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Bindong Liu

Faculty RankProfessor
InstitutionMeharry Medical College
DepartmentMicrobiology, Immunology and Microbiology, Immunology, & Physiology
Address5029 Hubbard Hospital BLDG
1005 Dr. D. B. Todd BLVD
Nashville TN 37208
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    Other Positions
    InstitutionMeharry Medical College
    DepartmentMicrobiology, Immunology and Physiology

    InstitutionMeharry Medical College

    TitleAssociate Director
    InstitutionTennessee Center for AIDS Research

    Collapse Affiliation 

    Collapse Biography 
    Collapse awards and honors
    1993Third Place: Outstanding Paper on Science and Technology, Heilongjiang Province
    1995National Science and Technology Progress Award, Equine Infectious Anemia (EIA)

    Collapse Overview 
    Collapse overview
    The research in our lab focuses on delineating the interactions between HIV-1 and host, as well as HIV-1 and other human microbes with the effort on finding a solution to inhibit HIV-1 replication. We have following three ongoing projects.

    1. Mucosal surfaces serve as the predominant point of transmission for human immunodeficiency virus (HIV-1). However, it is well-documented that the transmission/acquisition of HIV-1 through oro-genital contact is rare. The risk associated with the vaginal acquisition of HIV-1 after sexual contact with a HIV-1 positive individual is 0.03% to 0.2%, while the risk of oral acquisition is estimated to be 20 times less. This indicates that the protection provided by the innate and adaptive immune system of the host is robust, but varies according to the mucosal site. APOBEC3G (A3G) is a potent host restriction factor of HIV-1. It has been shown that A3G blocks HIV-1 replication or transmission when its expression is up-regulated. Streptococcus Cristatus CC5A is a non-pathogenic oral bacterial. We found that a small molecule of Streptococcus cristatus CC5A (S. cristatus CC5A) was able to up-regulate APOBEC3G expression and inhibit HIV replication. Now we are working on developing a novel, efficient anti-HIV/AIDS strategy using this molecule.

    2. GB virus type C (GBV-C, also called hepatitis G virus) is a single, positive strand RNA virus in the Flaviviridae family. It has not been conclusively associated with any known disease, although it is a very common infection in humans. Most of the cohort studies about the interaction of GBV-C and HIV-1 showed that GBV-C infection could prolong AIDS patient survival. Since GBV-C shares the same transmission pathway with HIV-1 and replicates in CD4+ T cells, it could be a very promising candidate for establishing novel anti-AIDS therapy strategies and gene therapy vectors which specifically deliver anti-HIV genes to CD4+ T cells. In our study, we found that when one of GBV-C structural protein E2 was co-expressed with the HIV-1 proviral construct, HIV-1 Gag processing was dramatically inhibited resulting less virus has been released. This may shed light on developing GBV-C as novel anti-HIV/AIDS strategy. We are working on elucidating the mechanism of GBV-C’s anti-HIV/AIDS effect and testing whether we could develop a novel anti-HIV/AIDS drug based on this discovery.

    3. We are trying to understand the interaction between HIV-1 Vif and APOBEC3G (A3G). A3G is a host restriction factor of HIV-1. HIV encodes Vif to overcome A3G antiviral effect. It is well-established that Vif counteracts A3G via proteasome-mediated A3G degradation and repression of A3G translation. Such a mechanism is essential for the production of infectious virions because inclusion of A3G in Vif-deficient virions has been shown to result in non-infectious particles. However, clinical and laboratory evidence, including that of our group, has shown that A3G is detectable in Vif competent HIV-1 viral particles without affecting their infectivity. How HIV solves this conundrum remains unclear. We have been addressing the above paradox by examining A3G activities in the presence of Vif. We showed that besides depleting A3G, Vif directly inhibits A3G cytidine deaminase activity, which is necessary for G-to-A hypermutation in an exogenous protein expression system. As a result, the presence of functional Vif significantly reduces the rate of G-to-A hypermutations generated by A3G to promote HIV replication. Right now we are further evaluating this phenotype under physiologically relevant condition and working on the identification of the specific interaction domains which play a role in inhibiting A3G cytidine deaminase activity. Understanding details of the interaction between APOBEC and HIV-1 Vif will shed light on anti-HIV/AIDS drug design.

    Collapse Research 
    Collapse research activities and funding
    SC1GM089269     (LIU, BINDONG)Sep 8, 2009 - May 31, 2021
    Characterizing a small molecule of Streptococcus cristatus for HIV drug design
    Role: Principal Investigator
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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Wang J, Chen P, Dong Y, Xie H, Wang Y, Soto F, Ma P, Feng X, Du W, Liu BF. Designer exosomes enabling tumor targeted efficient chemo/gene/photothermal therapy. Biomaterials. 2021 09; 276:121056. PMID: 34364178.
      Citations: 1     Fields:    Translation:AnimalsCells
    2. Li ZL, Ji JL, Wen Y, Cao JY, Kharbuja N, Ni WJ, Yin D, Feng ST, Liu H, Lv LL, Liu BC, Wang B. HIF-1a is transcriptionally regulated by NF-?B in acute kidney injury. Am J Physiol Renal Physiol. 2021 08 01; 321(2):F225-F235. PMID: 34229478.
      Citations: 1     Fields:    Translation:AnimalsCells
    3. Tang TT, Wang B, Li ZL, Wen Y, Feng ST, Wu M, Liu D, Cao JY, Yin Q, Yin D, Fu YQ, Gao YM, Ding ZY, Qian JY, Wu QL, Lv LL, Liu BC. Kim-1 Targeted Extracellular Vesicles: A New Therapeutic Platform for RNAi to Treat AKI. J Am Soc Nephrol. 2021 10; 32(10):2467-2483. PMID: 34127536.
      Citations: 2     Fields:    
    4. Cao JY, Wang B, Tang TT, Wen Y, Li ZL, Feng ST, Wu M, Liu D, Yin D, Ma KL, Tang RN, Wu QL, Lan HY, Lv LL, Liu BC. Exosomal miR-125b-5p deriving from mesenchymal stem cells promotes tubular repair by suppression of p53 in ischemic acute kidney injury. Theranostics. 2021; 11(11):5248-5266. PMID: 33859745.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    5. Lu J, Chen PP, Zhang JX, Li XQ, Wang GH, Yuan BY, Huang SJ, Liu XQ, Jiang TT, Wang MY, Liu WT, Ruan XZ, Liu BC, Ma KL. GPR43 deficiency protects against podocyte insulin resistance in diabetic nephropathy through the restoration of AMPKa activity. Theranostics. 2021; 11(10):4728-4742. PMID: 33754024.
      Citations:    Fields:    Translation:HumansAnimalsCells
    6. Wang J, Ma P, Kim DH, Liu BF, Demirci U. Towards Microfluidic-Based Exosome Isolation and Detection for Tumor Therapy. Nano Today. 2021 Apr; 37. PMID: 33777166.
    7. Dong Y, Wang L, Wang J, Wang S, Wang Y, Jin D, Chen P, Du W, Zhang L, Liu BF. Graphene-Based Helical Micromotors Constructed by "Microscale Liquid Rope-Coil Effect" with Microfluidics. ACS Nano. 2020 Oct 29. PMID: 33119265.
      Citations: 3     Fields:    
    8. Ge A, Hu L, Fan J, Ge M, Wang X, Wang S, Feng X, Du W, Liu BF. A low-cost microfluidic platform coupled with light emitting diode for optogenetic analysis of neuronal response in C. elegans. Talanta. 2021 Feb 01; 223(Pt 1):121646. PMID: 33303134.
      Citations:    Fields:    Translation:AnimalsCells
    9. Feng Y, Zhong X, Tang TT, Wang C, Wang LT, Li ZL, Ni HF, Wang B, Wu M, Liu D, Liu H, Tang RN, Liu BC, Lv LL. Rab27a dependent exosome releasing participated in albumin handling as a coordinated approach to lysosome in kidney disease. Cell Death Dis. 2020 07 08; 11(7):513. PMID: 32641688.
      Citations:    Fields:    Translation:HumansAnimalsCells
    10. Yan S, Zeng X, Wang Y, Liu BF. Biomineralization of Bacteria by a Metal-Organic Framework for Therapeutic Delivery. Adv Healthc Mater. 2020 06; 9(12):e2000046. PMID: 32400080.
      Citations: 2     Fields:    Translation:Cells
    11. Liu S, Fu Y, Huang Z, Liu Y, Liu BF, Cheng L, Liu X. A comprehensive analysis of subclass-specific IgG glycosylation in colorectal cancer progression by nanoLC-MS/MS. Analyst. 2020 Apr 14; 145(8):3136-3147. PMID: 32186558.
      Citations: 2     Fields:    Translation:HumansCells
    12. Xiang XF, Li PJ, Liu BF. Tuning the Superhydrophobic Properties of Hierarchical Nano-microstructural Silica Biomorph Arrays Grown at Triphasic Interfaces. Sci Rep. 2020 03 12; 10(1):4596. PMID: 32165719.
      Citations: 1     Fields:    
    13. Wang Y, Wang X, Ge A, Hu L, Du W, Liu BF. A dual-stimulation strategy in a micro-chip for the investigation of mechanical associative learning behavior of C. elegans. Talanta. 2020 Aug 01; 215:120900. PMID: 32312445.
      Citations:    Fields:    Translation:Animals
    14. Zeng X, Yan S, Di C, Lei M, Chen P, Du W, Jin Y, Liu BF. "All-in-One" Silver Nanoprism Platform for Targeted Tumor Theranostics. ACS Appl Mater Interfaces. 2020 Mar 11; 12(10):11329-11340. PMID: 32072808.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    15. Yang Y, Lin LH, Gao M, Tang RN, Ma KL, Tu Y, Liu H, Liu BC. Association Between the Serum Uric Acid Level and the Severity of Coronary Artery Disease in a Retrospective Study of China Nondialysis CKD Patients. Metab Syndr Relat Disord. 2020 05; 18(4):206-211. PMID: 32069163.
      Citations:    Fields:    Translation:Humans
    16. Liu S, Huang Z, Zhang Q, Fu Y, Cheng L, Liu BF, Liu X. Profiling of isomer-specific IgG N-glycosylation in cohort of Chinese colorectal cancer patients. Biochim Biophys Acta Gen Subj. 2020 03; 1864(3):129510. PMID: 31887339.
      Citations: 2     Fields:    Translation:HumansCells
    17. Wang B, Yin Q, Wang YY, Tu Y, Han Y, Gao M, Pan M, Yang Y, Xue Y, Zhang L, Zhang L, Liu H, Tang R, Zhang X, Xiao J, Wang XH, Liu BC. Diaphragmatic dysfunction associates with dyspnoea, fatigue, and hiccup in haemodialysis patients: a cross-sectional study. Sci Rep. 2019 12 18; 9(1):19382. PMID: 31853002.
      Citations: 1     Fields:    Translation:Humans
    18. Ma P, Wang S, Guan R, Hu L, Wang X, Ge A, Zhu J, Du W, Liu BF. An integrated microfluidic device for studying controllable gas embolism induced cellular responses. Talanta. 2020 Feb 01; 208:120484. PMID: 31816727.
      Citations:    Fields:    Translation:HumansCells
    19. Yan S, Zeng X, Tang Y, Liu BF, Wang Y, Liu X. Activating Antitumor Immunity and Antimetastatic Effect Through Polydopamine-Encapsulated Core-Shell Upconversion Nanoparticles. . 2019 Nov; 31(46):e1905825. PMID: 31566283.
    20. Jiang M, Fan J, Qu X, Li S, Nilsson SK, Sun YBY, Chen Y, Yu D, Liu D, Liu BC, Tang M, Chen W, Ren Y, Nikolic-Paterson DJ, Jiang X, Li J, Yu X. Combined Blockade of Smad3 and JNK Pathways Ameliorates Progressive Fibrosis in Folic Acid Nephropathy. Front Pharmacol. 2019; 10:880. PMID: 31447676.
    21. Chen N, Hao C, Peng X, Lin H, Yin A, Hao L, Tao Y, Liang X, Liu Z, Xing C, Chen J, Luo L, Zuo L, Liao Y, Liu BC, Leong R, Wang C, Liu C, Neff T, Szczech L, Yu KP. Roxadustat for Anemia in Patients with Kidney Disease Not Receiving Dialysis. N Engl J Med. 2019 09 12; 381(11):1001-1010. PMID: 31340089.
      Citations: 94     Fields:    Translation:HumansCTClinical Trials
    22. Chen N, Hao C, Liu BC, Lin H, Wang C, Xing C, Liang X, Jiang G, Liu Z, Li X, Zuo L, Luo L, Wang J, Zhao MH, Liu Z, Cai GY, Hao L, Leong R, Wang C, Liu C, Neff T, Szczech L, Yu KP. Roxadustat Treatment for Anemia in Patients Undergoing Long-Term Dialysis. N Engl J Med. 2019 09 12; 381(11):1011-1022. PMID: 31340116.
      Citations: 103     Fields:    Translation:HumansCTClinical Trials
    23. Ni LH, Yuan C, Song KY, Wang XC, Chen SJ, Wang LT, Zhang YX, Liu H, Liu BC, Tang RN. Efficacy and safety of cinacalcet and active vitamin D in the treatment of secondary hyperparathyroidism in patients with chronic kidney disease: a network meta-analysis. Ann Transl Med. 2019 Jul; 7(14):322. PMID: 31475192.
    24. Ni LH, Tang RN, Yuan C, Song KY, Wang LT, Zhang XL, Lv LL, Wang B, Wu M, Tang TT, Li ZL, Yin D, Cao JY, Wang XC, Liu H, Chen Q, Liu BC. Cinacalcet attenuated bone loss via inhibiting parathyroid hormone-induced endothelial-to-adipocyte transition in chronic kidney disease rats. Ann Transl Med. 2019 Jul; 7(14):312. PMID: 31475182.
    25. Ni LH, Tang RN, Yuan C, Song KY, Wang LT, Wang XC, Zhang YX, Zhang XL, Zhu DD, Liu BC. FK506 prevented bone loss in streptozotocin-induced diabetic rats via enhancing osteogenesis and inhibiting adipogenesis. Ann Transl Med. 2019 Jun; 7(12):265. PMID: 31355232.
    26. Lv LL, Feng Y, Wu M, Wang B, Li ZL, Zhong X, Wu WJ, Chen J, Ni HF, Tang TT, Tang RN, Lan HY, Liu BC. Exosomal miRNA-19b-3p of tubular epithelial cells promotes M1 macrophage activation in kidney injury. Cell Death Differ. 2020 01; 27(1):210-226. PMID: 31097789.
      Citations: 52     Fields:    Translation:HumansAnimalsCells
    27. Zhang L, Wang P, Wang C, Wu Y, Feng X, Huang H, Ren L, Liu BF, Gao S, Liu X. Bacteriophage T4 capsid as a nanocarrier for Peptide-N-Glycosidase F immobilization through self-assembly. Sci Rep. 2019 03 19; 9(1):4865. PMID: 30890747.
      Citations:    Fields:    Translation:Cells
    28. Wu M, Feng Y, Ye GX, Han YC, Wang SS, Ni HF, Wang FM, Gao M, Lv LL, Liu BC. Calcium-sensing receptor activation attenuates collagen expression in renal proximal tubular epithelial cells. Am J Physiol Renal Physiol. 2019 05 01; 316(5):F1006-F1015. PMID: 30838870.
      Citations:    Fields:    Translation:HumansAnimalsCells
    29. Li ZL, Lv LL, Tang TT, Wang B, Feng Y, Zhou LT, Cao JY, Tang RN, Wu M, Liu H, Crowley SD, Liu BC. HIF-1a inducing exosomal microRNA-23a expression mediates the cross-talk between tubular epithelial cells and macrophages in tubulointerstitial inflammation. Kidney Int. 2019 02; 95(2):388-404. PMID: 30551896.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
    30. Wang Y, Zhu J, Chen P, Hu L, Feng X, Du W, Liu BF. A microfluidic platform with pneumatically switchable single-cell traps for selective intracellular signals probing. Talanta. 2019 Jan 15; 192:431-438. PMID: 30348414.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    31. Dong XH, Ho MH, Liu B, Hildreth J, Dash C, Goodwin JS, Balasubramaniam M, Chen CH, Xie H. Role of Porphyromonas gingivalis outer membrane vesicles in oral mucosal transmission of HIV. Sci Rep. 2018 06 11; 8(1):8812. PMID: 29891956.
      Citations: 2     Fields:    Translation:HumansCells
    32. Liu S, Cheng L, Fu Y, Liu BF, Liu X. Characterization of IgG N-glycome profile in colorectal cancer progression by MALDI-TOF-MS. J Proteomics. 2018 06 15; 181:225-237. PMID: 29698801.
      Citations: 6     Fields:    Translation:HumansCells
    33. Hu L, Ge A, Wang X, Wang S, Yue X, Wang J, Feng X, Du W, Liu BF. Real-time monitoring of immune responses under pathogen invasion and drug interference by integrated microfluidic device coupled with worm-based biosensor. Biosens Bioelectron. 2018 Jul 01; 110:233-238. PMID: 29625331.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    34. Wen Y, Liu YR, Tang TT, Pan MM, Xu SC, Ma KL, Lv LL, Liu H, Liu BC. mROS-TXNIP axis activates NLRP3 inflammasome to mediate renal injury during ischemic AKI. Int J Biochem Cell Biol. 2018 05; 98:43-53. PMID: 29477360.
      Citations: 18     Fields:    Translation:AnimalsCells
    35. Lv LL, Feng Y, Wen Y, Wu WJ, Ni HF, Li ZL, Zhou LT, Wang B, Zhang JD, Crowley SD, Liu BC. Exosomal CCL2 from Tubular Epithelial Cells Is Critical for Albumin-Induced Tubulointerstitial Inflammation. J Am Soc Nephrol. 2018 03; 29(3):919-935. PMID: 29295871.
      Citations: 47     Fields:    Translation:HumansAnimalsCells
    36. Wang C, Wu Y, Zhang L, Liu BF, Lin Y, Liu X. Relative quantitation of neutral and sialylated N-glycans using stable isotopic labeled d0/d5-benzoyl chloride by MALDI-MS. Anal Chim Acta. 2018 Mar 09; 1002:50-61. PMID: 29306413.
      Citations: 1     Fields:    Translation:HumansCells
    37. Wang J, Li W, Zhang L, Ban L, Chen P, Du W, Feng X, Liu BF. Chemically Edited Exosomes with Dual Ligand Purified by Microfluidic Device for Active Targeted Drug Delivery to Tumor Cells. ACS Appl Mater Interfaces. 2017 Aug 23; 9(33):27441-27452. PMID: 28762264.
      Citations: 32     Fields:    Translation:Cells
    38. Liu S, Gao W, Wang Y, He Z, Feng X, Liu BF, Liu X. Comprehensive N-Glycan Profiling of Cetuximab Biosimilar Candidate by NP-HPLC and MALDI-MS. PLoS One. 2017; 12(1):e0170013. PMID: 28072827.
      Citations: 6     Fields:    Translation:AnimalsCells
    39. Zhou LT, Cao YH, Lv LL, Ma KL, Chen PS, Ni HF, Lei XD, Liu BC. Feature selection and classification of urinary mRNA microarray data by iterative random forest to diagnose renal fibrosis: a two-stage study. Sci Rep. 2017 01 03; 7:39832. PMID: 28045061.
      Citations: 8     Fields:    Translation:Humans
    40. Zhou LT, Lv LL, Pan MM, Cao YH, Liu H, Feng Y, Ni HF, Liu BC. Are Urinary Tubular Injury Markers Useful in Chronic Kidney Disease? A Systematic Review and Meta Analysis. PLoS One. 2016; 11(12):e0167334. PMID: 27907168.
      Citations: 10     Fields:    Translation:Humans
    41. Wei Q, Liu H, Tu Y, Tang RN, Wang YL, Pan MM, Liu BC. The characteristics and mortality risk factors for acute kidney injury in different age groups in China-a cross sectional study. Ren Fail. 2016 Oct; 38(9):1413-1417. PMID: 27756185.
      Citations: 5     Fields:    Translation:HumansPHPublic Health
    42. Hu L, Ge A, Wang X, Wang S, Gao Y, Feng X, Du W, Liu BF. An on-demand gas segmented flow generator with high spatiotemporal resolution for in vivo analysis of neuronal response in C. elegans. Lab Chip. 2016 10 05; 16(20):4020-4027. PMID: 27714011.
      Citations: 1     Fields:    Translation:AnimalsCells
    43. Zhu DD, Tang RN, Lv LL, Wen Y, Liu H, Zhang XL, Ma KL, Liu BC. Interleukin-1ß mediates high glucose induced phenotypic transition in human aortic endothelial cells. Cardiovasc Diabetol. 2016 Mar 05; 15:42. PMID: 26944557.
      Citations: 5     Fields:    Translation:HumansCells
    44. Han YC, Huang HM, Sun L, Tan CM, Gao M, Liu H, Tang RN, Wang YL, Wang B, Ma KL, Liu BC. Epidemiological Study of RRT-Treated ESRD in Nanjing - A Ten-Year Experience in Nearly Three Million Insurance Covered Population. PLoS One. 2016; 11(2):e0149038. PMID: 26889828.
      Citations: 3     Fields:    Translation:Humans
    45. Chen D, Fan F, Zhao X, Xu F, Chen P, Wang J, Ban L, Liu Z, Feng X, Zhang Y, Liu BF. Single Cell Chemical Proteomics with Membrane-Permeable Activity-Based Probe for Identification of Functional Proteins in Lysosome of Tumors. Anal Chem. 2016 Feb 16; 88(4):2466-71. PMID: 26810843.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    46. Liu D, Wen Y, Tang TT, Lv LL, Tang RN, Liu H, Ma KL, Crowley SD, Liu BC. Megalin/Cubulin-Lysosome-mediated Albumin Reabsorption Is Involved in the Tubular Cell Activation of NLRP3 Inflammasome and Tubulointerstitial Inflammation. J Biol Chem. 2015 Jul 17; 290(29):18018-18028. PMID: 26025362.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    47. Liu J, Ma KL, Zhang Y, Wu Y, Hu ZB, Lv LL, Tang RN, Liu H, Ruan XZ, Liu BC. Activation of mTORC1 disrupted LDL receptor pathway: a potential new mechanism for the progression of non-alcoholic fatty liver disease. Int J Biochem Cell Biol. 2015 Apr; 61:8-19. PMID: 25622557.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    48. Wang Y, Tang X, Feng X, Liu C, Chen P, Chen D, Liu BF. A microfluidic digital single-cell assay for the evaluation of anticancer drugs. Anal Bioanal Chem. 2015 Feb; 407(4):1139-48. PMID: 25433683.
      Citations: 9     Fields:    Translation:HumansCells
    49. Wang Y, Kinlock BL, Shao Q, Turner TM, Liu B. HIV-1 Vif inhibits G to A hypermutations catalyzed by virus-encapsidated APOBEC3G to maintain HIV-1 infectivity. Retrovirology. 2014 Oct 11; 11:89. PMID: 25304135.
      Citations: 5     Fields:    Translation:HumansCells
    50. Wang Z, Luo Y, Shao Q, Kinlock BL, Wang C, Hildreth JE, Xie H, Liu B. Heat-stable molecule derived from Streptococcus cristatus induces APOBEC3 expression and inhibits HIV-1 replication. PLoS One. 2014; 9(8):e106078. PMID: 25165817.
      Citations: 3     Fields:    Translation:HumansCells
    51. Kinlock BL, Wang Y, Turner TM, Wang C, Liu B. Transcytosis of HIV-1 through vaginal epithelial cells is dependent on trafficking to the endocytic recycling pathway. PLoS One. 2014; 9(5):e96760. PMID: 24830293.
      Citations: 22     Fields:    Translation:HumansCells
    52. Zhang Q, Li H, Feng X, Liu BF, Liu X. Purification of derivatized oligosaccharides by solid phase extraction for glycomic analysis. PLoS One. 2014; 9(4):e94232. PMID: 24705408.
      Citations: 3     Fields:    Translation:HumansCells
    53. Chen JF, Liu H, Ni HF, Lv LL, Zhang MH, Zhang AH, Tang RN, Chen PS, Liu BC. Improved mitochondrial function underlies the protective effect of pirfenidone against tubulointerstitial fibrosis in 5/6 nephrectomized rats. PLoS One. 2013; 8(12):e83593. PMID: 24349535.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    54. Lv LL, Cao Y, Liu D, Xu M, Liu H, Tang RN, Ma KL, Liu BC. Isolation and quantification of microRNAs from urinary exosomes/microvesicles for biomarker discovery. Int J Biol Sci. 2013; 9(10):1021-31. PMID: 24250247.
      Citations: 78     Fields:    Translation:Cells
    55. Ma KL, Liu J, Wang CX, Ni J, Zhang Y, Wu Y, Lv LL, Ruan XZ, Liu BC. Activation of mTOR modulates SREBP-2 to induce foam cell formation through increased retinoblastoma protein phosphorylation. Cardiovasc Res. 2013 Dec 01; 100(3):450-60. PMID: 24068000.
      Citations: 24     Fields:    Translation:AnimalsCells
    56. Li Y, Xu F, Liu C, Xu Y, Feng X, Liu BF. A novel microfluidic mixer based on dual-hydrodynamic focusing for interrogating the kinetics of DNA-protein interaction. Analyst. 2013 Aug 21; 138(16):4475-82. PMID: 23785706.
      Citations: 5     Fields:    Translation:Cells
    57. Song M, Chen D, Lu B, Wang C, Zhang J, Huang L, Wang X, Timmons CL, Hu J, Liu B, Wu X, Wang L, Wang J, Liu H. PTEN loss increases PD-L1 protein expression and affects the correlation between PD-L1 expression and clinical parameters in colorectal cancer. PLoS One. 2013; 8(6):e65821. PMID: 23785454.
      Citations: 102     Fields:    Translation:HumansCells
    58. Pan MM, Zhang MH, Ni HF, Chen JF, Xu M, Phillips AO, Liu BC. Inhibition of TGF-ß1/Smad signal pathway is involved in the effect of Cordyceps sinensis against renal fibrosis in 5/6 nephrectomy rats. Food Chem Toxicol. 2013 Aug; 58:487-94. PMID: 23624380.
      Citations: 7     Fields:    Translation:AnimalsCells
    59. Li Q, Lv LL, Wu M, Zhang XL, Liu H, Liu BC. Dexamethasone prevents monocyte-induced tubular epithelial-mesenchymal transition in HK-2 cells. J Cell Biochem. 2013 Mar; 114(3):632-8. PMID: 23060286.
      Citations: 5     Fields:    Translation:HumansCells
    60. Ma KL, Liu J, Ni J, Zhang Y, Lv LL, Tang RN, Ni HF, Ruan XZ, Liu BC. Inflammatory stress exacerbates the progression of cardiac fibrosis in high-fat-fed apolipoprotein E knockout mice via endothelial-mesenchymal transition. Int J Med Sci. 2013; 10(4):420-6. PMID: 23471419.
      Citations: 16     Fields:    Translation:Animals
    61. Timmons CL, Shao Q, Wang C, Liu L, Liu H, Dong X, Liu B. GB virus type C E2 protein inhibits human immunodeficiency virus type 1 assembly through interference with HIV-1 gag plasma membrane targeting. J Infect Dis. 2013 Apr; 207(7):1171-80. PMID: 23303812.
      Citations: 7     Fields:    Translation:HumansCells
    62. Liu J, Ma KL, Gao M, Wang CX, Ni J, Zhang Y, Zhang XL, Liu H, Wang YL, Liu BC. Inflammation disrupts the LDL receptor pathway and accelerates the progression of vascular calcification in ESRD patients. PLoS One. 2012; 7(10):e47217. PMID: 23115640.
      Citations: 8     Fields:    Translation:Humans
    63. Chen L, Wu YG, Liu D, Lv LL, Zheng M, Ni HF, Cao YH, Liu H, Zhang P, Zhang JD, Liu BC. Urinary mRNA expression of CCN2/CCN3 as a noninvasive marker for monitoring glomerular structure changes in nondiabetic chronic kidney disease. Biomarkers. 2012 Dec; 17(8):714-20. PMID: 23061738.
      Citations: 2     Fields:    Translation:Humans
    64. Zheng M, Lv LL, Cao YH, Liu H, Ni J, Dai HY, Liu D, Lei XD, Liu BC. A pilot trial assessing urinary gene expression profiling with an mRNA array for diabetic nephropathy. PLoS One. 2012; 7(5):e34824. PMID: 22629296.
      Citations: 10     Fields:    Translation:HumansPHPublic Health
    65. Zheng M, Lv LL, Cao YH, Zhang JD, Wu M, Ma KL, Phillips AO, Liu BC. Urinary mRNA markers of epithelial-mesenchymal transition correlate with progression of diabetic nephropathy. Clin Endocrinol (Oxf). 2012 May; 76(5):657-64. PMID: 21824169.
      Citations: 10     Fields:    Translation:Humans
    66. Dey A, Mantri CK, Pandhare-Dash J, Liu B, Pratap S, Dash C. Downregulation of APOBEC3G by xenotropic murine leukemia-virus related virus (XMRV) in prostate cancer cells. Virol J. 2011 Dec 12; 8:531. PMID: 22152111.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    67. Tang RN, Lv LL, Zhang JD, Dai HY, Li Q, Zheng M, Ni J, Ma KL, Liu BC. Effects of angiotensin II receptor blocker on myocardial endothelial-to-mesenchymal transition in diabetic rats. Int J Cardiol. 2013 Jan 10; 162(2):92-9. PMID: 21704391.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    68. Li Q, Liu BC, Lv LL, Ma KL, Zhang XL, Phillips AO. Monocytes induce proximal tubular epithelial-mesenchymal transition through NF-kappa B dependent upregulation of ICAM-1. J Cell Biochem. 2011 Jun; 112(6):1585-92. PMID: 21344487.
      Citations: 24     Fields:    Translation:HumansCells
    69. Zheng M, Lv LL, Ni J, Ni HF, Li Q, Ma KL, Liu BC. Urinary podocyte-associated mRNA profile in various stages of diabetic nephropathy. PLoS One. 2011; 6(5):e20431. PMID: 21655212.
      Citations: 33     Fields:    Translation:HumansCells
    70. Wang Y, Shao Q, Yu X, Kong W, Hildreth JE, Liu B. N-terminal hemagglutinin tag renders lysine-deficient APOBEC3G resistant to HIV-1 Vif-induced degradation by reduced polyubiquitination. J Virol. 2011 May; 85(9):4510-9. PMID: 21345952.
      Citations: 18     Fields:    Translation:HumansCells
    71. Shao Q, Wang Y, Hildreth JE, Liu B. Polyubiquitination of APOBEC3G is essential for its degradation by HIV-1 Vif. J Virol. 2010 May; 84(9):4840-4. PMID: 20147392.
      Citations: 15     Fields:    Translation:HumansCells
    72. Tie Y, Liu B, Fu H, Zheng X. Circulating miRNA and cancer diagnosis. Sci China C Life Sci. 2009 Dec; 52(12):1117-22. PMID: 20016968.
      Citations: 12     Fields:    Translation:HumansAnimals
    73. Moorman J, Zhang Y, Liu B, LeSage G, Chen Y, Stuart C, Prayther D, Yin D. HIV-1 gp120 primes lymphocytes for opioid-induced, beta-arrestin 2-dependent apoptosis. Biochim Biophys Acta. 2009 Aug; 1793(8):1366-71. PMID: 19477204.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    74. Wang T, Zhang W, Tian C, Liu B, Yu Y, Ding L, Spearman P, Yu XF. Distinct viral determinants for the packaging of human cytidine deaminases APOBEC3G and APOBEC3C. Virology. 2008 Jul 20; 377(1):71-9. PMID: 18495196.
      Citations: 32     Fields:    Translation:HumansCells
    75. Liu BC, Xia HL, Wu JN, Zhang XL, Liu DG, Gong YX. Influence of irbesartan on expression of ILK and its relationship with epithelial-mesenchymal transition in mice with unilateral ureteral obstruction. Acta Pharmacol Sin. 2007 Nov; 28(11):1810-8. PMID: 17959033.
      Citations: 4     Fields:    Translation:AnimalsCells
    76. Liu BC, Li MX, Zhang JD, Liu XC, Zhang XL, Phillips AO. Inhibition of integrin-linked kinase via a siRNA expression plasmid attenuates connective tissue growth factor-induced human proximal tubular epithelial cells to mesenchymal transition. Am J Nephrol. 2008; 28(1):143-51. PMID: 17951996.
      Citations: 12     Fields:    Translation:HumansCells
    77. Xu Y, Xu G, Liu B, Gu G. Cre reconstitution allows for DNA recombination selectively in dual-marker-expressing cells in transgenic mice. Nucleic Acids Res. 2007; 35(19):e126. PMID: 17893102.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    78. Wang T, Tian C, Zhang W, Luo K, Sarkis PT, Yu L, Liu B, Yu Y, Yu XF. 7SL RNA mediates virion packaging of the antiviral cytidine deaminase APOBEC3G. J Virol. 2007 Dec; 81(23):13112-24. PMID: 17881443.
      Citations: 109     Fields:    Translation:HumansCells
    79. Luo K, Wang T, Liu B, Tian C, Xiao Z, Kappes J, Yu XF. Cytidine deaminases APOBEC3G and APOBEC3F interact with human immunodeficiency virus type 1 integrase and inhibit proviral DNA formation. J Virol. 2007 Jul; 81(13):7238-48. PMID: 17428847.
      Citations: 141     Fields:    Translation:HumansCells
    80. Xia HL, Liu BC, Zhang XL, Liu DG, Wu JN, Zhang JD, Gong YX. [Role of integrin-linked kinase in renal tubular epithelial-mesenchymal transition of mice with obstructive nephropathy]. Zhonghua Bing Li Xue Za Zhi. 2007 Jan; 36(1):43-7. PMID: 17374238.
      Citations:    Fields:    Translation:AnimalsCells
    81. Wang J, Shackelford JM, Casella CR, Shivers DK, Rapaport EL, Liu B, Yu XF, Finkel TH. The Vif accessory protein alters the cell cycle of human immunodeficiency virus type 1 infected cells. Virology. 2007 Mar 15; 359(2):243-52. PMID: 17056089.
      Citations: 21     Fields:    Translation:HumansCells
    82. Chen L, Liu BC, Zhang XL, Zhang JD, Liu H, Li MX. Influence of connective tissue growth factor antisense oligonucleotide on angiotensin II-induced epithelial mesenchymal transition in HK2 cells. Acta Pharmacol Sin. 2006 Aug; 27(8):1029-36. PMID: 16867255.
      Citations: 9     Fields:    Translation:HumansCells
    83. Liu BC, Zhang JD, Zhang XL, Wu GQ, Li MX. Role of connective tissue growth factor (CTGF) module 4 in regulating epithelial mesenchymal transition (EMT) in HK-2 cells. Clin Chim Acta. 2006 Nov; 373(1-2):144-50. PMID: 16828074.
      Citations: 8     Fields:    Translation:HumansCells
    84. Lin J, Zhang Z, Yang J, Zeng S, Liu BF, Luo Q. Real-time detection of caspase-2 activation in a single living HeLa cell during cisplatin-induced apoptosis. J Biomed Opt. 2006 Mar-Apr; 11(2):024011. PMID: 16674201.
      Citations: 5     Fields:    Translation:HumansCells
    85. Liu BC, Chen L, Sun J, Huang HQ, Ma KL, Liu H, Liu DG, Zhang XL. Connective tissue growth factor-mediated angiotensin II-induced hypertrophy of proximal tubular cells. Nephron Exp Nephrol. 2006; 103(1):e16-26. PMID: 16374037.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    86. Luo K, Xiao Z, Ehrlich E, Yu Y, Liu B, Zheng S, Yu XF. Primate lentiviral virion infectivity factors are substrate receptors that assemble with cullin 5-E3 ligase through a HCCH motif to suppress APOBEC3G. Proc Natl Acad Sci U S A. 2005 Aug 09; 102(32):11444-9. PMID: 16076960.
      Citations: 113     Fields:    Translation:HumansCells
    87. Liu B, Sarkis PT, Luo K, Yu Y, Yu XF. Regulation of Apobec3F and human immunodeficiency virus type 1 Vif by Vif-Cul5-ElonB/C E3 ubiquitin ligase. J Virol. 2005 Aug; 79(15):9579-87. PMID: 16014920.
      Citations: 85     Fields:    Translation:HumansCells
    88. Xiong T, Zhang Z, Liu BF, Zeng S, Chen Y, Chu J, Luo Q. In vivo optical imaging of human adenoid cystic carcinoma cell metastasis. Oral Oncol. 2005 Aug; 41(7):709-15. PMID: 15935724.
      Citations: 4     Fields:    Translation:Animals
    89. Luo K, Liu B, Xiao Z, Yu Y, Yu X, Gorelick R, Yu XF. Amino-terminal region of the human immunodeficiency virus type 1 nucleocapsid is required for human APOBEC3G packaging. J Virol. 2004 Nov; 78(21):11841-52. PMID: 15479826.
      Citations: 112     Fields:    Translation:HumansCells
    90. Liu B, Yu X, Luo K, Yu Y, Yu XF. Influence of primate lentiviral Vif and proteasome inhibitors on human immunodeficiency virus type 1 virion packaging of APOBEC3G. J Virol. 2004 Feb; 78(4):2072-81. PMID: 14747572.
      Citations: 76     Fields:    Translation:HumansAnimalsCells
    91. Liu BC, Sun J, Chen Q, Ma KL, Ruan XZ, Phillips AO. Role of connective tissue growth factor in mediating hypertrophy of human proximal tubular cells induced by angiotensin II. Am J Nephrol. 2003 Nov-Dec; 23(6):429-37. PMID: 14583661.
      Citations: 7     Fields:    Translation:HumansCells
    92. Yu X, Yu Y, Liu B, Luo K, Kong W, Mao P, Yu XF. Induction of APOBEC3G ubiquitination and degradation by an HIV-1 Vif-Cul5-SCF complex. Science. 2003 Nov 07; 302(5647):1056-60. PMID: 14564014.
      Citations: 623     Fields:    Translation:HumansAnimalsCells
    93. Zhang L, Liu BF, Liang S, Jones RL, Lu YT. Molecular and biochemical characterization of a calcium/calmodulin-binding protein kinase from rice. Biochem J. 2002 Nov 15; 368(Pt 1):145-57. PMID: 12160464.
      Citations: 19     Fields:    Translation:AnimalsCells
    94. Kong W, Tian C, Liu B, Yu XF. Stable expression of primary human immunodeficiency virus type 1 structural gene products by use of a noncytopathic sindbis virus vector. J Virol. 2002 Nov; 76(22):11434-9. PMID: 12388704.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    95. Yu XF, Liu W, Chen J, Kong W, Liu B, Zhu Q, Liang F, McCutchan F, Piyasirisilp S, Lai S. Maintaining low HIV type 1 env genetic diversity among injection drug users infected with a B/C recombinant and CRF01_AE HIV type 1 in southern China. AIDS Res Hum Retroviruses. 2002 Jan 20; 18(2):167-70. PMID: 11839150.
      Citations: 8     Fields:    Translation:CellsPHPublic Health
    96. Qiu JT, Liu B, Tian C, Pavlakis GN, Yu XF. Enhancement of primary and secondary cellular immune responses against human immunodeficiency virus type 1 gag by using DNA expression vectors that target Gag antigen to the secretory pathway. J Virol. 2000 Jul; 74(13):5997-6005. PMID: 10846081.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    97. Liu B, Dai R, Tian CJ, Dawson L, Gorelick R, Yu XF. Interaction of the human immunodeficiency virus type 1 nucleocapsid with actin. J Virol. 1999 Apr; 73(4):2901-8. PMID: 10074138.
      Citations: 54     Fields:    Translation:HumansCells
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