"Calmodulin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A heat-stable, low-molecular-weight activator protein found mainly in the brain and heart. The binding of calcium ions to this protein allows this protein to bind to cyclic nucleotide phosphodiesterases and to adenyl cyclase with subsequent activation. Thereby this protein modulates cyclic AMP and cyclic GMP levels.
| Descriptor ID |
D002147
|
| MeSH Number(s) |
D12.644.360.372.249 D12.776.157.125.412.249 D12.776.476.387.249
|
| Concept/Terms |
Calmodulin- Calmodulin
- Calcium-Dependent Regulator
- Calcium Dependent Regulator
- Calcium-Dependent Activator Protein
- Activator Protein, Calcium-Dependent
- Calcium Dependent Activator Protein
- Protein, Calcium-Dependent Activator
- Phosphodiesterase Protein Activator
- Activator, Phosphodiesterase Protein
- Protein Activator, Phosphodiesterase
- Phosphodiesterase Activating Factor
- Activating Factor, Phosphodiesterase
- Factor, Phosphodiesterase Activating
- Phosphodiesterase Activator Protein
- Activator Protein, Phosphodiesterase
- Protein, Phosphodiesterase Activator
- Regulator, Calcium-Dependent
- Regulator, Calcium Dependent
Cyclic AMP-Phosphodiesterase Activator- Cyclic AMP-Phosphodiesterase Activator
- AMP-Phosphodiesterase Activator, Cyclic
- Activator, Cyclic AMP-Phosphodiesterase
- Cyclic AMP Phosphodiesterase Activator
|
Below are MeSH descriptors whose meaning is more general than "Calmodulin".
Below are MeSH descriptors whose meaning is more specific than "Calmodulin".
This graph shows the total number of publications written about "Calmodulin" by people in this website by year, and whether "Calmodulin" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1991 | 2 | 1 | 3 |
| 1992 | 1 | 1 | 2 |
| 1994 | 2 | 0 | 2 |
| 1995 | 1 | 1 | 2 |
| 1996 | 1 | 0 | 1 |
| 1997 | 1 | 0 | 1 |
| 1999 | 3 | 0 | 3 |
| 2002 | 0 | 1 | 1 |
| 2005 | 1 | 0 | 1 |
| 2009 | 1 | 1 | 2 |
| 2014 | 1 | 1 | 2 |
| 2016 | 2 | 0 | 2 |
| 2018 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
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click here.
Below are the most recent publications written about "Calmodulin" by people in Profiles.
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Lee K, Kumar EA, Dalby KN, Ghose R. The role of calcium in the interaction between calmodulin and a minimal functional construct of eukaryotic elongation factor 2 kinase. Protein Sci. 2019 12; 28(12):2089-2098.
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Will N, Lee K, Hajredini F, Giles DH, Abzalimov RR, Clarkson M, Dalby KN, Ghose R. Structural Dynamics of the Activation of Elongation Factor 2 Kinase by Ca2+-Calmodulin. J Mol Biol. 2018 08 17; 430(17):2802-2821.
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Tavares CD, Giles DH, Stancu G, Chitjian CA, Ferguson SB, Wellmann RM, Kaoud TS, Ghose R, Dalby KN. Signal Integration at Elongation Factor 2 Kinase: THE ROLES OF CALCIUM, CALMODULIN, AND SER-500 PHOSPHORYLATION. J Biol Chem. 2017 02 03; 292(5):2032-2045.
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Lee K, Alphonse S, Piserchio A, Tavares CD, Giles DH, Wellmann RM, Dalby KN, Ghose R. Structural Basis for the Recognition of Eukaryotic Elongation Factor 2 Kinase by Calmodulin. Structure. 2016 09 06; 24(9):1441-51.
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Liu M, Xu R, Merrill C, Hong L, Von Lanken C, Hunt AG, Li QQ. Integration of developmental and environmental signals via a polyadenylation factor in Arabidopsis. PLoS One. 2014; 9(12):e115779.
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Yong Chung H, Lacatus G, Sunter G. Geminivirus AL2 protein induces expression of, and interacts with, a calmodulin-like gene, an endogenous regulator of gene silencing. Virology. 2014 Jul; 460-461:108-18.
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de la Rica R, Matsui H. Biomimetic conformation-specific assembly of proteins at artificial binding sites nanopatterned on silicon. J Am Chem Soc. 2009 Oct 14; 131(40):14180-1.
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Venkatakrishnan P, Nakayasu ES, Almeida IC, Miller RT. Absence of nitric-oxide synthase in sequentially purified rat liver mitochondria. J Biol Chem. 2009 Jul 24; 284(30):19843-55.
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Shen C, Ye Y, Robertson SE, Lau AW, Mak DO, Chou MM. Calcium/calmodulin regulates ubiquitination of the ubiquitin-specific protease TRE17/USP6. J Biol Chem. 2005 Oct 28; 280(43):35967-73.
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Logan S, Cameron JA, Vig PJ. Calmodulin activity in aging rat heart. Biomed Sci Instrum. 2003; 39:561-6.