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Brian Derrick

InstitutionUniversity of Texas at San Antonio
Address1 UTSA Cir
San Antonio TX 78249
Phone(210) 458-5661
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    Dr. Derrick’s lab studies information processing in the hippocampal formation, a limbic structure crucial for encoding and the retrieval of episodic and semantic memory. They are interested in hippocampal function from a dynamical and cognitive/systems approach and are exploring the predictions of current computational theories of brain function using molecular, neurophysiological, neuropharmacological, and behavioral techniques. The lab is interested in the interactions among cortical inputs to the CA3 and CA1 hippocampal regions arising directly from the perforant pathway and indirectly from the CA3 and dentate gyrus regions, and their dynamics during encoding and retrieval in behaving animals. Related to these phenomena, they are also investigating the dual roles of the dentate and CA3 region in novelty detection, encoding, and pattern completion (retrieval).

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Gonzalez J, Villarreal DM, Morales IS, Derrick BE. Long-term Potentiation at Temporoammonic Path-CA1 Synapses in Freely Moving Rats. Front Neural Circuits. 2016; 10:2. PMID: 26903815.
      Citations: 2     Fields:    Translation:AnimalsCells
    2. Gonzalez J, Morales IS, Villarreal DM, Derrick BE. Low-frequency stimulation induces long-term depression and slow onset long-term potentiation at perforant path-dentate gyrus synapses in vivo. J Neurophysiol. 2014 Mar; 111(6):1259-73. PMID: 24335215.
      Citations: 8     Fields:    Translation:AnimalsCells
    3. Martinez CO, Do VH, Derrick BE. Endogenous opioid peptides contribute to associative LTP in the hippocampal CA3 region. Neurobiol Learn Mem. 2011 Sep; 96(2):207-17. PMID: 21571085.
      Citations: 3     Fields:    Translation:Animals
    4. Villarreal DM, Derrick B, Vathy I. Prenatal morphine exposure attenuates the maintenance of late LTP in lateral perforant path projections to the dentate gyrus and the CA3 region in vivo. J Neurophysiol. 2008 Mar; 99(3):1235-42. PMID: 18199817.
      Citations: 9     Fields:    Translation:AnimalsCells
    5. Villarreal DM, Gross AL, Derrick BE. Modulation of CA3 afferent inputs by novelty and theta rhythm. J Neurosci. 2007 Dec 05; 27(49):13457-67. PMID: 18057204.
      Citations: 7     Fields:    Translation:AnimalsCells
    6. Derrick BE. Plastic processes in the dentate gyrus: a computational perspective. Prog Brain Res. 2007; 163:417-51. PMID: 17765732.
      Citations: 12     Fields:    Translation:Animals
    7. Sanberg CD, Jones FL, Do VH, Dieguez D, Derrick BE. 5-HT1a receptor antagonists block perforant path-dentate LTP induced in novel, but not familiar, environments. Learn Mem. 2006 Jan-Feb; 13(1):52-62. PMID: 16452654.
      Citations: 12     Fields:    Translation:AnimalsCells
    8. Kosub KA, Do VH, Derrick BE. NMDA receptor antagonists block heterosynaptic long-term depression (LTD) but not long-term potentiation (LTP) in the CA3 region following lateral perforant path stimulation. Neurosci Lett. 2005 Feb 01; 374(1):29-34. PMID: 15631891.
      Citations: 6     Fields:    Translation:AnimalsCells
    9. Davis CD, Jones FL, Derrick BE. Novel environments enhance the induction and maintenance of long-term potentiation in the dentate gyrus. J Neurosci. 2004 Jul 21; 24(29):6497-506. PMID: 15269260.
      Citations: 32     Fields:    Translation:Animals
    10. Peng H, Derrick BE, Martinez JL. Time-course study of SCG10 mRNA levels associated with LTP induction and maintenance in the rat Schaffer-CA1 pathway in vivo. Brain Res Mol Brain Res. 2004 Jan 05; 120(2):182-7. PMID: 14741408.
      Citations: 2     Fields:    Translation:AnimalsCells
    11. O'Boyle MP, Do V, Derrick BE, Claiborne BJ. In vivo recordings of long-term potentiation and long-term depression in the dentate gyrus of the neonatal rat. J Neurophysiol. 2004 Feb; 91(2):613-22. PMID: 14645375.
      Citations: 2     Fields:    Translation:Animals
    12. Peng H, Derrick BE, Martinez JL. Identification of upregulated SCG10 mRNA expression associated with late-phase long-term potentiation in the rat hippocampal Schaffer-CA1 pathway in vivo. J Neurosci. 2003 Jul 23; 23(16):6617-26. PMID: 12878703.
      Citations: 3     Fields:    Translation:AnimalsCells
    13. Martinez CO, Do VH, Martinez JL, Derrick BE. Associative long-term potentiation (LTP) among extrinsic afferents of the hippocampal CA3 region in vivo. Brain Res. 2002 Jun 14; 940(1-2):86-94. PMID: 12020879.
      Citations: 12     Fields:    Translation:Animals
    14. Do VH, Martinez CO, Martinez JL, Derrick BE. Long-term potentiation in direct perforant path projections to the hippocampal CA3 region in vivo. J Neurophysiol. 2002 Feb; 87(2):669-78. PMID: 11826036.
      Citations: 24     Fields:    Translation:Animals
    15. Villarreal DM, Do V, Haddad E, Derrick BE. NMDA receptor antagonists sustain LTP and spatial memory: active processes mediate LTP decay. Nat Neurosci. 2002 Jan; 5(1):48-52. PMID: 11740500.
      Citations: 34     Fields:    Translation:AnimalsCells
    16. Jankowsky JL, Derrick BE, Patterson PH. Cytokine responses to LTP induction in the rat hippocampus: a comparison of in vitro and in vivo techniques. Learn Mem. 2000 Nov-Dec; 7(6):400-12. PMID: 11112799.
      Citations: 30     Fields:    Translation:AnimalsCells
    17. Derrick BE, York AD, Martinez JL. Increased granule cell neurogenesis in the adult dentate gyrus following mossy fiber stimulation sufficient to induce long-term potentiation. Brain Res. 2000 Feb 28; 857(1-2):300-7. PMID: 10700582.
      Citations: 16     Fields:    Translation:Animals
    18. Escobar ML, Barea-Rodríguez EJ, Derrick BE, Reyes JA, Martinez JL. Opioid receptor modulation of mossy fiber synaptogenesis: independence from long-term potentiation. Brain Res. 1997 Mar 21; 751(2):330-5. PMID: 9099823.
      Citations: 6     Fields:    Translation:AnimalsCells
    19. Derrick BE, Martinez JL. Associative, bidirectional modifications at the hippocampal mossy fibre-CA3 synapse. Nature. 1996 May 30; 381(6581):429-34. PMID: 8632800.
      Citations: 8     Fields:    Translation:AnimalsCells
    20. Martinez JL, Derrick BE. Long-term potentiation and learning. Annu Rev Psychol. 1996; 47:173-203. PMID: 8624136.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    21. Derrick BE, Martinez JL. Frequency-dependent associative long-term potentiation at the hippocampal mossy fiber-CA3 synapse. Proc Natl Acad Sci U S A. 1994 Oct 25; 91(22):10290-4. PMID: 7937943.
      Citations: 5     Fields:    Translation:AnimalsCells
    22. Hernandez RV, Derrick BE, Rodriguez WA, Martinez JL. (+/-) CPP, an NMDA receptor antagonist, blocks the induction of commissural-CA3 LTP in the anesthetized rat. Brain Res. 1994 Sep 05; 656(1):215-9. PMID: 7804841.
      Citations: 2     Fields:    Translation:AnimalsCells
    23. Derrick BE, Martinez JL. Opioid receptor activation is one factor underlying the frequency dependence of mossy fiber LTP induction. J Neurosci. 1994 Jul; 14(7):4359-67. PMID: 7913121.
      Citations: 9     Fields:    Translation:AnimalsCells
    24. Breindl A, Derrick BE, Rodriguez SB, Martinez JL. Opioid receptor-dependent long-term potentiation at the lateral perforant path-CA3 synapse in rat hippocampus. Brain Res Bull. 1994; 33(1):17-24. PMID: 8275323.
      Citations: 7     Fields:    Translation:AnimalsCells
    25. Derrick BE, Rodriguez SB, Lieberman DN, Martinez JL. Mu opioid receptors are associated with the induction of hippocampal mossy fiber long-term potentiation. J Pharmacol Exp Ther. 1992 Nov; 263(2):725-33. PMID: 1359112.
      Citations: 12     Fields:    Translation:AnimalsCells
    26. Derrick BE, Weinberger SB, Martinez JL. Opioid receptors are involved in an NMDA receptor-independent mechanism of LTP induction at hippocampal mossy fiber-CA3 synapses. Brain Res Bull. 1991 Aug; 27(2):219-23. PMID: 1660336.
      Citations: 8     Fields:    Translation:AnimalsCells
    27. Martinez JL, Janak PH, Weinberger SB, Schulteis G, Derrick BE. Enkephalin influences on behavioral and neural plasticity: mechanisms of action. NIDA Res Monogr. 1990; 97:48-78. PMID: 2174123.
      Citations: 1     Fields:    Translation:HumansAnimals
    28. Martinez JL, Schulteis G, Derrick BE, Weinberger SB, Patterson TA, Bennett EL, Rosenzweig MR. Opioid delta receptor involvement in behavioral and neural plasticity. NIDA Res Monogr. 1989; 95:174-9. PMID: 2561824.
      Citations:    Fields:    Translation:AnimalsCells
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