Deoxycholic Acid

"Deoxycholic Acid" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A bile acid formed by bacterial action from cholate. It is usually conjugated with glycine or taurine. Deoxycholic acid acts as a detergent to solubilize fats for intestinal absorption, is reabsorbed itself, and is used as a choleretic and detergent.

Descriptor ID	D003840
MeSH Number(s)	D04.210.500.105.225.272 D04.210.500.221.430.342
Concept/Terms	Deoxycholic Acid Deoxycholic Acid Acid, Deoxycholic Desoxycholic Acid Acid, Desoxycholic Dihydroxycholanoic Acid Acid, Dihydroxycholanoic Deoxycholate Deoxycholate Deoxycholic Acid, 12beta-Isomer Deoxycholic Acid, 12beta-Isomer 12beta-Isomer Deoxycholic Acid Deoxycholic Acid, 12beta Isomer Deoxycholic Acid, 3beta-Isomer Deoxycholic Acid, 3beta-Isomer 3beta-Isomer Deoxycholic Acid Deoxycholic Acid, 3beta Isomer Deoxycholic Acid, 5alpha-Isomer Deoxycholic Acid, 5alpha-Isomer 5alpha-Isomer Deoxycholic Acid Acid, 5alpha-Isomer Deoxycholic Deoxycholic Acid, 5alpha Isomer Deoxycholic Acid, Disodium Salt Deoxycholic Acid, Disodium Salt Deoxycholic Acid, Monoammonium Salt Deoxycholic Acid, Monoammonium Salt Deoxycholic Acid, Monopotassium Salt Deoxycholic Acid, Monopotassium Salt Deoxycholic Acid, Monosodium Salt Deoxycholic Acid, Monosodium Salt Sodium Deoxycholate Deoxycholate, Sodium Deoxycholic Acid, Sodium Salt, 12beta-Isomer Deoxycholic Acid, Sodium Salt, 12beta-Isomer Lagodeoxycholic Acid Lagodeoxycholic Acid Acid, Lagodeoxycholic Choleic Acid Choleic Acid Acid, Choleic Deoxycholic Acid, Magnesium (2:1) Salt Deoxycholic Acid, Magnesium (2:1) Salt

Below are MeSH descriptors whose meaning is more general than "Deoxycholic Acid".

Chemicals and Drugs [D]
Polycyclic Compounds [D04]
Fused-Ring Compounds [D04.210]
Steroids [D04.210.500]
Bile Acids and Salts [D04.210.500.105]
Cholic Acids [D04.210.500.105.225]
Deoxycholic Acid [D04.210.500.105.225.272]
Cholanes [D04.210.500.221]
Cholic Acids [D04.210.500.221.430]
Deoxycholic Acid [D04.210.500.221.430.342]

Below are MeSH descriptors whose meaning is related to "Deoxycholic Acid".

Below are MeSH descriptors whose meaning is more specific than "Deoxycholic Acid".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Deoxycholic Acid" by people in this website by year, and whether "Deoxycholic Acid" was a major or minor topic of these publications.

Bar chart showing 8 publications over 5 distinct years, with a maximum of 3 publications in 2012

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2001	0	1	1
2010	1	0	1
2012	1	2	3
2017	1	0	1
2019	2	0	2

Below are the most recent publications written about "Deoxycholic Acid" by people in Profiles.

Chen YJ, Zhang J, Zhu PP, Tan XW, Lin QH, Wang WX, Yin SS, Gao LZ, Su MM, Liu CX, Xu L, Jia W, Sevrioukova IF, Lan K. Stereoselective Oxidation Kinetics of Deoxycholate in Recombinant and Microsomal CYP3A Enzymes: Deoxycholate 19-Hydroxylation Is an In Vitro Marker of CYP3A7 Activity. Drug Metab Dispos. 2019 06; 47(6):574-581.

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Zhang J, Gao LZ, Chen YJ, Zhu PP, Yin SS, Su MM, Ni Y, Miao J, Wu WL, Chen H, Brouwer KLR, Liu CX, Xu L, Jia W, Lan K. Continuum of Host-Gut Microbial Co-metabolism: Host CYP3A4/3A7 are Responsible for Tertiary Oxidations of Deoxycholate Species. Drug Metab Dispos. 2019 03; 47(3):283-294.

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Le T, Kinh NV, Cuc NTK, Tung NLN, Lam NT, Thuy PTT, Cuong DD, Phuc PTH, Vinh VH, Hanh DTH, Tam VV, Thanh NT, Thuy TP, Hang NT, Long HB, Nhan HT, Wertheim HFL, Merson L, Shikuma C, Day JN, Chau NVV, Farrar J, Thwaites G, Wolbers M. A Trial of Itraconazole or Amphotericin B for HIV-Associated Talaromycosis. N Engl J Med. 2017 06 15; 376(24):2329-2340.

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Bonvillain RW, Danchuk S, Sullivan DE, Betancourt AM, Semon JA, Eagle ME, Mayeux JP, Gregory AN, Wang G, Townley IK, Borg ZD, Weiss DJ, Bunnell BA. A nonhuman primate model of lung regeneration: detergent-mediated decellularization and initial in vitro recellularization with mesenchymal stem cells. Tissue Eng Part A. 2012 Dec; 18(23-24):2437-52.

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Khatun Z, Nurunnabi M, Cho KJ, Lee YK. Oral delivery of near-infrared quantum dot loaded micelles for noninvasive biomedical imaging. ACS Appl Mater Interfaces. 2012 Aug; 4(8):3880-7.

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Khatun Z, Nurunnabi M, Cho KJ, Lee YK. Imaging of the GI tract by QDs loaded heparin-deoxycholic acid (DOCA) nanoparticles. Carbohydr Polym. 2012 Nov 06; 90(4):1461-8.

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Bhattacharjee J, Verma G, Aswal VK, Date AA, Nagarsenker MS, Hassan PA. Tween 80-sodium deoxycholate mixed micelles: structural characterization and application in doxorubicin delivery. J Phys Chem B. 2010 Dec 16; 114(49):16414-21.

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Rivera-Amill V, Kim BJ, Seshu J, Konkel ME. Secretion of the virulence-associated Campylobacter invasion antigens from Campylobacter jejuni requires a stimulatory signal. J Infect Dis. 2001 Jun 01; 183(11):1607-16.

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Stark RE, Manstein JL, Curatolo W, Sears B. Deuterium nuclear magnetic resonance studies of bile salt/phosphatidylcholine mixed micelles. Biochemistry. 1983 May 10; 22(10):2486-90.

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Spatz L, Strittmatter P. A form of reduced nicotinamide adenine dinucleotide-cytochrome b 5 reductase containing both the catalytic site and an additional hydrophobic membrane-binding segment. J Biol Chem. 1973 Feb 10; 248(3):793-9.

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