DNA Helicases

"DNA Helicases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Proteins that catalyze the unwinding of duplex DNA during replication by binding cooperatively to single-stranded regions of DNA or to short regions of duplex DNA that are undergoing transient opening. In addition DNA helicases are DNA-dependent ATPases that harness the free energy of ATP hydrolysis to translocate DNA strands.

Descriptor ID	D004265
MeSH Number(s)	D08.811.277.040.025.159 D08.811.399.340
Concept/Terms	DNA Helicases DNA Helicases Helicases, DNA DNA Unwinding Proteins Unwinding Proteins, DNA DNA Helicase A DNA Helicase A DNA Helicase II DNA Helicase II DNA Helicase III DNA Helicase III ATP-Dependent DNA Helicases ATP-Dependent DNA Helicases ATP Dependent DNA Helicases DNA Helicases, ATP-Dependent Helicases, ATP-Dependent DNA DNA Helicase E DNA Helicase E

Below are MeSH descriptors whose meaning is more general than "DNA Helicases".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Hydrolases [D08.811.277]
Acid Anhydride Hydrolases [D08.811.277.040]
Adenosine Triphosphatases [D08.811.277.040.025]
DNA Helicases [D08.811.277.040.025.159]
Isomerases [D08.811.399]
DNA Helicases [D08.811.399.340]

Below are MeSH descriptors whose meaning is more specific than "DNA Helicases".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "DNA Helicases" by people in this website by year, and whether "DNA Helicases" was a major or minor topic of these publications.

Bar chart showing 47 publications over 16 distinct years, with a maximum of 8 publications in 2005

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	0	1	1
2003	3	0	3
2004	2	1	3
2005	8	0	8
2006	4	2	6
2007	3	1	4
2008	1	0	1
2009	1	1	2
2011	2	1	3
2012	3	0	3
2013	2	1	3
2018	0	1	1
2020	1	0	1
2022	1	2	3
2023	0	2	2
2025	2	1	3

Below are the most recent publications written about "DNA Helicases" by people in Profiles.

Shatarupa A, Brown D, Olinares PDB, Chase J, Isiorho E, Chait BT, Jeruzalmi D. Distinct quaternary states, intermediates, and autoinhibition during loading of the DnaB-replicative helicase by the phage ?P helicase loader. Nucleic Acids Res. 2025 Nov 26; 53(22).

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Gao N, Mazzoletti D, Peng A, Olinares PDB, Morrone C, Garavaglia A, Gouda N, Tsoy S, Mendoza A, Chowdhury A, Cerullo A, Bhavsar H, Rossi F, Rizzi M, Chait BT, Miggiano R, Jeruzalmi D. DnaB and DciA: mechanisms of helicase loading and translocation on ssDNA. Nucleic Acids Res. 2025 Jun 20; 53(12).

View in: PubMed
Genta M, Ferrara G, Capelli R, Rondelli D, Sertic S, Bolognesi M, Rizzi M, Rossi F, Jeruzalmi D, Chaves-Sanjuan A, Miggiano R. Mechanistic understanding of UvrA damage detection and lesion hand-off to UvrB in Nucleotide Excision Repair. Nat Commun. 2025 Apr 10; 16(1):3416.

View in: PubMed
Tarasova E, Khayat R. Dynamics and Conformations of a Full-Length CRESS-DNA Replicase. Viruses. 2023 12 08; 15(12).

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Jian Y, Nie L, Liu S, Jiang Y, Dou Z, Liu X, Yao X, Fu C. The fission yeast kinetochore complex Mhf1-Mhf2 regulates the spindle assembly checkpoint and faithful chromosome segregation. J Cell Sci. 2023 01 15; 136(2).

View in: PubMed
He Q, Hao Q, Wu Y, Vadgama JV, Jiang Y. CircRAD54L2 promotes triple-negative breast cancer progression by regulating the miR-888 family/PDK1 axis. Life Sci. 2023 Jan 01; 312:121128.

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Ogunbona OB, Lin X, Hornick JL, Lubin DJ, Wang Q, Reid MD, Schneider F, Li D, Shin DM, Shi Q. Cytomorphologic and immunophenotypical analysis of SMARCA4 (BRG1)-deficient non-small cell lung carcinoma. J Am Soc Cytopathol. 2022 Jul-Aug; 11(4):183-193.

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Chase J, Berger J, Jeruzalmi D. Convergent evolution in two bacterial replicative helicase loaders. Trends Biochem Sci. 2022 07; 47(7):620-630.

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Kraithong T, Sucharitakul J, Buranachai C, Jeruzalmi D, Chaiyen P, Pakotiprapha D. Real-time investigation of the roles of ATP hydrolysis by UvrA and UvrB during DNA damage recognition in nucleotide excision repair. DNA Repair (Amst). 2021 01; 97:103024.

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Adeyemo AA, Zaghloul NA, Chen G, Doumatey AP, Leitch CC, Hostelley TL, Nesmith JE, Zhou J, Bentley AR, Shriner D, Fasanmade O, Okafor G, Eghan B, Agyenim-Boateng K, Chandrasekharappa S, Adeleye J, Balogun W, Owusu S, Amoah A, Acheampong J, Johnson T, Oli J, Adebamowo C, Collins F, Dunston G, Rotimi CN. ZRANB3 is an African-specific type 2 diabetes locus associated with beta-cell mass and insulin response. Nat Commun. 2019 07 19; 10(1):3195.

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