Quinazolinones

"Quinazolinones" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Chemicals with two conjoined aromatic rings incorporating two nitrogen atoms and one of the carbons oxidized with a keto oxygen.

Descriptor ID	D052999
MeSH Number(s)	D03.633.100.786.830
Concept/Terms	Quinazolinones Quinazolinones Quinazolinediones Quinazolinediones

Below are MeSH descriptors whose meaning is more general than "Quinazolinones".

Chemicals and Drugs [D]
Heterocyclic Compounds [D03]
Heterocyclic Compounds, Fused-Ring [D03.633]
Heterocyclic Compounds, 2-Ring [D03.633.100]
Quinazolines [D03.633.100.786]
Quinazolinones [D03.633.100.786.830]

Below are MeSH descriptors whose meaning is related to "Quinazolinones".

Below are MeSH descriptors whose meaning is more specific than "Quinazolinones".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Quinazolinones" by people in this website by year, and whether "Quinazolinones" was a major or minor topic of these publications.

Bar chart showing 10 publications over 7 distinct years, with a maximum of 2 publications in 2006 and 2008 and 2017

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2006	2	0	2
2008	1	1	2
2009	0	1	1
2014	1	0	1
2016	1	0	1
2017	1	1	2
2022	0	1	1

Below are the most recent publications written about "Quinazolinones" by people in Profiles.

Sebastian D, Willoughby PH, Lakshman MK. Cross-dehydrogenative coupling of ethers and amides with tautomerizable quinazolinones and mechanistic studies. Org Biomol Chem. 2022 07 27; 20(29):5735-5746.

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Wang W, Yin J, Ma X, Zhao F, Siedlak SL, Wang Z, Torres S, Fujioka H, Xu Y, Perry G, Zhu X. Inhibition of mitochondrial fragmentation protects against Alzheimer's disease in rodent model. Hum Mol Genet. 2017 11 01; 26(21):4118-4131.

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Wu P, Li Y, Zhu S, Wang C, Dai J, Zhang G, Zheng B, Xu S, Wang L, Zhang T, Zhou P, Zhang JH, Shi H. Mdivi-1 Alleviates Early Brain Injury After Experimental Subarachnoid Hemorrhage in Rats, Possibly via Inhibition of Drp1-Activated Mitochondrial Fission and Oxidative Stress. Neurochem Res. 2017 May; 42(5):1449-1458.

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Antypenko O, Kovalenko S, Rasulev B, Leszczynski J. Synthesis of 6-N-R-Tetrazolo[1,5-c]quinazolin-5(6H)-ones and Their Anticancer Activity. Acta Chim Slov. 2016; 63(3):638-45.

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Sergeieva TY, Voskoboynik OY, Okovytyy SI, Kovalenko SI, Shishkina SV, Shishkin OV, Leszczynski J. Hydrazinolysis of 3-R-[1,2,4]triazino[2,3-c]quinazolin-2-ones. Synthetic and theoretical aspects. J Phys Chem A. 2014 Mar 13; 118(10):1895-905.

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Yu PL, Chao HL, Wang SW, Wang PS. Effects of evodiamine and rutaecarpine on the secretion of corticosterone by zona fasciculata-reticularis cells in male rats. J Cell Biochem. 2009 Oct 01; 108(2):469-75.

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Hutchings KM, Tran TP, Ellsworth EL, Watson BM, Sanchez JP, Showalter HD, Stier MA, Shapiro M, Themis Joannides E, Huband M, Nguyen DQ, Maiti S, Li T, Tailor J, Thomas G, Ha C, Singh R. Synthesis and antibacterial activity of the C-7 side chain of 3-aminoquinazolinediones. Bioorg Med Chem Lett. 2008 Sep 15; 18(18):5087-90.

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Sherrin T, Todorovic C, Zeyda T, Tan CH, Wong PT, Hon PW, Zhu YZ, Spiess J. Chronic stimulation of corticotropin-releasing factor receptor 1 enhances the anxiogenic response of the cholecystokinin system. Mol Psychiatry. 2009 Mar; 14(3):291-307.

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Tran TP, Ellsworth EL, Sanchez JP, Watson BM, Stier MA, Showalter HD, Domagala JM, Shapiro MA, Joannides ET, Gracheck SJ, Nguyen DQ, Bird P, Yip J, Sharadendu A, Ha C, Ramezani S, Wu X, Singh R. Structure-activity relationships of 3-aminoquinazolinediones, a new class of bacterial type-2 topoisomerase (DNA gyrase and topo IV) inhibitors. Bioorg Med Chem Lett. 2007 Mar 01; 17(5):1312-20.

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Ellsworth EL, Tran TP, Showalter HD, Sanchez JP, Watson BM, Stier MA, Domagala JM, Gracheck SJ, Joannides ET, Shapiro MA, Dunham SA, Hanna DL, Huband MD, Gage JW, Bronstein JC, Liu JY, Nguyen DQ, Singh R. 3-aminoquinazolinediones as a new class of antibacterial agents demonstrating excellent antibacterial activity against wild-type and multidrug resistant organisms. J Med Chem. 2006 Nov 02; 49(22):6435-8.

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