"PDZ Domains" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Protein interaction domains of about 70-90 amino acid residues, named after a common structure found in PSD-95, Discs Large, and Zona Occludens 1 proteins. PDZ domains are involved in the recruitment and interaction of proteins, and aid the formation of protein scaffolds and signaling networks. This is achieved by sequence-specific binding between a PDZ domain in one protein and a PDZ motif in another protein.
| Descriptor ID |
D054731
|
| MeSH Number(s) |
G02.111.570.820.709.275.750.500.500
|
| Concept/Terms |
PDZ Domains- PDZ Domains
- Domain, PDZ
- Domains, PDZ
- PDZ Domain
- PDZ Interaction Domains
- Domain, PDZ Interaction
- Domains, PDZ Interaction
- Interaction Domain, PDZ
- Interaction Domains, PDZ
- PDZ Interaction Domain
- PSD95-DLG-ZO1 Domains
- Domain, PSD95-DLG-ZO1
- Domains, PSD95-DLG-ZO1
- PSD95 DLG ZO1 Domains
- PSD95-DLG-ZO1 Domain
- DLG Homology Repeats Domains
- GLGF Repeats Domains
- Domain, GLGF Repeats
- Domains, GLGF Repeats
- GLGF Repeats Domain
- Repeats Domain, GLGF
- Repeats Domains, GLGF
- DHR Domains
- DHR Domain
- Domain, DHR
- Domains, DHR
|
Below are MeSH descriptors whose meaning is more general than "PDZ Domains".
Below are MeSH descriptors whose meaning is more specific than "PDZ Domains".
This graph shows the total number of publications written about "PDZ Domains" by people in this website by year, and whether "PDZ Domains" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2009 | 1 | 0 | 1 |
| 2013 | 1 | 0 | 1 |
| 2015 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2019 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "PDZ Domains" by people in Profiles.
-
Bhattacharya S, Stanley CB, Heller WT, Friedman PA, Bu Z. Dynamic structure of the full-length scaffolding protein NHERF1 influences signaling complex assembly. J Biol Chem. 2019 07 19; 294(29):11297-11310.
-
Mamonova T, Zhang Q, Chandra M, Collins BM, Sarfo E, Bu Z, Xiao K, Bisello A, Friedman PA. Origins of PDZ Binding Specificity. A Computational and Experimental Study Using NHERF1 and the Parathyroid Hormone Receptor. Biochemistry. 2017 05 23; 56(20):2584-2593.
-
Mamonova T, Zhang Q, Khajeh JA, Bu Z, Bisello A, Friedman PA. Canonical and Noncanonical Sites Determine NPT2A Binding Selectivity to NHERF1 PDZ1. PLoS One. 2015; 10(6):e0129554.
-
Bhattacharya S, Ju JH, Orlova N, Khajeh JA, Cowburn D, Bu Z. Ligand-induced dynamic changes in extended PDZ domains from NHERF1. J Mol Biol. 2013 Jul 24; 425(14):2509-28.
-
Cheng H, Li J, Fazlieva R, Dai Z, Bu Z, Roder H. Autoinhibitory interactions between the PDZ2 and C-terminal domains in the scaffolding protein NHERF1. Structure. 2009 May 13; 17(5):660-9.