Hyperalgesia

"Hyperalgesia" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An increased sensation of pain or discomfort produced by mimimally noxious stimuli due to damage to soft tissue containing NOCICEPTORS or injury to a peripheral nerve.

Descriptor ID	D006930
MeSH Number(s)	C10.597.751.791.400 C23.888.592.763.770.400
Concept/Terms	Hyperalgesia Hyperalgesia Hyperalgesias Hyperalgesic Sensations Hyperalgesia, Primary Hyperalgesia, Primary Hyperalgesias, Primary Hyperalgesia, Secondary Hyperalgesia, Secondary Hyperalgesias, Secondary Mechanical Allodynia Mechanical Allodynia Allodynias, Mechanical Hyperalgesia, Mechanical Hyperalgesias, Mechanical Mechanical Hyperalgesia Allodynia, Mechanical Tactile Allodynia Tactile Allodynia Allodynias, Tactile Hyperalgesia, Tactile Hyperalgesias, Tactile Allodynia, Tactile Allodynia Allodynia Hyperalgesia, Thermal Hyperalgesia, Thermal Hyperalgesias, Thermal Thermal Hyperalgesia Thermal Allodynia Allodynia, Thermal Allodynias, Thermal

Below are MeSH descriptors whose meaning is more general than "Hyperalgesia".

Diseases [C]
Nervous System Diseases [C10]
Neurologic Manifestations [C10.597]
Sensation Disorders [C10.597.751]
Somatosensory Disorders [C10.597.751.791]
Hyperalgesia [C10.597.751.791.400]
Pathological Conditions, Signs and Symptoms [C23]
Signs and Symptoms [C23.888]
Neurologic Manifestations [C23.888.592]
Sensation Disorders [C23.888.592.763]
Somatosensory Disorders [C23.888.592.763.770]
Hyperalgesia [C23.888.592.763.770.400]

Below are MeSH descriptors whose meaning is related to "Hyperalgesia".

Below are MeSH descriptors whose meaning is more specific than "Hyperalgesia".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Hyperalgesia" by people in this website by year, and whether "Hyperalgesia" was a major or minor topic of these publications.

Bar chart showing 20 publications over 13 distinct years, with a maximum of 3 publications in 2006 and 2017

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2003	0	1	1
2005	1	0	1
2006	2	1	3
2009	1	0	1
2010	0	1	1
2011	1	0	1
2013	1	0	1
2015	1	1	2
2016	1	0	1
2017	1	2	3
2020	1	1	2
2021	2	0	2
2025	1	0	1

Below are the most recent publications written about "Hyperalgesia" by people in Profiles.

Altinok F, Petrella M, Masi A, Borruto A, Ciccocioppo R, Ozturk Y. Exploring the supraspinal antihyperalgesic effects of levetiracetam in the rat model of chronic constriction injury. Can J Physiol Pharmacol. 2025 Jul 01; 103(7):244-256.

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Abbasloo E, Abdollahi F, Saberi A, Esmaeili-Mahani S, Kaeidi A, Akhlaghinasab F, Sheibani V, Thomas TC, Kobeissy FH, Oryan S. Involvement of T-type calcium channels in the mechanism of low dose morphine-induced hyperalgesia in adult male rats. Neuropeptides. 2021 Dec; 90:102185.

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Meeker TJ, Schmid AC, Liu Y, Keaser ML, Dorsey SG, Seminowicz DA, Greenspan JD. During capsaicin-induced central sensitization, brush allodynia is associated with baseline warmth sensitivity, whereas mechanical hyperalgesia is associated with painful mechanical sensibility, anxiety and somatization. Eur J Pain. 2021 10; 25(9):1971-1993.

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Morales-Medina JC, Rastogi A, Mintz E, Caldwell HK. Increased immediate early gene activation in the basolateral amygdala following persistent peripheral inflammation. Neuroreport. 2020 07 10; 31(10):724-729.

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Salehi S, Kashfi K, Manaheji H, Haghparast A. Chemical stimulation of the lateral hypothalamus induces antiallodynic and anti-thermal hyperalgesic effects in animal model of neuropathic pain: Involvement of orexin receptors in the spinal cord. Brain Res. 2020 04 01; 1732:146674.

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Furman AJ, Meeker TJ, Rietschel JC, Yoo S, Muthulingam J, Prokhorenko M, Keaser ML, Goodman RN, Mazaheri A, Seminowicz DA. Cerebral peak alpha frequency predicts individual differences in pain sensitivity. Neuroimage. 2018 02 15; 167:203-210.

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Darbari DS, Vaughan KJ, Roskom K, Seamon C, Diaw L, Quinn M, Conrey A, Schechter AN, Haythornthwaite JA, Waclawiw MA, Wallen GR, Belfer I, Taylor JG. Central sensitization associated with low fetal hemoglobin levels in adults with sickle cell anemia. Scand J Pain. 2017 10; 17:279-286.

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Huang RY, Liao CC, Tsai SY, Yen CT, Lin CW, Chen TC, Lin WT, Chang CH, Wen YR. Rapid and Delayed Effects of Pulsed Radiofrequency on Neuropathic Pain: Electrophysiological, Molecular, and Behavioral Evidence Supporting Long-Term Depression. Pain Physician. 2017 02; 20(2):E269-E283.

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Morris MC, Walker LS, Bruehl S, Stone AL, Mielock AS, Rao U. Impaired conditioned pain modulation in youth with functional abdominal pain. Pain. 2016 10; 157(10):2375-2381.

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Nag S, Mokha SS. Activation of the trigeminal a2-adrenoceptor produces sex-specific, estrogen dependent thermal antinociception and antihyperalgesia using an operant pain assay in the rat. Behav Brain Res. 2016 11 01; 314:152-8.

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