In Situ Nick-End Labeling

"In Situ Nick-End Labeling" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An in situ method for detecting areas of DNA which are nicked during APOPTOSIS. Terminal deoxynucleotidyl transferase is used to add labeled dUTP, in a template-independent manner, to the 3 prime OH ends of either single- or double-stranded DNA. The terminal deoxynucleotidyl transferase nick end labeling, or TUNEL, assay labels apoptosis on a single-cell level, making it more sensitive than agarose gel electrophoresis for analysis of DNA FRAGMENTATION.

Descriptor ID	D020287
MeSH Number(s)	E05.393.475
Concept/Terms	In Situ Nick-End Labeling In Situ Nick-End Labeling TUNEL Nick-End Labeling, In Situ In Situ Nick End Labelling In Situ Nick End Labeling In Situ Nick End-Labelling In Situ Nick-End Labelling Nick End-Labeling, In Situ Nick End Labeling, In Situ Nick End-Labelling, In Situ Nick End Labelling, In Situ Nick-End Labelling, In Situ In Situ Nick End-Labeling

Below are MeSH descriptors whose meaning is more general than "In Situ Nick-End Labeling".

Analytical, Diagnostic and Therapeutic Techniques and Equipment [E]
Investigative Techniques [E05]
Genetic Techniques [E05.393]
In Situ Nick-End Labeling [E05.393.475]

Below are MeSH descriptors whose meaning is more specific than "In Situ Nick-End Labeling".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "In Situ Nick-End Labeling" by people in this website by year, and whether "In Situ Nick-End Labeling" was a major or minor topic of these publications.

Bar chart showing 97 publications over 19 distinct years, with a maximum of 11 publications in 2006

To see the data from this visualization as text, click here.

Year	Minor Topic	Total
1999	1	1
2000	4	4
2001	2	2
2002	4	4
2003	6	6
2004	9	9
2005	6	6
2006	11	11
2007	7	7
2008	7	7
2009	5	5
2010	9	9
2011	8	8
2012	2	2
2013	6	6
2014	1	1
2015	3	3
2016	2	2
2018	4	4

Below are the most recent publications written about "In Situ Nick-End Labeling" by people in Profiles.

Pang J, Peng J, Matei N, Yang P, Kuai L, Wu Y, Chen L, Vitek MP, Li F, Sun X, Zhang JH, Jiang Y. Apolipoprotein E Exerts a Whole-Brain Protective Property by Promoting M1? Microglia Quiescence After Experimental Subarachnoid Hemorrhage in Mice. Transl Stroke Res. 2018 12; 9(6):654-668.

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Rosario-Rodr?guez LJ, Col?n K, Borges-V?lez G, Negr?n K, Mel?ndez LM. Dimethyl Fumarate Prevents HIV-Induced Lysosomal Dysfunction and Cathepsin B Release from Macrophages. J Neuroimmune Pharmacol. 2018 09; 13(3):345-354.

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Zhang Y, Ding Y, Lu T, Zhang Y, Xu N, McBride DW, Tang J, Zhang JH. Biliverdin reductase-A attenuated GMH-induced inflammatory response in the spleen by inhibiting toll-like receptor-4 through eNOS/NO pathway. J Neuroinflammation. 2018 Apr 20; 15(1):118.

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Xu N, Zhang Y, Doycheva DM, Ding Y, Zhang Y, Tang J, Guo H, Zhang JH. Adiponectin attenuates neuronal apoptosis induced by hypoxia-ischemia via the activation of AdipoR1/APPL1/LKB1/AMPK pathway in neonatal rats. Neuropharmacology. 2018 05 01; 133:415-428.

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Liu P, Yang X, Hei C, Meli Y, Niu J, Sun T, Li PA. Rapamycin Reduced Ischemic Brain Damage in Diabetic Animals Is Associated with Suppressions of mTOR and ERK1/2 Signaling. Int J Biol Sci. 2016; 12(8):1032-40.

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Fujii M, Sherchan P, Soejima Y, Doycheva D, Zhang JH. Subarachnoid Hemorrhage-Triggered Acute Hypotension Is Associated with Left Ventricular Cardiomyocyte Apoptosis in a Rat Model. Acta Neurochir Suppl. 2016; 121:145-50.

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Fan Y, Feng Q, Lai K, Huang W, Zhang C, Li QX. Toxic effects of indoxacarb enantiomers on the embryonic development and induction of apoptosis in zebrafish larvae (Danio rerio). Environ Toxicol. 2017 Jan; 32(1):7-16.

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Yang X, Hei C, Liu P, Song Y, Thomas T, Tshimanga S, Wang F, Niu J, Sun T, Li PA. Inhibition of mTOR Pathway by Rapamycin Reduces Brain Damage in Rats Subjected to Transient Forebrain Ischemia. Int J Biol Sci. 2015; 11(12):1424-35.

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Zhdanov DD, Fahmi T, Wang X, Apostolov EO, Sokolov NN, Javadov S, Basnakian AG. Regulation of Apoptotic Endonucleases by EndoG. DNA Cell Biol. 2015 May; 34(5):316-26.

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Li L, Klebe D, Doycheva D, McBride DW, Krafft PR, Flores J, Zhou C, Zhang JH, Tang J. G-CSF ameliorates neuronal apoptosis through GSK-3? inhibition in neonatal hypoxia-ischemia in rats. Exp Neurol. 2015 Jan; 263:141-9.

View in: PubMed

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