Cyclooxygenase Inhibitors

"Cyclooxygenase Inhibitors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Compounds or agents that combine with cyclooxygenase (PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES) and thereby prevent its substrate-enzyme combination with arachidonic acid and the formation of eicosanoids, prostaglandins, and thromboxanes.

Descriptor ID	D016861
MeSH Number(s)	D27.505.519.389.310 D27.505.696.663.850.014.040.500.500 D27.505.954.158.030.500 D27.505.954.329.030.500
Concept/Terms	Cyclooxygenase Inhibitors Cyclooxygenase Inhibitors Inhibitors, Cyclo-Oxygenase Inhibitors, Cyclo Oxygenase Inhibitors, Cyclooxygenase Prostaglandin Synthesis Antagonists Antagonists, Prostaglandin Synthesis Inhibitors, Prostaglandin-Endoperoxide Synthase Inhibitors, Prostaglandin Endoperoxide Synthase Prostaglandin Endoperoxide Synthase Inhibitors Prostaglandin Synthase Inhibitors Cyclo-Oxygenase Inhibitors Cyclo Oxygenase Inhibitors Inhibitors, Prostaglandin Synthase

Below are MeSH descriptors whose meaning is more general than "Cyclooxygenase Inhibitors".

Chemicals and Drugs [D]
Chemical Actions and Uses [D27]
Pharmacologic Actions [D27.505]
Molecular Mechanisms of Pharmacological Action [D27.505.519]
Enzyme Inhibitors [D27.505.519.389]
Cyclooxygenase Inhibitors [D27.505.519.389.310]
Physiological Effects of Drugs [D27.505.696]
Peripheral Nervous System Agents [D27.505.696.663]
Sensory System Agents [D27.505.696.663.850]
Analgesics [D27.505.696.663.850.014]
Analgesics, Non-Narcotic [D27.505.696.663.850.014.040]
Anti-Inflammatory Agents, Non-Steroidal [D27.505.696.663.850.014.040.500]
Cyclooxygenase Inhibitors [D27.505.696.663.850.014.040.500.500]
Therapeutic Uses [D27.505.954]
Anti-Inflammatory Agents [D27.505.954.158]
Anti-Inflammatory Agents, Non-Steroidal [D27.505.954.158.030]
Cyclooxygenase Inhibitors [D27.505.954.158.030.500]
Antirheumatic Agents [D27.505.954.329]
Anti-Inflammatory Agents, Non-Steroidal [D27.505.954.329.030]
Cyclooxygenase Inhibitors [D27.505.954.329.030.500]

Below are MeSH descriptors whose meaning is related to "Cyclooxygenase Inhibitors".

Below are MeSH descriptors whose meaning is more specific than "Cyclooxygenase Inhibitors".

Cyclooxygenase Inhibitors
Cyclooxygenase 2 Inhibitors

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Cyclooxygenase Inhibitors" by people in this website by year, and whether "Cyclooxygenase Inhibitors" was a major or minor topic of these publications.

Bar chart showing 28 publications over 13 distinct years, with a maximum of 7 publications in 2005

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2000	1	0	1
2001	1	0	1
2002	1	0	1
2003	0	1	1
2004	2	1	3
2005	4	3	7
2006	1	0	1
2007	0	2	2
2008	1	1	2
2009	0	3	3
2012	2	2	4
2013	1	0	1
2015	1	0	1

Below are the most recent publications written about "Cyclooxygenase Inhibitors" by people in Profiles.

Boutaud O, Sosa IR, Amin T, Oram D, Adler D, Hwang HS, Crews BC, Milne G, Harris BK, Hoeksema M, Knollmann BC, Lammers PE, Marnett LJ, Massion PP, Oates JA. Inhibition of the Biosynthesis of Prostaglandin E2 By Low-Dose Aspirin: Implications for Adenocarcinoma Metastasis. Cancer Prev Res (Phila). 2016 Nov; 9(11):855-865.

View in: PubMed
Vannini F, Chattopadhyay M, Kodela R, Rao PPN, Kashfi K. Positional isomerism markedly affects the growth inhibition of colon cancer cells by NOSH-aspirin: COX inhibition and modeling. Redox Biol. 2015 Dec; 6:318-325.

View in: PubMed
Kodela R, Chattopadhyay M, Goswami S, Gan ZY, Rao PP, Nia KV, Vel?zquez-Mart?nez CA, Kashfi K. Positional isomers of aspirin are equally potent in inhibiting colon cancer cell growth: differences in mode of cyclooxygenase inhibition. J Pharmacol Exp Ther. 2013 Apr; 345(1):85-94.

View in: PubMed
Falk GW, Buttar NS, Foster NR, Ziegler KL, Demars CJ, Romero Y, Marcon NE, Schnell T, Corley DA, Sharma P, Cruz-Correa MR, Hur C, Fleischer DE, Chak A, Devault KR, Weinberg DS, Della'Zanna G, Richmond E, Smyrk TC, Mandrekar SJ, Limburg PJ. A combination of esomeprazole and aspirin reduces tissue concentrations of prostaglandin E(2) in patients with Barrett's esophagus. Gastroenterology. 2012 Oct; 143(4):917-26.e1.

View in: PubMed
Njie-Mbye YF, Kulkarni M, Opere CA, Ohia SE. Mechanism of action of hydrogen sulfide on cyclic AMP formation in rat retinal pigment epithelial cells. Exp Eye Res. 2012 May; 98:16-22.

View in: PubMed
Chattopadhyay M, Kodela R, Olson KR, Kashfi K. NOSH-aspirin (NBS-1120), a novel nitric oxide- and hydrogen sulfide-releasing hybrid is a potent inhibitor of colon cancer cell growth in vitro and in a xenograft mouse model. Biochem Biophys Res Commun. 2012 Mar 16; 419(3):523-8.

View in: PubMed
Jain S, Tran S, El Gendy MA, Kashfi K, Jurasz P, Vel?zquez-Mart?nez CA. Nitric oxide release is not required to decrease the ulcerogenic profile of nonsteroidal anti-inflammatory drugs. J Med Chem. 2012 Jan 26; 55(2):688-96.

View in: PubMed
Zhao M, Destache CJ, Ohia SE, Opere CA. Role of prostanoid production and receptors in the regulation of retinal endogenous amino acid neurotransmitters by 8-isoprostaglandin E2, ex vivo. Neurochem Res. 2009 Dec; 34(12):2170-80.

View in: PubMed
Jadhav V, Ostrowski RP, Tong W, Matus B, Jesunathadas R, Zhang JH. Cyclo-oxygenase-2 mediates hyperbaric oxygen preconditioning-induced neuroprotection in the mouse model of surgical brain injury. Stroke. 2009 Sep; 40(9):3139-42.

View in: PubMed
Beales IL, Ogunwobi OO. Glycine-extended gastrin inhibits apoptosis in Barrett's oesophageal and oesophageal adenocarcinoma cells through JAK2/STAT3 activation. J Mol Endocrinol. 2009 Apr; 42(4):305-18.

View in: PubMed

People

Explore

Similar Concepts

Top Journals