Blood-Brain Barrier

"Blood-Brain Barrier" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Specialized non-fenestrated tightly-joined ENDOTHELIAL CELLS with TIGHT JUNCTIONS that form a transport barrier for certain substances between the cerebral capillaries and the BRAIN tissue.

Descriptor ID	D001812
MeSH Number(s)	A07.035 A08.186.211.035
Concept/Terms	Blood-Brain Barrier Blood-Brain Barrier Barrier, Blood-Brain Barriers, Blood-Brain Blood Brain Barrier Blood-Brain Barriers Hemato-Encephalic Barrier Barrier, Hemato-Encephalic Barriers, Hemato-Encephalic Hemato Encephalic Barrier Hemato-Encephalic Barriers Brain-Blood Barrier Barrier, Brain-Blood Barriers, Brain-Blood Brain Blood Barrier Brain-Blood Barriers

Below are MeSH descriptors whose meaning is more general than "Blood-Brain Barrier".

Anatomy [A]
Cardiovascular System [A07]
Blood-Brain Barrier [A07.035]
Nervous System [A08]
Central Nervous System [A08.186]
Brain [A08.186.211]
Blood-Brain Barrier [A08.186.211.035]

Below are MeSH descriptors whose meaning is related to "Blood-Brain Barrier".

Below are MeSH descriptors whose meaning is more specific than "Blood-Brain Barrier".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Blood-Brain Barrier" by people in this website by year, and whether "Blood-Brain Barrier" was a major or minor topic of these publications.

Bar chart showing 137 publications over 27 distinct years, with a maximum of 9 publications in 2018 and 2019

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1999	1	1	2
2000	0	1	1
2002	1	2	3
2003	3	2	5
2004	0	2	2
2005	3	5	8
2006	1	3	4
2007	2	2	4
2008	1	4	5
2009	3	3	6
2010	3	5	8
2011	3	5	8
2012	2	3	5
2013	3	3	6
2014	2	4	6
2015	1	2	3
2016	5	2	7
2017	0	3	3
2018	3	6	9
2019	7	2	9
2020	4	4	8
2021	5	2	7
2022	1	2	3
2023	1	2	3
2024	5	0	5
2025	2	2	4
2026	2	1	3

Below are the most recent publications written about "Blood-Brain Barrier" by people in Profiles.

Brambila C, Sahebi Vaighan N, Youssef I, Chaudhary J, Anwar A, Bachoo R, Patel T, Chopra R, Corbin IR. Enhanced delivery of low-density lipoprotein-based nanoparticles to the mouse glioblastoma using focused ultrasound as a novel therapy. Biomaterials. 2026 Oct; 333:124198.

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Asante J, Barger SW. Impact of P-glycoprotein substrates on transendothelial transport of amyloid-? peptide in an in vitro model. Neuroscience. 2026 May 14; 602:104-111.

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Wolf EJ, Zhao X, Madison A, Carbaugh J, Fortier CB, Milberg WP, Logue MW, Miller MW. Trauma exposure, PTSD, and methylation of the blood brain barrier claudin-5 gene. Psychoneuroendocrinology. 2026 Apr; 186:107753.

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Salian VS, Curan GL, Lowe VJ, Tang X, Kalari KR, Kandimalla KK. Elucidating molecular mechanisms governing tumor necrosis factor-alpha-mediated regulation of amyloid beta 42 uptake in blood-brain barrier endothelial cells. Mol Pharmacol. 2026 Jan; 108(1):100088.

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Kucheryavykh L, Ortiz Rivera J, Ermolinsky B, Tsytsarev V, Cary L, Alves J, Reyes A, de la Cruz-Rivera N, Rosa Gonzalez K, Narvaez Irizarry F, Porter TR, Inyushin M. Targeting Gliomas with Beta-Amyloid-Specific Dyes: A Novel Approach for In Vivo Staining and Potential Therapeutic Applications. Int J Mol Sci. 2025 Oct 28; 26(21).

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Wang L, Curran GL, Zhong R, Xue Z, Veerareddy V, Thieschafer J, Min PH, Li L, Lowe VJ, Kandimalla KK. Amyloid beta peptides inhibit glucose transport at the blood-brain barrier by disrupting the insulin-AKT pathway. J Cereb Blood Flow Metab. 2025 Oct; 45(10):1961-1979.

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Bogadi S, Bhaskaran M, Ravichandran V, Nesamony J, Chelliah S, Kuppusamy G, Prakash GM, Karri VVSR, Mallick S, Farahim F, Ali T, Babu DR, Subramaniyan V. Functionalized Nanoparticles: A Promising Approach for Effective Management of Alzheimer's Disease. Mol Neurobiol. 2025 Aug; 62(8):10915-10934.

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Wang Z, Veerareddy V, Tang X, Thompson KJ, Krishnan S, Kalari KR, Kandimalla KK. QSP Modeling Shows Pathological Synergism Between Insulin Resistance and Amyloid-Beta Exposure in Upregulating VCAM1 Expression at the BBB Endothelium. CPT Pharmacometrics Syst Pharmacol. 2025 Mar; 14(3):561-571.

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Salian VS, Tang X, Thompson KJ, Curan GL, Lowe VJ, Li L, Kalari KR, Kandimalla KK. Molecular Mechanisms Underlying Amyloid Beta Peptide Mediated Upregulation of Vascular Cell Adhesion Molecule-1 in Alzheimer Disease. J Pharmacol Exp Ther. 2024 Nov 19; 391(3):430-440.

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Wang Z, Zhong R, Curran GL, Min P, Lowe VJ, Li L, Kandimalla KK. High-Density Lipoprotein Mimetic Peptide 4F Reduces Toxic Amyloid-Beta Exposure to the Blood-Brain Barrier Endothelium in Alzheimer's Disease Transgenic Mice. Mol Pharm. 2024 Nov 04; 21(11):5661-5671.

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