"RING Finger Domains" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A zinc-binding domain defined by the sequence Cysteine-X2-Cysteine-X(9-39)-Cysteine-X(l-3)-His-X(2-3)-Cysteine-X2-Cysteine -X(4-48)-Cysteine-X2-Cysteine, where X is any amino acid. The RING finger motif binds two atoms of zinc, with each zinc atom ligated tetrahedrally by either four cysteines or three cysteines and a histidine. The motif also forms into a unitary structure with a central cross-brace region and is found in many proteins that are involved in protein-protein interactions. The acronym RING stands for Really Interesting New Gene.
| Descriptor ID |
D054829
|
| MeSH Number(s) |
G02.111.570.820.709.275.500.985.500 G02.111.570.820.709.275.750.500.625
|
| Concept/Terms |
RING Finger Domains- RING Finger Domains
- Domains, RING Finger
- RING Finger Domain
- RING Finger Motifs
- RING Finger Motif
|
Below are MeSH descriptors whose meaning is more general than "RING Finger Domains".
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