Central Nervous System Depressants
"Central Nervous System Depressants" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A very loosely defined group of drugs that tend to reduce the activity of the central nervous system. The major groups included here are ethyl alcohol, anesthetics, hypnotics and sedatives, narcotics, and tranquilizing agents (antipsychotics and antianxiety agents).
| Descriptor ID |
D002492
|
| MeSH Number(s) |
D27.505.696.277 D27.505.954.427.210
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Central Nervous System Depressants".
Below are MeSH descriptors whose meaning is more specific than "Central Nervous System Depressants".
This graph shows the total number of publications written about "Central Nervous System Depressants" by people in this website by year, and whether "Central Nervous System Depressants" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 1 | 0 | 1 |
| 1999 | 1 | 0 | 1 |
| 2002 | 1 | 1 | 2 |
| 2003 | 1 | 0 | 1 |
| 2005 | 1 | 1 | 2 |
| 2007 | 2 | 0 | 2 |
| 2008 | 1 | 0 | 1 |
| 2009 | 1 | 1 | 2 |
| 2011 | 2 | 1 | 3 |
| 2013 | 3 | 0 | 3 |
| 2014 | 2 | 0 | 2 |
| 2015 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
| 2017 | 2 | 0 | 2 |
| 2018 | 1 | 2 | 3 |
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Below are the most recent publications written about "Central Nervous System Depressants" by people in Profiles.
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Getachew B, Hudson T, Heinbockel T, Csoka AB, Tizabi Y. Protective Effects of Donepezil Against Alcohol-Induced Toxicity in Cell Culture: Role of Caspase-3. Neurotox Res. 2018 Oct; 34(3):757-762.
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Zaveri NT, Marquez PV, Meyer ME, Polgar WE, Hamid A, Lutfy K. A Novel and Selective Nociceptin Receptor (NOP) Agonist (1-(1-((cis)-4-isopropylcyclohexyl)piperidin-4-yl)-1H-indol-2-yl)methanol (AT-312) Decreases Acquisition of Ethanol-Induced Conditioned Place Preference in Mice. Alcohol Clin Exp Res. 2018 Feb; 42(2):461-471.
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Tizabi Y, Getachew B, Ferguson CL, Csoka AB, Thompson KM, Gomez-Paz A, Ruda-Kucerova J, Taylor RE. Low Vs. High Alcohol: Central Benefits Vs. Detriments. Neurotox Res. 2018 Nov; 34(4):860-869.
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Hellberg SN, Levit JD, Robinson MJF. Under the influence: Effects of adolescent ethanol exposure and anxiety on motivation for uncertain gambling-like cues in male and female rats. Behav Brain Res. 2018 Jan 30; 337:17-33.
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Manavalan S, Getachew B, Manaye KF, Khundmiri SJ, Csoka AB, McKinley R, Tamas A, Reglodi D, Tizabi Y. PACAP Protects Against Ethanol and Nicotine Toxicity in SH-SY5Y Cells: Implications for Drinking-Smoking Co-morbidity. Neurotox Res. 2017 Jul; 32(1):8-13.
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Velázquez-Marrero C, Burgos A, García JO, Palacio S, Marrero HG, Bernardo A, Pérez-Laspiur J, Rivera-Oliver M, Seale G, Treistman SN. Alcohol Regulates BK Surface Expression via Wnt/ß-Catenin Signaling. J Neurosci. 2016 10 12; 36(41):10625-10639.
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Banerjee A, Abdelmegeed MA, Jang S, Song BJ. Increased Sensitivity to Binge Alcohol-Induced Gut Leakiness and Inflammatory Liver Disease in HIV Transgenic Rats. PLoS One. 2015; 10(10):e0140498.
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Hwa LS, Shimamoto A, Kayyali T, Norman KJ, Valentino RJ, DeBold JF, Miczek KA. Dissociation of µ-opioid receptor and CRF-R1 antagonist effects on escalated ethanol consumption and mPFC serotonin in C57BL/6J mice. Addict Biol. 2016 Jan; 21(1):111-24.
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Quadros IM, Hwa LS, Shimamoto A, Carlson J, DeBold JF, Miczek KA. Prevention of alcohol-heightened aggression by CRF-R1 antagonists in mice: critical role for DRN-PFC serotonin pathway. Neuropsychopharmacology. 2014 Nov; 39(12):2874-83.
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Lin X, Yang H, Zhang H, Zhou L, Guo Z. A novel transcription mechanism activated by ethanol: induction of Slc7a11 gene expression via inhibition of the DNA-binding activity of transcriptional repressor octamer-binding transcription factor 1 (OCT-1). J Biol Chem. 2013 May 24; 288(21):14815-23.