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Sehwan Jang

Faculty RankPostdoctoral Researcher
AddressUniversity of Puerto Rico - Medical Sciences Campus
Department of Physiology
PO Box 365067
San Juan PR
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    The goal of the proposed research is to investigate the role of tafazzin knockout on the mitochondrial function. Specifically, we plan to measure changes in mirochondrial repiratory supercomplexes from knockout and wild type mice. I have the expertise, leadership and motivation necessary to successfully carry out the proposed work. I have been developed a broad and detailed background in gene manipulation and biochemical analysis, with specific training and expertise in key research areas for this application. As a postdoctoral fellow at National Institute of Health, I analyzed the role of JNK on mitochondrial dysfunction using mouse model of oxidative stress. I carried out biochemical analysis as well as animal studies. At the National Institute on Alcohol Abuse and Alcoholism (NIAAA), I expanded my research to include the changes in phosphoproteome with mitochondrial dysfunction from oxidative stress. After finishing the study, I moved to University of Puerto Rico to continue my research on mitochondrial dysfunction on heart failure. As a molecular biologist and biochemist, I have been researching mitochondrial biology especially in the oxidative stress mediated dysfunction. In addition, I successfully carried out the projects collaborated with other researchers, and produced several peer-reviewed publications from each project. As a result of these previous experiences, I am aware of the importance of collaborative network and communication among scientists. During 2000-2004 my career was paused due to national obligations – mandatory military service as a South Korean citizen. However, I was partly lucky because my job was instructor/teacher/education coordinator. When I was discharged I immediately resumed my research and successfully competed for the support from National Research Foundation of Korea. In summary, I have a demonstrated record of accomplished and productive research projects in an area of high relevance, and my expertise and experience.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Javadov S, Jang S, Chapa-Dubocq XR, Khuchua Z, Camara AK. Mitochondrial respiratory supercomplexes in mammalian cells: structural versus functional role. J Mol Med (Berl). 2020 Nov 17. PMID: 33201259.
      Citations:    Fields:    
    2. Chapa-Dubocq XR, Rodríguez-Graciani KM, Guzmán-Hernández RA, Jang S, Brookes PS, Javadov S. Cardiac Function is not Susceptible to Moderate Disassembly of Mitochondrial Respiratory Supercomplexes. Int J Mol Sci. 2020 Feb 25; 21(5). PMID: 32106430.
      Citations: 1     Fields:    Translation:AnimalsCells
    3. Jang S, Javadov S. OPA1 regulates respiratory supercomplexes assembly: The role of mitochondrial swelling. Mitochondrion. 2020 03; 51:30-39. PMID: 31870826.
      Citations: 1     Fields:    
    4. M Parodi-Rullán R, Chapa-Dubocq X, Guzmán-Hernández R, Jang S, A Torres-Ramos C, Ayala-Peña S, Javadov S. The Role of Adenine Nucleotide Translocase in the Assembly of Respiratory Supercomplexes in Cardiac Cells. Cells. 2019 10 13; 8(10). PMID: 31614941.
      Citations: 2     Fields:    Translation:AnimalsCells
    5. Jang S, Javadov S. Elucidating the contribution of ETC complexes I and II to the respirasome formation in cardiac mitochondria. Sci Rep. 2018 12 07; 8(1):17732. PMID: 30531981.
      Citations: 6     Fields:    Translation:AnimalsCells
    6. Jang S, Javadov S. Current Challenges in Elucidating Respiratory Supercomplexes in Mitochondria: Methodological Obstacles. Front Physiol. 2018; 9:238. PMID: 29615931.
      Citations:    
    7. Jang S, Javadov S. Association between ROS production, swelling and the respirasome integrity in cardiac mitochondria. Arch Biochem Biophys. 2017 09 15; 630:1-8. PMID: 28736227.
      Citations: 7     Fields:    Translation:AnimalsCells
    8. Parodi-Rullán RM, Chapa-Dubocq X, Rullán PJ, Jang S, Javadov S. Corrigendum: High Sensitivity of SIRT3 Deficient Hearts to Ischemia-Reperfusion Is Associated with Mitochondrial Abnormalities. Front Pharmacol. 2017; 8:439. PMID: 28659809.
      Citations:    
    9. Parodi-Rullán RM, Chapa-Dubocq X, Rullán PJ, Jang S, Javadov S. High Sensitivity of SIRT3 Deficient Hearts to Ischemia-Reperfusion Is Associated with Mitochondrial Abnormalities. Front Pharmacol. 2017; 8:275. PMID: 28559847.
      Citations:    
    10. Javadov S, Jang S, Parodi-Rullán R, Khuchua Z, Kuznetsov AV. Mitochondrial permeability transition in cardiac ischemia-reperfusion: whether cyclophilin D is a viable target for cardioprotection? Cell Mol Life Sci. 2017 08; 74(15):2795-2813. PMID: 28378042.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    11. Abdelmegeed MA, Choi Y, Godlewski G, Ha SK, Banerjee A, Jang S, Song BJ. Corrigendum: Cytochrome P450-2E1 promotes fast food-mediated hepatic fibrosis. Sci Rep. 2017 02 17; 7:42566. PMID: 28211460.
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    12. Abdelmegeed MA, Choi Y, Godlewski G, Ha SK, Banerjee A, Jang S, Song BJ. Cytochrome P450-2E1 promotes fast food-mediated hepatic fibrosis. Sci Rep. 2017 01 04; 7:39764. PMID: 28051126.
      Citations: 6     Fields:    Translation:HumansAnimals
    13. Jang S, Lewis TS, Powers C, Khuchua Z, Baines CP, Wipf P, Javadov S. Elucidating Mitochondrial Electron Transport Chain Supercomplexes in the Heart During Ischemia-Reperfusion. Antioxid Redox Signal. 2017 07 01; 27(1):57-69. PMID: 27604998.
      Citations: 23     Fields:    Translation:AnimalsCells
    14. Javadov S, Jang S, Rodriguez-Reyes N, Rodriguez-Zayas AE, Soto Hernandez J, Krainz T, Wipf P, Frontera W. Mitochondria-targeted antioxidant preserves contractile properties and mitochondrial function of skeletal muscle in aged rats. Oncotarget. 2015 Nov 24; 6(37):39469-81. PMID: 26415224.
      Citations: 22     Fields:    Translation:AnimalsCells
    15. Banerjee A, Abdelmegeed MA, Jang S, Song BJ. Increased Sensitivity to Binge Alcohol-Induced Gut Leakiness and Inflammatory Liver Disease in HIV Transgenic Rats. PLoS One. 2015; 10(10):e0140498. PMID: 26484872.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    16. Jang S, Yu LR, Abdelmegeed MA, Gao Y, Banerjee A, Song BJ. Critical role of c-jun N-terminal protein kinase in promoting mitochondrial dysfunction and acute liver injury. Redox Biol. 2015 Dec; 6:552-564. PMID: 26491845.
      Citations: 10     Fields:    Translation:AnimalsCells
    17. Barreto-Torres G, Hernandez JS, Jang S, Rodríguez-Muñoz AR, Torres-Ramos CA, Basnakian AG, Javadov S. The beneficial effects of AMP kinase activation against oxidative stress are associated with prevention of PPARa-cyclophilin D interaction in cardiomyocytes. . 2015 Apr 01; 308(7):H749-58. PMID: 25617357.
      Citations:    
    18. Jang S, Javadov S. Inhibition of JNK aggravates the recovery of rat hearts after global ischemia: the role of mitochondrial JNK. PLoS One. 2014; 9(11):e113526. PMID: 25423094.
      Citations: 10     Fields:    Translation:AnimalsCells
    19. Escobales N, Nuñez RE, Jang S, Parodi-Rullan R, Ayala-Peña S, Sacher JR, Skoda EM, Wipf P, Frontera W, Javadov S. Mitochondria-targeted ROS scavenger improves post-ischemic recovery of cardiac function and attenuates mitochondrial abnormalities in aged rats. J Mol Cell Cardiol. 2014 Dec; 77:136-46. PMID: 25451170.
      Citations: 26     Fields:    Translation:AnimalsCells
    20. Javadov S, Jang S, Agostini B. Crosstalk between mitogen-activated protein kinases and mitochondria in cardiac diseases: therapeutic perspectives. Pharmacol Ther. 2014 Nov; 144(2):202-25. PMID: 24924700.
      Citations: 35     Fields:    Translation:HumansCells
    21. Banerjee A, Abdelmegeed MA, Jang S, Song BJ. Zidovudine (AZT) and hepatic lipid accumulation: implication of inflammation, oxidative and endoplasmic reticulum stress mediators. PLoS One. 2013; 8(10):e76850. PMID: 24146933.
      Citations: 10     Fields:    Translation:AnimalsCells
    22. Abdelmegeed MA, Banerjee A, Jang S, Yoo SH, Yun JW, Gonzalez FJ, Keshavarzian A, Song BJ. CYP2E1 potentiates binge alcohol-induced gut leakiness, steatohepatitis, and apoptosis. Free Radic Biol Med. 2013 Dec; 65:1238-1245. PMID: 24064383.
      Citations: 53     Fields:    Translation:AnimalsCells
    23. Abdelmegeed MA, Jang S, Banerjee A, Hardwick JP, Song BJ. Robust protein nitration contributes to acetaminophen-induced mitochondrial dysfunction and acute liver injury. Free Radic Biol Med. 2013 Jul; 60:211-22. PMID: 23454065.
      Citations: 32     Fields:    Translation:AnimalsCells
    24. Abdelmegeed MA, Banerjee A, Yoo SH, Jang S, Gonzalez FJ, Song BJ. Critical role of cytochrome P450 2E1 (CYP2E1) in the development of high fat-induced non-alcoholic steatohepatitis. J Hepatol. 2012 Oct; 57(4):860-6. PMID: 22668639.
      Citations: 84     Fields:    Translation:AnimalsCells
    25. Cha KI, Lim K, Jang S, Lim W, Kim T, Chang H. Molecular interactions of a replication initiator protein, RepA, with the replication origin of the enterococcal plasmid p703/5. J Microbiol Biotechnol. 2007 Nov; 17(11):1841-7. PMID: 18092469.
      Citations:    Fields:    Translation:Cells
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