Biophys Acta. 2009 Aug; 1793(8):1366-71. PMID: 19477204.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    68. Wang T, Zhang W, Tian C, Liu B, Yu Y, Ding L, Spearman P, Yu XF. Distinct viral determinants for the packaging of human cytidine deaminases APOBEC3G and APOBEC3C. Virology. 2008 Jul 20; 377(1):71-9. PMID: 18495196.
      Citations: 34     Fields:    Translation:HumansCells
    69. Liu BC, Xia HL, Wu JN, Zhang XL, Liu DG, Gong YX. Influence of irbesartan on expression of ILK and its relationship with epithelial-mesenchymal transition in mice with unilateral ureteral obstruction. Acta Pharmacol Sin. 2007 Nov; 28(11):1810-8. PMID: 17959033.
      Citations: 4     Fields:    Translation:AnimalsCells
    70. Liu BC, Li MX, Zhang JD, Liu XC, Zhang XL, Phillips AO. Inhibition of integrin-linked kinase via a siRNA expression plasmid attenuates connective tissue growth factor-induced human proximal tubular epithelial cells to mesenchymal transition. Am J Nephrol. 2008; 28(1):143-51. PMID: 17951996.
      Citations: 12     Fields:    Translation:HumansCells
    71. Xu Y, Xu G, Liu B, Gu G. Cre reconstitution allows for DNA recombination selectively in dual-marker-expressing cells in transgenic mice. Nucleic Acids Res. 2007; 35(19):e126. PMID: 17893102.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    72. Wang T, Tian C, Zhang W, Luo K, Sarkis PT, Yu L, Liu B, Yu Y, Yu XF. 7SL RNA mediates virion packaging of the antiviral cytidine deaminase APOBEC3G. J Virol. 2007 Dec; 81(23):13112-24. PMID: 17881443.
      Citations: 118     Fields:    Translation:HumansCells
    73. Luo K, Wang T, Liu B, Tian C, Xiao Z, Kappes J, Yu XF. Cytidine deaminases APOBEC3G and APOBEC3F interact with human immunodeficiency virus type 1 integrase and inhibit proviral DNA formation. J Virol. 2007 Jul; 81(13):7238-48. PMID: 17428847.
      Citations: 145     Fields:    Translation:HumansCells
    74. Xia HL, Liu BC, Zhang XL, Liu DG, Wu JN, Zhang JD, Gong YX. [Role of integrin-linked kinase in renal tubular epithelial-mesenchymal transition of mice with obstructive nephropathy]. Zhonghua Bing Li Xue Za Zhi. 2007 Jan; 36(1):43-7. PMID: 17374238.
      Citations:    Fields:    Translation:AnimalsCells
    75. Wang J, Shackelford JM, Casella CR, Shivers DK, Rapaport EL, Liu B, Yu XF, Finkel TH. The Vif accessory protein alters the cell cycle of human immunodeficiency virus type 1 infected cells. Virology. 2007 Mar 15; 359(2):243-52. PMID: 17056089.
      Citations: 23     Fields:    Translation:HumansCells
    76. Chen L, Liu BC, Zhang XL, Zhang JD, Liu H, Li MX. Influence of connective tissue growth factor antisense oligonucleotide on angiotensin II-induced epithelial mesenchymal transition in HK2 cells. Acta Pharmacol Sin. 2006 Aug; 27(8):1029-36. PMID: 16867255.
      Citations: 10     Fields:    Translation:HumansCells
    77. Liu BC, Zhang JD, Zhang XL, Wu GQ, Li MX. Role of connective tissue growth factor (CTGF) module 4 in regulating epithelial mesenchymal transition (EMT) in HK-2 cells. Clin Chim Acta. 2006 Nov; 373(1-2):144-50. PMID: 16828074.
      Citations: 12     Fields:    Translation:HumansCells
    78. Liu BC, Chen L, Sun J, Huang HQ, Ma KL, Liu H, Liu DG, Zhang XL. Connective tissue growth factor-mediated angiotensin II-induced hypertrophy of proximal tubular cells. Nephron Exp Nephrol. 2006; 103(1):e16-26. PMID: 16374037.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    79. Luo K, Xiao Z, Ehrlich E, Yu Y, Liu B, Zheng S, Yu XF. Primate lentiviral virion infectivity factors are substrate receptors that assemble with cullin 5-E3 ligase through a HCCH motif to suppress APOBEC3G. Proc Natl Acad Sci U S A. 2005 Aug 09; 102(32):11444-9. PMID: 16076960.
      Citations: 114     Fields:    Translation:HumansCells
    80. Liu B, Sarkis PT, Luo K, Yu Y, Yu XF. Regulation of Apobec3F and human immunodeficiency virus type 1 Vif by Vif-Cul5-ElonB/C E3 ubiquitin ligase. J Virol. 2005 Aug; 79(15):9579-87. PMID: 16014920.
      Citations: 88     Fields:    Translation:HumansCells
    81. Luo K, Liu B, Xiao Z, Yu Y, Yu X, Gorelick R, Yu XF. Amino-terminal region of the human immunodeficiency virus type 1 nucleocapsid is required for human APOBEC3G packaging. J Virol. 2004 Nov; 78(21):11841-52. PMID: 15479826.
      Citations: 115     Fields:    Translation:HumansCells
    82. Liu B, Yu X, Luo K, Yu Y, Yu XF. Influence of primate lentiviral Vif and proteasome inhibitors on human immunodeficiency virus type 1 virion packaging of APOBEC3G. J Virol. 2004 Feb; 78(4):2072-81. PMID: 14747572.
      Citations: 76     Fields:    Translation:HumansAnimalsCells
    83. Liu BC, Sun J, Chen Q, Ma KL, Ruan XZ, Phillips AO. Role of connective tissue growth factor in mediating hypertrophy of human proximal tubular cells induced by angiotensin II. Am J Nephrol. 2003 Nov-Dec; 23(6):429-37. PMID: 14583661.
      Citations: 8     Fields:    Translation:HumansCells
    84. Yu X, Yu Y, Liu B, Luo K, Kong W, Mao P, Yu XF. Induction of APOBEC3G ubiquitination and degradation by an HIV-1 Vif-Cul5-SCF complex. Science. 2003 Nov 07; 302(5647):1056-60. PMID: 14564014.
      Citations: 665     Fields:    Translation:HumansAnimalsCells
    85. Kong W, Tian C, Liu B, Yu XF. Stable expression of primary human immunodeficiency virus type 1 structural gene products by use of a noncytopathic sindbis virus vector. J Virol. 2002 Nov; 76(22):11434-9. PMID: 12388704.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    86. Yu XF, Liu W, Chen J, Kong W, Liu B, Zhu Q, Liang F, McCutchan F, Piyasirisilp S, Lai S. Maintaining low HIV type 1 env genetic diversity among injection drug users infected with a B/C recombinant and CRF01_AE HIV type 1 in southern China. AIDS Res Hum Retroviruses. 2002 Jan 20; 18(2):167-70. PMID: 11839150.
      Citations: 8     Fields:    Translation:CellsPHPublic Health
    87. Qiu JT, Liu B, Tian C, Pavlakis GN, Yu XF. Enhancement of primary and secondary cellular immune responses against human immunodeficiency virus type 1 gag by using DNA expression vectors that target Gag antigen to the secretory pathway. J Virol. 2000 Jul; 74(13):5997-6005. PMID: 10846081.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    88. Liu B, Dai R, Tian CJ, Dawson L, Gorelick R, Yu XF. Interaction of the human immunodeficiency virus type 1 nucleocapsid with actin. J Virol. 1999 Apr; 73(4):2901-8. PMID: 10074138.
      Citations: 60     Fields:    Translation:HumansCells
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