Complement Pathway, Classical
"Complement Pathway, Classical" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Complement activation initiated by the binding of COMPLEMENT C1 to ANTIGEN-ANTIBODY COMPLEXES at the COMPLEMENT C1Q subunit. This leads to the sequential activation of COMPLEMENT C1R and COMPLEMENT C1S subunits. Activated C1s cleaves COMPLEMENT C4 and COMPLEMENT C2 forming the membrane-bound classical C3 CONVERTASE (C4B2A) and the subsequent C5 CONVERTASE (C4B2A3B) leading to cleavage of COMPLEMENT C5 and the assembly of COMPLEMENT MEMBRANE ATTACK COMPLEX.
| Descriptor ID |
D003171
|
| MeSH Number(s) |
G12.274.698
|
| Concept/Terms |
Complement Pathway, Classical- Complement Pathway, Classical
- Classical Complement Activation Pathway
- Complement Activation Pathway, Classical
- Classical Complement Pathway
|
Below are MeSH descriptors whose meaning is more general than "Complement Pathway, Classical".
Below are MeSH descriptors whose meaning is more specific than "Complement Pathway, Classical".
This graph shows the total number of publications written about "Complement Pathway, Classical" by people in this website by year, and whether "Complement Pathway, Classical" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 0 | 1 | 1 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Complement Pathway, Classical" by people in Profiles.
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Sullivan KE. The yin and the yang of early classical pathway complement disorders. Clin Exp Immunol. 2022 08 19; 209(2):151-160.
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Bloch EF, Morrison K, McDonald-Pinkett S, Baskin S, Campbell S, Peters S, Dillahunt S, Evans D, Lucas S, Macatangay A, Kanaan Y. The deposition of C5b-9 complexes and its precursors on E. coli J5 during complement activation enhances uptake and toxicities of gentamicin. Immunol Invest. 2008; 37(3):245-61.