Phosphodiesterase Inhibitors

"Phosphodiesterase Inhibitors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Compounds which inhibit or antagonize the biosynthesis or actions of phosphodiesterases.

Descriptor ID	D010726
MeSH Number(s)	D27.505.519.389.735
Concept/Terms	Phosphodiesterase Inhibitors Phosphodiesterase Inhibitors Phosphodiesterase Antagonists Phosphoric Diester Hydrolase Inhibitors Antiphosphodiesterases

Below are MeSH descriptors whose meaning is more general than "Phosphodiesterase Inhibitors".

Chemicals and Drugs [D]
Chemical Actions and Uses [D27]
Pharmacologic Actions [D27.505]
Molecular Mechanisms of Pharmacological Action [D27.505.519]
Enzyme Inhibitors [D27.505.519.389]
Phosphodiesterase Inhibitors [D27.505.519.389.735]

Below are MeSH descriptors whose meaning is related to "Phosphodiesterase Inhibitors".

Below are MeSH descriptors whose meaning is more specific than "Phosphodiesterase Inhibitors".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Phosphodiesterase Inhibitors" by people in this website by year, and whether "Phosphodiesterase Inhibitors" was a major or minor topic of these publications.

Bar chart showing 29 publications over 14 distinct years, with a maximum of 6 publications in 2007

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1997	0	1	1
1998	0	2	2
2002	0	1	1
2003	1	0	1
2004	1	1	2
2005	1	1	2
2006	4	0	4
2007	4	2	6
2008	0	2	2
2009	0	1	1
2010	2	1	3
2011	0	1	1
2012	2	0	2
2013	0	1	1

Below are the most recent publications written about "Phosphodiesterase Inhibitors" by people in Profiles.

Yaniv Y, Ahmet I, Tsutsui K, Behar J, Moen JM, Okamoto Y, Guiriba TR, Liu J, Bychkov R, Lakatta EG. Deterioration of autonomic neuronal receptor signaling and mechanisms intrinsic to heart pacemaker cells contribute to age-associated alterations in heart rate variability in?vivo. Aging Cell. 2016 08; 15(4):716-24.

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Huang H, Wang H, Figueiredo-Pereira ME. Regulating the ubiquitin/proteasome pathway via cAMP-signaling: neuroprotective potential. Cell Biochem Biophys. 2013 Sep; 67(1):55-66.

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Wang JS, Kovanecz I, Vernet D, Nolazco G, Kopchok GE, Chow SL, White RA, Gonzalez-Cadavid NF. Effects of sildenafil and/or muscle derived stem cells on myocardial infarction. J Transl Med. 2012 Aug 07; 10:159.

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Freund YR, Akama T, Alley MR, Antunes J, Dong C, Jarnagin K, Kimura R, Nieman JA, Maples KR, Plattner JJ, Rock F, Sharma R, Singh R, Sanders V, Zhou Y. Boron-based phosphodiesterase inhibitors show novel binding of boron to PDE4 bimetal center. FEBS Lett. 2012 Sep 21; 586(19):3410-4.

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Thornton AM, Zhao X, Weisleder N, Brotto LS, Bougoin S, Nosek TM, Reid M, Hardin B, Pan Z, Ma J, Parness J, Brotto M. Store-operated Ca(2+) entry (SOCE) contributes to normal skeletal muscle contractility in young but not in aged skeletal muscle. Aging (Albany NY). 2011 Jun; 3(6):621-34.

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Gonzalez-Cadavid NF, Rajfer J. Treatment of Peyronie's disease with PDE5 inhibitors: an antifibrotic strategy. Nat Rev Urol. 2010 Apr; 7(4):215-21.

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Dong X, Ebalunode JO, Cho SJ, Zheng W. A novel structure-based multimode QSAR method affords predictive models for phosphodiesterase inhibitors. J Chem Inf Model. 2010 Feb 22; 50(2):240-50.

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Katz A, Katz A. Erectile dysfunction. CMAJ. 2010 Mar 09; 182(4):381-2.

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Njie-Mbye YF, Bongmba OY, Onyema CC, Chitnis A, Kulkarni M, Opere CA, LeDay AM, Ohia SE. Effect of hydrogen sulfide on cyclic AMP production in isolated bovine and porcine neural retinae. Neurochem Res. 2010 Mar; 35(3):487-94.

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Gonzalez-Cadavid NF, Rajfer J. Experimental models of Peyronie's disease. Implications for new therapies. J Sex Med. 2009 Feb; 6(2):303-13.

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