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Theodore C. Friedman, MD, PhD

Faculty RankProfessor
InstitutionCharles R. Drew University of Medicine and Science
DepartmentInternal Medicine
Address1731 E. 120th Street, Hawkins Building
1731 E. 120th Street, Hawkins Building
Los Angeles CA 90059
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    K21DA000276     (FRIEDMAN, THEODORE C)Jul 1, 1995 - Apr 30, 2001
    Role: Principal Investigator

    R01DA014659     (FRIEDMAN, THEODORE C)Aug 1, 2002 - Jul 31, 2010
    Genes and Proteins Leading to Addiction
    Role: Principal Investigator

    R21DA015466     (FRIEDMAN, THEODORE C)Jun 5, 2003 - Feb 29, 2008
    HPA Axis Activation and Nicotine Use
    Role: Principal Investigator

    R21DA016867     (FRIEDMAN, THEODORE C)Jul 20, 2003 - May 31, 2007
    Chronic Nicotine's Activation of the HPA Axis
    Role: Principal Investigator

    S06GM068510     (SINHA HIKIM, AMIYA P)Aug 1, 2003 - Aug 31, 2012
    Support of Competitive Research (SCORE) Institutional Development Award at Drew
    Role: Co-Principal Investigator

    U54HD041748     (FRIEDMAN, THEODORE C)Aug 15, 2003 - Oct 31, 2010
    Role: Principal Investigator

    R24DA017298     (FRIEDMAN, THEODORE C)Sep 1, 2003 - Mar 31, 2021
    CDU Diversity-promoting Institutions Drug Abuse Research Development Program
    Role: Principal Investigator

    R21DA022342     (FRIEDMAN, THEODORE C)Sep 30, 2007 - Aug 31, 2010
    The mechanisms of the nicotine-induction of insulin resistance
    Role: Principal Investigator

    R01MD012579     (FRIEDMAN, THEODORE C;NAJJAR, SONIA M. ;PURI, VISHWAJEET)Mar 12, 2019 - Nov 30, 2023
    Novel pathways in the pathogenesis and pathophysiology of NAFLD in Hispanics
    Role: Co-Principal Investigator

    R25DA050723     (FRIEDMAN, THEODORE C)Apr 1, 2020 - Mar 31, 2025
    The Next Generation Substance Abuse Research Training at Charles R. Drew University (CDU) and UCLA (NGSART-CU)
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Donovan A, Assari S, Grella C, Shaheen M, Richter L, Friedman TC. Neuroendocrine mechanisms in the links between early life stress, affect, and youth substance use: A conceptual model for the study of sex and gender differences. Front Neuroendocrinol. 2024 Jan 20; 73:101121. PMID: 38253240.
      Citations:    Fields:    
    2. Espinoza-Derout J, Arambulo JML, Ramirez-Trillo W, Rivera JC, Hasan KM, Lao CJ, Jordan MC, Shao XM, Roos KP, Sinha-Hikim AP, Friedman TC. The lipolysis inhibitor acipimox reverses the cardiac phenotype induced by electronic cigarettes. Sci Rep. 2023 10 25; 13(1):18239. PMID: 37880325.
      Citations:    Fields:    Translation:HumansAnimalsCells
    3. Meredith LR, Hurley B, Friedman TC, Lee ML, Rodriguez L, Lopez B, Mtume N, Dixon T, Belani HK, Hsieh S, Ray LA. Implementation of Specialty Tobacco Use Disorder Services in a Community Health Setting: Support for Enhanced Prescription Practices. J Addict Med. 2023 Nov-Dec 01; 17(6):677-684. PMID: 37934530.
      Citations:    Fields:    Translation:HumansPHPublic Health
    4. Wilson JB, Epstein M, Lopez B, Brown AK, Lutfy K, Friedman TC. The role of Neurochemicals, Stress Hormones and Immune System in the Positive Feedback Loops between Diabetes, Obesity and Depression. Front Endocrinol (Lausanne). 2023; 14:1224612. PMID: 37664841.
      Citations: 1     Fields:    Translation:Humans
    5. Hasan KM, Parveen M, Pena A, Bautista F, Rivera JC, Huerta RR, Martinez E, Espinoza-Derout J, Sinha-Hikim AP, Friedman TC. Fatty Acid Excess Dysregulates CARF to Initiate the Development of Hepatic Steatosis. Cells. 2023 04 01; 12(7). PMID: 37048142.
      Citations:    Fields:    Translation:HumansAnimalsCells
    6. Shaheen M, Schrode KM, Tedlos M, Pan D, Najjar SM, Friedman TC. Racial/ethnic and gender disparity in the severity of NAFLD among people with diabetes or prediabetes. Front Physiol. 2023; 14:1076730. PMID: 36891143.
    7. Espinoza-Derout J, Shao XM, Lao CJ, Hasan KM, Rivera JC, Jordan MC, Echeverria V, Roos KP, Sinha-Hikim AP, Friedman TC. Electronic Cigarette Use and the Risk of Cardiovascular Diseases. Front Cardiovasc Med. 2022; 9:879726. PMID: 35463745.
    8. Kim SC, Friedman TC. A New Ingenious Enemy: Heat-Not-Burn Products. Tob Use Insights. 2022; 15:1179173X221076419. PMID: 35237081.
    9. Baskerville WA, Friedman TC, Hurley B, Hsieh S, Dixon T, Mtume N, Lee ML, Rodriguez L, Lopez B, Ray LA. Embedding comprehensive smoking cessation programs into community clinics: study protocol for a cluster-randomized controlled trial. Trials. 2022 Feb 03; 23(1):109. PMID: 35115017.
      Citations:    Fields:    Translation:HumansCTClinical Trials
    10. Shaheen M, Schrode KM, Pan D, Kermah D, Puri V, Zarrinpar A, Elisha D, Najjar SM, Friedman TC. Sex-Specific Differences in the Association Between Race/Ethnicity and NAFLD Among US Population. Front Med (Lausanne). 2021; 8:795421. PMID: 34926533.
    11. Kim SCJ, Martinez JE, Liu Y, Friedman TC. US Tobacco 21 is Paving the Way for a Tobacco Endgame. Tob Use Insights. 2021; 14:1179173X211050396. PMID: 34866950.
    12. Meredith LR, Baskerville WA, Friedman TC, Hurley B, Dixon T, Mtume N, Rodriguez L, Lopez B, Hsieh S, Ray LA. Safety Net Provider Attitudes Toward Smoking Cessation Treatment. Front Psychiatry. 2021; 12:744816. PMID: 34650457.
    13. Shaheen M, Pan D, Schrode KM, Kermah D, Puri V, Zarrinpar A, Elisha D, Najjar SM, Friedman TC. Reassessment of the Hispanic Disparity: Hepatic Steatosis Is More Prevalent in Mexican Americans Than Other Hispanics. Hepatol Commun. 2021 12; 5(12):2068-2079. PMID: 34558824.
      Citations: 8     Fields:    Translation:Humans
    14. Martinez-Hollingsworth A, Kim L, Richardson TG, Angulo M, Liu R, Friedman T, Choi K. Supporting "Bleeders" and "Billers": How Safety-Net Administrators Mitigate Provider Burnout During the COVID-19 Pandemic and Beyond. J Ambul Care Manage. 2021 Jul-Sep 01; 44(3):172-183. PMID: 34016846.
      Citations: 1     Fields:    Translation:HumansCellsPHPublic Health
    15. Martinez JE, Kahana DD, Ghuman S, Wilson HP, Wilson J, Kim SCJ, Lagishetty V, Jacobs JP, Sinha-Hikim AP, Friedman TC. Unhealthy Lifestyle and Gut Dysbiosis: A Better Understanding of the Effects of Poor Diet and Nicotine on the Intestinal Microbiome. Front Endocrinol (Lausanne). 2021; 12:667066. PMID: 34168615.
      Citations: 38     Fields:    Translation:Humans
    16. Saldivar P, Mira V, Duran P, Moldovan C, Ang G, Parikh N, Lee ML, Friedman TC. Implementing texting programs in the P.O.W.E.R. (preventing obesity with eating right) medical group visit for weight loss. Obes Sci Pract. 2021 Oct; 7(5):583-590. PMID: 34631136.
    17. Wang Y, Wang J, Yang R, Wang P, Porche R, Kim S, Lutfy K, Liu L, Friedman TC, Jiang M, Liu Y. Decreased 11?-Hydroxysteroid Dehydrogenase Type 2 Expression in the Kidney May Contribute to Nicotine/Smoking-Induced Blood Pressure Elevation in Mice. Hypertension. 2021 06; 77(6):1940-1952. PMID: 33813843.
      Citations: 3     Fields:    Translation:AnimalsCells
    18. Nguyen S, Mangubat M, Eleswarapu S, Wilson JB, Molina J, Abraham A, Artaza JN, Friedman TC, Ferrini MG. The Combination of High-Fat Diet and Oral Marijuana Promotes the Development of Fibrosis in the Mouse Corpora Cavernosa. Sex Med. 2021 Apr; 9(2):100312. PMID: 33540365.
    19. Hsia SH, Nisis ML, Lee ML, Goldstein C, Friedman TC. Metabolic parameters in smokers undergoing smoking reduction. J Clin Transl Endocrinol. 2021 Mar; 23:100249. PMID: 33717989.
    20. Shaheen M, Schrode KM, Kermah D, Pan D, Puri V, Zarrinpar A, Elisha D, Najjar SM, Friedman TC. Prevalence and Predictors of Nonalcoholic Steatohepatitis Using Multiple Non-Invasive Methods: Data from NHANES III. J Liver. 2020; 9(3). PMID: 37786752.
    21. Jimenez T, Friedman T, Vadgama J, Singh V, Tucker A, Collazo J, Sinha S, Hikim AS, Singh R, Pervin S. Nicotine Synergizes with High-Fat Diet to Induce an Anti-Inflammatory Microenvironment to Promote Breast Tumor Growth. Mediators Inflamm. 2020; 2020:5239419. PMID: 33414685.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    22. Hasan KM, Munoz A, Tumoyan H, Parveen M, Espinoza-Derout J, Shao XM, Mahata SK, Friedman TC, Sinha-Hikim AP. Adverse effects of fetal exposure of electronic-cigarettes and high-fat diet on male neonatal hearts. Exp Mol Pathol. 2021 02; 118:104573. PMID: 33212125.
      Citations:    Fields:    Translation:AnimalsCells
    23. Wilson JB, Zopey M, Augustine J, Schaffer R, Chiang M, Friedman TC. High Prevalence of Adrenal Remnant Tissue in Patients Undergoing Bilateral Adrenalectomy for Cushing's Disease. Horm Metab Res. 2021 Mar; 53(3):161-168. PMID: 33091942.
      Citations:    Fields:    Translation:Humans
    24. Hasan KM, Friedman TC, Parveen M, Espinoza-Derout J, Bautista F, Razipour MM, Shao XM, Jordan MC, Roos KP, Mahata SK, Sinha-Hikim AP. Electronic cigarettes cause alteration in cardiac structure and function in diet-induced obese mice. PLoS One. 2020; 15(10):e0239671. PMID: 33002059.
      Citations: 9     Fields:    Translation:Animals
    25. Shao XM, Friedman TC. Last Word on Viewpoint: pH Buffer capacity and pharmacokinetics: two remaining questions. J Appl Physiol (1985). 2020 04 01; 128(4):1063-1064. PMID: 32284007.
      Citations: 1     Fields:    
    26. Shao XM, Friedman TC. Pod-mod vs. conventional e-cigarettes: nicotine chemistry, pH, and health effects. J Appl Physiol (1985). 2020 04 01; 128(4):1056-1058. PMID: 31854246.
      Citations: 29     Fields:    
    27. Wang J, Wang Y, Liu L, Lutfy K, Friedman TC, Liu Y, Jiang M, Liu Y. Lack of adipose-specific hexose-6-phosphate dehydrogenase causes inactivation of adipose glucocorticoids and improves metabolic phenotype in mice. Clin Sci (Lond). 2019 11 15; 133(21):2189-2202. PMID: 31696216.
      Citations: 1     Fields:    Translation:Animals
    28. Shao XM, Lopez B, Nathan D, Wilson J, Bankole E, Tumoyan H, Munoz A, Espinoza-Derout J, Hasan KM, Chang S, Du C, Sinha-Hikim AP, Lutfy K, Friedman TC. A mouse model for chronic intermittent electronic cigarette exposure exhibits nicotine pharmacokinetics resembling human vapers. J Neurosci Methods. 2019 10 01; 326:108376. PMID: 31361999.
      Citations: 18     Fields:    Translation:Animals
    29. Espinoza-Derout J, Hasan KM, Shao XM, Jordan MC, Sims C, Lee DL, Sinha S, Simmons Z, Mtume N, Liu Y, Roos KP, Sinha-Hikim AP, Friedman TC. Chronic intermittent electronic cigarette exposure induces cardiac dysfunction and atherosclerosis in apolipoprotein-E knockout mice. Am J Physiol Heart Circ Physiol. 2019 08 01; 317(2):H445-H459. PMID: 31172811.
      Citations: 42     Fields:    Translation:AnimalsCellsPHPublic Health
    30. Espinoza-Derout J, Shao XM, Bankole E, Hasan KM, Mtume N, Liu Y, Sinha-Hikim AP, Friedman TC. Hepatic DNA Damage Induced by Electronic Cigarette Exposure Is Associated With the Modulation of NAD+/PARP1/SIRT1 Axis. Front Endocrinol (Lausanne). 2019; 10:320. PMID: 31214115.
      Citations: 12     Fields:    
    31. Hasan KM, Friedman TC, Shao X, Parveen M, Sims C, Lee DL, Espinoza-Derout J, Sinha-Hikim I, Sinha-Hikim AP. E-cigarettes and Western Diet: Important Metabolic Risk Factors for Hepatic Diseases. Hepatology. 2019 06; 69(6):2442-2454. PMID: 30664268.
      Citations: 16     Fields:    Translation:HumansAnimals
    32. Mojtahedzadeh M, Shaesteh N, Haykani M, Tran JLA, Mangubat M, Shahinian HK, Nachnani R, Zopey M, Saidian J, Thomas A, Lee ML, McCutcheon IE, Friedman TC. Low-Dose and Standard Overnight and Low Dose-Two Day Dexamethasone Suppression Tests in Patients with Mild and/or Episodic Hypercortisolism. Horm Metab Res. 2018 Jun; 50(6):453-461. PMID: 29719879.
      Citations: 1     Fields:    Translation:Humans
    33. Liu L, Wang Y, Wang J, Dong Y, Chang S, Liu X, Lutfy K, Chen H, Friedman TC, Jiang M, Liu Y. Enhanced hexose-6-phosphate dehydrogenase expression in adipose tissue may contribute to diet-induced visceral adiposity. Int J Obes (Lond). 2018 12; 42(12):1999-2011. PMID: 29568102.
      Citations: 4     Fields:    Translation:AnimalsCells
    34. Hasan MK, Friedman TC, Sims C, Lee DL, Espinoza-Derout J, Ume A, Chalfant V, Lee ML, Sinha-Hikim I, Lutfy K, Liu Y, Mahata SK, Sinha-Hikim AP. a7-Nicotinic Acetylcholine Receptor Agonist Ameliorates Nicotine Plus High-Fat Diet-Induced Hepatic Steatosis in Male Mice by Inhibiting Oxidative Stress and Stimulating AMPK Signaling. Endocrinology. 2018 02 01; 159(2):931-944. PMID: 29272360.
      Citations: 12     Fields:    Translation:AnimalsCells
    35. Kermah D, Shaheen M, Pan D, Friedman TC. Association between secondhand smoke and obesity and glucose abnormalities: data from the National Health and Nutrition Examination Survey (NHANES 1999-2010). BMJ Open Diabetes Res Care. 2017; 5(1):e000324. PMID: 28405342.
    36. Sinha-Hikim AP, Sinha-Hikim I, Friedman TC. Connection of Nicotine to Diet-Induced Obesity and Non-Alcoholic Fatty Liver Disease: Cellular and Mechanistic Insights. Front Endocrinol (Lausanne). 2017; 8:23. PMID: 28239368.
      Citations: 21     Fields:    
    37. Sinha-Hikim I, Friedman TC, Falz M, Chalfant V, Hasan MK, Espinoza-Derout J, Lee DL, Sims C, Tran P, Mahata SK, Sinha-Hikim AP. Nicotine plus a high-fat diet triggers cardiomyocyte apoptosis. Cell Tissue Res. 2017 04; 368(1):159-170. PMID: 27917437.
      Citations: 12     Fields:    Translation:AnimalsCells
    38. Harris KK, Zopey M, Friedman TC. Metabolic effects of smoking cessation. Nat Rev Endocrinol. 2016 11; 12(11):684. PMID: 27688045.
      Citations: 11     Fields:    
    39. Harris KK, Zopey M, Friedman TC. Metabolic effects of smoking cessation. Nat Rev Endocrinol. 2016 May; 12(5):299-308. PMID: 26939981.
      Citations: 58     Fields:    Translation:Humans
    40. Mojtahedzadeh M, Lee ML, Friedman TC. Continuation or discontinuation of pioglitazone when starting bedtime insulin in patients with poorly controlled type 2 diabetes in an inner-city population. J Diabetes Complications. 2015 Nov-Dec; 29(8):1248-52. PMID: 26215435.
      Citations: 1     Fields:    Translation:Humans
    41. Wang Y, Yan C, Liu L, Wang W, Du H, Fan W, Lutfy K, Jiang M, Friedman TC, Liu Y. 11?-Hydroxysteroid dehydrogenase type 1 shRNA ameliorates glucocorticoid-induced insulin resistance and lipolysis in mouse abdominal adipose tissue. Am J Physiol Endocrinol Metab. 2015 Jan 01; 308(1):E84-95. PMID: 25389364.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    42. Huang G, Basaria S, Travison TG, Ho MH, Davda M, Mazer NA, Miciek R, Knapp PE, Zhang A, Collins L, Ursino M, Appleman E, Dzekov C, Stroh H, Ouellette M, Rundell T, Baby M, Bhatia NN, Khorram O, Friedman T, Storer TW, Bhasin S. Testosterone dose-response relationships in hysterectomized women with or without oophorectomy: effects on sexual function, body composition, muscle performance and physical function in a randomized trial. Menopause. 2014 Jun; 21(6):612-23. PMID: 24281237.
      Citations: 33     Fields:    Translation:Humans
    43. Sinha-Hikim I, Friedman TC, Shin CS, Lee D, Ivey R, Sinha-Hikim AP. Nicotine in combination with a high-fat diet causes intramyocellular mitochondrial abnormalities in male mice. Endocrinology. 2014 Mar; 155(3):865-72. PMID: 24424058.
      Citations: 17     Fields:    Translation:AnimalsCells
    44. Wang Y, Liu L, Du H, Nagaoka Y, Fan W, Lutfy K, Friedman TC, Jiang M, Liu Y. Transgenic overexpression of hexose-6-phosphate dehydrogenase in adipose tissue causes local glucocorticoid amplification and lipolysis in male mice. Am J Physiol Endocrinol Metab. 2014 Mar 01; 306(5):E543-51. PMID: 24381005.
      Citations: 6     Fields:    Translation:AnimalsCells
    45. Natividad LA, Torres OV, Friedman TC, O'Dell LE. Adolescence is a period of development characterized by short- and long-term vulnerability to the rewarding effects of nicotine and reduced sensitivity to the anorectic effects of this drug. Behav Brain Res. 2013 Nov 15; 257:275-85. PMID: 24120402.
      Citations: 24     Fields:    Translation:Animals
    46. Liu L, Nagashima K, Yasuda T, Liu Y, Hu HR, He G, Feng B, Zhao M, Zhuang L, Zheng T, Friedman TC, Xiang K. Mutations in KCNJ11 are associated with the development of autosomal dominant, early-onset type 2 diabetes. Diabetologia. 2013 Dec; 56(12):2609-18. PMID: 24018988.
      Citations: 16     Fields:    Translation:Humans
    47. Ren X, Lutfy K, Mangubat M, Ferrini MG, Lee ML, Liu Y, Friedman TC. Alterations in phosphorylated CREB expression in different brain regions following short- and long-term morphine exposure: relationship to food intake. J Obes. 2013; 2013:764742. PMID: 24073333.
      Citations: 10     Fields:    Translation:AnimalsCells
    48. Nie Y, Ferrini MG, Liu Y, Anghel A, Paez Espinosa EV, Stuart RC, Lutfy K, Nillni EA, Friedman TC. Morphine treatment selectively regulates expression of rat pituitary POMC and the prohormone convertases PC1/3 and PC2. Peptides. 2013 Sep; 47:99-109. PMID: 23891651.
      Citations: 2     Fields:    Translation:Animals
    49. O'Dell LE, Natividad LA, Pipkin JA, Roman F, Torres I, Jurado J, Torres OV, Friedman TC, Tenayuca JM, Nazarian A. Enhanced nicotine self-administration and suppressed dopaminergic systems in a rat model of diabetes. Addict Biol. 2014 Nov; 19(6):1006-19. PMID: 23834715.
      Citations: 22     Fields:    Translation:Animals
    50. Du H, Liu L, Wang Y, Nakagawa Y, Lyzlov A, Lutfy K, Friedman TC, Peng X, Liu Y. Specific reduction of G6PT may contribute to downregulation of hepatic 11?-HSD1 in diabetic mice. J Mol Endocrinol. 2013 Apr; 50(2):167-78. PMID: 23267038.
      Citations: 7     Fields:    Translation:AnimalsCells
    51. Teruya SA, Bazargan-Hejazi S, Mojtahedzadeh M, Doshi M, Russell K, Parker-Kelly D, Friedman TC. A Review of Programs, Components and Outcomes in Biomedical Research Faculty Development. Int J Univ Teach Fac Dev. 2013; 4(4):223-236. PMID: 26120379.
    52. Friedman TC, Sinha-Hikim I, Parveen M, Najjar SM, Liu Y, Mangubat M, Shin CS, Lyzlov A, Ivey R, Shaheen M, French SW, Sinha-Hikim AP. Additive effects of nicotine and high-fat diet on hepatic steatosis in male mice. Endocrinology. 2012 Dec; 153(12):5809-20. PMID: 23093702.
      Citations: 32     Fields:    Translation:AnimalsCells
    53. Davidson MB, Duran P, Lee ML, Friedman TC. High-dose vitamin D supplementation in people with prediabetes and hypovitaminosis D. Diabetes Care. 2013 Feb; 36(2):260-6. PMID: 23033239.
      Citations: 89     Fields:    Translation:Humans
    54. Tweed JO, Hsia SH, Lutfy K, Friedman TC. The endocrine effects of nicotine and cigarette smoke. Trends Endocrinol Metab. 2012 Jul; 23(7):334-42. PMID: 22561025.
      Citations: 70     Fields:    Translation:HumansAnimals
    55. Nguyen AT, Marquez P, Hamid A, Kieffer B, Friedman TC, Lutfy K. The rewarding action of acute cocaine is reduced in ?-endorphin deficient but not in ? opioid receptor knockout mice. Eur J Pharmacol. 2012 Jul 05; 686(1-3):50-4. PMID: 22575525.
      Citations: 17     Fields:    Translation:Animals
    56. Rajavashisth TB, Shaheen M, Norris KC, Pan D, Sinha SK, Ortega J, Friedman TC. Decreased prevalence of diabetes in marijuana users: cross-sectional data from the National Health and Nutrition Examination Survey (NHANES) III. BMJ Open. 2012; 2:e000494. PMID: 22368296.
      Citations: 59     Fields:    
    57. Lutfy K, Aimiuwu O, Mangubat M, Shin CS, Nerio N, Gomez R, Liu Y, Friedman TC. Nicotine stimulates secretion of corticosterone via both CRH and AVP receptors. J Neurochem. 2012 Mar; 120(6):1108-16. PMID: 22191943.
      Citations: 17     Fields:    Translation:Animals
    58. Mangubat M, Lutfy K, Lee ML, Pulido L, Stout D, Davis R, Shin CS, Shahbazian M, Seasholtz S, Sinha-Hikim A, Sinha-Hikim I, O'Dell LE, Lyzlov A, Liu Y, Friedman TC. Effect of nicotine on body composition in mice. J Endocrinol. 2012 Mar; 212(3):317-26. PMID: 22138237.
      Citations: 30     Fields:    Translation:Animals
    59. Friedman TC. Vitamin D supplementation to prevent the progression of prediabetes to diabetes: getting closer to a recommendation. Transl Res. 2011 Nov; 158(5):273-5. PMID: 22005266.
      Citations: 3     Fields:    Translation:Humans
    60. Parikh D, Hamid A, Friedman TC, Nguyen K, Tseng A, Marquez P, Lutfy K. Stress-induced analgesia and endogenous opioid peptides: the importance of stress duration. Eur J Pharmacol. 2011 Jan 15; 650(2-3):563-7. PMID: 21044625.
      Citations: 31     Fields:    Translation:AnimalsCells
    61. Kilimnik G, Kim A, Steiner DF, Friedman TC, Hara M. Intraislet production of GLP-1 by activation of prohormone convertase 1/3 in pancreatic a-cells in mouse models of ?-cell regeneration. Islets. 2010 May-Jun; 2(3):149-55. PMID: 20657753.
      Citations: 62     Fields:    Translation:AnimalsCells
    62. Chen J, Patel R, Friedman TC, Jones KS. The Behavioral and Pharmacological Actions of NMDA Receptor Antagonism are Conserved in Zebrafish Larvae. Int J Comp Psychol. 2010; 23(1):82-90. PMID: 21278812.
    63. Vuong C, Van Uum SH, O'Dell LE, Lutfy K, Friedman TC. The effects of opioids and opioid analogs on animal and human endocrine systems. Endocr Rev. 2010 Feb; 31(1):98-132. PMID: 19903933.
      Citations: 172     Fields:    Translation:HumansAnimals
    64. Liu Y, Nakagawa Y, Wang Y, Liu L, Du H, Wang W, Ren X, Lutfy K, Friedman TC. Reduction of hepatic glucocorticoid receptor and hexose-6-phosphate dehydrogenase expression ameliorates diet-induced obesity and insulin resistance in mice. J Mol Endocrinol. 2008 Aug; 41(2):53-64. PMID: 18524870.
      Citations: 19     Fields:    Translation:AnimalsCells
    65. Yuen KC, Cook DM, Sahasranam P, Patel P, Ghods DE, Shahinian HK, Friedman TC. Prevalence of GH and other anterior pituitary hormone deficiencies in adults with nonsecreting pituitary microadenomas and normal serum IGF-1 levels. Clin Endocrinol (Oxf). 2008 Aug; 69(2):292-8. PMID: 18221393.
      Citations: 15     Fields:    Translation:Humans
    66. Sahasranam P, Tran MT, Mohamed H, Friedman TC. Multiglandular parathyroid carcinoma: a case report and brief review. South Med J. 2007 Aug; 100(8):841-4. PMID: 17713315.
      Citations: 7     Fields:    Translation:Humans
    67. Lutfy K, Brown MC, Nerio N, Aimiuwu O, Tran B, Anghel A, Friedman TC. Repeated stress alters the ability of nicotine to activate the hypothalamic-pituitary-adrenal axis. J Neurochem. 2006 Dec; 99(5):1321-7. PMID: 17064351.
      Citations: 22     Fields:    Translation:Animals
    68. Espinosa VP, Ferrini M, Shen X, Lutfy K, Nillni EA, Friedman TC. Cellular colocalization and coregulation between hypothalamic pro-TRH and prohormone convertases in hypothyroidism. Am J Physiol Endocrinol Metab. 2007 Jan; 292(1):E175-86. PMID: 16926379.
      Citations: 4     Fields:    Translation:AnimalsCells
    69. Liu Y, Yan C, Wang Y, Nakagawa Y, Nerio N, Anghel A, Lutfy K, Friedman TC. Liver X receptor agonist T0901317 inhibition of glucocorticoid receptor expression in hepatocytes may contribute to the amelioration of diabetic syndrome in db/db mice. Endocrinology. 2006 Nov; 147(11):5061-8. PMID: 16873540.
      Citations: 28     Fields:    Translation:AnimalsCells
    70. Perello M, Friedman T, Paez-Espinosa V, Shen X, Stuart RC, Nillni EA. Thyroid hormones selectively regulate the posttranslational processing of prothyrotropin-releasing hormone in the paraventricular nucleus of the hypothalamus. Endocrinology. 2006 Jun; 147(6):2705-16. PMID: 16497799.
      Citations: 22     Fields:    Translation:AnimalsCells
    71. Marquez P, Baliram R, Gajawada N, Friedman TC, Lutfy K. Differential involvement of enkephalins in analgesic tolerance, locomotor sensitization, and conditioned place preference induced by morphine. Behav Neurosci. 2006 Feb; 120(1):10-5. PMID: 16492112.
      Citations: 16     Fields:    Translation:Animals
    72. McGirr R, Ejbick CE, Carter DE, Andrews JD, Nie Y, Friedman TC, Dhanvantari S. Glucose dependence of the regulated secretory pathway in alphaTC1-6 cells. Endocrinology. 2005 Oct; 146(10):4514-23. PMID: 15994347.
      Citations: 18     Fields:    Translation:AnimalsCells
    73. Hardiman A, Friedman TC, Grunwald WC, Furuta M, Zhu Z, Steiner DF, Cool DR. Endocrinomic profile of neurointermediate lobe pituitary prohormone processing in PC1/3- and PC2-Null mice using SELDI-TOF mass spectrometry. J Mol Endocrinol. 2005 Jun; 34(3):739-51. PMID: 15956344.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    74. Shen X, Li QL, Brent GA, Friedman TC. Regulation of regional expression in rat brain PC2 by thyroid hormone/characterization of novel negative thyroid hormone response elements in the PC2 promoter. Am J Physiol Endocrinol Metab. 2005 Jan; 288(1):E236-45. PMID: 15585599.
      Citations: 3     Fields:    Translation:AnimalsCells
    75. Liu Y, Nakagawa Y, Wang Y, Sakurai R, Tripathi PV, Lutfy K, Friedman TC. Increased glucocorticoid receptor and 11{beta}-hydroxysteroid dehydrogenase type 1 expression in hepatocytes may contribute to the phenotype of type 2 diabetes in db/db mice. Diabetes. 2005 Jan; 54(1):32-40. PMID: 15616008.
      Citations: 41     Fields:    Translation:AnimalsCells
    76. Sanchez VC, Goldstein J, Stuart RC, Hovanesian V, Huo L, Munzberg H, Friedman TC, Bjorbaek C, Nillni EA. Regulation of hypothalamic prohormone convertases 1 and 2 and effects on processing of prothyrotropin-releasing hormone. J Clin Invest. 2004 Aug; 114(3):357-69. PMID: 15286802.
      Citations: 40     Fields:    Translation:AnimalsCells
    77. Wang C, Swerdloff R, Kipnes M, Matsumoto AM, Dobs AS, Cunningham G, Katznelson L, Weber TJ, Friedman TC, Snyder P, Levine HL. New testosterone buccal system (Striant) delivers physiological testosterone levels: pharmacokinetics study in hypogonadal men. J Clin Endocrinol Metab. 2004 Aug; 89(8):3821-9. PMID: 15292312.
      Citations: 21     Fields:    Translation:HumansCTClinical Trials
    78. Friedman TC. Prolactinomas. N Engl J Med. 2004 Mar 04; 350(10):1054-7; author reply 1054-7. PMID: 14999121.
      Citations:    Fields:    Translation:Humans
    79. Choi HJ, Cornford M, Wang L, Sun J, Friedman TC. Acute chagas' disease presenting with a suprasellar mass and panhypopituitarism. Pituitary. 2004; 7(2):111-4. PMID: 15761661.
      Citations:    Fields:    Translation:HumansAnimals
    80. Friedman TC, Shahinian H. Bilateral cerebral aneurysms impinging on the pituitary. Pituitary. 2004; 7(3):193-194. PMID: 16328569.
      Citations:    Fields:    Translation:Humans
    81. Liu Y, Nakagawa Y, Wang Y, Li R, Li X, Ohzeki T, Friedman TC. Leptin activation of corticosterone production in hepatocytes may contribute to the reversal of obesity and hyperglycemia in leptin-deficient ob/ob mice. Diabetes. 2003 Jun; 52(6):1409-16. PMID: 12765951.
      Citations: 22     Fields:    Translation:AnimalsCells
    82. Li QL, Naqvi S, Shen X, Liu YJ, Lindberg I, Friedman TC. Prohormone convertase 2 enzymatic activity and its regulation in neuro-endocrine cells and tissues. Regul Pept. 2003 Feb 28; 110(3):197-205. PMID: 12573800.
      Citations: 5     Fields:    Translation:AnimalsCells
    83. Padero MC, Bhasin S, Friedman TC. Androgen supplementation in older women: too much hype, not enough data. J Am Geriatr Soc. 2002 Jun; 50(6):1131-40. PMID: 12110078.
      Citations: 7     Fields:    Translation:Humans
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