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Robert Meller

Faculty RankAssociate Professor
InstitutionMorehouse School of Medicine
Address720 Westview Drive, SW
Atlanta GA 30310
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    Collapse Research 
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    R21NS050669     (MELLER, ROBERT)Jan 15, 2005 - Jun 30, 2007
    Protein ubiquitination based neuroprotection for stroke
    Role: Principal Investigator

    R21NS054023     (MELLER, ROBERT)Sep 1, 2006 - Dec 30, 2008
    Rapid ischemic tolerance: Ubiquitin-mediated structural reorganization
    Role: Principal Investigator

    R01NS059588     (MELLER, ROBERT)Sep 30, 2008 - Aug 31, 2014
    Rapid ischemic tolerance: Synaptic re-organization and reduced excitotoxicity
    Role: Principal Investigator

    R21NS116726     (MELLER, ROBERT)May 1, 2020 - Oct 31, 2021
    Blood transcriptome profiling following seizures
    Role: Principal Investigator

    R01NS112422     (MELLER, ROBERT)Jul 15, 2020 - Apr 30, 2025
    Blood transcriptomics as CT adjuvant to exclude hemorrhage in acute stroke
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. McDonald JT, Enguita FJ, Taylor D, Griffin RJ, Priebe W, Emmett MR, Sajadi MM, Harris AD, Clement J, Dybas JM, Aykin-Burns N, Guarnieri JW, Singh LN, Grabham P, Baylin SB, Yousey A, Pearson AN, Corry PM, Saravia-Butler A, Aunins TR, Sharma S, Nagpal P, Meydan C, Foox J, Mozsary C, Cerqueira B, Zaksas V, Singh U, Wurtele ES, Costes SV, Davanzo GG, Galeano D, Paccanaro A, Meinig SL, Hagan RS, Bowman NM, Wolfgang MC, Altinok S, Sapoval N, Treangen TJ, Moraes-Vieira PM, Vanderburg C, Wallace DC, Schisler JC, Mason CE, Chatterjee A, Meller R, Beheshti A. Role of miR-2392 in driving SARS-CoV-2 infection. Cell Rep. 2021 10 19; 37(3):109839. PMID: 34624208.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    2. McDonald JT, Enguita FJ, Taylor D, Griffin RJ, Priebe W, Emmett MR, McGrath M, Sajadi MM, Harris AD, Clement J, Dybas JM, Aykin-Burns N, Guarnieri JW, Singh LN, Grabham P, Baylin SB, Yousey A, Pearson AN, Corry PM, Saravia-Butler A, Aunins TR, Nagpal P, Meydan C, Foox J, Mozsary C, Cerqueira B, Zaksas V, Singh U, Wurtele ES, Costes SV, Galeano D, Paccanaro A, Meinig SL, Hagan RS, Bowman NM, Wolfgang MC, Altinok S, Sapoval N, Treangen TJ, Frieman M, Vanderburg C, Wallace DC, Schisler J, Mason CE, Chatterjee A, Meller R, Beheshti A. The Great Deceiver: miR-2392's Hidden Role in Driving SARS-CoV-2 Infection. bioRxiv. 2021 Apr 27. PMID: 33948587.
    3. Overbey EG, Saravia-Butler AM, Zhang Z, Rathi KS, Fogle H, da Silveira WA, Barker RJ, Bass JJ, Beheshti A, Berrios DC, Blaber EA, Cekanaviciute E, Costa HA, Davin LB, Fisch KM, Gebre SG, Geniza M, Gilbert R, Gilroy S, Hardiman G, Herranz R, Kidane YH, Kruse CPS, Lee MD, Liefeld T, Lewis NG, McDonald JT, Meller R, Mishra T, Perera IY, Ray S, Reinsch SS, Rosenthal SB, Strong M, Szewczyk NJ, Tahimic CGT, Taylor DM, Vandenbrink JP, Villacampa A, Weging S, Wolverton C, Wyatt SE, Zea L, Costes SV, Galazka JM. NASA GeneLab RNA-seq consensus pipeline: standardized processing of short-read RNA-seq data. iScience. 2021 Apr 23; 24(4):102361. PMID: 33870146.
    4. Paul AM, Cheng-Campbell M, Blaber EA, Anand S, Bhattacharya S, Zwart SR, Crucian BE, Smith SM, Meller R, Grabham P, Beheshti A. Beyond Low-Earth Orbit: Characterizing Immune and microRNA Differentials following Simulated Deep Spaceflight Conditions in Mice. iScience. 2020 Dec 18; 23(12):101747. PMID: 33376970.
    5. da Silveira WA, Fazelinia H, Rosenthal SB, Laiakis EC, Kim MS, Meydan C, Kidane Y, Rathi KS, Smith SM, Stear B, Ying Y, Zhang Y, Foox J, Zanello S, Crucian B, Wang D, Nugent A, Costa HA, Zwart SR, Schrepfer S, Elworth RAL, Sapoval N, Treangen T, MacKay M, Gokhale NS, Horner SM, Singh LN, Wallace DC, Willey JS, Schisler JC, Meller R, McDonald JT, Fisch KM, Hardiman G, Taylor D, Mason CE, Costes SV, Beheshti A. Comprehensive Multi-omics Analysis Reveals Mitochondrial Stress as a Central Biological Hub for Spaceflight Impact. Cell. 2020 11 25; 183(5):1185-1201.e20. PMID: 33242417.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    6. Flippo KH, Lin Z, Dickey AS, Zhou X, Dhanesha NA, Walters GC, Liu Y, Merrill RA, Meller R, Simon RP, Chauhan AK, Usachev YM, Strack S. Deletion of a Neuronal Drp1 Activator Protects against Cerebral Ischemia. J Neurosci. 2020 04 08; 40(15):3119-3129. PMID: 32144179.
      Citations: 15     Fields:    Translation:AnimalsCells
    7. McDonald JT, Stainforth R, Miller J, Cahill T, da Silveira WA, Rathi KS, Hardiman G, Taylor D, Costes SV, Chauhan V, Meller R, Beheshti A. NASA GeneLab Platform Utilized for Biological Response to Space Radiation in Animal Models. Cancers (Basel). 2020 Feb 07; 12(2). PMID: 32045996.
    8. Ohandjo AQ, Liu Z, Dammer EB, Dill CD, Griffen TL, Carey KM, Hinton DE, Meller R, Lillard JW. Transcriptome Network Analysis Identifies CXCL13-CXCR5 Signaling Modules in the Prostate Tumor Immune Microenvironment. Sci Rep. 2019 10 18; 9(1):14963. PMID: 31628349.
      Citations: 10     Fields:    Translation:HumansCells
    9. Simon R, Meller R, Yang T, Pearson A, Wilson G. Enhancing Base Excision Repair of Mitochondrial DNA to Reduce Ischemic Injury Following Reperfusion. Transl Stroke Res. 2019 12; 10(6):664-671. PMID: 30535792.
      Citations: 12     Fields:    Translation:AnimalsCells
    10. Hardy JJ, Mooney SR, Pearson AN, McGuire D, Correa DJ, Simon RP, Meller R. Assessing the accuracy of blood RNA profiles to identify patients with post-concussion syndrome: A pilot study in a military patient population. PLoS One. 2017; 12(9):e0183113. PMID: 28863142.
      Citations: 4     Fields:    Translation:HumansCells
    11. Brager AJ, Yang T, Ehlen JC, Simon RP, Meller R, Paul KN. Sleep Is Critical for Remote Preconditioning-Induced Neuroprotection. Sleep. 2016 Nov 01; 39(11):2033-2040. PMID: 27568798.
      Citations: 3     Fields:    Translation:Animals
    12. Meller R, Pearson AN, Hardy JJ, Hall CL, McGuire D, Frankel MR, Simon RP. Blood transcriptome changes after stroke in an African American population. Ann Clin Transl Neurol. 2016 02; 3(2):70-81. PMID: 26900583.
      Citations: 9     Fields:    
    13. Meller R, Pearson A, Simon RP. Dynamic changes in DNA methylation in ischemic tolerance. Front Neurol. 2015; 6:102. PMID: 26029158.
    14. Meller R, Simon RP. A critical review of mechanisms regulating remote preconditioning-induced brain protection. J Appl Physiol (1985). 2015 Nov 15; 119(10):1135-42. PMID: 25953834.
      Citations: 18     Fields:    Translation:HumansAnimals
    15. Jessick VJ, Xie M, Pearson AN, Torrey DJ, Ashley MD, Thompson S, Meller R. Investigating the role of the actin regulating complex ARP2/3 in rapid ischemic tolerance induced neuro-protection. Int J Physiol Pathophysiol Pharmacol. 2013; 5(4):216-27. PMID: 24379906.
    16. Meller R, Galvan L, Lan JQ, Han E, Bauer J, Morris KT. Programmed cell death in a patient with hepatocellular carcinoma treated with yttrium-90 and doxorubicin-loaded beads. J Vasc Interv Radiol. 2013 Oct; 24(10):1537-42.e2. PMID: 24070510.
      Citations: 1     Fields:    Translation:Humans
    17. Meller R, Simon RP. Tolerance to ischemia - an increasingly complex biology. Transl Stroke Res. 2013 Feb; 4(1):40-50. PMID: 23504451.
      Citations: 15     Fields:    Translation:HumansAnimals
    18. McKiernan RC, Jimenez-Mateos EM, Bray I, Engel T, Brennan GP, Sano T, Michalak Z, Moran C, Delanty N, Farrell M, O'Brien D, Meller R, Simon RP, Stallings RL, Henshall DC. Reduced mature microRNA levels in association with dicer loss in human temporal lobe epilepsy with hippocampal sclerosis. PLoS One. 2012; 7(5):e35921. PMID: 22615744.
      Citations: 57     Fields:    Translation:HumansAnimals
    19. Meller CL, Meller R, Simon RP, Culpepper KM, Podrabsky JE. Cell cycle arrest associated with anoxia-induced quiescence, anoxic preconditioning, and embryonic diapause in embryos of the annual killifish Austrofundulus limnaeus. J Comp Physiol B. 2012 Oct; 182(7):909-20. PMID: 22570106.
      Citations: 10     Fields:    Translation:Animals
    20. Simon RP, Meller R, Zhou A, Henshall D. Can genes modify stroke outcome and by what mechanisms? Stroke. 2012 Jan; 43(1):286-91. PMID: 22156698.
      Citations: 10     Fields:    Translation:Humans
    21. Thompson SJ, Ashley MD, Stöhr S, Schindler C, Li M, McCarthy-Culpepper KA, Pearson AN, Xiong ZG, Simon RP, Henshall DC, Meller R. Suppression of TNF receptor-1 signaling in an in vitro model of epileptic tolerance. Int J Physiol Pathophysiol Pharmacol. 2011; 3(2):120-32. PMID: 21760970.
    22. Thompson S, Pearson AN, Ashley MD, Jessick V, Murphy BM, Gafken P, Henshall DC, Morris KT, Simon RP, Meller R. Identification of a novel Bcl-2-interacting mediator of cell death (Bim) E3 ligase, tripartite motif-containing protein 2 (TRIM2), and its role in rapid ischemic tolerance-induced neuroprotection. J Biol Chem. 2011 Jun 03; 286(22):19331-9. PMID: 21478148.
      Citations: 22     Fields:    Translation:AnimalsCells
    23. Engel T, Schindler CK, Sanz-Rodriguez A, Conroy RM, Meller R, Simon RP, Henshall DC. Expression of neurogenesis genes in human temporal lobe epilepsy with hippocampal sclerosis. Int J Physiol Pathophysiol Pharmacol. 2011; 3(1):38-47. PMID: 21479101.
    24. Ordonez AN, Jessick VJ, Clayton CE, Ashley MD, Thompson SJ, Simon RP, Meller R. Rapid ischemic tolerance induced by adenosine preconditioning results in Bcl-2 interacting mediator of cell death (Bim) degradation by the proteasome. Int J Physiol Pathophysiol Pharmacol. 2010; 2(1):36-44. PMID: 20957068.
    25. Loftus LT, Gala R, Yang T, Jessick VJ, Ashley MD, Ordonez AN, Thompson SJ, Simon RP, Meller R. Sumo-2/3-ylation following in vitro modeled ischemia is reduced in delayed ischemic tolerance. Brain Res. 2009 May 26; 1272:71-80. PMID: 19332039.
      Citations: 23     Fields:    Translation:AnimalsCells
    26. Meller R. The role of the ubiquitin proteasome system in ischemia and ischemic tolerance. Neuroscientist. 2009 Jun; 15(3):243-60. PMID: 19181875.
      Citations: 27     Fields:    Translation:HumansAnimals
    27. Sato Y, Meller R, Yang T, Taki W, Simon RP. Stereo-selective neuroprotection against stroke with vitamin A derivatives. Brain Res. 2008 Nov 19; 1241:188-92. PMID: 18824156.
      Citations: 5     Fields:    Translation:Animals
    28. Jimenez-Mateos EM, Hatazaki S, Johnson MB, Bellver-Estelles C, Mouri G, Bonner C, Prehn JH, Meller R, Simon RP, Henshall DC. Hippocampal transcriptome after status epilepticus in mice rendered seizure damage-tolerant by epileptic preconditioning features suppressed calcium and neuronal excitability pathways. Neurobiol Dis. 2008 Dec; 32(3):442-53. PMID: 18804535.
      Citations: 40     Fields:    Translation:AnimalsCells
    29. Meller R, Thompson SJ, Lusardi TA, Ordonez AN, Ashley MD, Jessick V, Wang W, Torrey DJ, Henshall DC, Gafken PR, Saugstad JA, Xiong ZG, Simon RP. Ubiquitin proteasome-mediated synaptic reorganization: a novel mechanism underlying rapid ischemic tolerance. J Neurosci. 2008 Jan 02; 28(1):50-9. PMID: 18171922.
      Citations: 46     Fields:    Translation:AnimalsCells
    30. Thompson SJ, Loftus LT, Ashley MD, Meller R. Ubiquitin-proteasome system as a modulator of cell fate. Curr Opin Pharmacol. 2008 Feb; 8(1):90-5. PMID: 17981502.
      Citations: 32     Fields:    Translation:HumansAnimals
    31. Pignataro G, Meller R, Inoue K, Ordonez AN, Ashley MD, Xiong Z, Gala R, Simon RP. In vivo and in vitro characterization of a novel neuroprotective strategy for stroke: ischemic postconditioning. J Cereb Blood Flow Metab. 2008 Feb; 28(2):232-41. PMID: 17882162.
      Citations: 92     Fields:    Translation:Animals
    32. Murphy B, Dunleavy M, Shinoda S, Schindler C, Meller R, Bellver-Estelles C, Hatazaki S, Dicker P, Yamamoto A, Koegel I, Chu X, Wang W, Xiong Z, Prehn J, Simon R, Henshall D. Bcl-w protects hippocampus during experimental status epilepticus. Am J Pathol. 2007 Oct; 171(4):1258-68. PMID: 17702891.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    33. Rosenzweig HL, Minami M, Lessov NS, Coste SC, Stevens SL, Henshall DC, Meller R, Simon RP, Stenzel-Poore MP. Endotoxin preconditioning protects against the cytotoxic effects of TNFalpha after stroke: a novel role for TNFalpha in LPS-ischemic tolerance. J Cereb Blood Flow Metab. 2007 Oct; 27(10):1663-74. PMID: 17327883.
      Citations: 84     Fields:    Translation:AnimalsCells
    34. Simon R, Henshall D, Stoehr S, Meller R. Endogenous mechanisms of neuroprotection. Epilepsia. 2007; 48 Suppl 8:72-3. PMID: 18330006.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    35. Yamamoto A, Schindler CK, Murphy BM, Bellver-Estelles C, So NK, Taki W, Meller R, Simon RP, Henshall DC. Evidence of tumor necrosis factor receptor 1 signaling in human temporal lobe epilepsy. Exp Neurol. 2006 Dec; 202(2):410-20. PMID: 16919273.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    36. Meller R, Cameron JA, Torrey DJ, Clayton CE, Ordonez AN, Henshall DC, Minami M, Schindler CK, Saugstad JA, Simon RP. Rapid degradation of Bim by the ubiquitin-proteasome pathway mediates short-term ischemic tolerance in cultured neurons. J Biol Chem. 2006 Mar 17; 281(11):7429-36. PMID: 16431916.
      Citations: 45     Fields:    Translation:AnimalsCells
    37. Meller R, Minami M, Cameron JA, Impey S, Chen D, Lan JQ, Henshall DC, Simon RP. CREB-mediated Bcl-2 protein expression after ischemic preconditioning. J Cereb Blood Flow Metab. 2005 Feb; 25(2):234-46. PMID: 15647742.
      Citations: 91     Fields:    Translation:AnimalsCells
    38. Meller R, Stevens SL, Minami M, Cameron JA, King S, Rosenzweig H, Doyle K, Lessov NS, Simon RP, Stenzel-Poore MP. Neuroprotection by osteopontin in stroke. J Cereb Blood Flow Metab. 2005 Feb; 25(2):217-25. PMID: 15678124.
      Citations: 85     Fields:    Translation:HumansAnimalsCells
    39. Henshall DC, Schindler CK, So NK, Lan JQ, Meller R, Simon RP. Death-associated protein kinase expression in human temporal lobe epilepsy. Ann Neurol. 2004 Apr; 55(4):485-94. PMID: 15048887.
      Citations: 14     Fields:    Translation:HumansCells
    40. Shinoda S, Schindler CK, Meller R, So NK, Araki T, Yamamoto A, Lan JQ, Taki W, Simon RP, Henshall DC. Bim regulation may determine hippocampal vulnerability after injurious seizures and in temporal lobe epilepsy. J Clin Invest. 2004 Apr; 113(7):1059-68. PMID: 15057313.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
    41. Araki T, Shinoda S, Schindler CK, Quan-Lan J, Meller R, Taki W, Simon RP, Henshall DC. Expression, interaction, and proteolysis of death-associated protein kinase and p53 within vulnerable and resistant hippocampal subfields following seizures. Hippocampus. 2004; 14(3):326-36. PMID: 15132432.
      Citations: 11     Fields:    Translation:AnimalsCells
    42. Stenzel-Poore MP, Stevens SL, Xiong Z, Lessov NS, Harrington CA, Mori M, Meller R, Rosenzweig HL, Tobar E, Shaw TE, Chu X, Simon RP. Effect of ischaemic preconditioning on genomic response to cerebral ischaemia: similarity to neuroprotective strategies in hibernation and hypoxia-tolerant states. Lancet. 2003 Sep 27; 362(9389):1028-37. PMID: 14522533.
      Citations: 174     Fields:    Translation:HumansAnimalsCells
    43. Shinoda S, Skradski SL, Araki T, Schindler CK, Meller R, Lan JQ, Taki W, Simon RP, Henshall DC. Formation of a tumour necrosis factor receptor 1 molecular scaffolding complex and activation of apoptosis signal-regulating kinase 1 during seizure-induced neuronal death. Eur J Neurosci. 2003 May; 17(10):2065-76. PMID: 12786973.
      Citations: 31     Fields:    Translation:AnimalsCells
    44. Chen D, Minami M, Henshall DC, Meller R, Kisby G, Simon RP. Upregulation of mitochondrial base-excision repair capability within rat brain after brief ischemia. J Cereb Blood Flow Metab. 2003 Jan; 23(1):88-98. PMID: 12500094.
      Citations: 10     Fields:    Translation:AnimalsCells
    45. Henshall DC, Skradski SL, Meller R, Araki T, Minami M, Schindler CK, Lan JQ, Bonislawski DP, Simon RP. Expression and differential processing of caspases 6 and 7 in relation to specific epileptiform EEG patterns following limbic seizures. Neurobiol Dis. 2002 Jul; 10(2):71-87. PMID: 12127146.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    46. Meller R, Skradski SL, Simon RP, Henshall DC. Expression, proteolysis and activation of caspases 6 and 7 during rat C6 glioma cell apoptosis. Neurosci Lett. 2002 May 10; 324(1):33-6. PMID: 11983288.
      Citations: 7     Fields:    Translation:AnimalsCells
    47. Meller R, Babity JM, Grahame-Smith DG. 5-HT2A receptor activation leads to increased BDNF mRNA expression in C6 glioma cells. Neuromolecular Med. 2002; 1(3):197-205. PMID: 12095161.
      Citations: 10     Fields:    Translation:AnimalsCells
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