Granulocyte Colony-Stimulating Factor

"Granulocyte Colony-Stimulating Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A glycoprotein of MW 25 kDa containing internal disulfide bonds. It induces the survival, proliferation, and differentiation of neutrophilic granulocyte precursor cells and functionally activates mature blood neutrophils. Among the family of colony-stimulating factors, G-CSF is the most potent inducer of terminal differentiation to granulocytes and macrophages of leukemic myeloid cell lines.

Descriptor ID	D016179
MeSH Number(s)	D12.644.276.374.410.240.350 D12.776.395.240.200 D12.776.467.374.410.240.350 D23.529.374.410.240.350
Concept/Terms	Granulocyte Colony-Stimulating Factor Granulocyte Colony-Stimulating Factor G-CSF

Below are MeSH descriptors whose meaning is more general than "Granulocyte Colony-Stimulating Factor".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intercellular Signaling Peptides and Proteins [D12.644.276]
Cytokines [D12.644.276.374]
Hematopoietic Cell Growth Factors [D12.644.276.374.410]
Colony-Stimulating Factors [D12.644.276.374.410.240]
Granulocyte Colony-Stimulating Factor [D12.644.276.374.410.240.350]
Proteins [D12.776]
Glycoproteins [D12.776.395]
Colony-Stimulating Factors [D12.776.395.240]
Granulocyte Colony-Stimulating Factor [D12.776.395.240.200]
Intercellular Signaling Peptides and Proteins [D12.776.467]
Cytokines [D12.776.467.374]
Hematopoietic Cell Growth Factors [D12.776.467.374.410]
Colony-Stimulating Factors [D12.776.467.374.410.240]
Granulocyte Colony-Stimulating Factor [D12.776.467.374.410.240.350]
Biological Factors [D23]
Intercellular Signaling Peptides and Proteins [D23.529]
Cytokines [D23.529.374]
Hematopoietic Cell Growth Factors [D23.529.374.410]
Colony-Stimulating Factors [D23.529.374.410.240]
Granulocyte Colony-Stimulating Factor [D23.529.374.410.240.350]

Below are MeSH descriptors whose meaning is related to "Granulocyte Colony-Stimulating Factor".

Below are MeSH descriptors whose meaning is more specific than "Granulocyte Colony-Stimulating Factor".

Granulocyte Colony-Stimulating Factor
Filgrastim

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Granulocyte Colony-Stimulating Factor" by people in this website by year, and whether "Granulocyte Colony-Stimulating Factor" was a major or minor topic of these publications.

Bar chart showing 40 publications over 17 distinct years, with a maximum of 6 publications in 2000

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	3	2	5
1997	0	1	1
1998	1	3	4
1999	2	0	2
2000	4	2	6
2001	4	0	4
2002	0	2	2
2005	2	0	2
2007	1	1	2
2008	3	0	3
2009	1	0	1
2010	1	0	1
2013	0	1	1
2014	3	0	3
2017	1	0	1
2022	0	1	1
2023	0	1	1

Below are the most recent publications written about "Granulocyte Colony-Stimulating Factor" by people in Profiles.

Matilionyte G, Forsyth G, Guo J, Rimmer MP, Hermann BP, Anderson RA, Mitchell RT. Granulocyte-colony stimulating factor does not prevent in vitro cisplatin-induced germ cell reduction in immature human and mouse testis. BMC Cancer. 2023 Mar 16; 23(1):251.

View in: PubMed
Jim?nez Nieves Y, Ortiz-Ortiz KJ, R?os Motta RE, Casta?eda-Avila MA, Tortolero-Luna G. Granulocyte colony stimulating factor use and adherence to clinical practice guidelines among women with breast cancer living in Puerto Rico: a population-based study. BMC Health Serv Res. 2022 Jul 20; 22(1):935.

View in: PubMed
Shasthry SM, Sharma MK, Shasthry V, Pande A, Sarin SK. Efficacy of Granulocyte Colony-stimulating Factor in the Management of Steroid-Nonresponsive Severe Alcoholic Hepatitis: A Double-Blind Randomized Controlled Trial. Hepatology. 2019 09; 70(3):802-811.

View in: PubMed
Anand L, Bihari C, Kedarisetty CK, Rooge SB, Kumar D, Shubham S, Kumar G, Sahney A, Sharma MK, Maiwall R, Kumar A, Sarin SK. Early cirrhosis and a preserved bone marrow niche favour regenerative response to growth factors in decompensated cirrhosis. Liver Int. 2019 01; 39(1):115-126.

View in: PubMed
Kotzur T, Benavides-Garcia R, Mecklenburg J, Sanchez JR, Reilly M, Hermann BP. Granulocyte colony-stimulating factor (G-CSF) promotes spermatogenic regeneration from surviving spermatogonia after high-dose alkylating chemotherapy. Reprod Biol Endocrinol. 2017 Jan 11; 15(1):7.

View in: PubMed
Simmons LJ, Surles-Zeigler MC, Li Y, Ford GD, Newman GD, Ford BD. Regulation of inflammatory responses by neuregulin-1 in brain ischemia and microglial cells in vitro involves the NF-kappa B pathway. J Neuroinflammation. 2016 09 06; 13(1):237.

View in: PubMed
Benavides-Garcia R, Joachim R, Pina NA, Mutoji KN, Reilly MA, Hermann BP. Granulocyte colony-stimulating factor prevents loss of spermatogenesis after sterilizing busulfan chemotherapy. Fertil Steril. 2015 Jan; 103(1):270-80.e8.

View in: PubMed
Li L, Klebe D, Doycheva D, McBride DW, Krafft PR, Flores J, Zhou C, Zhang JH, Tang J. G-CSF ameliorates neuronal apoptosis through GSK-3? inhibition in neonatal hypoxia-ischemia in rats. Exp Neurol. 2015 Jan; 263:141-9.

View in: PubMed
Doycheva DM, Hadley T, Li L, Applegate RL, Zhang JH, Tang J. Anti-neutrophil antibody enhances the neuroprotective effects of G-CSF by decreasing number of neutrophils in hypoxic ischemic neonatal rat model. Neurobiol Dis. 2014 Sep; 69:192-9.

View in: PubMed
Hsu DM, Agarwal S, Benham A, Coarfa C, Trahan DN, Chen Z, Stowers PN, Courtney AN, Lakoma A, Barbieri E, Metelitsa LS, Gunaratne P, Kim ES, Shohet JM. G-CSF receptor positive neuroblastoma subpopulations are enriched in chemotherapy-resistant or relapsed tumors and are highly tumorigenic. Cancer Res. 2013 Jul 01; 73(13):4134-46.

View in: PubMed

People

Explore

Similar Concepts

Top Journals