Spermine

"Spermine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A biogenic polyamine formed from spermidine. It is found in a wide variety of organisms and tissues and is an essential growth factor in some bacteria. It is found as a polycation at all pH values. Spermine is associated with nucleic acids, particularly in viruses, and is thought to stabilize the helical structure.

Descriptor ID	D013096
MeSH Number(s)	D02.092.211.415.701.801.821 D02.092.782.802
Concept/Terms	Spermine Spermine

Below are MeSH descriptors whose meaning is more general than "Spermine".

Chemicals and Drugs [D]
Organic Chemicals [D02]
Amines [D02.092]
Biogenic Amines [D02.092.211]
Biogenic Polyamines [D02.092.211.415]
Putrescine [D02.092.211.415.701]
Spermidine [D02.092.211.415.701.801]
Spermine [D02.092.211.415.701.801.821]
Polyamines [D02.092.782]
Spermine [D02.092.782.802]

Below are MeSH descriptors whose meaning is related to "Spermine".

Below are MeSH descriptors whose meaning is more specific than "Spermine".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Spermine" by people in this website by year, and whether "Spermine" was a major or minor topic of these publications.

Bar chart showing 25 publications over 17 distinct years, with a maximum of 2 publications in 1997 and 1999 and 2000 and 2010 and 2011 and 2017 and 2020 and 2022

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1997	2	0	2
1998	1	0	1
1999	1	1	2
2000	2	0	2
2004	0	1	1
2007	1	0	1
2010	1	1	2
2011	1	1	2
2012	1	0	1
2014	1	0	1
2015	1	0	1
2017	1	1	2
2019	1	0	1
2020	0	2	2
2021	1	0	1
2022	2	0	2
2023	1	0	1

Below are the most recent publications written about "Spermine" by people in Profiles.

Zayas-Santiago A, Malpica-Nieves CJ, Santiago JM, Hern?ndez Y, Rivera-Aponte DE, M?ndez-Gonz?lez M, Veh RW, Rojas LV, Skatchkov SN. Age-Dependent Redistribution of the Life-Important Enzyme in the Retina: Adult M?ller Glial Cells' Endfeet Lack Spermine Synthase Expression. Biomolecules. 2025 09 27; 15(10).

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Weiss T, Bernard R, Laube G, Rieck J, Eaton MJ, Skatchkov SN, Veh RW. As Verified with the Aid of Biotinylated Spermine, the Brain Cannot Take up Polyamines from the Bloodstream Leaving It Solely Dependent on Local Biosynthesis. Biomolecules. 2023 07 13; 13(7).

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Benedikt J, Malpica-Nieves CJ, Rivera Y, M?ndez-Gonz?lez M, Nichols CG, Veh RW, Eaton MJ, Skatchkov SN. The Polyamine Spermine Potentiates the Propagation of Negatively Charged Molecules through the Astrocytic Syncytium. Biomolecules. 2022 12 05; 12(12).

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Rieck J, Skatchkov SN, Derst C, Eaton MJ, Veh RW. Unique Chemistry, Intake, and Metabolism of Polyamines in the Central Nervous System (CNS) and Its Body. Biomolecules. 2022 03 25; 12(4).

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Malpica-Nieves CJ, Rivera Y, Rivera-Aponte DE, Phanstiel O, Veh RW, Eaton MJ, Skatchkov SN. Uptake of Biotinylated Spermine in Astrocytes: Effect of Cx43 siRNA, HIV-Tat Protein and Polyamine Transport Inhibitor on Polyamine Uptake. Biomolecules. 2021 08 11; 11(8).

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Malpica-Nieves CJ, Rivera-Aponte DE, Tejeda-Bayron FA, Mayor AM, Phanstiel O, Veh RW, Eaton MJ, Skatchkov SN. The involvement of polyamine uptake and synthesis pathways in the proliferation of neonatal astrocytes. Amino Acids. 2020 Aug; 52(8):1169-1180.

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Schnatz PJ, Brisendine JM, Laing CC, Everson BH, French CA, Molinaro PM, Koder RL. Designing heterotropically activated allosteric conformational switches using supercharging. Proc Natl Acad Sci U S A. 2020 03 10; 117(10):5291-5297.

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Bhupathiraju NVSDK, Younes A, Cao M, Ali J, Cicek HT, Tully KM, Ponnala S, Babich JW, Deri MA, Lewis JS, Francesconi LC, Drain CM. Improved synthesis of the bifunctional chelator p-SCN-Bn-HOPO. Org Biomol Chem. 2019 07 17; 17(28):6866-6871.

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Kucheryavykh LY, Benedikt J, Cubano LA, Skatchkov SN, Bukauskas FF, Kucheryavykh YV. Polyamines preserve connexin 43-mediated gap junctional communication during intracellular hypercalcemia and acidosis. Neuroreport. 2017 Mar 01; 28(4):208-213.

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Lin YH, Romo JA, Smith TC, Reyes AN, Karna SLR, Miller CL, Van Laar TA, Yendapally R, Chambers JP, Seshu J. Spermine and Spermidine Alter Gene Expression and Antigenic Profile of Borrelia burgdorferi. Infect Immun. 2017 03; 85(3).

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