Alu Elements

"Alu Elements" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The Alu sequence family (named for the restriction endonuclease cleavage enzyme Alu I) is the most highly repeated interspersed repeat element in humans (over a million copies). It is derived from the 7SL RNA component of the SIGNAL RECOGNITION PARTICLE and contains an RNA polymerase III promoter. Transposition of this element into coding and regulatory regions of genes is responsible for many heritable diseases.

Descriptor ID	D020087
MeSH Number(s)	G02.111.570.080.708.330.800.800.050 G05.360.080.708.330.800.800.050 G05.360.340.024.425.800.800.050
Concept/Terms	Alu Elements Alu Elements Alu Element Element, Alu Elements, Alu Alu Family Alu Families Families, Alu Family, Alu Alu Repetitive Sequences Alu Repetitive Sequence Repetitive Sequence, Alu Repetitive Sequences, Alu Sequence, Alu Repetitive Sequences, Alu Repetitive Alu-Like Repetitive Sequence Alu-Like Repetitive Sequence

Below are MeSH descriptors whose meaning is more general than "Alu Elements".

Biological Sciences [G]
Chemical Phenomena [G02]
Biochemical Phenomena [G02.111]
Molecular Structure [G02.111.570]
Base Sequence [G02.111.570.080]
Repetitive Sequences, Nucleic Acid [G02.111.570.080.708]
Interspersed Repetitive Sequences [G02.111.570.080.708.330]
Retroelements [G02.111.570.080.708.330.800]
Short Interspersed Nucleotide Elements [G02.111.570.080.708.330.800.800]
Alu Elements [G02.111.570.080.708.330.800.800.050]
Genetic Phenomena [G05]
Genetic Structures [G05.360]
Base Sequence [G05.360.080]
Repetitive Sequences, Nucleic Acid [G05.360.080.708]
Interspersed Repetitive Sequences [G05.360.080.708.330]
Retroelements [G05.360.080.708.330.800]
Short Interspersed Nucleotide Elements [G05.360.080.708.330.800.800]
Alu Elements [G05.360.080.708.330.800.800.050]
Genome [G05.360.340]
Genome Components [G05.360.340.024]
Interspersed Repetitive Sequences [G05.360.340.024.425]
Retroelements [G05.360.340.024.425.800]
Short Interspersed Nucleotide Elements [G05.360.340.024.425.800.800]
Alu Elements [G05.360.340.024.425.800.800.050]

Below are MeSH descriptors whose meaning is related to "Alu Elements".

Below are MeSH descriptors whose meaning is more specific than "Alu Elements".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Alu Elements" by people in this website by year, and whether "Alu Elements" was a major or minor topic of these publications.

Bar chart showing 10 publications over 8 distinct years, with a maximum of 2 publications in 2007 and 2011

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1999	0	1	1
2000	1	0	1
2004	0	1	1
2007	2	0	2
2009	1	0	1
2010	1	0	1
2011	2	0	2
2018	0	1	1

Below are the most recent publications written about "Alu Elements" by people in Profiles.

Aneichyk T, Hendriks WT, Yadav R, Shin D, Gao D, Vaine CA, Collins RL, Domingo A, Currall B, Stortchevoi A, Multhaupt-Buell T, Penney EB, Cruz L, Dhakal J, Brand H, Hanscom C, Antolik C, Dy M, Ragavendran A, Underwood J, Cantsilieris S, Munson KM, Eichler EE, Acu?a P, Go C, Jamora RDG, Rosales RL, Church DM, Williams SR, Garcia S, Klein C, M?ller U, Wilhelmsen KC, Timmers HTM, Sapir Y, Wainger BJ, Henderson D, Ito N, Weisenfeld N, Jaffe D, Sharma N, Breakefield XO, Ozelius LJ, Bragg DC, Talkowski ME. Dissecting the Causal Mechanism of X-Linked Dystonia-Parkinsonism by Integrating Genome and Transcriptome Assembly. Cell. 2018 02 22; 172(5):897-909.e21.

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Tarallo V, Hirano Y, Gelfand BD, Dridi S, Kerur N, Kim Y, Cho WG, Kaneko H, Fowler BJ, Bogdanovich S, Albuquerque RJ, Hauswirth WW, Chiodo VA, Kugel JF, Goodrich JA, Ponicsan SL, Chaudhuri G, Murphy MP, Dunaief JL, Ambati BK, Ogura Y, Yoo JW, Lee DK, Provost P, Hinton DR, N??ez G, Baffi JZ, Kleinman ME, Ambati J. DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88. Cell. 2012 May 11; 149(4):847-59.

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Zhang W, Edwards A, Fan W, Deininger P, Zhang K. Alu distribution and mutation types of cancer genes. BMC Genomics. 2011 Mar 23; 12:157.

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Kaneko H, Dridi S, Tarallo V, Gelfand BD, Fowler BJ, Cho WG, Kleinman ME, Ponicsan SL, Hauswirth WW, Chiodo VA, Karik? K, Yoo JW, Lee DK, Hadziahmetovic M, Song Y, Misra S, Chaudhuri G, Buaas FW, Braun RE, Hinton DR, Zhang Q, Grossniklaus HE, Provis JM, Madigan MC, Milam AH, Justice NL, Albuquerque RJ, Blandford AD, Bogdanovich S, Hirano Y, Witta J, Fuchs E, Littman DR, Ambati BK, Rudin CM, Chong MM, Provost P, Kugel JF, Goodrich JA, Dunaief JL, Baffi JZ, Ambati J. DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration. Nature. 2011 Mar 17; 471(7338):325-30.

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Khatua AK, Taylor HE, Hildreth JE, Popik W. Inhibition of LINE-1 and Alu retrotransposition by exosomes encapsidating APOBEC3G and APOBEC3F. Virology. 2010 Apr 25; 400(1):68-75.

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Zhang K, Fan W, Deininger P, Edwards A, Xu Z, Zhu D. Breaking the computational barrier: a divide-conquer and aggregate based approach for Alu insertion site characterisation. Int J Comput Biol Drug Des. 2009; 2(4):302-22.

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Umylny B, Presting G, Efird JT, Klimovitsky BI, Ward WS. Most human Alu and murine B1 repeats are unique. J Cell Biochem. 2007 Sep 01; 102(1):110-21.

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Umylny B, Presting G, Ward WS. Evidence of Alu and B1 expression in dbEST. Arch Androl. 2007 Jul-Aug; 53(4):207-18.

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Wilder JA, Kingan SB, Mobasher Z, Pilkington MM, Hammer MF. Global patterns of human mitochondrial DNA and Y-chromosome structure are not influenced by higher migration rates of females versus males. Nat Genet. 2004 Oct; 36(10):1122-5.

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Kukanskis KA, Siddiquee Z, Shohet RV, Garner HR. Mix of sequencing technologies for sequence closure: an example. Biotechniques. 2000 Apr; 28(4):630-2, 634.

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