Hypoxic response contributes to altered gene expression and precapillary pulmonary hypertension in patients with sickle cell disease.

Zhang X, Zhang W, Ma SF, Desai AA, Saraf S, Miasniakova G, Sergueeva A, Ammosova T, Xu M, Nekhai S, Abbasi T, Casanova NG, Steinberg MH, Baldwin CT, Sebastiani P, Prchal JT, Kittles R, Garcia JG, Machado RF, Gordeuk VR. Hypoxic response contributes to altered gene expression and precapillary pulmonary hypertension in patients with sickle cell disease. Circulation. 2014 Apr 22; 129(16):1650-8.

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subject areas

Adult
Anemia, Sickle Cell
Apoptosis
Cell Hypoxia
Cohort Studies
Female
Gene Expression Regulation, Enzymologic
Humans
Hypertension, Pulmonary
Inflammation
Leukocytes, Mononuclear
Male
Mitogen-Activated Protein Kinase 8
Prospective Studies
Quantitative Trait Loci
T-Lymphocytes

authors with profiles

Sergei Nekhai
Tatiana Ammosova
Rick Kittles, PhD

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